Rat cytochrome P450 1A and 3A enzymes involved in bioactivation of tegafur to 5-fluorouracil and autoinduced by tegafur in liver microsomes

Drug Metabolism and Disposition

Volumn 29, Issue 6, 2001, Pages 794-797

  Yamazaki, Hiroshi ^a   Komatsu, Tomoko ^a   Takemoto, Kei ^a   Shimada, Noriaki ^b   Nakajima, Miki ^a   Yokoi, Tsuyoshi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b DAIICHI PURE CHEMICALS CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA NAPHTHOFLAVONE; COMPLEMENTARY DNA; CYTOCHROME P450 1A2; CYTOCHROME P450 2C11; CYTOCHROME P450 3A; DEXAMETHASONE; FLUOROURACIL; ISONIAZID; PHENOBARBITAL; TEGAFUR;

ANIMAL EXPERIMENT; ARTICLE; BIOTRANSFORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSFORMATION; ENZYME INDUCTION; FEMALE; HUMAN; IN VIVO STUDY; LIVER MICROSOME; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; FEMALE; FLUOROURACIL; MALE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; PRODRUGS; RATS; RATS, WISTAR; TEGAFUR;

EID: 0035000706     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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