Novel D-penicillamine carrying nanoparticles for metal chelation therapy in Alzheimer's and other CNS diseases

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 59, Issue 2, 2005, Pages 263-272

  Cui, Zhengrong ^a   Lockman, Paul R ^b   Atwood, Craig S ^c,d   Hsu, Cheng Hsuan ^a   Gupte, Anshul ^a   Allen, David D ^b   Mumper, Russell J ^a  

^a University of Kentucky   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d EDITH COWAN UNIVERSITY   (Australia)

Author keywords

Amyloid; Aggregates; Alzheimer's disease; Copper; Metal chelation; Resolubilization; Wilson's disease

Indexed keywords

COPPER; DITHIOTHREITOL; GLUTATHIONE; INORGANIC SALT; METAL CHELATE; NANOPARTICLE; PENICILLAMINE; REDUCING AGENT; SULFIDE;

ALZHEIMER DISEASE; AQUEOUS SOLUTION; ARTICLE; BIOACCUMULATION; CENTRAL NERVOUS SYSTEM DISEASE; CHELATION THERAPY; COVALENT BOND; DISULFIDE BOND; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG FORMULARY; DRUG POTENCY; DRUG RELEASE; DRUG SCREENING; DRUG SOLUBILITY; DRUG STABILITY; IONIZATION; PH MEASUREMENT; PROVOCATION; SERUM; SUSPENDED PARTICULATE MATTER; TEMPERATURE DEPENDENCE;

ALZHEIMER DISEASE; CENTRAL NERVOUS SYSTEM DISEASES; CHELATING AGENTS; COPPER; DRUG CARRIERS; DRUG STABILITY; NANOSTRUCTURES; PARTICLE SIZE; PENICILLAMINE;

EID: 12344251715     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2004.07.009     Document Type: Article

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