메뉴 건너뛰기




Volumn 5, Issue 11, 2006, Pages 2757-2766

The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair system and contributes to temozolomide-induced G2 arrest and cytotoxicity

Author keywords

[No Author keywords available]

Indexed keywords

6 O METHYLGUANINE; CYCLINE; DOUBLE STRANDED DNA; HISTONE H2AX; MRE11 PROTEIN; NIBRIN; PROTEIN MLH1; RAD50 PROTEIN; RNA; TEMOZOLOMIDE;

EID: 33845214070     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-06-0183     Document Type: Article
Times cited : (42)

References (51)
  • 1
    • 21744439869 scopus 로고    scopus 로고
    • Treatment of metastatic malignant melanoma
    • Atallah E, Flaherty L. Treatment of metastatic malignant melanoma. Curr Treat Options Oncol 2005;6:185-93.
    • (2005) Curr Treat Options Oncol , vol.6 , pp. 185-193
    • Atallah, E.1    Flaherty, L.2
  • 2
    • 19644388733 scopus 로고    scopus 로고
    • Treatment of brain tumors
    • Seiter K. Treatment of brain tumors. N Engl J Med 2005;352:2350-3.
    • (2005) N Engl J Med , vol.352 , pp. 2350-2353
    • Seiter, K.1
  • 4
    • 0030993717 scopus 로고    scopus 로고
    • Temozolomide: A review of its discovery, chemical properties, pre-clinical development and clinical trials
    • Newlands ES, Stevens MF, Wedge SR, Wheelhouse RT, Brock C. Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials. Cancer Treat Rev 1997;23:35-61.
    • (1997) Cancer Treat Rev , vol.23 , pp. 35-61
    • Newlands, E.S.1    Stevens, M.F.2    Wedge, S.R.3    Wheelhouse, R.T.4    Brock, C.5
  • 5
    • 0027502938 scopus 로고
    • Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage
    • Branch P, Aquilina G, Bignami M, Karran P. Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature 1993; 362:652-4.
    • (1993) Nature , vol.362 , pp. 652-654
    • Branch, P.1    Aquilina, G.2    Bignami, M.3    Karran, P.4
  • 6
    • 0026750738 scopus 로고
    • Self-destruction and tolerance in resistance of mammalian cells to alkylation damage
    • Karran P, Bignami M. Self-destruction and tolerance in resistance of mammalian cells to alkylation damage. Nucleic Acids Res 1992;20: 2933-40.
    • (1992) Nucleic Acids Res , vol.20 , pp. 2933-2940
    • Karran, P.1    Bignami, M.2
  • 7
    • 0035266245 scopus 로고    scopus 로고
    • 2/M arrest and the fate of temozolomide-treated human glioblastoma cells
    • 2/M arrest and the fate of temozolomide-treated human glioblastoma cells. Cancer Res 2001;61:1957-63.
    • (2001) Cancer Res , vol.61 , pp. 1957-1963
    • Hirose, Y.1    Berger, M.S.2    Pieper, R.O.3
  • 8
    • 0034028030 scopus 로고    scopus 로고
    • Repair of O(6)-alkylguanine by alkyltransferases
    • Pegg AE. Repair of O(6)-alkylguanine by alkyltransferases. Mutat Res 2000;462:83-100.
    • (2000) Mutat Res , vol.462 , pp. 83-100
    • Pegg, A.E.1
  • 10
    • 0025196019 scopus 로고
    • 6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents
    • 6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proc Natl Aced Sci U S A 1990;87:5368-72.
    • (1990) Proc Natl Aced Sci U S A , vol.87 , pp. 5368-5372
    • Dolan, M.E.1    Moschel, R.C.2    Pegg, A.E.3
  • 11
    • 0025924488 scopus 로고
    • 6 -benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents
    • 6 -benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents. Cancer Res 1991; 51:3367-72.
    • (1991) Cancer Res , vol.51 , pp. 3367-3372
    • Dolan, M.E.1    Mitchell, R.B.2    Mummert, C.3    Moschel, R.C.4    Pegg, A.E.5
  • 12
    • 0030479125 scopus 로고    scopus 로고
    • Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea
    • Liu L, Markowitz S, Gerson SL. Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea. Cancer Res 1996;56:5375-9.
    • (1996) Cancer Res , vol.56 , pp. 5375-5379
    • Liu, L.1    Markowitz, S.2    Gerson, S.L.3
  • 13
    • 0030834332 scopus 로고    scopus 로고
    • Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft
    • Friedman HS, Johnson SP, Dong Q, et al. Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft. Cancer Res 1997;57:2933-6.
    • (1997) Cancer Res , vol.57 , pp. 2933-2936
    • Friedman, H.S.1    Johnson, S.P.2    Dong, Q.3
  • 14
    • 33646256145 scopus 로고    scopus 로고
    • A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy
    • Hunter C, Smith R, Cahill DP, et al. A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. Cancer Res 2006;66:3987-91.
    • (2006) Cancer Res , vol.66 , pp. 3987-3991
    • Hunter, C.1    Smith, R.2    Cahill, D.P.3
  • 15
    • 0032588748 scopus 로고    scopus 로고
    • 6-Methylguanine-DNA methyltransferase-deficient phenotype in human gliomas: Frequency and time to tumor progression after alkylating agent-based chemotherapy
    • 6-Methylguanine-DNA methyltransferase-deficient phenotype in human gliomas: frequency and time to tumor progression after alkylating agent-based chemotherapy. Clin Cancer Res 1999;5:807-14.
    • (1999) Clin Cancer Res , vol.5 , pp. 807-814
    • Silber, J.R.1    Blank, A.2    Bobola, M.S.3    Ghatan, S.4    Kolstoe, D.D.5    Berger, M.S.6
  • 18
    • 4944242445 scopus 로고    scopus 로고
    • DNA damage induced by temozolomide signals to both ATM and ATR: Role of the mismatch repair system
    • Caporali S, Falcinelli S, Starace G, et al. DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system. Mol Pharmacol 2004;66:478-91.
    • (2004) Mol Pharmacol , vol.66 , pp. 478-491
    • Caporali, S.1    Falcinelli, S.2    Starace, G.3
  • 23
    • 0033625759 scopus 로고    scopus 로고
    • Involvement of the MKK6-38γ cascade in γ-radiation-induced cell cycle arrest
    • Wang X, McGowan CH, Zhao M, et al. Involvement of the MKK6-38γ cascade in γ-radiation-induced cell cycle arrest. Mol Cell Biol 2000;20: 4543-52.
    • (2000) Mol Cell Biol , vol.20 , pp. 4543-4552
    • Wang, X.1    McGowan, C.H.2    Zhao, M.3
  • 24
    • 25144469291 scopus 로고    scopus 로고
    • The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM
    • Paull TT, Lee JH. The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM. Cell Cycle 2005;4:737-40.
    • (2005) Cell Cycle , vol.4 , pp. 737-740
    • Paull, T.T.1    Lee, J.H.2
  • 25
    • 17644409069 scopus 로고    scopus 로고
    • ATM activation by DNA double-strand breaks through the Mre11-50-Nbs1 complex
    • Lee JH, Paull TT. ATM activation by DNA double-strand breaks through the Mre11-50-Nbs1 complex. Science 2005;308:551-4.
    • (2005) Science , vol.308 , pp. 551-554
    • Lee, J.H.1    Paull, T.T.2
  • 26
    • 20744436198 scopus 로고    scopus 로고
    • ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1
    • You Z, Chahwan C, Bailis J, Hunter T, Russell P. ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol 2005;25:5363-79.
    • (2005) Mol Cell Biol , vol.25 , pp. 5363-5379
    • You, Z.1    Chahwan, C.2    Bailis, J.3    Hunter, T.4    Russell, P.5
  • 27
    • 0034749425 scopus 로고    scopus 로고
    • DNA damage-dependent nuclear dynamics of the Mre11 complex
    • Mirzoeva OK, Petrini JH. DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol Cell Biol 2001;21:281-8.
    • (2001) Mol Cell Biol , vol.21 , pp. 281-288
    • Mirzoeva, O.K.1    Petrini, J.H.2
  • 30
    • 0038143321 scopus 로고    scopus 로고
    • Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX
    • Ward IM, Minn K, Jorda KG, Chen J. Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J Biol Chem 2003;278:19579-82.
    • (2003) J Biol Chem , vol.278 , pp. 19579-19582
    • Ward, I.M.1    Minn, K.2    Jorda, K.G.3    Chen, J.4
  • 31
    • 0037226818 scopus 로고    scopus 로고
    • DNA replication-dependent nuclear dynamics of the Mre11 complex
    • Mirzoeva OK, Petrini JH. DNA replication-dependent nuclear dynamics of the Mre11 complex. Mol Cancer Res 2003;3:207-18.
    • (2003) Mol Cancer Res , vol.3 , pp. 207-218
    • Mirzoeva, O.K.1    Petrini, J.H.2
  • 32
    • 0035422203 scopus 로고    scopus 로고
    • Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells
    • Hirose Y, Berger MS, Pieper RO. Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells. Cancer Res 2001; 61:5843-9.
    • (2001) Cancer Res , vol.61 , pp. 5843-5849
    • Hirose, Y.1    Berger, M.S.2    Pieper, R.O.3
  • 33
    • 0037365825 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase resulting in failure to protect the human glioblastoma cell line SF767 from temozolomide-induced cytotoxicity
    • 6-methylguanine-DNA methyltransferase resulting in failure to protect the human glioblastoma cell line SF767 from temozolomide-induced cytotoxicity. J Neurosurg 2003;98:591-8.
    • (2003) J Neurosurg , vol.98 , pp. 591-598
    • Hirose, Y.1    Kreklau, E.L.2    Erickson, L.C.3    Berger, M.S.4    Pieper, R.O.5
  • 34
    • 0014733394 scopus 로고
    • Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N′-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation
    • Lawley PD, Thatcher CJ. Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N′-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation. Biochem J 1970; 116:693-707.
    • (1970) Biochem J , vol.116 , pp. 693-707
    • Lawley, P.D.1    Thatcher, C.J.2
  • 35
    • 0032562595 scopus 로고    scopus 로고
    • In situ visualization of DNA double-strand break repair in human fibroblasts
    • Nelms BE, Maser RS, MacKay JF, Lagally MG, Petrini JH. In situ visualization of DNA double-strand break repair in human fibroblasts. Science 1998;280:590-2.
    • (1998) Science , vol.280 , pp. 590-592
    • Nelms, B.E.1    Maser, R.S.2    MacKay, J.F.3    Lagally, M.G.4    Petrini, J.H.5
  • 36
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • Rogakou EP, Boon C, Redon C, Bonner WM. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 1999; 146:905-16.
    • (1999) J Cell Biol , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 37
    • 0034739853 scopus 로고    scopus 로고
    • p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
    • Schultz LB, Chehab NH, Malikzay A, Halazonetis TD. p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J Cell Biol 2000;151:1381-90.
    • (2000) J Cell Biol , vol.151 , pp. 1381-1390
    • Schultz, L.B.1    Chehab, N.H.2    Malikzay, A.3    Halazonetis, T.D.4
  • 38
    • 0034903925 scopus 로고    scopus 로고
    • Mre11 complex and DNA replication: Linkage to E2F and sites of DNA synthesis
    • Maser RS, Mirzoeva OK, Wells J, et al. Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis. Mol Cell Biol 2001; 21:6006-16.
    • (2001) Mol Cell Biol , vol.21 , pp. 6006-6016
    • Maser, R.S.1    Mirzoeva, O.K.2    Wells, J.3
  • 39
    • 0035868951 scopus 로고    scopus 로고
    • hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci
    • Kleczkowska HE, Marra G, Lettieri T, Jiricny J. hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci. Genes Dev 2001;15:724-36.
    • (2001) Genes Dev , vol.15 , pp. 724-736
    • Kleczkowska, H.E.1    Marra, G.2    Lettieri, T.3    Jiricny, J.4
  • 40
    • 3242891189 scopus 로고    scopus 로고
    • The Mre11 complex and the metabolism of chromosome breaks: The importance of communicating and holding things together
    • Stracker TH, Theunissen JW, Morales M, Petrini JH. The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together. DNA Repair (Amst) 2004;3: 845-54.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 845-854
    • Stracker, T.H.1    Theunissen, J.W.2    Morales, M.3    Petrini, J.H.4
  • 41
    • 0037019607 scopus 로고    scopus 로고
    • Evidence for a direct association of hMRE11 with the human mismatch repair protein hMLH1
    • Her C, Vo AT, Wu X. Evidence for a direct association of hMRE11 with the human mismatch repair protein hMLH1. DNA Repair (Amst) 2002;1:719-29.
    • (2002) DNA Repair (Amst) , vol.1 , pp. 719-729
    • Her, C.1    Vo, A.T.2    Wu, X.3
  • 42
    • 0034655991 scopus 로고    scopus 로고
    • BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
    • Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev 2000;14:927-39.
    • (2000) Genes Dev , vol.14 , pp. 927-939
    • Wang, Y.1    Cortez, D.2    Yazdi, P.3    Neff, N.4    Elledge, S.J.5    Qin, J.6
  • 43
    • 0037468169 scopus 로고    scopus 로고
    • MDC1 is required for the intra-S-phase DNA damage checkpoint
    • Goldberg M, Stucki M, Falck J, et al. MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature 2003;421:952-6.
    • (2003) Nature , vol.421 , pp. 952-956
    • Goldberg, M.1    Stucki, M.2    Falck, J.3
  • 45
    • 30344463835 scopus 로고    scopus 로고
    • ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
    • Jazayeri A, Falck J, Lukas C, et al. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 2006;8:37-45.
    • (2006) Nat Cell Biol , vol.8 , pp. 37-45
    • Jazayeri, A.1    Falck, J.2    Lukas, C.3
  • 46
    • 0026616913 scopus 로고
    • 6-methylguanine on DNA damage and cytotoxicity of temozolomide in L1210 mouse leukemia sensitive and resistant to chloroethylnitrosoureas
    • 6-methylguanine on DNA damage and cytotoxicity of temozolomide in L1210 mouse leukemia sensitive and resistant to chloroethylnitrosoureas. Anticancer Drugs 1992;3:401-5.
    • (1992) Anticancer Drugs , vol.3 , pp. 401-405
    • Taverna, P.1    Catapano, C.V.2    Citti, L.3    Bonfanti, M.4    D'Incalci, M.5
  • 47
    • 0034953719 scopus 로고    scopus 로고
    • Chk2 activation dependence on Nbs1 after DNA damage
    • Buscemi G, Savio C, Zannini L, et al. Chk2 activation dependence on Nbs1 after DNA damage. Mol Cell Biol 2001;21:5214-22.
    • (2001) Mol Cell Biol , vol.21 , pp. 5214-5222
    • Buscemi, G.1    Savio, C.2    Zannini, L.3
  • 49
    • 0036146085 scopus 로고    scopus 로고
    • Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation
    • Xu B, Kim ST, Lim DS, Kasten MB. Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol 2002;22: 1049-59.
    • (2002) Mol Cell Biol , vol.22 , pp. 1049-1059
    • Xu, B.1    Kim, S.T.2    Lim, D.S.3    Kasten, M.B.4
  • 50
    • 0035032649 scopus 로고    scopus 로고
    • Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation
    • Xu B, Kim S, Kastan MB. Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol Cell Biol 2001;21: 3445-50.
    • (2001) Mol Cell Biol , vol.21 , pp. 3445-3450
    • Xu, B.1    Kim, S.2    Kastan, M.B.3
  • 51
    • 19444379003 scopus 로고    scopus 로고
    • hMRE11 deficiency leads to microsatellite instability and defective DNA mismatch repair
    • Vo AT, Zhu F, Wu X, et al. hMRE11 deficiency leads to microsatellite instability and defective DNA mismatch repair. EMBO Rep 2005;6: 438-44.
    • (2005) EMBO Rep , vol.6 , pp. 438-444
    • Vo, A.T.1    Zhu, F.2    Wu, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.