Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides

Nature Genetics

Volumn 14, Issue 1, 1996, Pages 55-61

  Miyata, Masaaki ^a   Smith, Jonathan D ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; HYDROGEN PEROXIDE;

ALLELE; ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; CARDIOVASCULAR DISEASE; CELL LINE; CYTOTOXICITY; LONGEVITY; OXIDATION; PRIORITY JOURNAL;

ALLELES; AMYLOID BETA-PROTEIN; ANIMALS; ANTIOXIDANTS; APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; CELL DEATH; CELL LINE; HYDROGEN PEROXIDE; METALS; OXIDATION-REDUCTION; PEPTIDE FRAGMENTS; RATS;

EID: 0029765553     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng0996-55     Document Type: Article

References (46)

1. Corder, E.H. et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Sdence 261, 921 -923 (1993).
2. Mayeux, R. et al. The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease. Ann. Neurol. 34, 752-754 (1993).
3. van Duijin, C.M. et al. Apolipoprotein E4 allele in a population-based study of early-onset alzheimer's disease. Nature Genetics 7, 74-78 (1994).
4. Hendrie, H.C. et al. Apolipoprotein E genotypes and AD in a community study of elderly African Americans. Ann. Neurol. 37, 118-120 (1995).
5. Saunders, A.M. et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43, 1467-1472(1993).
6. Corder, E.H. et al. Protective effect of apolipoprotein E type 2 allele for late onset alzheimer disease. Nature Genet. 7, 180-184 (1994).
7. Maestre, G. et al. Apolipoprotein E and Alzheimer's disease: ethnic variation in genotypic risks. Ann. Neurol. 37, 254-259 (1995).
8. Xhignesse, M., Lussier-Cacan, S., Sing, C.F., Kessling, A.M. & Davignon, J. Influences of common variants of apolipoprotein E on measures of lipid metabolism in a sample selected for health. Arterioscler. Thromb. 11, 1100-1110(1991).
9. Stengard, J.H. et al. Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Rnnish men. Circulation 91, 265-269 (1995).
10. van Bockxmeer, P.M., Mamotte, C.D., Gibbons, F.R. & Taylor, R.R. Apolipoprotein epsilon 4 homozygosity -a determinant of restenosis after coronary angioplasty./Afheroscfe/: 110, 195-202(1994).
11. Schachter, F. et al. Genetic associations with human longevity at the apoE and ACE loci. Nature Genet 6, 29-32 (1994).
12. Louhija, J. et al. Aging and genetic variation of plasma apolipoproteins., Arterioscler. Thromb. 14, 1084-1089(1994).
13. Goate, A. et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349, 704706(1991).
14. Pike, C.J., Burdick, D., Walencewicz, A.J., Gabe, C.G. & Cotman, C.W. Neurodegeneration induced by ß-amyloid peptides in vitro: the role of peptide assembly state. J. Neuroscl. 13, 1676-1687 (1993).
15. Behl. C., Davis, J., Cole, G.M. & Schubert. D. Vitamin E protects nerve cells from amyloid ßprotein toxicity. Biochem. Biophys. Res. Comm. 186, 944-950(1992).
16. Behl, C., Davis, J., Lesley, R. & Schubert, D. Hydrogen peroxide mediates amyloid ßprotein toxicity. Cell 77, 817-827 (1994).
17. Butterfield, DA, Hensley, K., Harris, M., Mattson, M. & Carney, J. ßamyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence specific fashion: implications to Alzheimer's disease. Biochem. Biophys. Res. Comm. 200, 710-715 (1994).
18. Wisniewski, T. & Frangione, B. Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci. Lett 135, 235-238(1992).
19. Sanan, DA et al. Apolipoprotein E associates with ßamyloid peptide of Alzheimer's disease to form novel monofibrils. J. Clin. Invest. 94, 860-869 (1994).
20. Ma, J., Yee, A., Brewer, H.B., Das, S. & Potter, H. Amyloid-associated proteins a1 -antichymotrypsin and apolipoprotein E promote assembly of Alzheimer ß-protein into filaments. Nature 372, 92-94 (1994). '
21. Nathan, B.P. et al. Differential effects of apolipoprotein E3 and E4 on neuronal growth in vitro. Sdence 264, 850-852 (1994).
22. Hartmann, H., Eckert, A. & Muller, W.E. Apolipoprotein E and cholesterol affect neuronal calcium signaling: the possible relationship between ßamyloid and neurotoxicity. Biochem. Biophys. Res. Comm. 200, 11851192(1994).
23. Strittmater, W.J. et al. Isoform-specific interactions of apolipoprotein E with microtubule associated protein tau: Implications for Alzheimer disease. Proc. Nail. Acad. Sci. U.S.A. 91, 11183-11186 (1994).
24. Hayek. T., Oikinine, J., Brook, J.G. & Avriam, M. Increased plasma and lipoprotein lipid peroxidation in apolipoprotein E deficient mice. Biochem. Biophys. Res. Comm. 201, 1567-1574 (1994).
25. Rinninger, F. & Pittman, R.C. Mechanism of the cholesteryl ester transfer protein-mediated uptake of high density lipoprotein cholesteryl esters by Hep G2 cells. J.Biol.Chem. 264, 6111-6118(1989).
26. Jaeckle, S., Brady, S.E. & Havel, R.J. Membrane binding sites for plasma lipoproteins on endosomes from rat liver. Proc. Watt Acad. Sci. U.S.A. 86, 1880-1884(1989).
27. Weisgraber, K.H., Innerarity, T.L & Mahley, R.W. Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts. J. Biol. Chem. 253, 9053-9062 (1978).
28. Maxwell, S.J.R., Wiklund, O. & Bondjers, G. Measurement of antioxidant activity in lipoproteins using enhanced chemiluminescence. Atheroscler. 111, 79-89 (1994).
29. Dong, LM. et al. Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. J. Biol. Chem. 269, 22358-22365(1994).
30. Schaefer, E.J. et al. Familial apolipoprotein E deficiency. J. Clin. Invest. 78, 1206-1219(1986).
31. Plump, A.S. et al. Severe hypercholesterolaemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Ce 71, 343-353 (1992).
32. Lehtimaki, T. et al. Apolipoprotein E polymorphism and its influence on apoE concentrations in cerebrospinal fluid in Finnish patients with Alzheimer's disease. Hum. Genet. 95, 39-42 (1995).
33. Burdick, D. et al. Assembly and aggregation properties of synthetic Alzheimer's A/4ß amyloid peptide analogs. J. Biol. Chem. 267, 546554(1992).
34. Strittmatter, W.J. et al. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset alzheimer disease. Proc. Watt Acad. Scl. U.S.A. 90, 8098-8102(1993).
35. Wisniewski, T., Golabek, A., Matsubara, E., Ghiso, J. & Frangione, B. Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid. Biochem. Biophys. Res. Comm. 192, 359-365 (1993).
36. Evans, K.C., Berger, E.P., Cho, C.-G., Weisgraber, K.H. & Lansbury, P.T.J. Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: Implications forthepathogenesisand treatment of Alzheimer disease. Proc. Watt Acad. Soi. U.S.A. 92, 763-767 (1995).
37. LaDu, M.J. et al. Isoform-specific binding of apolipoprotein E to ßamyloid. J. Biol. Chem. 269, 23403-23406 (1994).
38. LaDu, M.J. et al. Purification of apoE attenuates isoform-specific binding to ß-amyloid. J. Biol. Chem. 270, 9039-9042 (1995).
39. Whitson, J.S. et al. Attenuation of the neurotoxic effect of ßamyloid by apolipoprotein E. Biochem. Biophys. Res. Comm. 199, 163-170 (1994).
40. Buettner, G.R. The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. Arch. Biochem. Biophys. 300, 535-543 (1993).
41. Kunitake, S.T., Jarvis, M.R., Hamilton, R.L & Kane, J.P. Binding of transition metals by apolipoprotein A-l-containing plasma lipoproteins: inhibition of oxidation of low density lipoproteins. Proc. Watt Acad. Sci. U.S.A 89, 6993-6997 (1992).
42. Ehrenwald. E., Chisolm, G.M. & Fox, P.L Intact human ceruloplasmin oxidatively modifies low density lipoprotein. J. Clin. Invest. 93, 1493-1501 (1994).
43. Mantyh, P.W. et al. Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide. J. Neurochem. 61, 1171 -1174 (1993).
44. Regan, L Protein design: novel metal-binding sites. Trends Biochem. Sci. 20, 280-285(1995).
45. Smith, J.D., Melian, A., Left, T. & Breslow, J.L. Expression of the human apolipoprotein E gene is regulated by multiple positive and negative elements. J. Biol. Chem. 263, 8300-8308 (1988).
46. Buege, J.A.& Aust, S.D. Microsomal lipid peroxidation. Meth. Enzymol. 52, 302-310(1978).