Alzheimer's disease amyloid β-protein forms Zn2+-sensitive, cation- selective channels across excised membrane patches from hypothalamic neurons

Biophysical Journal

Volumn 73, Issue 1, 1997, Pages 67-75

  Kawahara, M ^a   Arispe, N ^b   Kuroda, Y ^a   Rojas, E ^b,c,d,e  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF CHILE   (Chile)

^e NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CATION CHANNEL; ZINC;

ALZHEIMER DISEASE; ARTICLE; BILAYER MEMBRANE; CELL MEMBRANE; CONFOCAL MICROSCOPY; HUMAN; HUMAN CELL; HYPOTHALAMUS; IMMUNOCYTOCHEMISTRY; ION CURRENT; NEUROTOXICITY; PHOSPHOLIPID BILAYER; PROTEIN BINDING;

EID: 0030966536     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(97)78048-2     Document Type: Article

References (35)

1. Arispe, N., H. B. Pollard, and E. Rojas. 1993a. Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein (AβP-[1-40]) in bilayer membranes. Proc. Natl. Acad. Sci. USA. 90: 10573-10577.
2. 2+-channel hypothesis for neuronal death in Alzheimer disease. Mol. Cell. Biochem. 140:119-125.
3. 2+ interaction with Alzheimer amyloid β-protein calcium channels. Proc. Natl. Acad. Sci. USA. 93:1710-1715.
4. Arispe, N., E. Rojas, and H. B. Pollard. 1993b. Alzheimer disease amyloid β-protein forms calcium channels in bilayer membranes: blockade by thrometamine and aluminum. Proc. Natl. Acad. Sci. USA. 90:567-571.
5. Bush, A. I., G. Multhaup, R. D. Moir, T. G. Williamson, D. H. Small, B. Rumble, P. Pollwein, K. Beyreuther, and C. L. Masters. 1993. A novel zinc binding site modulates the function of the βA4 amyloid protein precursor of Alzheimer's disease. J. Biol. Chem. 268:16109-16112.
6. Bush, A. I., W. H. Pettingell, G. Multhaup, and M. D. Paradis. 1994. Rapid induction of Alzheimer A beta amyloid formation by zinc. Science. 265:1464-1467.
7. Durell, S. R., H. R. Guy, N. Arispe, E. Rojas, and H. B. Pollard. 1994. Theoretical models of the ion channel structure of amyloid β-protein. Biophys. J. 67:2137-2145.
8. Ellisman, M. H., T. J. Deerinck, Y. Ouyang, C. F. Beck, S. J. Tanksley, P. D. Walton, J. A. Airey, and J. L. Sutko. 1990. Identification and location of ryanodine binding proteins in the avian central nervous system. Neuron. 5:135-146.
9. Ellisman, M. H., J. D. Lindsey, B. O. Carragher, S. H. Kiyonaga, L. R. McEwen, and B. F. McEwen. 1991. Ryanodine and inositol triphosphate receptors coexist in avian cerebellar Purkinje neurons. J. Cell. Biol. 113:1145-1157.
10. Frautschy, S. A., A. Baird, and G. M. Cole. 1991. Effects of injected Alzheimer β-amyloid cores in rat brain. Proc. Natl. Acad. Sci. USA. 88:8362-8366.
11. Frazer, S. P., Y-H. Suh, and M. B. A. Djamgoz. 1997. Ionic effects of the Alzheimer's disease β-amyloid precursor protein and its metabolic fragments. Trends Neurosci. 20:67-72.
12. Fuson, K. S., L. N. Boggs, and P. C. May. 1996. Zinc attenuates amyloid β-protein [1-40] neurotoxicity. Abstr. Soc. Neurosci. 22:195.
13. Goldgaber, D., M. I. Lerman, O. W. McBride, U. Saffiotti, and C. Gajdusek. 1987. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science. 235:877-880.
14. Hardy, J. A., and G. A. Higgins. 1992. Alzheimer's disease: the amyloid cascade hypothesis. Science. 256:780-783.
15. Hass, C., and D. J. Selkoe. 1993. Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide. Cell. 75: 1039-1042.
16. Kawahara, M., Y. Kuroda, N. Arispe, and E. Rojas. 1996. Direct incorporation of amyloid β-protein cation channels into excised membrane patches from GnRH neurons. Biophys. J. 70:A241.
17. Kowall, N. C., A. C. McKee, B. A. Yankner, and M. F. Beal. 1992. In vivo neurotoxicity of beta amyloid (β(1-40)] and the β(25-35) fragment. Neurobiol. Aging. 13:537-542.
18. Malouf, A. T. 1992. Effect of beta amyloid peptides on neurons in hippocampal slice cultures. Neurobiol. Aging. 13:543-551.
19. Martone, M. E., Y. Zhang, V. M. Simpliacino, B. O. Carragher, and M. H. Ellisman. 1993. Three-dimensional visualization of the smooth endoplasmic reticulum in Purkinje cell dendrites. J. Neurosci. 13: 4636-4646.
20. Masters, C. L., G. Simms, N. A. Weinman, G. Multhaup, B. L. McDonald, and K. Beyreuther. 1985. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. Natl. Acad. Sci. USA. 82: 4245-4249.
21. Matson, M. P., B. Cheng, D. Davis, K. Bryant, I. Lieberberg, and R. E. Rydel. 1992. β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to exocitotoxicity. J. Neurosci. 12:376-389.
22. May, P. C., L. N. Boggs, Z. Zhang, G. J. Drsewiecki, P. A. Hyslop, and K. S. Fuson. 1996. Zinc interferes with AβP[1-40] deposition onto cultured neurons: correlation with neuroprotection. Abstr. Soc. Neurosci. 22:196.
23. Mellon, P. L., J. J. Windle, P. C. Goldsmith, J. L. Padula, and R. I. Weiner. 1990. Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron. 5:1-10.
24. Neve, R. L., L. R. Dawes, B. A. Yankner, L. L. Benowitz, W. Rodriguez, and G. A. Higgins. 1990. Genetics and biology of the Alzheimer amyloid precursor. Prog. Brain Res. 86:257-267.
25. Pollard, J. R., N. Arispe, E. Rojas, and H. B. Pollard. 1994. A geometric sequence that accurately describes allowed multiple conductance levels of ion channels: the "three-halves (3/2) rule." Biophys. J. 67:647-655.
26. Rojas, E., J. Hidalgo, P. B. Carroll, M-X. Xu Li, and I. Atwater. 1990. A new class of calcium channels activated by glucose in human pancreatic β-cells. FEBS Lett. 261:265-270.
27. Selkoe, D. J. 1991. The molecular pathology of Alzheimer's disease. Neuron. 6:487-498.
28. Seubert, P., C. Vigo-Pelfrey, F. Esh, M. Lee, L. Dovey, D. Davis, S. Sinha, M. Schlossmacher, J. Whaley, C. Swindlehurst, R. McCormack, D. Selkoe, I. Lieberburg, and D. Schenk. 1992. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids. Nature. 259: 325-327.
29. Sharp, A. H., T. M. Dawson, C. A. Ross, M. Fotuhi, R. J. Mourey, and S. Snyder. 1993. Inositol 1,4,5-triphosphate receptors: immunohistochemical localization to discrete areas of rat central nervous system. Neuroscience. 53:927-942.
30. Spergel, D. J., K. J. Catt, and E. Rojas. 1996. Immortalized GnRH neurons express large-conductance calcium-activated potassium channels. Neuroendocrinology. 63:101-111.
31. i and neuropeptide secretion in immortalized gonadotropin-releasing hormone neurons. Neuroendocrinology. 61: 499-508.
32. Tabaton, M., M. G. Nunzi, R. Xue, M. Usiak, L. Autilio-Gambetti, and P. Gambetti. 1994. Soluble amyloid β protein is a marker of Alzheimer amyloid in brain but not in cerebrospinal fluid. Biochem. Biophys. Res. Commun. 200:1598-1603.
33. Tanzi, R. E., J. F. Gusella, P. C. Watkins, G. A. P. Bruns, P. St. George-Hyslop, M. L. Van Keuren, D. Patterson, S. Pagan, D. M. Kurnit, and R. L. Neve. 1987. Amyloid β-protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science. 235:880-882.
34. Yankner, B. A. 1992. Commentary and perspective on studies of beta amyloid neurotoxicity. Neurobiol. Aging. 13:615-616.
35. Yankner, B. L., L. K. Duffy, and D. A. Kirschner. 1990. Neurotropic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science. 250:279-282.