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Volumn 51, Issue 3-4, 1996, Pages 297-301

Characterization of the cytochrome P450 involved in side-chain oxidation of cyclophosphamide in humans

Author keywords

cyclophosphamide; CYP 3A4; side chain oxidation; dechloroethylcyclophosphamide

Indexed keywords

CYCLOPHOSPHAMIDE; CYTOCHROME P450; DECHLOROETHYLCYCLOPHOSPHAMIDE; DRUG METABOLITE; UNCLASSIFIED DRUG;

EID: 0030444353     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050201     Document Type: Article
Times cited : (52)

References (22)
  • 1
    • 0015968586 scopus 로고
    • Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamide
    • Connors TA, Cox PJ, Farmer PB, Foster AB, Jarman M (1974) Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamide. Biochem Pharmacol 23:115-129
    • (1974) Biochem Pharmacol , vol.23 , pp. 115-129
    • Connors, T.A.1    Cox, P.J.2    Farmer, P.B.3    Foster, A.B.4    Jarman, M.5
  • 2
    • 0017656505 scopus 로고
    • Identification of aldophosphamide as a metabolite of cyclophosphamide in vitro and in vivo in humans
    • Fenselau C, Kan MNN, Rao SS, Myles A, Friedman OM, Colvin M (1977) Identification of aldophosphamide as a metabolite of cyclophosphamide in vitro and in vivo in humans. Cancer Res 37: 2538-2543
    • (1977) Cancer Res , vol.37 , pp. 2538-2543
    • Fenselau, C.1    Kan, M.N.N.2    Rao, S.S.3    Myles, A.4    Friedman, O.M.5    Colvin, M.6
  • 3
    • 0019129531 scopus 로고
    • Metabolism of 4-hydroxycyclophosphamide/ald phosphamide in vitro
    • Domeyer BE, Sladek NE (1980) Metabolism of 4-hydroxycyclophosphamide/ald phosphamide in vitro. Biochem Pharmacol 29:2903-2912
    • (1980) Biochem Pharmacol , vol.29 , pp. 2903-2912
    • Domeyer, B.E.1    Sladek, N.E.2
  • 4
    • 0026657789 scopus 로고
    • Cytochrom P-450 mediated N-dechloroethylation of cyclophosphamide and ifosfamide in the rat
    • Ruzicka JA, Ruenitz PC (1992) Cytochrom P-450 mediated N-dechloroethylation of cyclophosphamide and ifosfamide in the rat. Drug Metab Dispos 20:770-772
    • (1992) Drug Metab Dispos , vol.20 , pp. 770-772
    • Ruzicka, J.A.1    Ruenitz, P.C.2
  • 5
    • 0023035082 scopus 로고
    • Dechloroethylation of ifosfamide and neurotoxicity
    • Goren MP, Wright RK, Pratt CB, Pell FE (1986) Dechloroethylation of ifosfamide and neurotoxicity. Lancet II No. 8517:1219-1220
    • (1986) Lancet , vol.2 , Issue.8517 , pp. 1219-1220
    • Goren, M.P.1    Wright, R.K.2    Pratt, C.B.3    Pell, F.E.4
  • 6
    • 0027369366 scopus 로고
    • Differential activation of cyclophosphamide and ifosphamide by cytochromes P450 2B and 3A in human liver microsomes
    • Chang TKH, Weber GF, Crespi CL, Waxman DJ (1993) Differential activation of cyclophosphamide and ifosphamide by cytochromes P450 2B and 3A in human liver microsomes. Cancer Res 53:5629-5637
    • (1993) Cancer Res , vol.53 , pp. 5629-5637
    • Chang, T.K.H.1    Weber, G.F.2    Crespi, C.L.3    Waxman, D.J.4
  • 7
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP (1994) Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 270: 414-423
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 10
    • 0028858603 scopus 로고
    • Direct gas chromatographic determination of dechloroethylcyclophosphamide following microsomal incubation of cyclophosphamide
    • Bohnenstengel F, Johnson S, Hofmann U, Eichelbaum M, Kroemer HK (1995) Direct gas chromatographic determination of dechloroethylcyclophosphamide following microsomal incubation of cyclophosphamide. J Chromatogr B 672:271-276
    • (1995) J Chromatogr B , vol.672 , pp. 271-276
    • Bohnenstengel, F.1    Johnson, S.2    Hofmann, U.3    Eichelbaum, M.4    Kroemer, H.K.5
  • 11
    • 0020635141 scopus 로고
    • Hepatic monooxygenase activities in subjects with genetic defect in drug oxidation
    • Meier PJ, Müller HK, Dick B, Meyer UA (1983) Hepatic monooxygenase activities in subjects with genetic defect in drug oxidation. Gastroenterology 85:682-692
    • (1983) Gastroenterology , vol.85 , pp. 682-692
    • Meier, P.J.1    Müller, H.K.2    Dick, B.3    Meyer, U.A.4
  • 13
    • 78651165715 scopus 로고
    • The carbon monoxide binding pigment of liver microsomes
    • Omura T, Sato R (1964) The carbon monoxide binding pigment of liver microsomes. J Biol Chem 239:2370-2378
    • (1964) J Biol Chem , vol.239 , pp. 2370-2378
    • Omura, T.1    Sato, R.2
  • 15
    • 0027380074 scopus 로고
    • Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline
    • Kunze KL, Trager WF (1993) Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline. Chem Res Toxicol 6:649-656
    • (1993) Chem Res Toxicol , vol.6 , pp. 649-656
    • Kunze, K.L.1    Trager, W.F.2
  • 17
    • 0029582977 scopus 로고
    • The role of human cytochrome P450 enzymes in the metabolism of anti-cancer agents: Implications for drug interactions
    • Kivistö KT, Kroemer HK, Eichelbaum M (1995) The role of human cytochrome P450 enzymes in the metabolism of anti-cancer agents: implications for drug interactions. Br J Clin Pharmacol 40:523-530
    • (1995) Br J Clin Pharmacol , vol.40 , pp. 523-530
    • Kivistö, K.T.1    Kroemer, H.K.2    Eichelbaum, M.3
  • 18
    • 0026448886 scopus 로고
    • Interindividual variation in the activation and inactivation of metabolic pathways of cyclophosphamide
    • Boddy AV, Furtun Y, Sardas S, Sardas O, Idle JR (1992) Interindividual variation in the activation and inactivation of metabolic pathways of cyclophosphamide. J Nat Cancer Inst 84:1744-1748
    • (1992) J Nat Cancer Inst , vol.84 , pp. 1744-1748
    • Boddy, A.V.1    Furtun, Y.2    Sardas, S.3    Sardas, O.4    Idle, J.R.5
  • 19
    • 0028048031 scopus 로고
    • Competitive inhibition of human liver microsomal cytochrome P450 3A-dependent steroid 6β-hydroxylation activity by cyclophosphamide and ifosfamide in vitro
    • Murray M, Butler AM, Stupans I (1994) Competitive inhibition of human liver microsomal cytochrome P450 3A-dependent steroid 6β-hydroxylation activity by cyclophosphamide and ifosfamide in vitro. J Pharmacol Exp Ther 270:645-649
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 645-649
    • Murray, M.1    Butler, A.M.2    Stupans, I.3
  • 20
    • 0027454275 scopus 로고
    • Optimizing high-dose therapy-using pharmacokinetic principles
    • Zorsky PE, Perkins JB (1993) Optimizing high-dose therapy-using pharmacokinetic principles. Semin Oncol 20:2-18
    • (1993) Semin Oncol , vol.20 , pp. 2-18
    • Zorsky, P.E.1    Perkins, J.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.