Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles

Drug Metabolism and Disposition

Volumn 27, Issue 6, 1999, Pages 655-666

  Roy, Partha ^a   Yu, Li J ^a   Crespi, Charles L ^b   Waxman, David J ^a  

^a Boston University   (United States)

^b Gentest Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYCLOPHOSPHAMIDE; CYTOCHROME P450; IFOSFAMIDE; PRODRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CATALYST; DRUG ACTIVATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG RESEARCH; ENZYME ANALYSIS; ENZYME SUBSTRATE; HUMAN; HUMAN TISSUE; LIVER METABOLISM; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS, ALKYLATING; ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; CELL LINE; CYCLOPHOSPHAMIDE; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DNA, COMPLEMENTARY; ENZYME INHIBITORS; HUMANS; HYDROXYLATION; IFOSFAMIDE; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING;

ANIMALIA; INSECTA; UNIDENTIFIED BACULOVIRUS;

EID: 0033051029     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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