Cytochrome P450-activated prodrugs: Targeted drug delivery

Current Medicinal Chemistry

Volumn 15, Issue 23, 2008, Pages 2346-2365

  Huttunen, Kristiina M ^a   Mähönen, Niina ^a   Raunio, Hannu ^a   Rautio, Jarkko ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Antibody directed enzyme prodrug therapy (ADEPT); Cyclic phosphate; Cytochrome P450 enzyme; Gene directedenzyme prodrug therapy (GDEPT); N oxide; Nucleoside; Oxazaphosphorine; Oxime; Prodrug; Targeted drug delivery

Indexed keywords

1,4 BIS[[2 (DIMETHYLAMINO N OXIDE)ETHYL]AMINO] 5,8 DIHYDROXYANTHRAQUINONE; 2,5 BIS(4 AMIDINOPHENYL)FURAN; ADEFOVIR; ADEFOVIR TRIPHOSPHATE; BUPARVAQUONE; BUPARVAQUONE HYDROXYIMINE; CLOPIDOGREL; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTOCHROME; CYTOCHROME P450; CYTOCHROME P450 2B11; CYTOCHROME P450 2B6; CYTOCHROME P450 INHIBITOR; DACARBAZINE; DRUG METABOLIZING ENZYME; GUANABENZ; GUANOXABENZ; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IFOSFAMIDE; ISTUBAL; METXIA; MW 1201; MW 28; NABUMETONE; PAFURAMIDINE; PHOSPHORAMIDE MUSTARD; PRADEFOVIR; PRODRUG; RETROVIRUS VECTOR; SIBRAFIBAN; TAMOXIFEN; TAMOXIFEN CITRATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; XIMELAGATRAN; OXIME; PHOSPHORUS;

ANTIBODY DIRECTED ENZYME PRODRUG THERAPY; ANTIHYPERTENSIVE ACTIVITY; ANTINEOPLASTIC ACTIVITY; ATHEROSCLEROSIS; BIOTRANSFORMATION; BREAST CANCER; CLINICAL TRIAL; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENTIATION; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG TARGETING; DRUG WITHDRAWAL; ENZYME ACTIVATION; GENE DIRECTED ENZYME PRODRUG THERAPY; HEPATITIS B; HODGKIN DISEASE; HUMAN; LIVER TOXICITY; LOW DRUG DOSE; MALARIA; NONHUMAN; REVIEW; SARCOMA; THROMBOEMBOLISM; TUMOR CELL; VIRAL GENE DELIVERY SYSTEM; ANIMAL; CHEMISTRY; DRUG DELIVERY SYSTEM; METABOLISM;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DELIVERY SYSTEMS; ENZYME ACTIVATION; HUMANS; OXIMES; PHOSPHORUS; PRODRUGS;

EID: 55249095031     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986708785909120     Document Type: Review

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