O-alkoxyamidine prodrugs of furamidine: In vitro transport and microsomal metabolism as indicators of in vivo efficacy in a mouse model of Trypanosoma brucei rhodesiense infection

Journal of Medicinal Chemistry

Volumn 47, Issue 17, 2004, Pages 4335-4338

  Ansede, John H ^a,d   Anbazhagan, Mariappan ^b   Brun, Reto ^c   Easterbrook, Judy D ^c   Hall, James Edwin ^a   Boykin, David W ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b GEORGIA STATE UNIVERSITY   (United States)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d Qualyst Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,5 BIS[4 HYDROXYAMIDINOPHENYL]FURAN; 2,5 BIS[4 METHOXYAMIDINOPHENYL]FURAN; ALKYL GROUP; AMIDINE; ANTIINFECTIVE AGENT; ANTITRYPANOSOMAL AGENT; DB 289; DB 290; FURAMIDINE; FURAN DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG METABOLISM; DRUG SCREENING; DRUG SYNTHESIS; DRUG TRANSPORT; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIVER MICROSOME; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA RHODESIENSE; TRYPANOSOMIASIS;

ADMINISTRATION, ORAL; ANIMALS; BENZAMIDINES; BIOLOGICAL TRANSPORT; CACO-2 CELLS; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICROSOMES, LIVER; PERMEABILITY; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMIASIS, AFRICAN;

EID: 3843134198     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030604o     Document Type: Article

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