Zinc-induced aggregation of human and rat β-amyloid peptides in vitro

Journal of Neurochemistry

Volumn 66, Issue 2, 1996, Pages 723-732

  Esler, William P ^a   Stimson, Evelyn R ^a   Jennings, Joan M ^a   Ghilardi, Joseph R ^b,c   Mantyh, Patrick W ^b,c   Maggio, John E ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Aggregation; Alzheimer's disease; Zinc; Amyloid

Indexed keywords

AMYLOID BETA PROTEIN; ZINC;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; NEUROTOXICITY; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; RADIOIODINATION; RAT; RISK FACTOR;

ANIMALIA;

EID: 0030066143     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66020723.x     Document Type: Article

References (63)

1. 2- from brain tissue during activity. Nature 308, 734-736.
2. Benson J. R., Louie P. C., and Bradshaw R. A. (1981) Amino acid analysis of peptides, in The Peptides, Vol 4 (Gross E. and Meienhofer J., eds), pp. 217-260. Academic Press, New York.
3. Brown A. M., Tummolo D. M., Hofmann J., Jacobsen J. S., and Sonnenberg-Reines J. (1995) Zinc induces aggregation of PN2 and βAP in dog, monkey, and human cerebrosional fluid. Soc. Neurosci. Abstr. 21, 1281.
4. Burdick D., Soreghan B., Kwon M., Kosmoski J., Knauer M., Henschen A., Yates J., Cotman C., and Glabe C. (1992) Assembly and aggregation properties of synthetic Alzheimer's A4/β amyloid peptide analogs. J. Biol. Chem. 267, 546-554.
5. Busciglio J., Lorenzo A., and Yankner B. A. (1992) Methodological variables in the assessment of beta amyloid neurotoxicity. Neurobiol. Aging 13, 609-612.
6. Busciglio J., Gabuzda D. H., Matsudaira P., and Yankner B. A. (1993) Generation of β-amyloid in the secretory pathway in neuronal and nonneuronal cells. Proc. Natl. Acad. Sci. USA. 90, 2092-2096.
7. Bush A. I., Pettingell W. H., d. Paradis M., and Tanzi R. E. (1994a) Modulation of Aβ adhesiveness and secretase site cleavage by zinc. J. Biol. Chem. 269, 12152-12158.
8. Bush A. I., Pettingell W. H., Multhaup G., d. Paradis M., Vonstattel J.-P., Gusella J. F., Beyreuther K., Masters C. L., and Tanzi R. E. (1994b) Rapid induction of Alzheimer Aβ amyloid formation by zinc. Science 265, 1464-1467.
9. Bush A. I., Moir R. D., Rosenkranz K. M., and Tanzi R. E. (1995) Zinc and Alzheimer's disease (response). Science 268, 1921-1923.
10. Castaño E. M., Ghiso J., Prelli F., Gorevic P. D., Migheli A., and Frangione B. (1986) In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to Alzheimer's disease β-protein. Biochem. Biophys. Res. Commun. 141, 782-789.
11. Castaňo E. M., Prelli F., Wisniewski T., Golabek A., Kumar R. A., Soto C., and Frangione B. (1995) Fibrillogenesis in Alzheimer's disease of amyloid β peptides and apolipoprotein E. Biochem. J. 205, 599-604.
12. Clements A., Allsop D., Walsh D. M., and Williams C. H. (1996) Aggregation and metal-binding properties of mutant forms of the amyloid Aβ peptide of Alzheimer's disease. J. Neurochem. 66, 740-747.
13. Connor J. R., Menzies S. L., Martin S., and Mufson E. J. ( 1992) A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains. J. Neurosci. Res. 31, 75-83.
14. d'Albis A. and Gratzer W. B. (1970) Spectroscopy, in Companion to Biochemistry (Bull A. T., ed), p. 175. Longmans, London.
15. Davies I. J. T., Musa M., and Dormandy T. L. (1968) Measurements of plasma zinc. I. In health and disease. J. Clin. Pathol. 21, 359-363.
16. Dawson R. M. C., Elliot D. C., Elliot W. H., and Jones K. M. (1986) Data for Biochemical Research, 3rd edit., p. 410. Clarendon Press, Oxford.
17. Duncan M. W., Marini A. M., Watters R., Kopin I. J., and Markey S. P. (1992) Zinc, a neurotoxin to cultured neurons, contaminates cycad flour prepared by traditional Guamanian methods. J. Neurosci. 12, 1523-1537.
18. Evans K. C., Berger E. P., Cho C.-G., Weisgraber K. H., and Lansbury P. T. Jr. (1995) Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 92, 763-767.
19. Fraser P. E., Duffy L. K., O'Malley M. B., Nguyen J., Inouye H., and Kirschner D. A. (1991) Morphology and antibody recognition of synthetic β-amyloid peptides. J. Neurosci. Res. 28, 474-485.
20. Fraser P. E., Nguyen J. T., Chin D. T., and Kirschner D. A. (1992) Effects of sulfate ions on Alzheimer β/A4 peptide assemblies: implications for amyloid fibril-proteoglycan interactions. J. Neurochem. 59, 1531-1540.
21. 1-Antichymotrypsin binding to Alzheimer Aβ is sequence specific and induces fibril disaggregation in vitro. J. Neurochem. 61, 298-305.
22. Fraser P. E., Lévesque L., and McLachlan D. R. (1994) Alzheimer Aβ amyloid forms an inhibitory neuronal substrate. J. Neurochem. 62, 1227-1230.
23. Frederickson C. J. (1989) Neurobiology of zinc and zinc-containing neurons. Int. Rev. Neurobiol. 31, 145-238.
24. Frederickson C. J., Klitenick M. A., Manton W. I., and Kirkpatrick J. B. (1983) Cytoarchitectonic distribution of zinc in the hippocampus of man and the rat. Brain Res. 273, 335-339.
25. Garruto R. M., Fukatsu R., Yanagihara R. T., Gajdusek D. C., Hook G., and Fiori C. E. (1984) Imaging of calcium and aluminum in neurofibrillary tangle-bearing neurons in parkinsonism-dementia of Guam. Proc. Natl. Acad. Sci USA 81, 1875-1879.
26. Glenner G. G. and Wong C. W. (1984) Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem. Biophys. Res. Commun. 122, 1131-1135.
27. Goldgeber D., Lerman J. I., McBride O. W., Saffioti U., and Gajdusek D. C. (1987) Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 235, 877-880.
28. Haass C., Schlossmacher M. G., Hung A. Y., Vigo-Pelfrey C., Mellon A., Ostaszewski B. L., Lieberburg I., Koo E. H., Schenk D., Teplow D. B., and Selkoe D. J. (1992) Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 359, 322-325.
29. Halverson K., Fraser P. E., Kirschner D. A., and Lansbury P. T. Jr. (1990) Molecular determinants of amyloid deposition in Alzheimer's disease: conformational studies of synthetic β-protein fragments. Biochemistry 29, 2639-2644.
30. Hardy J. and Allsop D. (1991) Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol. Sci. 12, 383-388.
31. Hershey C. O., Hershey L. A., Varnes A., Vibhakar S. D., Lavin P., and Strain W. H. (1983) Cerebrospinal fluid trace element content in dementia: clinical, radiologic, and pathologic correlations. Neurology 33, 1350-1353.
32. Hilbich C., Kisters-Woike B., Reed J., Masters C. L., and Beyreuther K. (1991) Aggregation and secondary structure of synthetic amyloid βA4 peptides of Alzheimer's disease. J. Mol. Biol. 218, 149-163.
33. Hyman B. T., Van Hoesen G. W., Kroner L. J., and Damasio A. R. (1986) Perforant pathway changes and memory impairment of Alzheimer's disease. Ann. Neurol. 20, 472-481.
34. Imahori K. and Tanaka J. (1959) Ultraviolet absorption spectra of poly-L-glutamic acid. J. Mol. Biol. 1, 359-364.
35. Joachim C. L. and Selkoe D. J. (1992) The seminal role of β-amyloid in the pathogenesis of Alzheimer disease. Alzheimer Dis. Assoc. Disord. 6, 7-34.
36. Kang J., Lemaire K. H., Unterbeck A., Salbaum J., Masters C. L., Grsechik K. H., Multhaup G., Beyreuther K., and Müller-Hill B. (1987) The precursor of Alzheimer's disease indicates cross-beta conformation. Nature 325, 733-736.
37. Kirschner D. A., Inouye H., Duffy L. K., Sinclair A., Lind M, and Selkoe D. J. (1987) Synthetic peptide homologous to β protein from Alzheimer's disease forms amyloid-like fibrils in vitro. Proc. Natl. Acad. Sci. USA 84, 6953-6957.
38. Kowall N. W., McKee A. C., Yankner B. A., and Beal M. F. (1992) In vivo neurotoxicity of β-amyloid [β(1-40)] and the β(25-35) fragment. Neurobiol. Aging 13, 537-542.
39. Maggio J. E., Stimson E. R., Ghilardi J. R., Allen C. J., Dahl C. E., Whitcomb D. C., Vigna S. R., Vinters H. V., Labenski M. E., and Mantyh P. W. (1992) Reversible in vitro growth of Alzheimer disease β-amyloid plaques by deposition of labeled amyloid peptide. Proc. Natl. Acad. Sci. USA 89, 5462-5466.
40. Maggio J. E., Esler W. P., Stimson E. R., Jennings J. M., Ghilardi J., and Mantyh P. W. (1995) Zinc and Alzheimer's disease (Technical comment). Science 268, 1920-1921.
41. Mantyh P. W., Stimson E. R., Ghilardi J. R., Allen C. J., Dahl C. E., Whitcomb D. C., Vigna S. R., Vinters H. V., Labenski M. E., and Maggio J. E. (1991) Reversible in vitro growth of Alzheimer disease β-amyloid plaques. Bull. Clin. Neurosci. 56, 73-85.
42. Mantyh P. W., Ghilardi J. R., Rogers S., DeMaster E., Allen C. J., Stimson E. R., and Maggio J. E. (1993) Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of β-amyloid peptide. J. Neurochem. 61, 1171-1174.
43. Mattson M. P., Cheng B., Davis D., Bryant K., Leiberburg I., and Rydel R. (1992) β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12, 376-389.
44. Perl D. P., Gajdusek D. C., Garruto R. M., Yanagihara R. T., and Gibbs C. J. (1982) Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Science 217, 1053-1055.
45. Pike C. J., Walencewicz J., Glabe C. G., and Cotman C. W. (1991a) Aggregation-related toxicity of synthetic β-amyloid protein in hippocampal cultures. Eur. J. Pharmacol. 207, 367-368.
46. Pike C. J., Walencewicz J., Glabe C. G., and Cotman C. W. (1991b) In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res. 563, 311-314.
47. Pike C. J., Cummings B. J., and Cotman C. W. (1992) β-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology. Neuroreport 3, 769-772.
48. Pike C. J., Burdick D., Walencewicz A. J., Glabe C. G., and Cotman C. W. (1993) Neurodegeneration induced by β-amyloid peptides in vitro: the role of peptide assembly state. J. Neurosci. 13, 1676-1687.
49. Pike C. J., Walencewicz-Wasserman A. J., Kosmoski J., Cribbs D. H., Glabe C. G., and Cotman C W. (1995) Structure-activity analyses of β-amyloid peptides: contributions of the β25-35 region to aggregation and neurotoxicity. J. Neurochem. 64, 253-265.
50. Roberts G. C. K. (1993) NMR of Macromolecules, pp. 15-16. IRL Press at Oxford University Press, Oxford.
51. Roher A. E., Ball M. I., Bhave S. V., and Wakade A. R. (1991) β-Amyloid from Alzheimer disease brains inhibits sprouting and survival of sympathetic neurons. Biochem. Biophys. Res. Commun. 174, 572-579.
52. Rosenheck K. and Doty P. (1961) The far ultraviolet absorption spectra of polypeptide and protein solutions and their depen-dence on conformation. Proc. Natl. Acad. Sci. USA 47, 1775-1789.
53. Selkoe D. J. (1991) The molecular pathology of Alzheimer's disease. Neuron 6, 487-498.
54. Selkoe D. J. (1994) Alzheimer's disease: a central role for amyloid. J. Neuropathol. Exp. Neurol. 53, 438-447.
55. Seubert P., Vigo-Pelfrey C., Esch F., Lee M., Dovey H., Davis D., Sinha S., Schlossmacher M., Whaley J., Swindelhurst C., McCormack R., Wolfert R., Selkoe D., Lieberburg I., and Schenk D. (1992) Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids. Nature 359, 325-327.
56. Shoji M., Golde T. E., Ghiso J., Cheung T. T., Estus S., Shaffer L. M., Cai X. D., McKay D. M., Titner R., and Frangione B. (1992) Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science 258, 126-129.
57. Tanzi R. E., McClatchey A. I , Lamperti E. D., Villa-Komaroff L. L., Gusella J. F., and Neve R. L. (1987) Protease inhibitor domain encoded by an amyloid precursor protein mRNA associated with Alzheimer's disease. Nature 331, 528-530.
58. Tomaoka A., Kalaria R., Lieberburg I., and Selkoe D. (1992) Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels. Proc. Natl. Acad. Sci. USA 89, 1345-1349.
59. Tomski S. J. and Murphy R. M. (1992) Kinetics of aggregation of synthetic β-amyloid peptide. Arch. Biochem. Biophys. 294, 630-638.
60. Too H. P. and Maggio J. E. (1991) Radioimmunoassay of tachykinins. Methods Neurosci. 6, 232-247.
61. van Gool W. A., Kuiper M. A., Walstra G. J. M., Wolters E. Ch, and Bolhuis P. A. (1994) Concentrations of amyloid β-protein in cerebrospinal fluid of patients with Alzheimer's disease. Ann. Neurol. 37, 277-279.
62. Wetlaufer D. B. (1962) Ultraviolet spectra of proteins and amino acids. Adv. Protein Chem. 17, 304-405.
63. Yankner B. A., Duffy L. K., and Kirschner D. A. (1990) Neurotrophic and neurotoxic effects of β-protein: reversal by tachykinin neuropeptides. Science 250, 279-282.