-
1
-
-
0032557425
-
Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis
-
Atwood C.S., Moir R.D., Huang X., Scarpa R.C., Bacarra N.M., Romano D.M., Hartshorn M.A., Tanzi R.E., and Bush A.I. Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. J. Biol. Chem. 273 (1998) 12817-12826
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 12817-12826
-
-
Atwood, C.S.1
Moir, R.D.2
Huang, X.3
Scarpa, R.C.4
Bacarra, N.M.5
Romano, D.M.6
Hartshorn, M.A.7
Tanzi, R.E.8
Bush, A.I.9
-
2
-
-
12844273354
-
The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain
-
Basha M.R., Wei W., Bakheet S.A., Benitez N., Siddiqi H.K., Ge Y.W., Lahiri D.K., and Zawia N.H. The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain. J. Neurosci. 25 (2005) 823-829
-
(2005)
J. Neurosci.
, vol.25
, pp. 823-829
-
-
Basha, M.R.1
Wei, W.2
Bakheet, S.A.3
Benitez, N.4
Siddiqi, H.K.5
Ge, Y.W.6
Lahiri, D.K.7
Zawia, N.H.8
-
3
-
-
10744226316
-
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice
-
Bayer T.A., Schafer S., Simons A., Kemmling A., Kamer T., Tepest R., Eckert A., Schussel K., Eikenberg O., Sturchler-Pierrat C., Abramowski D., Staufenbiel M., and Multhaup G. Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice. Proc. Natl. Acad. Sci. USA 100 (2003) 14187-14192
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 14187-14192
-
-
Bayer, T.A.1
Schafer, S.2
Simons, A.3
Kemmling, A.4
Kamer, T.5
Tepest, R.6
Eckert, A.7
Schussel, K.8
Eikenberg, O.9
Sturchler-Pierrat, C.10
Abramowski, D.11
Staufenbiel, M.12
Multhaup, G.13
-
4
-
-
0037305525
-
Aluminum and copper interact in the promotion of oxidative but not inflammatory events: implications for Alzheimer's disease
-
Becaria A., Bondy S.C., and Campbell A. Aluminum and copper interact in the promotion of oxidative but not inflammatory events: implications for Alzheimer's disease. J. Alzheimers Dis. 5 (2003) 31-38
-
(2003)
J. Alzheimers Dis.
, vol.5
, pp. 31-38
-
-
Becaria, A.1
Bondy, S.C.2
Campbell, A.3
-
5
-
-
5444235015
-
Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts
-
Bellingham S.A., Ciccotosto G.D., Needham B.E., Fodero L.R., White A.R., Masters C.L., Cappai R., and Camakaris J. Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts. J. Neurochem. 91 (2004) 423-428
-
(2004)
J. Neurochem.
, vol.91
, pp. 423-428
-
-
Bellingham, S.A.1
Ciccotosto, G.D.2
Needham, B.E.3
Fodero, L.R.4
White, A.R.5
Masters, C.L.6
Cappai, R.7
Camakaris, J.8
-
6
-
-
2442586535
-
Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene
-
Bellingham S.A., Lahiri D.K., Maloney B., La Fontaine S., Multhaup G., and Camakaris J. Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene. J. Biol. Chem. 279 (2004) 20378-20386
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 20378-20386
-
-
Bellingham, S.A.1
Lahiri, D.K.2
Maloney, B.3
La Fontaine, S.4
Multhaup, G.5
Camakaris, J.6
-
7
-
-
0030726659
-
Laser capture microdissection: molecular analysis of tissue
-
Bonner R.F., Emmert-Buck M., Cole K., Pohida T., Chuaqui R., Goldstein S., and Liotta L.A. Laser capture microdissection: molecular analysis of tissue. Science 278 (1997) 1481-1483
-
(1997)
Science
, vol.278
, pp. 1481-1483
-
-
Bonner, R.F.1
Emmert-Buck, M.2
Cole, K.3
Pohida, T.4
Chuaqui, R.5
Goldstein, S.6
Liotta, L.A.7
-
8
-
-
0027980901
-
Rapid induction of Alzheimer Aβ amyloid formation by zinc
-
Bush A.I., Pettingell W.H., Multhaup G., Paradis M.d., Vonsattel J.-P., Gusella J.F., Beyreuther K., Masters C.L., and Tanzi R.E. Rapid induction of Alzheimer Aβ amyloid formation by zinc. Science 265 (1994) 1464-1467
-
(1994)
Science
, vol.265
, pp. 1464-1467
-
-
Bush, A.I.1
Pettingell, W.H.2
Multhaup, G.3
Paradis, M.d.4
Vonsattel, J.-P.5
Gusella, J.F.6
Beyreuther, K.7
Masters, C.L.8
Tanzi, R.E.9
-
9
-
-
0034964390
-
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice
-
Cherny R.A., Atwood C.S., Xilinas M.E., Gray D.N., Jones W.D., McLean C.A., Barnham K.J., Volitakis I., Fraser F.W., Kim Y., Huang X., Goldstein L.E., Moir R.D., Lim J.T., Beyreuther K., Zheng H., Tanzi R.E., Masters C.L., and Bush A.I. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 30 (2001) 665-676
-
(2001)
Neuron
, vol.30
, pp. 665-676
-
-
Cherny, R.A.1
Atwood, C.S.2
Xilinas, M.E.3
Gray, D.N.4
Jones, W.D.5
McLean, C.A.6
Barnham, K.J.7
Volitakis, I.8
Fraser, F.W.9
Kim, Y.10
Huang, X.11
Goldstein, L.E.12
Moir, R.D.13
Lim, J.T.14
Beyreuther, K.15
Zheng, H.16
Tanzi, R.E.17
Masters, C.L.18
Bush, A.I.19
-
10
-
-
0033551782
-
Aqueous dissolution of Alzheimer's disease Aβ amyloid deposits by biometal depletion
-
Cherny R.A., Legg J.T., McLean C.A., Fairlie D.P., Huang X., Atwood C.S., Beyreuther K., Tanzi R.E., Masters C.L., and Bush A.I. Aqueous dissolution of Alzheimer's disease Aβ amyloid deposits by biometal depletion. J. Biol. Chem. 274 (1999) 23223-23228
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 23223-23228
-
-
Cherny, R.A.1
Legg, J.T.2
McLean, C.A.3
Fairlie, D.P.4
Huang, X.5
Atwood, C.S.6
Beyreuther, K.7
Tanzi, R.E.8
Masters, C.L.9
Bush, A.I.10
-
11
-
-
0037010289
-
Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling
-
Colangelo V., Schurr J., Ball M.J., Pelaez R.P., Bazan N.G., and Lukiw W.J. Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling. J. Neurosci. Res. 70 (2002) 462-473
-
(2002)
J. Neurosci. Res.
, vol.70
, pp. 462-473
-
-
Colangelo, V.1
Schurr, J.2
Ball, M.J.3
Pelaez, R.P.4
Bazan, N.G.5
Lukiw, W.J.6
-
12
-
-
0025726462
-
Intramuscular desferrioxamine in patients with Alzheimer's disease
-
Crapper McLachlan D.R., Dalton A.J., Kruck T.P.A., Bell M.Y., Smith W.L., Kalow W., and Andrews D.F. Intramuscular desferrioxamine in patients with Alzheimer's disease. Lancet 337 (1991) 1304-1308
-
(1991)
Lancet
, vol.337
, pp. 1304-1308
-
-
Crapper McLachlan, D.R.1
Dalton, A.J.2
Kruck, T.P.A.3
Bell, M.Y.4
Smith, W.L.5
Kalow, W.6
Andrews, D.F.7
-
13
-
-
0034733705
-
Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc
-
Cuajungco M.P., Goldstein L.E., Nunomura A., Smith M.A., Lim J.T., Atwood C.S., Huang X., Farrag Y.W., Perry G., and Bush A.I. Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc. J. Biol. Chem. 275 (2000) 19439-19442
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 19439-19442
-
-
Cuajungco, M.P.1
Goldstein, L.E.2
Nunomura, A.3
Smith, M.A.4
Lim, J.T.5
Atwood, C.S.6
Huang, X.7
Farrag, Y.W.8
Perry, G.9
Bush, A.I.10
-
14
-
-
0031902295
-
Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities
-
Cummings J.L., Vinters H.V., Cole G.M., and Khachaturian Z.S. Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology 51S (1998) S2-S17
-
(1998)
Neurology
, vol.51 S
-
-
Cummings, J.L.1
Vinters, H.V.2
Cole, G.M.3
Khachaturian, Z.S.4
-
15
-
-
0035827681
-
Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits
-
Curtain C.C., Ali F., Volitakis I., Cherny R.A., Norton R.S., Beyreuther K., Barrow C.J., Masters C.L., Bush A.I., and Barnham K.J. Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits. J. Biol. Chem. 276 (2001) 20466-20473
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 20466-20473
-
-
Curtain, C.C.1
Ali, F.2
Volitakis, I.3
Cherny, R.A.4
Norton, R.S.5
Beyreuther, K.6
Barrow, C.J.7
Masters, C.L.8
Bush, A.I.9
Barnham, K.J.10
-
16
-
-
9744219638
-
Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis
-
Dedeoglu A., Cormier K., Payton S., Tseitlin K.A., Kremsky J.N., Lai L., Li X., Moir R.D., Tanzi R.E., Bush A.I., Kowall N.W., Rogers J.T., and Huang X. Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis. Exp. Gerontol. 39 (2004) 1641-1649
-
(2004)
Exp. Gerontol.
, vol.39
, pp. 1641-1649
-
-
Dedeoglu, A.1
Cormier, K.2
Payton, S.3
Tseitlin, K.A.4
Kremsky, J.N.5
Lai, L.6
Li, X.7
Moir, R.D.8
Tanzi, R.E.9
Bush, A.I.10
Kowall, N.W.11
Rogers, J.T.12
Huang, X.13
-
17
-
-
0033515564
-
Amyloid β peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides
-
Dikalov S.I., Vitek M.P., Maples K.R., and Mason R.P. Amyloid β peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides. J. Biol. Chem. 274 (1999) 9392-9399
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 9392-9399
-
-
Dikalov, S.I.1
Vitek, M.P.2
Maples, K.R.3
Mason, R.P.4
-
18
-
-
1642440240
-
Cupric-amyloid beta peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical
-
Dikalov S.I., Vitek M.P., and Mason R.P. Cupric-amyloid beta peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical. Free Radic. Biol. Med. 36 (2004) 340-347
-
(2004)
Free Radic. Biol. Med.
, vol.36
, pp. 340-347
-
-
Dikalov, S.I.1
Vitek, M.P.2
Mason, R.P.3
-
19
-
-
0030575911
-
Laser capture microdissection [see comments]
-
Emmert-Buck M.R., Bonner R.F., Smith P.D., Chuaqui R.F., Zhuang Z., Goldstein S.R., Weiss R.A., and Liotta L.A. Laser capture microdissection [see comments]. Science 274 (1996) 998-1001
-
(1996)
Science
, vol.274
, pp. 998-1001
-
-
Emmert-Buck, M.R.1
Bonner, R.F.2
Smith, P.D.3
Chuaqui, R.F.4
Zhuang, Z.5
Goldstein, S.R.6
Weiss, R.A.7
Liotta, L.A.8
-
20
-
-
14044272119
-
S-glutathionylation: from redox regulation of protein functions to human diseases
-
Giustarini D., Rossi R., Milzani A., Colombo R., and Dalle-Donne I. S-glutathionylation: from redox regulation of protein functions to human diseases. J. Cell. Mol. Med. 8 (2004) 201-212
-
(2004)
J. Cell. Mol. Med.
, vol.8
, pp. 201-212
-
-
Giustarini, D.1
Rossi, R.2
Milzani, A.3
Colombo, R.4
Dalle-Donne, I.5
-
21
-
-
0021256895
-
Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein
-
Glenner G.G., and Wong C.W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120 (1984) 885-890
-
(1984)
Biochem. Biophys. Res. Commun.
, vol.120
, pp. 885-890
-
-
Glenner, G.G.1
Wong, C.W.2
-
22
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
-
Hardy J., and Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297 (2002) 353-356
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
23
-
-
0042023711
-
Alzheimer disease in the US population: prevalence estimates using the 2000 census
-
Hebert L.E., Scherr P.A., Bienias J.L., Bennett D.A., and Evans D.A. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch. Neurol. 60 (2003) 1119-1122
-
(2003)
Arch. Neurol.
, vol.60
, pp. 1119-1122
-
-
Hebert, L.E.1
Scherr, P.A.2
Bienias, J.L.3
Bennett, D.A.4
Evans, D.A.5
-
24
-
-
18344414746
-
The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction
-
Huang X., Atwood C.S., Hartshorn M.A., Multhaup G., Goldstein L.E., Scrapa S.C., Cuajungco M.P., Gray D.N., Lim J., Moir R.D., Tanzi R.E., and Bush A.I. The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry 38 (1999) 7609-7616
-
(1999)
Biochemistry
, vol.38
, pp. 7609-7616
-
-
Huang, X.1
Atwood, C.S.2
Hartshorn, M.A.3
Multhaup, G.4
Goldstein, L.E.5
Scrapa, S.C.6
Cuajungco, M.P.7
Gray, D.N.8
Lim, J.9
Moir, R.D.10
Tanzi, R.E.11
Bush, A.I.12
-
25
-
-
12144282992
-
Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides
-
Huang X., Atwood C.S., Moir R.D., Hartshorn M.A., Tanzi R.E., and Bush A.I. Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides. J. Biol. Inorg. Chem. 9 (2004) 954-960
-
(2004)
J. Biol. Inorg. Chem.
, vol.9
, pp. 954-960
-
-
Huang, X.1
Atwood, C.S.2
Moir, R.D.3
Hartshorn, M.A.4
Tanzi, R.E.5
Bush, A.I.6
-
26
-
-
0030704680
-
Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors
-
Huang X., Atwood C.S., Moir R.D., Hartshorn M.A., Vonsattel J.P., Tanzi R.E., and Bush A.I. Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors. J. Biol. Chem. 272 (1997) 26464-26470
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 26464-26470
-
-
Huang, X.1
Atwood, C.S.2
Moir, R.D.3
Hartshorn, M.A.4
Vonsattel, J.P.5
Tanzi, R.E.6
Bush, A.I.7
-
27
-
-
0033601338
-
Cu(II) potentiation of Alzheimer Aβ neurotoxicity: correlation with cell-free hydrogen peroxide production and metal reduction
-
Huang X., Cuajungco M.P., Atwood C.S., Hartshorn M.A., Tyndall J., Hanson G.R., Stokes K.C., Leopold M., Multhaup G., Goldstein L.E., Scarpa R.C., Saunders A.J., Lim J., Moir R.D., Glabe C., Bowden E.F., Masters C.L., Fairlie D.P., Tanzi R.E., and Bush A.I. Cu(II) potentiation of Alzheimer Aβ neurotoxicity: correlation with cell-free hydrogen peroxide production and metal reduction. J. Biol. Chem. 274 (1999) 37111-37116
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37111-37116
-
-
Huang, X.1
Cuajungco, M.P.2
Atwood, C.S.3
Hartshorn, M.A.4
Tyndall, J.5
Hanson, G.R.6
Stokes, K.C.7
Leopold, M.8
Multhaup, G.9
Goldstein, L.E.10
Scarpa, R.C.11
Saunders, A.J.12
Lim, J.13
Moir, R.D.14
Glabe, C.15
Bowden, E.F.16
Masters, C.L.17
Fairlie, D.P.18
Tanzi, R.E.19
Bush, A.I.20
more..
-
28
-
-
1842504323
-
Redox-active metals, oxidative stress, and Alzheimer's disease pathology
-
Huang X., Moir R.D., Tanzi R.E., Bush A.I., and Rogers J.T. Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Ann. NY Acad. Sci. 1012 (2004) 153-163
-
(2004)
Ann. NY Acad. Sci.
, vol.1012
, pp. 153-163
-
-
Huang, X.1
Moir, R.D.2
Tanzi, R.E.3
Bush, A.I.4
Rogers, J.T.5
-
29
-
-
13744252408
-
The impact of mercury on human health and the environment
-
Hyman M.H. The impact of mercury on human health and the environment. Altern. Ther. Health Med. 10 (2004) 70-75
-
(2004)
Altern. Ther. Health Med.
, vol.10
, pp. 70-75
-
-
Hyman, M.H.1
-
30
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
-
Kang J., Lemaire H.G., Unterbeck A., Salbaum J.M., Masters C.L., Grzeschik K.H., Multhaup G., Beyreuther K., and Muller-Hill B. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325 (1987) 733-736
-
(1987)
Nature
, vol.325
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
Grzeschik, K.H.6
Multhaup, G.7
Beyreuther, K.8
Muller-Hill, B.9
-
31
-
-
16844373633
-
N-Terminal deletions modify the Cu2+ binding site in amyloid-beta
-
Karr J.W., Akintoye H., Kaupp L.J., and Szalai V.A. N-Terminal deletions modify the Cu2+ binding site in amyloid-beta. Biochemistry 44 (2005) 5478-5487
-
(2005)
Biochemistry
, vol.44
, pp. 5478-5487
-
-
Karr, J.W.1
Akintoye, H.2
Kaupp, L.J.3
Szalai, V.A.4
-
33
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed R., Head E., Thompson J.L., McIntire T.M., Milton S.C., Cotman C.W., and Glabe C.G. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300 (2003) 486-489
-
(2003)
Science
, vol.300
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
McIntire, T.M.4
Milton, S.C.5
Cotman, C.W.6
Glabe, C.G.7
-
34
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
-
Lambert M.P., Barlow A.K., Chromy B.A., Edwards C., Freed R., Liosatos M., Morgan T.E., Rozovsky I., Trommer B., Viola K.L., Wals P., Zhang C., Finch C.E., Krafft G.A., and Klein W.L. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc. Natl. Acad. Sci. USA 95 (1998) 6448-6453
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
Liosatos, M.6
Morgan, T.E.7
Rozovsky, I.8
Trommer, B.9
Viola, K.L.10
Wals, P.11
Zhang, C.12
Finch, C.E.13
Krafft, G.A.14
Klein, W.L.15
-
35
-
-
0037188530
-
Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice
-
Lee J.Y., Cole T.B., Palmiter R.D., Suh S.W., and Koh J.Y. Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice. Proc. Natl. Acad. Sci. USA 99 (2002) 7705-7710
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 7705-7710
-
-
Lee, J.Y.1
Cole, T.B.2
Palmiter, R.D.3
Suh, S.W.4
Koh, J.Y.5
-
36
-
-
0028172886
-
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red
-
Lorenzo A., and Yankner B.A. Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc. Natl. Acad. Sci. USA 91 (1994) 12243-12247
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 12243-12247
-
-
Lorenzo, A.1
Yankner, B.A.2
-
37
-
-
0035692472
-
A gene expression profile of Alzheimer's disease
-
Loring J.F., Wen X., Lee J.M., Seilhamer J., and Somogyi R. A gene expression profile of Alzheimer's disease. DNA Cell Biol. 20 (2001) 683-695
-
(2001)
DNA Cell Biol.
, vol.20
, pp. 683-695
-
-
Loring, J.F.1
Wen, X.2
Lee, J.M.3
Seilhamer, J.4
Somogyi, R.5
-
38
-
-
0032507975
-
Copper, iron and zinc in Alzheimer's disease senile plaques
-
Lovell M.A., Robertson J.D., Teesdale W.J., Campbell J.L., and Markesbery W.R. Copper, iron and zinc in Alzheimer's disease senile plaques. J. Neurol. Sci. 158 (1998) 47-52
-
(1998)
J. Neurol. Sci.
, vol.158
, pp. 47-52
-
-
Lovell, M.A.1
Robertson, J.D.2
Teesdale, W.J.3
Campbell, J.L.4
Markesbery, W.R.5
-
39
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
Masters C.L., Simms G., Weinman N.A., Multhaup G., McDonald B.L., and Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. Natl. Acad. Sci. USA 82 (1985) 4245-4249
-
(1985)
Proc. Natl. Acad. Sci. USA
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
40
-
-
0037202124
-
Metal switch for amyloid formation: insight into the structure of the nucleus
-
Morgan D.M., Dong J., Jacob J., Lu K., Apkarian R.P., Thiyagarajan P., and Lynn D.G. Metal switch for amyloid formation: insight into the structure of the nucleus. J. Am. Chem. Soc. 124 (2002) 12644-12645
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 12644-12645
-
-
Morgan, D.M.1
Dong, J.2
Jacob, J.3
Lu, K.4
Apkarian, R.P.5
Thiyagarajan, P.6
Lynn, D.G.7
-
41
-
-
0029935396
-
The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)
-
Multhaup G., Schlicksupp A., Hesse L., Beher D., Ruppert T., Masters C.L., and Beyreuther K. The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I). Science 271 (1996) 1406-1409
-
(1996)
Science
, vol.271
, pp. 1406-1409
-
-
Multhaup, G.1
Schlicksupp, A.2
Hesse, L.3
Beher, D.4
Ruppert, T.5
Masters, C.L.6
Beyreuther, K.7
-
42
-
-
0037174856
-
2
-
2. J. Biol. Chem. 277 (2002) 40302-40308
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 40302-40308
-
-
Opazo, C.1
Huang, X.2
Cherny, R.A.3
Moir, R.D.4
Roher, A.E.5
White, A.R.6
Cappai, R.7
Masters, C.L.8
Tanzi, R.E.9
Inestrosa, N.C.10
Bush, A.I.11
-
43
-
-
33644539236
-
Chemical elements distribution in cells
-
Ortega R. Chemical elements distribution in cells. Nucl. Instr. Meth. Phys. Res. B231 (2005) 218-223
-
(2005)
Nucl. Instr. Meth. Phys. Res.
, vol.B231
, pp. 218-223
-
-
Ortega, R.1
-
44
-
-
10744228112
-
In vivo reduction of amyloid-beta by a mutant copper transporter
-
Phinney A.L., Drisaldi B., Schmidt S.D., Lugowski S., Coronado V., Liang Y., Horne P., Yang J., Sekoulidis J., Coomaraswamy J., Chishti M.A., Cox D.W., Mathews P.M., Nixon R.A., Carlson G.A., St George-Hyslop P., and Westaway D. In vivo reduction of amyloid-beta by a mutant copper transporter. Proc. Natl. Acad. Sci. USA 100 (2003) 14193-14198
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 14193-14198
-
-
Phinney, A.L.1
Drisaldi, B.2
Schmidt, S.D.3
Lugowski, S.4
Coronado, V.5
Liang, Y.6
Horne, P.7
Yang, J.8
Sekoulidis, J.9
Coomaraswamy, J.10
Chishti, M.A.11
Cox, D.W.12
Mathews, P.M.13
Nixon, R.A.14
Carlson, G.A.15
St George-Hyslop, P.16
Westaway, D.17
-
45
-
-
0025992417
-
In vitro aging of β amyloid protein causes peptide aggregation and neurotoxicity
-
Pike C.J., Walencewicz A.J., Glabe C.G., and Cotman C.W. In vitro aging of β amyloid protein causes peptide aggregation and neurotoxicity. Brain Res. 563 (1991) 311-314
-
(1991)
Brain Res.
, vol.563
, pp. 311-314
-
-
Pike, C.J.1
Walencewicz, A.J.2
Glabe, C.G.3
Cotman, C.W.4
-
46
-
-
0023914178
-
Different processing of Alzheimer's beta-protein precursor in the vessel wall of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type
-
Prelli F., Castano E.M., van Duinen S.G., Bots G.T., Luyendijk W., and Frangione B. Different processing of Alzheimer's beta-protein precursor in the vessel wall of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type. Biochem. Biophys. Res. Commun. 151 (1988) 1150-1155
-
(1988)
Biochem. Biophys. Res. Commun.
, vol.151
, pp. 1150-1155
-
-
Prelli, F.1
Castano, E.M.2
van Duinen, S.G.3
Bots, G.T.4
Luyendijk, W.5
Frangione, B.6
-
47
-
-
18444399243
-
Treatment of Alzheimer's disease with clioquinol
-
Regland B., Lehmann W., Abedini I., Blennow K., Jonsson M., Karlsson I., Sjogren M., Wallin A., Xilinas M., and Gottfries C.G. Treatment of Alzheimer's disease with clioquinol. Dement. Geriatr. Cogn. Disord. 12 (2001) 408-414
-
(2001)
Dement. Geriatr. Cogn. Disord.
, vol.12
, pp. 408-414
-
-
Regland, B.1
Lehmann, W.2
Abedini, I.3
Blennow, K.4
Jonsson, M.5
Karlsson, I.6
Sjogren, M.7
Wallin, A.8
Xilinas, M.9
Gottfries, C.G.10
-
48
-
-
10744224267
-
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial
-
Ritchie C.W., Bush A.I., Mackinnon A., Macfarlane S., Mastwyk M., MacGregor L., Kiers L., Cherny R., Li Q.X., Tammer A., Carrington D., Mavros C., Volitakis I., Xilinas M., Ames D., Davis S., Beyreuther K., Tanzi R.E., and Masters C.L. Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch. Neurol. 60 (2003) 1685-1691
-
(2003)
Arch. Neurol.
, vol.60
, pp. 1685-1691
-
-
Ritchie, C.W.1
Bush, A.I.2
Mackinnon, A.3
Macfarlane, S.4
Mastwyk, M.5
MacGregor, L.6
Kiers, L.7
Cherny, R.8
Li, Q.X.9
Tammer, A.10
Carrington, D.11
Mavros, C.12
Volitakis, I.13
Xilinas, M.14
Ames, D.15
Davis, S.16
Beyreuther, K.17
Tanzi, R.E.18
Masters, C.L.19
-
49
-
-
0023107655
-
Chromosome 21q21 sublocalisation of gene encoding β amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome [letter]
-
Robakis N.K., Wisniewski H.M., Jenkins E.C., Devine-Gage E.A., Houck G.E., Yao X.L., Ramakrishna N., Wolfe G., Silverman W.P., and Brown W.T. Chromosome 21q21 sublocalisation of gene encoding β amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome [letter]. Lancet 1 (1987) 384-385
-
(1987)
Lancet
, vol.1
, pp. 384-385
-
-
Robakis, N.K.1
Wisniewski, H.M.2
Jenkins, E.C.3
Devine-Gage, E.A.4
Houck, G.E.5
Yao, X.L.6
Ramakrishna, N.7
Wolfe, G.8
Silverman, W.P.9
Brown, W.T.10
-
50
-
-
3442888291
-
Metal and inflammatory targets for Alzheimer's disease
-
Rogers J.T., and Lahiri D.K. Metal and inflammatory targets for Alzheimer's disease. Curr. Drug Targets 5 (2004) 535-551
-
(2004)
Curr. Drug Targets
, vol.5
, pp. 535-551
-
-
Rogers, J.T.1
Lahiri, D.K.2
-
51
-
-
0347928847
-
An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript
-
Rogers J.T., Randall J.D., Cahill C.M., Eder P.S., Huang X., Gunshin H., Leiter L., McPhee J., Sarang S.S., Utsuki T., Greig N.H., Lahiri D.K., Tanzi R.E., Bush A.I., Giordano T., and Gullans S.R. An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript. J. Biol. Chem. 277 (2002) 45518-45528
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 45518-45528
-
-
Rogers, J.T.1
Randall, J.D.2
Cahill, C.M.3
Eder, P.S.4
Huang, X.5
Gunshin, H.6
Leiter, L.7
McPhee, J.8
Sarang, S.S.9
Utsuki, T.10
Greig, N.H.11
Lahiri, D.K.12
Tanzi, R.E.13
Bush, A.I.14
Giordano, T.15
Gullans, S.R.16
-
52
-
-
0035066332
-
Alzheimer's disease: genes, proteins, and therapy
-
Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81 (2001) 741-766
-
(2001)
Physiol. Rev.
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
53
-
-
0041817542
-
The amyloid beta peptide (Abeta(1-40)) is thermodynamically soluble at physiological concentrations
-
Sengupta P., Garai K., Sahoo B., Shi Y., Callaway D.J., and Maiti S. The amyloid beta peptide (Abeta(1-40)) is thermodynamically soluble at physiological concentrations. Biochemistry 42 (2003) 10506-10513
-
(2003)
Biochemistry
, vol.42
, pp. 10506-10513
-
-
Sengupta, P.1
Garai, K.2
Sahoo, B.3
Shi, Y.4
Callaway, D.J.5
Maiti, S.6
-
54
-
-
0029982815
-
Oxidative damage in Alzheimer's
-
Smith M.A., Perry G., Richey P.L., Sayre L.M., Anderson V.E., Beal M.F., and Kowall N. Oxidative damage in Alzheimer's. Nature 382 (1996) 120-121
-
(1996)
Nature
, vol.382
, pp. 120-121
-
-
Smith, M.A.1
Perry, G.2
Richey, P.L.3
Sayre, L.M.4
Anderson, V.E.5
Beal, M.F.6
Kowall, N.7
-
55
-
-
0141702360
-
Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease
-
Sparks D.L., and Schreurs B.G. Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 100 (2003) 11065-11069
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 11065-11069
-
-
Sparks, D.L.1
Schreurs, B.G.2
-
56
-
-
2442461177
-
Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques
-
Syme C.D., Nadal R.C., Rigby S.E., and Viles J.H. Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques. J. Biol. Chem. 279 (2004) 18169-18177
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 18169-18177
-
-
Syme, C.D.1
Nadal, R.C.2
Rigby, S.E.3
Viles, J.H.4
-
57
-
-
13944276825
-
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective
-
Tanzi R.E., and Bertram L. Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 120 (2005) 545-555
-
(2005)
Cell
, vol.120
, pp. 545-555
-
-
Tanzi, R.E.1
Bertram, L.2
-
58
-
-
0023109592
-
Amyloid β protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
-
Tanzi R.E., Gusella J.F., Watkins P.C., Bruns G.A., St George-Hyslop P., Van Keuren M.L., Patterson D., Pagan S., Kurnit D.M., and Neve R.L. Amyloid β protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 235 (1987) 880-884
-
(1987)
Science
, vol.235
, pp. 880-884
-
-
Tanzi, R.E.1
Gusella, J.F.2
Watkins, P.C.3
Bruns, G.A.4
St George-Hyslop, P.5
Van Keuren, M.L.6
Patterson, D.7
Pagan, S.8
Kurnit, D.M.9
Neve, R.L.10
-
59
-
-
0023850791
-
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease
-
Tanzi R.E., McClatchey A.I., Lamperti E.D., Villa-Komaroff L., Gusella J.F., and Neve R.L. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. Nature 331 (1988) 528-530
-
(1988)
Nature
, vol.331
, pp. 528-530
-
-
Tanzi, R.E.1
McClatchey, A.I.2
Lamperti, E.D.3
Villa-Komaroff, L.4
Gusella, J.F.5
Neve, R.L.6
-
60
-
-
4444276735
-
Clearance of Alzheimer's Abeta peptide: the many roads to perdition
-
Tanzi R.E., Moir R.D., and Wagner S.L. Clearance of Alzheimer's Abeta peptide: the many roads to perdition. Neuron 43 (2004) 605-608
-
(2004)
Neuron
, vol.43
, pp. 605-608
-
-
Tanzi, R.E.1
Moir, R.D.2
Wagner, S.L.3
-
61
-
-
0025768860
-
The growth-inhibitory factor that is deficient in the Alzheimer's disease brain is a 68-amino acid metallothionein-like protein
-
Uchida Y., Takio K., Titani K., Ihara Y., and Tomonaga M. The growth-inhibitory factor that is deficient in the Alzheimer's disease brain is a 68-amino acid metallothionein-like protein. Neuron 7 (1991) 337-347
-
(1991)
Neuron
, vol.7
, pp. 337-347
-
-
Uchida, Y.1
Takio, K.2
Titani, K.3
Ihara, Y.4
Tomonaga, M.5
-
62
-
-
0027379395
-
Characterization of β amyloid peptide from human cerebrospinal fluid
-
Vigo-Pelfrey C., Lee D., Keim P., Lieberburg I., and Schenk D.B. Characterization of β amyloid peptide from human cerebrospinal fluid. J. Neurochem. 61 (1993) 1965-1968
-
(1993)
J. Neurochem.
, vol.61
, pp. 1965-1968
-
-
Vigo-Pelfrey, C.1
Lee, D.2
Keim, P.3
Lieberburg, I.4
Schenk, D.B.5
-
63
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh D.M., Klyubin I., Fadeeva J.V., Cullen W.K., Anwyl R., Wolfe M.S., Rowan M.J., and Selkoe D.J. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416 (2002) 535-539
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
Rowan, M.J.7
Selkoe, D.J.8
-
64
-
-
0035093878
-
Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways
-
White A.R., Huang X., Jobling M.F., Barrow C.J., Beyreuther K., Masters C.L., Bush A.I., and Cappai R. Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways. J. Neurochem. 76 (2001) 1509-1520
-
(2001)
J. Neurochem.
, vol.76
, pp. 1509-1520
-
-
White, A.R.1
Huang, X.2
Jobling, M.F.3
Barrow, C.J.4
Beyreuther, K.5
Masters, C.L.6
Bush, A.I.7
Cappai, R.8
-
65
-
-
0033232709
-
The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures
-
White A.R., Multhaup G., Maher F., Bellingham S., Camakaris J., Zheng H., Bush A.I., Beyreuther K., Masters C.L., and Cappai R. The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures. J. Neurosci. 19 (1999) 9170-9179
-
(1999)
J. Neurosci.
, vol.19
, pp. 9170-9179
-
-
White, A.R.1
Multhaup, G.2
Maher, F.3
Bellingham, S.4
Camakaris, J.5
Zheng, H.6
Bush, A.I.7
Beyreuther, K.8
Masters, C.L.9
Cappai, R.10
-
66
-
-
0035831110
-
Metallothionein III is reduced in Alzheimer's disease
-
Yu W.H., Lukiw W.J., Bergeron C., Niznik H.B., and Fraser P.E. Metallothionein III is reduced in Alzheimer's disease. Brain Res. 894 (2001) 37-45
-
(2001)
Brain Res.
, vol.894
, pp. 37-45
-
-
Yu, W.H.1
Lukiw, W.J.2
Bergeron, C.3
Niznik, H.B.4
Fraser, P.E.5
-
67
-
-
13544268809
-
Neurovascular mechanisms of Alzheimer's neurodegeneration
-
Zlokovic B.V. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci. 28 (2005) 202-208
-
(2005)
Trends Neurosci.
, vol.28
, pp. 202-208
-
-
Zlokovic, B.V.1
|