-
1
-
-
0015968586
-
Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamide
-
Connors TA, Cox PJ, Farmer PB, Foster AB, Jarman M (1974) Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamide. Biochem Pharmacol 23:115-129
-
(1974)
Biochem Pharmacol
, vol.23
, pp. 115-129
-
-
Connors, T.A.1
Cox, P.J.2
Farmer, P.B.3
Foster, A.B.4
Jarman, M.5
-
2
-
-
0017656505
-
Identification of aldophosphamide as a metabolite of cyclophosphamide in vitro and in vivo in humans
-
Fenselau C, Kan MNN, Rao SS, Myles A, Friedman OM, Colvin M (1977) Identification of aldophosphamide as a metabolite of cyclophosphamide in vitro and in vivo in humans. Cancer Res 37: 2538-2543
-
(1977)
Cancer Res
, vol.37
, pp. 2538-2543
-
-
Fenselau, C.1
Kan, M.N.N.2
Rao, S.S.3
Myles, A.4
Friedman, O.M.5
Colvin, M.6
-
3
-
-
0019129531
-
Metabolism of 4-hydroxycyclophosphamide/ald phosphamide in vitro
-
Domeyer BE, Sladek NE (1980) Metabolism of 4-hydroxycyclophosphamide/ald phosphamide in vitro. Biochem Pharmacol 29:2903-2912
-
(1980)
Biochem Pharmacol
, vol.29
, pp. 2903-2912
-
-
Domeyer, B.E.1
Sladek, N.E.2
-
4
-
-
0026657789
-
Cytochrom P-450 mediated N-dechloroethylation of cyclophosphamide and ifosfamide in the rat
-
Ruzicka JA, Ruenitz PC (1992) Cytochrom P-450 mediated N-dechloroethylation of cyclophosphamide and ifosfamide in the rat. Drug Metab Dispos 20:770-772
-
(1992)
Drug Metab Dispos
, vol.20
, pp. 770-772
-
-
Ruzicka, J.A.1
Ruenitz, P.C.2
-
5
-
-
0023035082
-
Dechloroethylation of ifosfamide and neurotoxicity
-
Goren MP, Wright RK, Pratt CB, Pell FE (1986) Dechloroethylation of ifosfamide and neurotoxicity. Lancet II No. 8517:1219-1220
-
(1986)
Lancet
, vol.2
, Issue.8517
, pp. 1219-1220
-
-
Goren, M.P.1
Wright, R.K.2
Pratt, C.B.3
Pell, F.E.4
-
6
-
-
0027369366
-
Differential activation of cyclophosphamide and ifosphamide by cytochromes P450 2B and 3A in human liver microsomes
-
Chang TKH, Weber GF, Crespi CL, Waxman DJ (1993) Differential activation of cyclophosphamide and ifosphamide by cytochromes P450 2B and 3A in human liver microsomes. Cancer Res 53:5629-5637
-
(1993)
Cancer Res
, vol.53
, pp. 5629-5637
-
-
Chang, T.K.H.1
Weber, G.F.2
Crespi, C.L.3
Waxman, D.J.4
-
7
-
-
0028237729
-
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
-
Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP (1994) Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 270: 414-423
-
(1994)
J Pharmacol Exp Ther
, vol.270
, pp. 414-423
-
-
Shimada, T.1
Yamazaki, H.2
Mimura, M.3
Inui, Y.4
Guengerich, F.P.5
-
8
-
-
0028890757
-
Cyclophosphamide metabolism in children
-
Yule SM, Boddy AV, Cole M, Price L, Wyllie R, Tasso MJ, Pearson ADJ, Idle JR (1995) Cyclophosphamide metabolism in children. Cancer Res 55:803-809
-
(1995)
Cancer Res
, vol.55
, pp. 803-809
-
-
Yule, S.M.1
Boddy, A.V.2
Cole, M.3
Price, L.4
Wyllie, R.5
Tasso, M.J.6
Pearson, A.D.J.7
Idle, J.R.8
-
9
-
-
0028178551
-
Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide
-
Walker D, Flinois JP, Monkman SC, Beloc C, Boddy AV, Cholerton S, Daly AK, Lind MJ, Pearson DJ, Beaune PH, Idle JR (1994) Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide. Biochem Pharmacol 47:1157-11631
-
(1994)
Biochem Pharmacol
, vol.47
, pp. 1157-11631
-
-
Walker, D.1
Flinois, J.P.2
Monkman, S.C.3
Beloc, C.4
Boddy, A.V.5
Cholerton, S.6
Daly, A.K.7
Lind, M.J.8
Pearson, D.J.9
Beaune, P.H.10
Idle, J.R.11
-
10
-
-
0028858603
-
Direct gas chromatographic determination of dechloroethylcyclophosphamide following microsomal incubation of cyclophosphamide
-
Bohnenstengel F, Johnson S, Hofmann U, Eichelbaum M, Kroemer HK (1995) Direct gas chromatographic determination of dechloroethylcyclophosphamide following microsomal incubation of cyclophosphamide. J Chromatogr B 672:271-276
-
(1995)
J Chromatogr B
, vol.672
, pp. 271-276
-
-
Bohnenstengel, F.1
Johnson, S.2
Hofmann, U.3
Eichelbaum, M.4
Kroemer, H.K.5
-
11
-
-
0020635141
-
Hepatic monooxygenase activities in subjects with genetic defect in drug oxidation
-
Meier PJ, Müller HK, Dick B, Meyer UA (1983) Hepatic monooxygenase activities in subjects with genetic defect in drug oxidation. Gastroenterology 85:682-692
-
(1983)
Gastroenterology
, vol.85
, pp. 682-692
-
-
Meier, P.J.1
Müller, H.K.2
Dick, B.3
Meyer, U.A.4
-
13
-
-
78651165715
-
The carbon monoxide binding pigment of liver microsomes
-
Omura T, Sato R (1964) The carbon monoxide binding pigment of liver microsomes. J Biol Chem 239:2370-2378
-
(1964)
J Biol Chem
, vol.239
, pp. 2370-2378
-
-
Omura, T.1
Sato, R.2
-
14
-
-
0028970047
-
Keto conazole and sulphaphenazole as the respective selective inhibitors of P450 3A and 2C9
-
Baldwin SJ, Bloomer JC, Smith GJ, Ayrton AD, Clarke SE, Chenery RJ (1995) Keto conazole and sulphaphenazole as the respective selective inhibitors of P450 3A and 2C9. Xenobiotica 25:261-270
-
(1995)
Xenobiotica
, vol.25
, pp. 261-270
-
-
Baldwin, S.J.1
Bloomer, J.C.2
Smith, G.J.3
Ayrton, A.D.4
Clarke, S.E.5
Chenery, R.J.6
-
15
-
-
0027380074
-
Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline
-
Kunze KL, Trager WF (1993) Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline. Chem Res Toxicol 6:649-656
-
(1993)
Chem Res Toxicol
, vol.6
, pp. 649-656
-
-
Kunze, K.L.1
Trager, W.F.2
-
16
-
-
0025294782
-
Furafylline is a potent and selective inhibitor of cytochrome P450 1A2 in man
-
Sesardic D, Boobis AR, Murray BP, Murray S, Segura J, de la Torre R, Davies DS (1990) Furafylline is a potent and selective inhibitor of cytochrome P450 1A2 in man. Br J Clin Pharmacol 29:651-663
-
(1990)
Br J Clin Pharmacol
, vol.29
, pp. 651-663
-
-
Sesardic, D.1
Boobis, A.R.2
Murray, B.P.3
Murray, S.4
Segura, J.5
De La Torre, R.6
Davies, D.S.7
-
17
-
-
0029582977
-
The role of human cytochrome P450 enzymes in the metabolism of anti-cancer agents: Implications for drug interactions
-
Kivistö KT, Kroemer HK, Eichelbaum M (1995) The role of human cytochrome P450 enzymes in the metabolism of anti-cancer agents: implications for drug interactions. Br J Clin Pharmacol 40:523-530
-
(1995)
Br J Clin Pharmacol
, vol.40
, pp. 523-530
-
-
Kivistö, K.T.1
Kroemer, H.K.2
Eichelbaum, M.3
-
18
-
-
0026448886
-
Interindividual variation in the activation and inactivation of metabolic pathways of cyclophosphamide
-
Boddy AV, Furtun Y, Sardas S, Sardas O, Idle JR (1992) Interindividual variation in the activation and inactivation of metabolic pathways of cyclophosphamide. J Nat Cancer Inst 84:1744-1748
-
(1992)
J Nat Cancer Inst
, vol.84
, pp. 1744-1748
-
-
Boddy, A.V.1
Furtun, Y.2
Sardas, S.3
Sardas, O.4
Idle, J.R.5
-
19
-
-
0028048031
-
Competitive inhibition of human liver microsomal cytochrome P450 3A-dependent steroid 6β-hydroxylation activity by cyclophosphamide and ifosfamide in vitro
-
Murray M, Butler AM, Stupans I (1994) Competitive inhibition of human liver microsomal cytochrome P450 3A-dependent steroid 6β-hydroxylation activity by cyclophosphamide and ifosfamide in vitro. J Pharmacol Exp Ther 270:645-649
-
(1994)
J Pharmacol Exp Ther
, vol.270
, pp. 645-649
-
-
Murray, M.1
Butler, A.M.2
Stupans, I.3
-
20
-
-
0027454275
-
Optimizing high-dose therapy-using pharmacokinetic principles
-
Zorsky PE, Perkins JB (1993) Optimizing high-dose therapy-using pharmacokinetic principles. Semin Oncol 20:2-18
-
(1993)
Semin Oncol
, vol.20
, pp. 2-18
-
-
Zorsky, P.E.1
Perkins, J.B.2
-
21
-
-
0026748897
-
Cyclophosphamide pharmacokinetic: Correlation with cardiac toxicity and tumor response
-
Ayash LJ, Wright JE, Tretyakov O, Gonin R, Elias A, Wheeler C, Eder JP, Rosowsky A, Antman K, Frei III E (1992) Cyclophosphamide pharmacokinetic: correlation with cardiac toxicity and tumor response. J Clin Oncol 10:995-1000
-
(1992)
J Clin Oncol
, vol.10
, pp. 995-1000
-
-
Ayash, L.J.1
Wright, J.E.2
Tretyakov, O.3
Gonin, R.4
Elias, A.5
Wheeler, C.6
Eder, J.P.7
Rosowsky, A.8
Antman, K.9
Frei III, E.10
-
22
-
-
8044258665
-
Pharmacokinetics and metabolism of cyclophosphamide during "conventional" and "high dose" chemotherapy
-
Busse D, Bohnenstengel F, Eichelbaum M, Fischer P, Kroemer HK, Schumacher K, Schweizer E, Busch FW (1996) Pharmacokinetics and metabolism of cyclophosphamide during "conventional" and "high dose" chemotherapy. Naunyn-Schmiedeberg's Arch Pharmacol 353 Suppl:R147
-
(1996)
Naunyn-Schmiedeberg's Arch Pharmacol
, vol.353
, Issue.SUPPL.
-
-
Busse, D.1
Bohnenstengel, F.2
Eichelbaum, M.3
Fischer, P.4
Kroemer, H.K.5
Schumacher, K.6
Schweizer, E.7
Busch, F.W.8
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