-
1
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
C.J. Bakkenist, and M.B. Kastan DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation Nature 421 2003 499 506
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
2
-
-
0037711771
-
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
-
A. Celeste, O. Fernandez-Capetillo, M.J. Kruhlak, D.R. Pilch, D.W. Staudt, A. Lee, R.F. Bonner, W.M. Bonner, and A. Nussenzweig Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks Nat. Cell Biol. 5 2003 675 679
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 675-679
-
-
Celeste, A.1
Fernandez-Capetillo, O.2
Kruhlak, M.J.3
Pilch, D.R.4
Staudt, D.W.5
Lee, A.6
Bonner, R.F.7
Bonner, W.M.8
Nussenzweig, A.9
-
3
-
-
4444245893
-
Determination of the catalytic activities of mTOR and other members of the phosphoinositide-3-kinase-related kinase family
-
G.G. Chiang, and R.T. Abraham Determination of the catalytic activities of mTOR and other members of the phosphoinositide-3-kinase-related kinase family Methods Mol. Biol. 281 2004 125 141
-
(2004)
Methods Mol. Biol.
, vol.281
, pp. 125-141
-
-
Chiang, G.G.1
Abraham, R.T.2
-
4
-
-
0024397415
-
The structure and regulation of protein phosphatases
-
P. Cohen The structure and regulation of protein phosphatases Annu. Rev. Biochem. 58 1989 453 508
-
(1989)
Annu. Rev. Biochem.
, vol.58
, pp. 453-508
-
-
Cohen, P.1
-
5
-
-
0035374588
-
Protein phosphatases regulate DNA-dependent protein kinase activity
-
P. Douglas, G.B. Moorhead, R. Ye, and S.P. Lees-Miller Protein phosphatases regulate DNA-dependent protein kinase activity J. Biol. Chem. 276 2001 18992 18998
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 18992-18998
-
-
Douglas, P.1
Moorhead, G.B.2
Ye, R.3
Lees-Miller, S.P.4
-
6
-
-
10944267160
-
Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites
-
J.A. Downs, S. Allard, O. Jobin-Robitaille, A. Javaheri, A. Auger, N. Bouchard, S.J. Kron, S.P. Jackson, and J. Cote Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites Mol. Cell 16 2004 979 990
-
(2004)
Mol. Cell
, vol.16
, pp. 979-990
-
-
Downs, J.A.1
Allard, S.2
Jobin-Robitaille, O.3
Javaheri, A.4
Auger, A.5
Bouchard, N.6
Kron, S.J.7
Jackson, S.P.8
Cote, J.9
-
7
-
-
21644447887
-
Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B′ regulatory subunit
-
C. Dozier, M. Bonyadi, L. Baricault, L. Tonasso, and J.M. Darbon Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B′ regulatory subunit Biol. Cell. 96 2004 509 517
-
(2004)
Biol. Cell.
, vol.96
, pp. 509-517
-
-
Dozier, C.1
Bonyadi, M.2
Baricault, L.3
Tonasso, L.4
Darbon, J.M.5
-
8
-
-
0029848286
-
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice
-
A. Elson, Y. Wang, C.J. Daugherty, C.C. Morton, F. Zhou, J. Campos-Torres, and P. Leder Pleiotropic defects in ataxia-telangiectasia protein-deficient mice Proc. Natl. Acad. Sci. USA 93 1996 13084 13089
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 13084-13089
-
-
Elson, A.1
Wang, Y.2
Daugherty, C.J.3
Morton, C.C.4
Zhou, F.5
Campos-Torres, J.6
Leder, P.7
-
9
-
-
0037423932
-
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor
-
Z. Fan, P.J. Beresford, D.Y. Oh, D. Zhang, and J. Lieberman Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor Cell 112 2003 659 672
-
(2003)
Cell
, vol.112
, pp. 659-672
-
-
Fan, Z.1
Beresford, P.J.2
Oh, D.Y.3
Zhang, D.4
Lieberman, J.5
-
11
-
-
0038820065
-
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes
-
T. Furuta, H. Takemura, Z.Y. Liao, G.J. Aune, C. Redon, O.A. Sedelnikova, D.R. Pilch, E.P. Rogakou, A. Celeste, and H.T. Chen Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes J. Biol. Chem. 278 2003 20303 20312
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 20303-20312
-
-
Furuta, T.1
Takemura, H.2
Liao, Z.Y.3
Aune, G.J.4
Redon, C.5
Sedelnikova, O.A.6
Pilch, D.R.7
Rogakou, E.P.8
Celeste, A.9
Chen, H.T.10
-
12
-
-
0037468169
-
MDC1 is required for the intra-S-phase DNA damage checkpoint
-
M. Goldberg, M. Stucki, J. Falck, D. D'Amours, D. Rahman, D. Pappin, J. Bartek, and S.P. Jackson MDC1 is required for the intra-S-phase DNA damage checkpoint Nature 421 2003 952 956
-
(2003)
Nature
, vol.421
, pp. 952-956
-
-
Goldberg, M.1
Stucki, M.2
Falck, J.3
D'Amours, D.4
Rahman, D.5
Pappin, D.6
Bartek, J.7
Jackson, S.P.8
-
13
-
-
10044225999
-
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A
-
A.A. Goodarzi, J.C. Jonnalagadda, P. Douglas, D. Young, R. Ye, G.B. Moorhead, S.P. Lees-Miller, and K.K. Khanna Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A EMBO J. 23 2004 4451 4461
-
(2004)
EMBO J.
, vol.23
, pp. 4451-4461
-
-
Goodarzi, A.A.1
Jonnalagadda, J.C.2
Douglas, P.3
Young, D.4
Ye, R.5
Moorhead, G.B.6
Lees-Miller, S.P.7
Khanna, K.K.8
-
14
-
-
0036032778
-
Regulators of serine/threonine protein phosphatases at the dawn of a clinical era?
-
R.E. Honkanen, and T. Golden Regulators of serine/threonine protein phosphatases at the dawn of a clinical era? Curr. Med. Chem. 9 2002 2055 2075
-
(2002)
Curr. Med. Chem.
, vol.9
, pp. 2055-2075
-
-
Honkanen, R.E.1
Golden, T.2
-
15
-
-
25144461206
-
Phosphorylation of histone H2AX at M phase in human cells without DNA damage response
-
Y. Ichijima, R. Sakasai, N. Okita, K. Asahina, S. Mizutani, and H. Teraoka Phosphorylation of histone H2AX at M phase in human cells without DNA damage response Biochem. Biophys. Res. Commun. 336 2005 807 812
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.336
, pp. 807-812
-
-
Ichijima, Y.1
Sakasai, R.2
Okita, N.3
Asahina, K.4
Mizutani, S.5
Teraoka, H.6
-
17
-
-
24944494048
-
Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis
-
D. Keefe, L. Shi, S. Feske, R. Massol, F. Navarro, T. Kirchhausen, and J. Lieberman Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis Immunity 23 2005 249 262
-
(2005)
Immunity
, vol.23
, pp. 249-262
-
-
Keefe, D.1
Shi, L.2
Feske, S.3
Massol, R.4
Navarro, F.5
Kirchhausen, T.6
Lieberman, J.7
-
18
-
-
27744510841
-
A phosphatase complex that dephosphorylates γh2AX regulates DNA damage checkpoint recovery
-
M.C. Keogh, J.A. Kim, M. Downey, J. Fillingham, D. Chowdhury, J.C. Harrison, M. Onishi, N. Datta, S. Galicia, and A. Emili A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery Nature 2005 in press
-
(2005)
Nature
-
-
Keogh, M.C.1
Kim, J.A.2
Downey, M.3
Fillingham, J.4
Chowdhury, D.5
Harrison, J.C.6
Onishi, M.7
Datta, N.8
Galicia, S.9
Emili, A.10
-
19
-
-
9144269660
-
A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1
-
N.J. Krogan, M.C. Keogh, N. Datta, C. Sawa, O.W. Ryan, H. Ding, R.A. Haw, J. Pootoolal, A. Tong, and V. Canadien A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1 Mol. Cell 12 2003 1565 1576
-
(2003)
Mol. Cell
, vol.12
, pp. 1565-1576
-
-
Krogan, N.J.1
Keogh, M.C.2
Datta, N.3
Sawa, C.4
Ryan, O.W.5
Ding, H.6
Haw, R.A.7
Pootoolal, J.8
Tong, A.9
Canadien, V.10
-
20
-
-
10844233155
-
Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions
-
T. Kusch, L. Florens, W.H. Macdonald, S.K. Swanson, R.L. Glaser, J.R. Yates 3rd, S.M. Abmayr, M.P. Washburn, and J.L. Workman Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions Science 306 2004 2084 2087
-
(2004)
Science
, vol.306
, pp. 2084-2087
-
-
Kusch, T.1
Florens, L.2
MacDonald, W.H.3
Swanson, S.K.4
Glaser, R.L.5
Yates III, J.R.6
Abmayr, S.M.7
Washburn, M.P.8
Workman, J.L.9
-
21
-
-
0037040974
-
Biochemical analysis of chromatin containing recombinant Drosophila core histones
-
M.E. Levenstein, and J.T. Kadonaga Biochemical analysis of chromatin containing recombinant Drosophila core histones J. Biol. Chem. 277 2002 8749 8754
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 8749-8754
-
-
Levenstein, M.E.1
Kadonaga, J.T.2
-
22
-
-
0037468232
-
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
-
Z. Lou, K. Minter-Dykhouse, X. Wu, and J. Chen MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways Nature 421 2003 957 961
-
(2003)
Nature
, vol.421
, pp. 957-961
-
-
Lou, Z.1
Minter-Dykhouse, K.2
Wu, X.3
Chen, J.4
-
23
-
-
0033039285
-
Preparation of nucleosome core particle from recombinant histones
-
K. Luger, T.J. Rechsteiner, and T.J. Richmond Preparation of nucleosome core particle from recombinant histones Methods Enzymol. 304 1999 3 19
-
(1999)
Methods Enzymol.
, vol.304
, pp. 3-19
-
-
Luger, K.1
Rechsteiner, T.J.2
Richmond, T.J.3
-
24
-
-
26244439873
-
ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells
-
K.J. McManus, and M.J. Hendzel ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells Mol. Biol. Cell 16 2005 5013 5025
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 5013-5025
-
-
McManus, K.J.1
Hendzel, M.J.2
-
25
-
-
10944224673
-
INO80 and γ-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair
-
A.J. Morrison, J. Highland, N.J. Krogan, A. Arbel-Eden, J.F. Greenblatt, J.E. Haber, and X. Shen INO80 and γ-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair Cell 119 2004 767 775
-
(2004)
Cell
, vol.119
, pp. 767-775
-
-
Morrison, A.J.1
Highland, J.2
Krogan, N.J.3
Arbel-Eden, A.4
Greenblatt, J.F.5
Haber, J.E.6
Shen, X.7
-
26
-
-
0042820464
-
Dephosphorylation of histone γ-H2AX during repair of DNA double-strand breaks in mammalian cells and its inhibition by calyculin a
-
I.B. Nazarov, A.N. Smirnova, R.I. Krutilina, M.P. Svetlova, L.V. Solovjeva, A.A. Nikiforov, S.L. Oei, I.A. Zalenskaya, P.M. Yau, E.M. Bradbury, and N.V. Tomilin Dephosphorylation of histone γ-H2AX during repair of DNA double-strand breaks in mammalian cells and its inhibition by calyculin A Radiat. Res. 160 2003 309 317
-
(2003)
Radiat. Res.
, vol.160
, pp. 309-317
-
-
Nazarov, I.B.1
Smirnova, A.N.2
Krutilina, R.I.3
Svetlova, M.P.4
Solovjeva, L.V.5
Nikiforov, A.A.6
Oei, S.L.7
Zalenskaya, I.A.8
Yau, P.M.9
Bradbury, E.M.10
Tomilin, N.V.11
-
27
-
-
0037474198
-
Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17
-
A.V. Pandey, S.H. Mellon, and W.L. Miller Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17 J. Biol. Chem. 278 2003 2837 2844
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2837-2844
-
-
Pandey, A.V.1
Mellon, S.H.2
Miller, W.L.3
-
28
-
-
0343280013
-
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
-
T.T. Paull, E.P. Rogakou, V. Yamazaki, C.U. Kirchgessner, M. Gellert, and W.M. Bonner A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage Curr. Biol. 10 2000 886 895
-
(2000)
Curr. Biol.
, vol.10
, pp. 886-895
-
-
Paull, T.T.1
Rogakou, E.P.2
Yamazaki, V.3
Kirchgessner, C.U.4
Gellert, M.5
Bonner, W.M.6
-
29
-
-
0142011461
-
The cellular response to DNA double-strand breaks: Defining the sensors and mediators
-
J.H. Petrini, and T.H. Stracker The cellular response to DNA double-strand breaks: defining the sensors and mediators Trends Cell Biol. 13 2003 458 462
-
(2003)
Trends Cell Biol.
, vol.13
, pp. 458-462
-
-
Petrini, J.H.1
Stracker, T.H.2
-
30
-
-
0032861343
-
Megabase chromatin domains involved in DNA double-strand breaks in vivo
-
E.P. Rogakou, C. Boon, C. Redon, and W.M. Bonner Megabase chromatin domains involved in DNA double-strand breaks in vivo J. Cell Biol. 146 1999 905 916
-
(1999)
J. Cell Biol.
, vol.146
, pp. 905-916
-
-
Rogakou, E.P.1
Boon, C.2
Redon, C.3
Bonner, W.M.4
-
31
-
-
0033104517
-
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes
-
R.G. Shao, C.X. Cao, H. Zhang, K.W. Kohn, M.S. Wold, and Y. Pommier Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes EMBO J. 18 1999 1397 1406
-
(1999)
EMBO J.
, vol.18
, pp. 1397-1406
-
-
Shao, R.G.1
Cao, C.X.2
Zhang, H.3
Kohn, K.W.4
Wold, M.S.5
Pommier, Y.6
-
32
-
-
4644257681
-
Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break
-
R. Shroff, A. Arbel-Eden, D. Pilch, G. Ira, W.M. Bonner, J.H. Petrini, J.E. Haber, and M. Lichten Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break Curr. Biol. 14 2004 1703 1711
-
(2004)
Curr. Biol.
, vol.14
, pp. 1703-1711
-
-
Shroff, R.1
Arbel-Eden, A.2
Pilch, D.3
Ira, G.4
Bonner, W.M.5
Petrini, J.H.6
Haber, J.E.7
Lichten, M.8
-
33
-
-
0036402522
-
Photobleaching of GFP-labeled H2AX in chromatin: H2AX has low diffusional mobility in the nucleus
-
J.S. Siino, I.B. Nazarov, M.P. Svetlova, L.V. Solovjeva, R.H. Adamson, I.A. Zalenskaya, P.M. Yau, E.M. Bradbury, and N.V. Tomilin Photobleaching of GFP-labeled H2AX in chromatin: H2AX has low diffusional mobility in the nucleus Biochem. Biophys. Res. Commun. 297 2002 1318 1323
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.297
, pp. 1318-1323
-
-
Siino, J.S.1
Nazarov, I.B.2
Svetlova, M.P.3
Solovjeva, L.V.4
Adamson, R.H.5
Zalenskaya, I.A.6
Yau, P.M.7
Bradbury, E.M.8
Tomilin, N.V.9
-
34
-
-
0037468192
-
MDC1 is a mediator of the mammalian DNA damage checkpoint
-
G.S. Stewart, B. Wang, C.R. Bignell, A.M. Taylor, and S.J. Elledge MDC1 is a mediator of the mammalian DNA damage checkpoint Nature 421 2003 961 966
-
(2003)
Nature
, vol.421
, pp. 961-966
-
-
Stewart, G.S.1
Wang, B.2
Bignell, C.R.3
Taylor, A.M.4
Elledge, S.J.5
-
35
-
-
10944232673
-
Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair
-
L. Strom, H.B. Lindroos, K. Shirahige, and C. Sjogren Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair Mol. Cell 16 2004 1003 1015
-
(2004)
Mol. Cell
, vol.16
, pp. 1003-1015
-
-
Strom, L.1
Lindroos, H.B.2
Shirahige, K.3
Sjogren, C.4
-
36
-
-
20444391346
-
Chromatin in need of a fix: Phosphorylation of H2AX connects chromatin to DNA repair
-
C. Thiriet, and J.J. Hayes Chromatin in need of a fix: phosphorylation of H2AX connects chromatin to DNA repair Mol. Cell 18 2005 617 622
-
(2005)
Mol. Cell
, vol.18
, pp. 617-622
-
-
Thiriet, C.1
Hayes, J.J.2
-
37
-
-
0028940016
-
Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression
-
P. Turowski, A. Fernandez, B. Favre, N.J. Lamb, and B.A. Hemmings Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression J. Cell Biol. 129 1995 397 410
-
(1995)
J. Cell Biol.
, vol.129
, pp. 397-410
-
-
Turowski, P.1
Fernandez, A.2
Favre, B.3
Lamb, N.J.4
Hemmings, B.A.5
-
38
-
-
10944262393
-
DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain
-
E. Unal, A. Arbel-Eden, U. Sattler, R. Shroff, M. Lichten, J.E. Haber, and D. Koshland DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain Mol. Cell 16 2004 991 1002
-
(2004)
Mol. Cell
, vol.16
, pp. 991-1002
-
-
Unal, E.1
Arbel-Eden, A.2
Sattler, U.3
Shroff, R.4
Lichten, M.5
Haber, J.E.6
Koshland, D.7
-
39
-
-
10944233962
-
Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair
-
H. van Attikum, O. Fritsch, B. Hohn, and S.M. Gasser Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair Cell 119 2004 777 788
-
(2004)
Cell
, vol.119
, pp. 777-788
-
-
Van Attikum, H.1
Fritsch, O.2
Hohn, B.3
Gasser, S.M.4
-
40
-
-
0034009389
-
Protein phosphatase 2A: A panoply of enzymes
-
D.M. Virshup Protein phosphatase 2A: a panoply of enzymes Curr. Opin. Cell Biol. 12 2000 180 185
-
(2000)
Curr. Opin. Cell Biol.
, vol.12
, pp. 180-185
-
-
Virshup, D.M.1
-
41
-
-
0030720062
-
Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A
-
A.H. Walsh, A. Cheng, and R.E. Honkanen Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A FEBS Lett. 416 1997 230 234
-
(1997)
FEBS Lett.
, vol.416
, pp. 230-234
-
-
Walsh, A.H.1
Cheng, A.2
Honkanen, R.E.3
-
42
-
-
10944219768
-
Control of sister chromatid recombination by histone H2AX
-
A. Xie, N. Puget, I. Shim, S. Odate, I. Jarzyna, C.H. Bassing, F.W. Alt, and R. Scully Control of sister chromatid recombination by histone H2AX Mol. Cell 16 2004 1017 1025
-
(2004)
Mol. Cell
, vol.16
, pp. 1017-1025
-
-
Xie, A.1
Puget, N.2
Shim, I.3
Odate, S.4
Jarzyna, I.5
Bassing, C.H.6
Alt, F.W.7
Scully, R.8
-
43
-
-
0036375567
-
The Saccharomyces cerevisiae type 2A protein phosphatase Pph22p is biochemically different from mammalian PP2A
-
P. Zabrocki, W. Swiatek, E. Sugajska, J.M. Thevelein, S. Wera, and S. Zolnierowicz The Saccharomyces cerevisiae type 2A protein phosphatase Pph22p is biochemically different from mammalian PP2A Eur. J. Biochem. 269 2002 3372 3382
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 3372-3382
-
-
Zabrocki, P.1
Swiatek, W.2
Sugajska, E.3
Thevelein, J.M.4
Wera, S.5
Zolnierowicz, S.6
|