Targeting cytochrome P450 enzymes: A new approach in anti-cancer drug development

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 15, 2007, Pages 5047-5060

  Bruno, Robert D ^a   Njar, Vincent C O ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

Cancer; Chemotherapy; Cytochrome P450s; Drug development

Indexed keywords

17 BENZOIMIDAZOLE; ABIRATERONE; ACACETIN; ANASTROZOLE; ANDROGEN RECEPTOR; AROMATASE INHIBITOR; BICALUTAMIDE; CALCITRIOL; CYP 24; CYP 26; CYP 27B1; CYTOCHROME P450; CYTOCHROME P450 17; CYTOCHROME P450 INHIBITOR; ESTROGEN RECEPTOR; EXEMESTANE; FLUTAMIDE; FORMESTANE; GENISTEIN; GLUCOCORTICOID; GONADORELIN AGONIST; KAEMPFEROL; KETOCONAZOLE; LETROZOLE; LIAROZOLE; LIAROZOLE FUMARATE; N [4 [2 ETHYL 1 (1H 1,2,4 TRIAZOL 1 YL)BUTYL]PHENYL] 2 BENZOTHIAZOLAMINE; PICEATANNOL; QW 1624F 2 2; R 116010; RETINOIC ACID RECEPTOR; SEOCALCITOL; TAMOXIFEN; TRICHOSTATIN A; UNCLASSIFIED DRUG; UNINDEXED DRUG; VID 400; VN 124 1;

ADJUVANT THERAPY; BREAST CANCER; CANCER; CANCER CHEMOTHERAPY; CLINICAL TRIAL; DRUG MEGADOSE; ENZYME ACTIVITY; HUMAN; LOW DRUG DOSE; NONHUMAN; PROMYELOCYTIC LEUKEMIA; PROSTATE CANCER; PROTEIN EXPRESSION; REVIEW; VITAMIN METABOLISM;

ANTINEOPLASTIC AGENTS; CYTOCHROME P-450 ENZYME SYSTEM; NEOPLASMS;

EID: 34249930470     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.05.046     Document Type: Review

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