Metabolism of a liver-selective nitric oxide-releasing agent, V-PYRRO/NO, by human microsomal cytochromes P450

Nitric Oxide - Biology and Chemistry

Volumn 14, Issue 4, 2006, Pages 309-315

  Inami, Keiko ^a   Nims, Raymond W ^a   Srinivasan, Aloka ^a   Citro, Michael L ^b   Saavedra, Joseph E ^b   Cederbaum, Arthur I ^c   Keefer, Larry K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Cytochrome P450; Diazeniumdiolate; Nitric oxide; Prodrug

Indexed keywords

ALCOHOL; ALDEHYDE DERIVATIVE; COMPLEMENTARY DNA; CYTOCHROME P450; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2E1; EPOXIDE; NITRATE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRITE; O 2 VINYL 1 (PYRROLIDIN 1 YL)DIAZEN 1 IUM 1,2 DIOLATE; PRODRUG; PYRROLIDINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ARTICLE; CATALYSIS; DRUG METABOLISM; ENZYME METABOLISM; EPOXIDATION; HYDRATION; HYDROLYSIS; HYPOTHESIS; LIVER; LIVER METABOLISM; METABOLITE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TURNOVER TIME;

ACETALDEHYDE; ARYL HYDROCARBON HYDROXYLASES; CATALYSIS; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; DNA, COMPLEMENTARY; HUMANS; KINETICS; LIVER; MIXED FUNCTION OXYGENASES; NADP; NITRATES; NITRIC OXIDE; NITRITES; OXIDOREDUCTASES, N-DEMETHYLATING; PYRROLIDINES;

EID: 33744537973     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.niox.2006.01.003     Document Type: Article

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