The nitric oxide prodrug, V-PYRRO/NO, mitigates arsenic-induced liver cell toxicity and apoptosis

Cancer Letters

Volumn 256, Issue 2, 2007, Pages 238-245

  Qu, Wei ^a   Liu, Jie ^a   Fuquay, Richard ^a   Saavedra, Joseph E ^b   Keefer, Larry K ^c   Waalkes, Michael P ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b SAIC FREDERICK INC   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Apoptotic resistance; Arsenic; In vitro; Liver cells; V PYRRO NO

Indexed keywords

ARSENITE SODIUM; LIVER PROTECTIVE AGENT; METALLOTHIONEIN; NITRATE; NITRIC OXIDE; NITRITE; O 2 VINYL 1 (PYRROLIDIN 1 YL)DIAZEN 1 IUM 1,2 DIOLATE; PRODRUG; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG METABOLISM; ENZYME ACTIVATION; LC 50; LIVER PROTECTION; LIVER TOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; TOXICITY TESTING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARSENITES; CELL LINE; CELL SURVIVAL; CYTOCHROME P-450 ENZYME SYSTEM; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; INHIBITORY CONCENTRATION 50; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER; METALLOTHIONEIN; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRITES; PHOSPHORYLATION; PROTECTIVE AGENTS; PYRROLIDINES; RATS; SODIUM COMPOUNDS; UP-REGULATION;

RATTUS;

EID: 34548720374     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2007.06.009     Document Type: Article

References (33)

1. Flora S.J., and Tripathi N. Hepatic and renal metallothionein induction following single oral administration of gallium arsenide in rats. Biochem. Mol. Biol. Int. 45 (1998) 1121-1127
2. 4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-Raα/PML proteins. Blood 88 (1996) 1052-1061
3. 3) in the treatment of acute promyelocytic leukemia (APL). II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood 89 (1997) 3354-3360
4. Douer D., and Tallman M.S. Arsenic trioxide: new clinical experience with an old medication in hematologic malignancies. J. Clin. Oncol. 23 (2005) 2396-2410
5. Mathews V., Desire S., George B., Lakshmi K.M., Rao G.J., Viswabandya A., Bajel A., Srivastava V.M., Srivastava A., and Chandy M. Hepatotoxicity profile of single agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia, its impact on clinical outcome and the effect of genetic polymorphisms on the incidence of hepatotoxicity. Leukemia 20 (2006) 881-883
6. St. Croix C.M., Wasserloos K.J., Dineley K.E., Reynolds I.J., Levitan E.S., and Pitt B.R. Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein. Am. J. Physiol. Lung Cell Mol. Physiol. 282 (2002) L185-L192
7. Keefer L.K. Progress toward clinical application of the nitric oxide-releasing diazeniumdiolates. Annu. Rev. Pharmacol. Toxicol. 43 (2003) 585-607
8. Ricciardi R., Foley D.P., Quarfordt S.H., Saavedra J.E., Keefer L.K., Wheeler S.M., Donohue S.E., Callery M.P., and Meyers W.C. V-PYRRO/NO: an hepato-selective nitric oxide donor improves porcine liver hemodynamics and function after ischemia reperfusion. Transplantation 71 (2001) 193-198
9. Saavedra J.E., Billiar T.R., Williams D.L., Kim Y.M., Watkins S.C., and Keefer L.K. Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver. J. Med. Chem. 40 (1997) 1947-1954
10. Liu J., and Waalkes M.P. Nitric oxide and chemically induced hepatotoxicity: beneficial effects of the liver-selective nitric oxide donor, V-PYRRO/NO. Toxicology 208 (2005) 289-297
11. Liu J., Saavedra J.E., Lu T., Song J.G., Clark J., Waalkes M.P., and Keefer L.K. O(2)-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate protection against D-galactosamine/endotoxin-induced hepatotoxicity in mice: genomic analysis using microarrays. J. Pharmacol. Exp. Ther. 300 (2002) 18-25
12. Liu J., Li C., Waalkes M.P., Clark J., Myers P., Saavedra J.E., and Keefer L.K. The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice. Hepatology 37 (2003) 324-333
13. Liu J., Qu W., Saavedra J.E., and Waalkes M.P. The nitric oxide donor, O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), protects against cadmium-induced hepatotocity in mice. J. Pharmacol. Exp. Ther. 310 (2004) 18-24
14. Qu W., Liu J., Fuquay R., Shimoda R., Sakurai T., Saavedra J.E., Keefer L.K., and Waalkes M.P. The nitric oxide prodrug, V-PYRRO/NO, protects against cadmium toxicity and apoptosis at the cellular level. Nitric Oxide 12 (2005) 114-120
15. Klaassen C.D., Liu J., and Choudhuri S. Metallothionein: an intracellular protein to protect against cadmium toxicity. Annu. Rev. Pharmacol. Toxicol. 39 (1999) 267-294
16. Jiang G., Gong Z., Li X.F., Cullen W.R., and Le X.C. Interaction of trivalent arsenicals with metallothionein. Chem. Res. Toxicol. 16 (2003) 873-880
17. Kreppel H., Bauman J.W., Liu J., McKim Jr. J.M., and Klaassen C.D. Induction of metallothionein by arsenicals in mice. Fundam. Appl. Toxicol. 20 (1993) 184-189
18. Falnoga I., Stibilj E., Tusek-Znidaric M., Slejkovec Z., Mazej D., Jacimovic R., and Scancar J. Effect of arsenic trioxide on metallothionein and its conversion to different arsenic metabolites in hen liver. Biol. Trace. Elem. Res. 78 (2001) 241-254
19. Liu J., Cheng M.L., Yang Q., Shan K.R., Shen J., Zhou Y., Zhang X., Dill A.L., and Waalkes M.P. Blood metallothionein transcript as a biomarker for metal sensitivity: low blood metallothionein transcripts in arsenicosis patients from Guizhou, China. Environ. Health Perspect 115 (2007) 1101-1106
20. Katakai K., Liu J., Nakajima K., Keefer L.K., and Waalkes M.P. Nitric oxide induces metallothionein (MT) gene expression apparently by displacing zinc bound to MT. Toxicol. Lett. 119 (2001) 103-108
21. Lluch P., Torondel B., Medina P., Segarra G., Del Olmo J.A., Serra M.A., and Rodrigo J.M. Plasma concentrations of nitric oxide and asymmetric dimethylarginine in human alcoholic cirrhosis. J. Hepatol. 41 (2004) 55-59
22. Qu W., Bortner C.D., Sakurai T., Hobson M.J., and Waalkes M.P. Acquisition of apoptotic resistance in arsenic-induced malignant transformation: role of the JNK signal transduction pathway. Carcinogenesis 23 (2002) 151-159
23. Eaton D.L., and Toal B.F. Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues. Toxicol. Appl. Pharmacol. 66 (2001) 134-142
24. Ngu T.T., and Stillman M.J. Arsenic binding to human metallothionein. J. Am. Chem. Soc. 128 (2006) 12473-12483
25. Liu J., Liu Y., Goyer R.A., Achanzar W., and Waalkes M.P. Metallothionein-I/II null mice are more sensitive than wild-type mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals. Toxicol. Sci. 55 (2000) 460-467
26. Xia Z., Dickens M., Raingeaud J., Davis R.J., and Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270 (1995) 1326-1331
27. Samet J.M., Graves L.M., Quay J., Dailey L.A., Devlin R.B., Ghio A.J., Wu W., Bromberg P.A., and Reed W. Activation of MAPKs in human bronchial epithelial cells exposed to metals. Am. J. Physiol. 275 (1998) L551-L558
28. Huang C., Ma W.Y., Li J., and Dong Z. Arsenic induces apoptosis through a c-Jun NH2-terminal kinase-dependent, p53-independent pathway. Cancer Res. 59 (1999) 3053-3058
29. Park H.S., Huh S.H., Kim M.S., Lee S.H., and Choi E.J. Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means of S-nitrosylation. Proc. Natl. Acad. Sci. USA 97 (2000) 14382-14387
30. Lo Y.Y., Wong J.M., and Cruz T.F. Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases. J. Biol. Chem. 271 (1996) 15703-15707
31. Wang D., Yu X., and Brecher P. Nitric oxide and N-acetylcysteine inhibit the activation of mitogen-activated protein kinases by angiotensin II in rat cardiac fibroblasts. J. Biol. Chem. 273 (1998) 33027-33034
32. Lander H.M., Jacovina A.T., Davis R.J., and Tauras J.M. Differential activation of mitogen-activated protein kinases by nitric oxide-related species. J. Biol. Chem. 271 (1996) 19705-19709
33. Jun C.D., Oh C.D., Kwak H.J., Pae H.O., Yoo J.C., Choi B.M., Chun J.S., Park R.K., and Chung H.T. Overexpression of protein kinase C isoforms protects RAW 264.7 macrophages from nitric oxide-induced apoptosis: involvement of c-Jun N-terminal kinase/stress-activated protein kinase, p38 kinase, and CPP-32 protease pathways. J. Immunol. 162 (1999) 3395-3401