메뉴 건너뛰기




Volumn 40, Issue 4, 2004, Pages 508-514

Phase I trial of UFT/leucovorin and irinotecan in patients with advanced cancer

Author keywords

Colorectal cancer; Irinotecan; MTHFR; Non small cell lung cancer; UFT

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ANTINEOPLASTIC AGENT; FLUOROPYRIMIDINE; FOLINIC ACID; IRINOTECAN; TEGAFUR; UFT; UNCLASSIFIED DRUG; URACIL;

EID: 10744228712     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2003.10.022     Document Type: Article
Times cited : (15)

References (52)
  • 1
    • 0018746994 scopus 로고
    • Pharmacokinetics and metabolism of ftorafur in man
    • Au J.L., Wu A.T., Friedman M.A., Sadee W. Pharmacokinetics and metabolism of ftorafur in man. Cancer Treat Rep. 63:1979;343-350.
    • (1979) Cancer Treat Rep , vol.63 , pp. 343-350
    • Au, J.L.1    Wu, A.T.2    Friedman, M.A.3    Sadee, W.4
  • 2
    • 0020643556 scopus 로고
    • Metabolic activation of R,S-1-[tetrahydro-2-furanyl]-5-fluorouracil (ftorafur) to 5-fluorouracil by soluble enzymes
    • El Sayed Y.M., Sadee W. Metabolic activation of R,S-1-[tetrahydro-2- furanyl]-5-fluorouracil (ftorafur) to 5-fluorouracil by soluble enzymes. Cancer Res. 43:1983;4039-4044.
    • (1983) Cancer Res. , vol.43 , pp. 4039-4044
    • El Sayed, Y.M.1    Sadee, W.2
  • 3
    • 0026465480 scopus 로고
    • Clinical pharmacology of combined oral uracil and ftorafur
    • Ho D.H., Covington W.P., Pazdur R.et al. Clinical pharmacology of combined oral uracil and ftorafur. Drug Metab Disp. 20:1992;936-940.
    • (1992) Drug Metab Disp , vol.20 , pp. 936-940
    • Ho, D.H.1    Covington, W.P.2    Pazdur, R.3
  • 4
    • 0023726563 scopus 로고
    • Report on nationwide pooled data and cohort investigation in UFT phase II study
    • Ota K., Taguchi T., Kimura K. Report on nationwide pooled data and cohort investigation in UFT phase II study. Cancer Chemother Pharmacol. 22:1988;333-338.
    • (1988) Cancer Chemother Pharmacol. , vol.22 , pp. 333-338
    • Ota, K.1    Taguchi, T.2    Kimura, K.3
  • 5
    • 0030981514 scopus 로고    scopus 로고
    • Phase I trial of uracil-tegafur (UFT) plus oral leucovorin - 14-day schedule
    • Pazdur R., Lassere Y., Diazcanton E., Bready B., Ho D.H. Phase I trial of uracil-tegafur (UFT) plus oral leucovorin - 14-day schedule. Invest New Drugs. 15:1997;123-128.
    • (1997) Invest New Drugs , vol.15 , pp. 123-128
    • Pazdur, R.1    Lassere, Y.2    Diazcanton, E.3    Bready, B.4    Ho, D.H.5
  • 6
    • 0029972388 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of oral uracil, ftorafur, and leucovorin in patients with advanced cancer
    • Meropol N.J., Rustum Y.M., Petrelli N.J.et al. A phase I and pharmacokinetic study of oral uracil, ftorafur, and leucovorin in patients with advanced cancer. Cancer Chemother Pharmacol. 37:1996;581-586.
    • (1996) Cancer Chemother Pharmacol. , vol.37 , pp. 581-586
    • Meropol, N.J.1    Rustum, Y.M.2    Petrelli, N.J.3
  • 7
    • 0029966745 scopus 로고    scopus 로고
    • Phase I trias of uracil-tegafur (UFT) using 5 and 28 day administration schedules - Demonstration of schedule dependent toxicities
    • Pazdur R., Lassere Y., Diazcanton E., Bready B., Ho D.H. Phase I trias of uracil-tegafur (UFT) using 5 and 28 day administration schedules - demonstration of schedule dependent toxicities. Anti-Cancer Drugs. 7:1996;728-733.
    • (1996) Anti-Cancer Drugs , vol.7 , pp. 728-733
    • Pazdur, R.1    Lassere, Y.2    Diazcanton, E.3    Bready, B.4    Ho, D.H.5
  • 8
    • 0030223052 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of oral UFT, a combination of the 5-fluorouracil prodrug tegafur and uracil
    • Muggia F.M., Wu X.Y., Spicer D.et al. Phase I and pharmacokinetic study of oral UFT, a combination of the 5-fluorouracil prodrug tegafur and uracil. Clin. Cancer Res. 2:1996;1461-1467.
    • (1996) Clin. Cancer Res. , vol.2 , pp. 1461-1467
    • Muggia, F.M.1    Wu, X.Y.2    Spicer, D.3
  • 9
    • 0028099423 scopus 로고
    • Phase II trial of uracil and tegafur plus oral leucovorin: An effective oral regimen in the treatment of metastatic colorectal carcinoma
    • Pazdur R., Lassere Y., Rhodes V.et al. Phase II trial of uracil and tegafur plus oral leucovorin: an effective oral regimen in the treatment of metastatic colorectal carcinoma. J Clin Oncol. 12:1994;2296-2300.
    • (1994) J Clin Oncol , vol.12 , pp. 2296-2300
    • Pazdur, R.1    Lassere, Y.2    Rhodes, V.3
  • 10
    • 0028820944 scopus 로고
    • A fixed-ratio combination of uracil and ftorafur (UFT) with low dose leucovorin. An active oral regimen for advanced colorectal cancer
    • Saltz L.B., Leichman C.G., Young C.W.et al. A fixed-ratio combination of uracil and ftorafur (UFT) with low dose leucovorin. An active oral regimen for advanced colorectal cancer. Cancer. 75:1995;782-785.
    • (1995) Cancer , vol.75 , pp. 782-785
    • Saltz, L.B.1    Leichman, C.G.2    Young, C.W.3
  • 11
    • 0029563823 scopus 로고
    • Efficacy of oral tegafur modulation by uracil and leucovorin in advanced colorectal cancer. a phase II study
    • Gonzales-Baron M., Feliu J., de la Gandara I.et al. Efficacy of oral tegafur modulation by uracil and leucovorin in advanced colorectal cancer. A phase II study. Eur J Cancer. 31A:1995;2215-2219.
    • (1995) Eur J Cancer , vol.31 , pp. 2215-2219
    • Gonzales-Baron, M.1    Feliu, J.2    De La Gandara, I.3
  • 12
    • 0027972726 scopus 로고
    • Topoisomerase I inhibitors: Topotecan and irinotecan
    • Creemers J.G., Lun D., Verweiij J.et al. Topoisomerase I inhibitors: topotecan and irinotecan. Cancer Treat Rev. 20:1994;73-96.
    • (1994) Cancer Treat Rev. , vol.20 , pp. 73-96
    • Creemers, J.G.1    Lun, D.2    Verweiij, J.3
  • 13
    • 0031014627 scopus 로고    scopus 로고
    • Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naïve patients and patients pretreated with fluorouracil-based chemotherapy
    • Rougier P., Bugat R., Douillard J.Y.et al. Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naïve patients and patients pretreated with fluorouracil-based chemotherapy. J Clin Oncol. 15:1997;251-260.
    • (1997) J Clin Oncol , vol.15 , pp. 251-260
    • Rougier, P.1    Bugat, R.2    Douillard, J.Y.3
  • 14
    • 0032585197 scopus 로고    scopus 로고
    • Randomized trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer
    • Rougier P., Cutsem E.V., Bajetta E.et al. Randomized trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer. Lancet. 352:1998;1407-1412.
    • (1998) Lancet , vol.352 , pp. 1407-1412
    • Rougier, P.1    Cutsem, E.V.2    Bajetta, E.3
  • 15
    • 0032585232 scopus 로고    scopus 로고
    • Randomized trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer
    • Cunningham D., Pyrhonen S., James R.D.et al. Randomized trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer. Lancet. 352:1998;1413-1418.
    • (1998) Lancet , vol.352 , pp. 1413-1418
    • Cunningham, D.1    Pyrhonen, S.2    James, R.D.3
  • 16
    • 0032032201 scopus 로고    scopus 로고
    • Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell line
    • Guichard S., Hennebelle I., Bugat R.et al. Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell line. Biochem. Pharmacol. 55:1998;667-676.
    • (1998) Biochem. Pharmacol. , vol.55 , pp. 667-676
    • Guichard, S.1    Hennebelle, I.2    Bugat, R.3
  • 17
    • 0032738164 scopus 로고    scopus 로고
    • Sequence-dependent growth inhibition and DNA damage formation by the irinotecan-5-fluorouracil combination in human colon carcinoma cell lines
    • Mans D.R.A., Grivicich I., Peters G.J., Schwartsmann X. Sequence-dependent growth inhibition and DNA damage formation by the irinotecan-5-fluorouracil combination in human colon carcinoma cell lines. Eur J Cancer. 35:1999;1851-1861.
    • (1999) Eur J Cancer , vol.35 , pp. 1851-1861
    • Mans, D.R.A.1    Grivicich, I.2    Peters, G.J.3    Schwartsmann, X.4
  • 18
  • 19
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metatstatic colorectal cancer. Irinotecan study group
    • Saltz L.B., Cox J.V., Blanke C.et al. Irinotecan plus fluorouracil and leucovorin for metatstatic colorectal cancer. Irinotecan study group. N Engl J Med. 343:2000;905-914.
    • (2000) N Engl J Med. , vol.343 , pp. 905-914
    • Saltz, L.B.1    Cox, J.V.2    Blanke, C.3
  • 20
    • 0034712536 scopus 로고    scopus 로고
    • Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicenter randomised trial
    • Douillard J.Y., Cunningham D., Roth A.D.et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicenter randomised trial. Lancet. 355:2000;1041-1047.
    • (2000) Lancet , vol.355 , pp. 1041-1047
    • Douillard, J.Y.1    Cunningham, D.2    Roth, A.D.3
  • 21
    • 0029084773 scopus 로고
    • CPT-11 (Irinotecan) in the treatment of colorectal cancer
    • Armand J.P., Ducreux M., Mahjoubi X.et al. CPT-11 (Irinotecan) in the treatment of colorectal cancer. Eur J Cancer. 31A:1995;1283-1287.
    • (1995) Eur J Cancer , vol.31 , pp. 1283-1287
    • Armand, J.P.1    Ducreux, M.2    Mahjoubi, X.3
  • 22
    • 0028854897 scopus 로고
    • Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients
    • Abigerges D., Chabot G.G., Armand J.P., Herart P., Gouyette A., Gandia D. Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients. J Clin Oncol. 13:1995;210-211.
    • (1995) J Clin Oncol , vol.13 , pp. 210-211
    • Abigerges, D.1    Chabot, G.G.2    Armand, J.P.3    Herart, P.4    Gouyette, A.5    Gandia, D.6
  • 24
    • 0035750549 scopus 로고    scopus 로고
    • Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy
    • Pullarkat S.T., Stoehlmacher J., Ghaderi V.et al. Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy. Pharmacogenomics J. 1:2001;65-70.
    • (2001) Pharmacogenomics J. , vol.1 , pp. 65-70
    • Pullarkat, S.T.1    Stoehlmacher, J.2    Ghaderi, V.3
  • 25
    • 0000776887 scopus 로고    scopus 로고
    • Functional folate status as a prognostic indicator of toxicity in clinical trials of the multitargeted antifolate LY231514
    • Zervos P.H., Allen R.H., Thornton D.E.et al. Functional folate status as a prognostic indicator of toxicity in clinical trials of the multitargeted antifolate LY231514. Proc Am Soc Clin Oncol. 16:1997;907.
    • (1997) Proc Am Soc Clin Oncol , vol.16 , pp. 907
    • Zervos, P.H.1    Allen, R.H.2    Thornton, D.E.3
  • 26
    • 0025944322 scopus 로고
    • Schedule-dependent enhancement of the cytotoxicity of fluoropyrimidines to human carcinoma cells in the presence of folinic acid
    • Moran R.G., Scanlon K.L. Schedule-dependent enhancement of the cytotoxicity of fluoropyrimidines to human carcinoma cells in the presence of folinic acid. Cancer Res. 51:1991;4618-4623.
    • (1991) Cancer Res. , vol.51 , pp. 4618-4623
    • Moran, R.G.1    Scanlon, K.L.2
  • 27
    • 0033998678 scopus 로고    scopus 로고
    • MTHFR gene polymorphism and severe toxicity during adjuvant treatment of early breast cancer with cyclophosphamide, methotrexate, and fluorouracil
    • Toffoli G., Veronesi A., Boiocchi M.et al. MTHFR gene polymorphism and severe toxicity during adjuvant treatment of early breast cancer with cyclophosphamide, methotrexate, and fluorouracil. Ann Oncol. 22:2000;373-374.
    • (2000) Ann Oncol , vol.22 , pp. 373-374
    • Toffoli, G.1    Veronesi, A.2    Boiocchi, M.3
  • 28
    • 0019365237 scopus 로고
    • Reporting results of cancer treatment
    • Miller A.B., Hoogstraten B., Staquet M.et al. Reporting results of cancer treatment. Cancer. 47:1981;207-214.
    • (1981) Cancer , vol.47 , pp. 207-214
    • Miller, A.B.1    Hoogstraten, B.2    Staquet, M.3
  • 29
    • 0024284028 scopus 로고
    • A simple salting out procedure for extracting DNA from human nucleated cells
    • Miller S.A., Dykes D.D., Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acid Res. 16:1988;1215.
    • (1988) Nucleic Acid Res. , vol.16 , pp. 1215
    • Miller, S.A.1    Dykes, D.D.2    Polesky, H.F.3
  • 30
    • 0033927120 scopus 로고    scopus 로고
    • Accurate and rapid multiplex heteroduplexing method for genotyping key enzymes involved in folate/homocysteine metabolism
    • Barbaux S., Kluijtmans L.A., Whitehead A.S. Accurate and rapid multiplex heteroduplexing method for genotyping key enzymes involved in folate/homocysteine metabolism. Clin Chem. 46:2000;907-912.
    • (2000) Clin Chem. , vol.46 , pp. 907-912
    • Barbaux, S.1    Kluijtmans, L.A.2    Whitehead, A.S.3
  • 31
    • 0025604967 scopus 로고
    • Phase II trial of UFT in advanced colorectal and gastric cancer
    • Malik S.T.A., Talbot D., Clarke P.I.et al. Phase II trial of UFT in advanced colorectal and gastric cancer. Br J Cancer. 62:1990;1023-1025.
    • (1990) Br J Cancer , vol.62 , pp. 1023-1025
    • Malik, S.T.A.1    Talbot, D.2    Clarke, P.I.3
  • 32
    • 0036727089 scopus 로고    scopus 로고
    • Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer
    • Carmichael J., Papiela T., Radstone D.et al. Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer. J Clin Oncol. 20:2002;3617-3627.
    • (2002) J Clin Oncol , vol.20 , pp. 3617-3627
    • Carmichael, J.1    Papiela, T.2    Radstone, D.3
  • 33
    • 0036731818 scopus 로고    scopus 로고
    • Multicenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer
    • Douillard J.Y., Hoff P.M., Skillings J.R.et al. Multicenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer. J Clin Oncol. 20:2002;3605-3616.
    • (2002) J Clin Oncol , vol.20 , pp. 3605-3616
    • Douillard, J.Y.1    Hoff, P.M.2    Skillings, J.R.3
  • 34
    • 0035503151 scopus 로고    scopus 로고
    • Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer. Results of a large phase III study
    • Van Cutsem E., Twelves C., Cassidy J.et al. Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer. Results of a large phase III study. J Clin Onc. 19:2001;4097-4107.
    • (2001) J Clin Onc , vol.19 , pp. 4097-4107
    • Van Cutsem, E.1    Twelves, C.2    Cassidy, J.3
  • 35
    • 0036176033 scopus 로고    scopus 로고
    • On behalf of the Xeloda Colorectal Cancer Group: Capecitabine as first-line treatment in colorectal cancer:pooled data from two large, phase III trials
    • Twelves C. On behalf of the Xeloda Colorectal Cancer Group. capecitabine as first-line treatment in colorectal cancer:pooled data from two large, phase III trials Eur J Cancer. 38(Suppl. 2):2002;S15-S20.
    • (2002) Eur J Cancer , vol.38 , Issue.SUPPL. 2
    • Twelves, C.1
  • 36
    • 0344870269 scopus 로고    scopus 로고
    • Irinotecan improves the activity of the AIO regimen in metastatic colorectal cancer: Results of EORTC GI Group study 40986
    • Kohne C.H., Cutsem E.V., Wils J.A.et al. Irinotecan improves the activity of the AIO regimen in metastatic colorectal cancer: results of EORTC GI Group study 40986. Proc Am Soc Clin Oncol. 22:2003;1018.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 1018
    • Kohne, C.H.1    Cutsem, E.V.2    Wils, J.A.3
  • 37
    • 0035884212 scopus 로고    scopus 로고
    • Mortality associated with irinotecan plus bolus fluorouracil/leucovorin: Summary findings of an independent panel
    • Rothemberg M.L., Meropol N.J., Poplin E.A., Cutsem E.V., Wadler S. Mortality associated with irinotecan plus bolus fluorouracil/leucovorin. summary findings of an independent panel J Clin Oncol. 19:2001;3801-3807.
    • (2001) J Clin Oncol , vol.19 , pp. 3801-3807
    • Rothemberg, M.L.1    Meropol, N.J.2    Poplin, E.A.3    Cutsem, E.V.4    Wadler, S.5
  • 38
    • 0042714530 scopus 로고    scopus 로고
    • Randomized phase II trial of capecitabine plus irinotecan (Caplri) vs capecitabine plus oxaliplatin (CapOx) as first-line therapy of advanced colorectal cancer (ACRC)
    • Grothey A., Jordan K., Kellner O.et al. Randomized phase II trial of capecitabine plus irinotecan (Caplri) vs capecitabine plus oxaliplatin (CapOx) as first-line therapy of advanced colorectal cancer (ACRC). Proc Am Soc Clin Oncol. 22:2003;1022.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 1022
    • Grothey, A.1    Jordan, K.2    Kellner, O.3
  • 39
    • 0036988907 scopus 로고    scopus 로고
    • Can capecitabine replace 5-FU/leucovorin in combination with oxaliplatin for the treatment of advanced colorectal cancer?
    • Twelves C. Can capecitabine replace 5-FU/leucovorin in combination with oxaliplatin for the treatment of advanced colorectal cancer? Oncology. 16(Suppl. 12):2002;23-26.
    • (2002) Oncology , vol.16 , Issue.SUPPL. 12 , pp. 23-26
    • Twelves, C.1
  • 40
    • 0012465969 scopus 로고    scopus 로고
    • A phase I/II study of CPT-11 in combination with capecitabine as first-line chemotherapy for metastatic colorectal cancer
    • Kerr D.J., Ten Bokkel Huinink W.W., Ferry D.R.et al. A phase I/II study of CPT-11 in combination with capecitabine as first-line chemotherapy for metastatic colorectal cancer. Proc Am Soc Clin Oncol. 21:2002;643.
    • (2002) Proc Am Soc Clin Oncol , vol.21 , pp. 643
    • Kerr, D.J.1    Ten Bokkel Huinink, W.W.2    Ferry, D.R.3
  • 41
    • 0036982734 scopus 로고    scopus 로고
    • Capecitabine/irinotecan in colorectal cancer: European early-phase data and planned trials
    • Kerr D. Capecitabine/irinotecan in colorectal cancer. european early-phase data and planned trials Oncology. 16(Suppl. 12):2002;12-15.
    • (2002) Oncology , vol.16 , Issue.SUPPL. 12 , pp. 12-15
    • Kerr, D.1
  • 42
    • 0032032201 scopus 로고    scopus 로고
    • Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell line
    • Guichard S., Hennebelle I., Bugat R.et al. Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell line. Biochem. Pharmacol. 55:1998;667-676.
    • (1998) Biochem. Pharmacol. , vol.55 , pp. 667-676
    • Guichard, S.1    Hennebelle, I.2    Bugat, R.3
  • 43
    • 0031771777 scopus 로고    scopus 로고
    • Combination of irinotecan (CPT-11) and 5-fluorouracil with an analysis of cellular determinants of drug activity
    • Pavillard V., Formento P., Rostagno P.et al. Combination of irinotecan (CPT-11) and 5-fluorouracil with an analysis of cellular determinants of drug activity. Biochem. Pharmacol. 56:1998;1315-1322.
    • (1998) Biochem. Pharmacol. , vol.56 , pp. 1315-1322
    • Pavillard, V.1    Formento, P.2    Rostagno, P.3
  • 44
    • 0011855371 scopus 로고
    • Enhanced antitumour activity of SN-38, an active metabolite of CPT-11, and 5-fluorouracil combination for human colorectal cancer cell lines
    • Funakoshi S., Aiba K., Shibata H.et al. Enhanced antitumour activity of SN-38, an active metabolite of CPT-11, and 5-fluorouracil combination for human colorectal cancer cell lines. Proc Am Soc Clin Oncol. 12:1993;193.
    • (1993) Proc Am Soc Clin Oncol , vol.12 , pp. 193
    • Funakoshi, S.1    Aiba, K.2    Shibata, H.3
  • 45
    • 0035204403 scopus 로고    scopus 로고
    • Phase I trial of weekly irinotecan combined with UFT as second line treatment for advanced colorectal cancer
    • Alonso V., Escudero P., Zorrilla M.et al. Phase I trial of weekly irinotecan combined with UFT as second line treatment for advanced colorectal cancer. Eur J Cancer. 37:2001;2385-2391.
    • (2001) Eur J Cancer , vol.37 , pp. 2385-2391
    • Alonso, V.1    Escudero, P.2    Zorrilla, M.3
  • 46
    • 0001867492 scopus 로고    scopus 로고
    • Phase I/II study of oral uracil/tegafur (UFT), leucovorin (LV) and irinotecan (CPT-11) in patients with advanced colorectal cancer
    • Hill M., Mackay H., Cunningham D.et al. Phase I/II study of oral uracil/tegafur (UFT), leucovorin (LV) and irinotecan (CPT-11) in patients with advanced colorectal cancer. Ann Oncol. 11(Suppl. 4):2000;45.
    • (2000) Ann Oncol , vol.11 , Issue.SUPPL. 4 , pp. 45
    • Hill, M.1    MacKay, H.2    Cunningham, D.3
  • 47
    • 0037364658 scopus 로고    scopus 로고
    • Phase III comparison of two irinotecan dosing regimens in second-line therapy of metastatic colorectal cancer
    • Fuchs C.S., Moore M.R., Harker G., Villa L., Rinaldi D., Hecht J.R. Phase III comparison of two irinotecan dosing regimens in second-line therapy of metastatic colorectal cancer. J Clin Oncol. 21:2003;807-814.
    • (2003) J Clin Oncol , vol.21 , pp. 807-814
    • Fuchs, C.S.1    Moore, M.R.2    Harker, G.3    Villa, L.4    Rinaldi, D.5    Hecht, J.R.6
  • 48
    • 0035886707 scopus 로고    scopus 로고
    • Phase I clinical and pharmacogenetic trial of irinotecan and raltitrexed administered every 21 days to patients with cancer
    • Stevenson J.P., Redlinger M., Klujtmans L.A.J.et al. Phase I clinical and pharmacogenetic trial of irinotecan and raltitrexed administered every 21 days to patients with cancer. J Clin Oncol. 19:2001;4081-4087.
    • (2001) J Clin Oncol , vol.19 , pp. 4081-4087
    • Stevenson, J.P.1    Redlinger, M.2    Klujtmans, L.A.J.3
  • 49
    • 0034771287 scopus 로고    scopus 로고
    • The role of UFT and the combination of UFT/leucovorin in non small cell lung cancer
    • Langer C.J. The role of UFT and the combination of UFT/leucovorin in non small cell lung cancer. Lung Cancer. 34:2001;297-303.
    • (2001) Lung Cancer , vol.34 , pp. 297-303
    • Langer, C.J.1
  • 50
    • 0026531753 scopus 로고
    • A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer
    • Fukuoka M., Niitani H., Suzuki A.et al. A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer. J Clin Oncol. 10:1992;16-20.
    • (1992) J Clin Oncol , vol.10 , pp. 16-20
    • Fukuoka, M.1    Niitani, H.2    Suzuki, A.3
  • 51
    • 0036731360 scopus 로고    scopus 로고
    • Topoisomerase I-based nonplatinum combinations in non-small-cell lung cancer
    • Rocha Lima C.M.S., Joppert M.G. Topoisomerase I-based nonplatinum combinations in non-small-cell lung cancer. Oncology. 16(Suppl. 9):2002;25-32.
    • (2002) Oncology , vol.16 , Issue.SUPPL. 9 , pp. 25-32
    • Rocha Lima, C.M.S.1    Joppert, M.G.2
  • 52
    • 0006829912 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of irinotecan (CPT-11) given by 24 hours infusion plus oral uracil/tegafur (UFT) in patients with lung cancer
    • Yamazaki H., Hirano A., Funakoshi S.et al. Phase I and pharmacokinetic study of irinotecan (CPT-11) given by 24 hours infusion plus oral uracil/ tegafur (UFT) in patients with lung cancer. Eur J Cancer. 35(Suppl. 4):1999;266.
    • (1999) Eur J Cancer , vol.35 , Issue.SUPPL. 4 , pp. 266
    • Yamazaki, H.1    Hirano, A.2    Funakoshi, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.