Synthesis and antileishmanial activity of novel buparvaquone oxime derivatives

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 13, 2004, Pages 3497-3502

  Mäntylä, Antti ^a   Rautio, Jarkko ^a   Nevalainen, Tapio ^a   Vepsälainen, Jouko ^a   Juvonen, Risto ^a   Kendrick, Howard ^b   Garnier, Tracy ^b   Croft, Simon L ^b   Järvinen, Tomi ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Buparvaquone; Leishmaniasis; Nitric oxide; Oxime; Prodrug

Indexed keywords

3 (4 TERT BUTYLCYCLOHEXYLMETHYL) 2 HYDROXY[1,4]NAPHTHOQUINON 1 (O METHOXIME); 3 (4 TERT BUTYLCYCLOHEXYLMETHYL) 2 HYDROXY[1,4]NAPHTHOQUINON 1 OXIME; 3 (4 TERT BUTYLCYCLOHEXYLMETHYL) 2 METHOXY[1,4]NAPHTHOQUINON 1 OXIME; 3 (4 TERT BUTYLCYCLOHEXYLMETHYL) 2 METHOXY[1,4]NAPHTHOQUINONE; ANTILEISHMANIAL AGENT; BUPARVAQUONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; LEISHMANIA DONOVANI; LIVER MICROSOME; NONHUMAN; OXIDATION; RAT; VISCERAL LEISHMANIASIS;

ANIMALS; ANTIPROTOZOAL AGENTS; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; MACROPHAGES; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES, LIVER; MOLECULAR STRUCTURE; NAPHTHOQUINONES; OXIMES; RATS; RATS, WISTAR;

LEISHMANIA DONOVANI;

EID: 2942601915     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.04.032     Document Type: Article

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