Amyloid-targeted metal chelation, anti-oxidative stress, and anti-inflammation as potential Alzheimer's therapies

Current Bioactive Compounds

Volumn 4, Issue 3, 2008, Pages 140-149

  Fydrych, A ^a   Moir, R D ^b   Huang, C ^b   Shi, Y ^a   Rogers, J T ^b   Huang, X ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

A amyloidosis; Alzheimer's disease; Amyloid precursor protein; Antioxidant; Metal chelator; Metals; Neuroinflammation; Oxidative stress

Indexed keywords

8 QUINOLINOL; ALPHA 2 MACROGLOBULIN; ALPHA TOCOPHEROL; ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; ANTIOXIDANT; APOLIPOPROTEIN E; CATALASE; CHELATING AGENT; CLIOQUINOL; COPPER; COPPER ZINC SUPEROXIDE DISMUTASE; DEFEROXAMINE; FERRITIN; HEME OXYGENASE 1; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; IRON; MANGANESE SUPEROXIDE DISMUTASE; PAROXETINE; PENTOSIDINE; PLACEBO; PRESENILIN 1; PRESENILIN 2; TAU PROTEIN; UNINDEXED DRUG; ZINC;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; CHELATION THERAPY; CLINICAL TRIAL; DRUG EFFICACY; DRUG FATALITY; DRUG PENETRATION; DRUG SELECTIVITY; DRUG TARGETING; ENCEPHALITIS; GENE MUTATION; HUMAN; MENINGOENCEPHALITIS; NEUROFIBRILLARY TANGLE; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SENILE PLAQUE; UNSPECIFIED SIDE EFFECT; VACCINATION;

EID: 62149136247     PISSN: 15734072     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340708786305989     Document Type: Review

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