Reduction of β‐amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease

Annals of Neurology

Volumn 38, Issue 4, 1995, Pages 643-648

  Motter, R ^a   Vigo Pelfrey C ^a   Kholodenko, D ^a   Barbour, R ^a   Johnson Wood K ^a   Galasko, D ^b,g   Chang, L ^c   Miller, B ^c   Clark, C ^d   Green, R ^e   Olson, D ^e   Southwick, P ^f   Wolfert, R ^f   Munroe, B ^f   Lieberburg, I ^a   Seubert, P ^a   Schenk, D ^a  

^a Athena Neurosciences Inc   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HARBOR UCLA MEDICAL CENTER   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e EMORY UNIVERSITY   (United States)

^f Hybritech Incorporated   (United States)

^g VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PROTEIN; APOLIPOPROTEIN E; BIOCHEMICAL MARKER; TAU PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CEREBROSPINAL FLUID ANALYSIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMENTIA; DIAGNOSTIC VALUE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENOTYPE; HUMAN; MALE; NEUROLOGIC DISEASE; PEPTIDE ANALYSIS; PRIORITY JOURNAL;

AGED; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; APOLIPOPROTEINS E; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; TAU PROTEINS;

EID: 0028982454     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.410380413     Document Type: Article

References (25)

1. Diagnosis of Alzheimer's disease
2. Association of apolipoprotein E allele 4 with late‐onset familial and sporadic Alzheimer's disease
3. Detection of τ proteins in normal and Alzheimer's disease cerebrospinal fluid with a sensitive sandwich ELISA
4. Elevation of microtubule‐associated protein tau in the cerebrospinal fluid of Alzheimer's patients
5. Amyloid β protein levels in cerebrospinal fluid are elevated in early‐onset Alzheimer's disease
6. Visualization of Aβ42(43) and Aβ40 in senile plaques with end‐specific monoclonals: evidence that an initially deposited species is Aβ42(43)
7. Structural alterations in the peptide backbone of β‐amyloid core protein may account for its deposition and stability in Alzheimer's disease
8. Characterization of β‐amyloid peptides from normal cerebral spinal fluid
9. “Mini‐mental State”: a practical method for grading the cognitive state of patients for the clinician
10. Development of a rating scale for primary depressive illness
11. Cerebral blood flow in dementia
12. Clinical neuropathological correlations in Alzheimer's disease and related dementias
13. Clinical diagnosis of AD
14. The Lund and Manchester Groups. Clinical and neuropathological criteria for frontotemporal dementia
15. Sample preparation from blood, cells, and other fluids
16. Apolipoprotein E genotyping by one‐stage PCR
17. Isolation and quantification of soluble Alzheimer's β‐peptide from biological fluids
18. Brain levels of microtubule associated protein τ are elevated in Alzheimer's disease: a radioimmunoslot‐blot assay for nanograms of protein
19. Abnormal metabolism of gamma‐trace alkaline micro proteins. The basic defect in hereditary cerebral hemorrhage with amyloidosis
20. The time course of pathological events in Down's syndrome with particular reference to the involvement of microglial cells and deposits of β/A4
21. The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease
22. Apolipoprotein E: high affinity binding to βA amyloid and increased frequency of type 4 allele in familial Alzheimer's
23. Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer's disease brain are related to apolipoprotein E genotype
24. Alzheimer's disease. A double labeling immunohistochemical study of senile plaques