-
1
-
-
0034002261
-
Role of the development scientist in the compound lead selection and optimization
-
Venkatesh, S., Lipper,R. A. (2000). Role of the development scientist in the compound lead selection and optimization. J. Pharm. Sci., 89, 145-154.
-
(2000)
J. Pharm. Sci
, vol.89
, pp. 145-154
-
-
Venkatesh, S.1
Lipper, R.A.2
-
2
-
-
0001199533
-
Chemical aspects of selective toxicity
-
Alber, A. (1958). Chemical aspects of selective toxicity. Nature, 16, 421-423.
-
(1958)
Nature
, vol.16
, pp. 421-423
-
-
Alber, A.1
-
3
-
-
7944229057
-
Prodrugs: A year of renewed interest in an old concept
-
Krise, J. P., Stella, V. J. (2003). Prodrugs: A year of renewed interest in an old concept. AAPS Newsmag., 16, 25.
-
(2003)
AAPS Newsmag
, vol.16
, pp. 25
-
-
Krise, J.P.1
Stella, V.J.2
-
4
-
-
0021800252
-
Prodrugs. Do they have advantages in clinical practice
-
Stella,V. J., Charman,W. N. A., Naringrekar,V. H. (1985). Prodrugs. Do they have advantages in clinical practice? Drugs, 29, 455-473.
-
(1985)
Drugs
, vol.29
, pp. 455-473
-
-
Stella, V.J.1
Charman, W.N.A.2
Naringrekar, V.H.3
-
5
-
-
0037075836
-
Design and synthesis of a novel L-dopa-entacapone codrugs
-
Leppänen, J., Huuskonen, J., Nevalainen, T., Gynther, J., Taipale, H., Järvinen, T. (2002). Design and synthesis of a novel L-dopa-entacapone codrugs. J. Med. Chem., 45, 1379-1382.
-
(2002)
J. Med. Chem
, vol.45
, pp. 1379-1382
-
-
Leppänen, J.1
Huuskonen, J.2
Nevalainen, T.3
Gynther, J.4
Taipale, H.5
Järvinen, T.6
-
6
-
-
0342833001
-
A case for prodrugs: Fosphenytoin
-
Stella, V. J. (1996). A case for prodrugs: Fosphenytoin. Adv. Drug Delivery Rev., 19, 311-330.
-
(1996)
Adv. Drug Delivery Rev
, vol.19
, pp. 311-330
-
-
Stella, V.J.1
-
7
-
-
0031430945
-
Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs
-
Shaw, J. P., Sueoko,C. M., Oliyai, R., Lee,W. A., Arimilli, M. N., Kim,C. U., Cundy, K. C. (1997). Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs. Pharm. Res., 14, 1824-1829.
-
(1997)
Pharm. Res
, vol.14
, pp. 1824-1829
-
-
Shaw, J.P.1
Sueoko, C.M.2
Oliyai, R.3
Lee, W.A.4
Arimilli, M.N.5
Kim, C.U.6
Cundy, K.C.7
-
8
-
-
0022543135
-
Pilocarpine prodrugs II: Synthesis, stability, bioconversion, and physicochemical properties of sequentially labile pilocarpine acid diesters
-
Bundgaard, H., Falch, E., Larsen, C., Mosher, G. L., Mikkelson, T. J. (1986). Pilocarpine prodrugs II: Synthesis, stability, bioconversion, and physicochemical properties of sequentially labile pilocarpine acid diesters. J. Pharm. Sci., 75, 775-783.
-
(1986)
J. Pharm. Sci
, vol.75
, pp. 775-783
-
-
Bundgaard, H.1
Falch, E.2
Larsen, C.3
Mosher, G.L.4
Mikkelson, T.J.5
-
9
-
-
0038545721
-
Soft antibacterial agents
-
Thorsteinsson,T., Loftsson,T., Masson, M. (2003). Soft antibacterial agents. Curr. Med. Chem., 10, 1129-1136.
-
(2003)
Curr. Med. Chem
, vol.10
, pp. 1129-1136
-
-
Thorsteinsson, T.1
Loftsson, T.2
Masson, M.3
-
10
-
-
0031278026
-
Drug targeting via retrometabolic approaches
-
Bodor, N., Buchwald, P. (1997). Drug targeting via retrometabolic approaches. Pharmacol. Ther., 76, 1-27.
-
(1997)
Pharmacol. Ther
, vol.76
, pp. 1-27
-
-
Bodor, N.1
Buchwald, P.2
-
11
-
-
0033966357
-
Soft drug design: General principals and recent applications
-
Bodor, N., Buchwald, P. (2000). Soft drug design: General principals and recent applications. Med. Res. Rev., 20, 58-101.
-
(2000)
Med. Res. Rev
, vol.20
, pp. 58-101
-
-
Bodor, N.1
Buchwald, P.2
-
12
-
-
0006645882
-
Prodrugs versus soft drugs
-
H. Bundgaard (Ed.), Amsterdam
-
Bodor, N. (1985). Prodrugs versus soft drugs. In H. Bundgaard (Ed.), Design of Prodrugs. Elsevier Science, Amsterdam, pp. 333-354.
-
(1985)
Design of Prodrugs. Elsevier Science
, pp. 333-354
-
-
Bodor, N.1
-
13
-
-
0028948839
-
A theoretical basis for a bipharmaceutic classification: The correlation of in vitro drug product dissolution and in vivo bioavailability
-
Amidon, G. L., Lennernas, H., Shah,V. P., Crison, J. R. (1995). A theoretical basis for a bipharmaceutic classification: The correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res., 12, 413-420.
-
(1995)
Pharm. Res
, vol.12
, pp. 413-420
-
-
Amidon, G.L.1
Lennernas, H.2
Shah, V.P.3
Crison, J.R.4
-
14
-
-
0021891369
-
Formation of prodrugs of amines, amides, ureides, and imides
-
Bundgaard, H. (1985). Formation of prodrugs of amines, amides, ureides, and imides. Methods Enzymol., 112, 347-359.
-
(1985)
Methods Enzymol
, vol.112
, pp. 347-359
-
-
Bundgaard, H.1
-
15
-
-
0342832999
-
Improved oral drug delivery: Solubility limitations overcome by the use of prodrugs
-
Fleisher, D., Bong, R., Stewart, B. H. (1996). Improved oral drug delivery: Solubility limitations overcome by the use of prodrugs. Adv. Drug Delivery Rev., 19, 115-130.
-
(1996)
Adv. Drug Delivery Rev
, vol.19
, pp. 115-130
-
-
Fleisher, D.1
Bong, R.2
Stewart, B.H.3
-
16
-
-
0343930710
-
Improved passive oral drug delivery via prodrugs
-
Taylor, M. D. (1996). Improved passive oral drug delivery via prodrugs. Adv. Drug Delivery Rev., 19, 131-148.
-
(1996)
Adv. Drug Delivery Rev
, vol.19
, pp. 131-148
-
-
Taylor, M.D.1
-
17
-
-
0027449074
-
In-vitro evaluation of dexamethasone-beta-d-glucuronide for colon-specific drug-delivery
-
Haeberlin, B., Rubas,W., Nolen, H. W., Friend, D. R. (1993). In-vitro evaluation of dexamethasone-beta-d-glucuronide for colon-specific drug-delivery. Pharm. Res., 10, 1553-1562.
-
(1993)
Pharm. Res
, vol.10
, pp. 1553-1562
-
-
Haeberlin, B.1
Rubas, W.2
Nolen, H.W.3
Friend, D.R.4
-
18
-
-
0038725720
-
Pharmaceutical approaches to colon targeted drug delivery systems
-
Chourasia, M. K., Jain, S. K. (2003). Pharmaceutical approaches to colon targeted drug delivery systems. J. Pharm. Pharm. Sci., 6, 33-66.
-
(2003)
J. Pharm. Pharm. Sci
, vol.6
, pp. 33-66
-
-
Chourasia, M.K.1
Jain, S.K.2
-
19
-
-
0013106233
-
From Bench to Market
-
Oxford University Press, Oxford
-
Cabri,W., Di Fabio, R. (2000). From Bench to Market. Oxford University Press, Oxford, p. 148.
-
(2000)
, pp. 148
-
-
Cabri, W.1
Di Fabio, R.2
-
20
-
-
84889787452
-
Prodrugs. Injectable Drug Development.Techniques to Reduce Pain and Irritation
-
P. K. Gupta and G. A. Brazeau (Eds.), Interpharm, Denver, CO
-
Prokai, L., Prokai-Tatarai, K. (1999). In P. K. Gupta and G. A. Brazeau (Eds.), Prodrugs. Injectable Drug Development.Techniques to Reduce Pain and Irritation. Interpharm, Denver, CO, pp. 267-306.
-
(1999)
, pp. 267-306
-
-
Prokai, L.1
Prokai-Tatarai, K.2
-
21
-
-
0016430387
-
Rationale for design of biologically reversible drug derivatives-prodrugs
-
Sinkula, A. A., Yalkowsky, S. H. (1975). Rationale for design of biologically reversible drug derivatives-prodrugs. J. Pharm. Sci., 64, 181-210.
-
(1975)
J. Pharm. Sci
, vol.64
, pp. 181-210
-
-
Sinkula, A.A.1
Yalkowsky, S.H.2
-
22
-
-
0035063859
-
Angiotensin-converting enzyme inhibitors
-
Menard, J., Patchett,A. A. (2001). Angiotensin-converting enzyme inhibitors. Adv. Protein Chem., 56, 13-75.
-
(2001)
Adv. Protein Chem
, vol.56
, pp. 13-75
-
-
Menard, J.1
Patchett, A.A.2
-
23
-
-
0027200613
-
Synthesis and evaluation of morpholinoalkyl ester prodrugs of indomethacin and naproxen
-
Tammara, V. K., Narurkar, M. M., Crider, A. M., Khan, M. A. (1993). Synthesis and evaluation of morpholinoalkyl ester prodrugs of indomethacin and naproxen. Pharm. Res., 10, 1191-1199.
-
(1993)
Pharm. Res
, vol.10
, pp. 1191-1199
-
-
Tammara, V.K.1
Narurkar, M.M.2
Crider, A.M.3
Khan, M.A.4
-
24
-
-
0031743198
-
Vitro evaluation of acyloxyalkyl esters as dermal prodrugs of ketoprofen and naproxen
-
Rautio, J., Taipale, H., Gynther, J., Vepsäläinen, J., Nevalainen, T., Järvinen, T. (1998). In vitro evaluation of acyloxyalkyl esters as dermal prodrugs of ketoprofen and naproxen. J. Pharm. Sci., 87, 1622-1628.
-
(1998)
J. Pharm. Sci
, vol.87
, pp. 1622-1628
-
-
Rautio, J.1
Taipale, H.2
Gynther, J.3
Vepsäläinen, J.4
Nevalainen, T.5
Järvinen, T.6
-
25
-
-
0020566638
-
Pro-drugs of b-lactam antibiotics
-
Ferres, H. (1983). Pro-drugs of b-lactam antibiotics. Drugs of Today, 19, 499-538.
-
(1983)
Drugs of Today
, vol.19
, pp. 499-538
-
-
Ferres, H.1
-
26
-
-
0026557715
-
Ester and amide prodrugs of ibuprofen and naproxen-Synthesis, antiinflammatory activity, and gastrointestinal toxicity
-
Shanbhag, V. R., Crider, A. M., Gokhale, R., Harpalani, A., Dick, R. M. (1992). Ester and amide prodrugs of ibuprofen and naproxen-Synthesis, antiinflammatory activity, and gastrointestinal toxicity. J. Pharm. Sci., 81, 149-154.
-
(1992)
J. Pharm. Sci
, vol.81
, pp. 149-154
-
-
Shanbhag, V.R.1
Crider, A.M.2
Gokhale, R.3
Harpalani, A.4
Dick, R.M.5
-
27
-
-
0343844454
-
Prodrugs of phosphates, phosphonates, and phosphinates
-
Krise, J. P., Stella, V. J. (1996). Prodrugs of phosphates, phosphonates, and phosphinates. Adv. Drug Delivery Rev., 19, 287-310.
-
(1996)
Adv. Drug Delivery Rev
, vol.19
, pp. 287-310
-
-
Krise, J.P.1
Stella, V.J.2
-
28
-
-
0028357498
-
Haloalkyl phosphate derivatives of act as inhibitors of HIV-Studies in the phosphate region
-
McGuigan, C., Turner, S., Nicholls, S. R., Oconnor, T. J., Kinchington, D. (1994). Haloalkyl phosphate derivatives of act as inhibitors of HIV-Studies in the phosphate region. Antiviral Chem. Chemother., 5, 162-168.
-
(1994)
Antiviral Chem. Chemother
, vol.5
, pp. 162-168
-
-
McGuigan, C.1
Turner, S.2
Nicholls, S.R.3
Oconnor, T.J.4
Kinchington, D.5
-
29
-
-
0032708044
-
Synthesis and in vitro anti-HIV activities of amphiphilic heterodinucleoside phosphate derivatives containing the 2¢,3¢-dideoxynucleosides ddC, AZT and ddI
-
Schott, H., Ludwig, P. S., Immelmann, A., Schwendener, R. A. (1999). Synthesis and in vitro anti-HIV activities of amphiphilic heterodinucleoside phosphate derivatives containing the 2¢,3¢-dideoxynucleosides ddC, AZT and ddI. Eur. J. Med. Chem., 34, 343-352.
-
(1999)
Eur. J. Med. Chem
, vol.34
, pp. 343-352
-
-
Schott, H.1
Ludwig, P.S.2
Immelmann, A.3
Schwendener, R.A.4
-
30
-
-
0028290089
-
Decomposition pathways of the mono-(pivaloyl-oxymethyl) and bis(pivaloyl-oxymethyl) esters of azidothymidine 5¢-monophosphate in cell extract and in tissue-culture medium-An application of the online Isrp-cleaning HPLC technique
-
Pompon, A., Lefebvre, I., Imbach, J. L., Kahn, S., Farquhar, D. (1994). Decomposition pathways of the mono-(pivaloyl-oxymethyl) and bis(pivaloyl-oxymethyl) esters of azidothymidine 5¢-monophosphate in cell extract and in tissue-culture medium-An application of the online Isrp-cleaning HPLC technique. Antiviral Chem. Chemother., 5, 91-98.
-
(1994)
Antiviral Chem. Chemother
, vol.5
, pp. 91-98
-
-
Pompon, A.1
Lefebvre, I.2
Imbach, J.L.3
Kahn, S.4
Farquhar, D.5
-
31
-
-
0027136229
-
Acyclovir diphosphate dimyristoylglycerol-A phospholipid prodrug with activity against acyclovir-resistant herpes-simplex virus
-
Hostetler, K. Y., Parker, S., Sridhar, C. N., Martin, M. J., Li, J. L., Stuhmiller, L. M., Vanwijk, G. M. T., Vandenbosch, H., Gardner, M. F., Aldern, K. A., Richman, D. D. (1993). Acyclovir diphosphate dimyristoylglycerol-A phospholipid prodrug with activity against acyclovir-resistant herpes-simplex virus. Proc. Nat. Acad. Sci. USA, 90, 11,835-11,839.
-
(1993)
Proc. Nat. Acad. Sci. USA
, vol.90
, pp. 11835-11839
-
-
Hostetler, K.Y.1
Parker, S.2
Sridhar, C.N.3
Martin, M.J.4
Li, J.L.5
Stuhmiller, L.M.6
Vanwijk, G.M.T.7
Vandenbosch, H.8
Gardner, M.F.9
Aldern, K.A.10
Richman, D.D.11
-
32
-
-
0032834955
-
Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine
-
Saboulard, D., Naesens, L., Cahard, D., Salgado, A., Pathirana, R., Velazquez, S., McGuigan, C., De Clercq, E., Balzarini, J. (1999). Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine. Mol. Pharmacol., 56, 693-704.
-
(1999)
Mol. Pharmacol
, vol.56
, pp. 693-704
-
-
Saboulard, D.1
Naesens, L.2
Cahard, D.3
Salgado, A.4
Pathirana, R.5
Velazquez, S.6
McGuigan, C.7
De Clercq, E.8
Balzarini, J.9
-
33
-
-
0028925262
-
Synthesis and in vivo evaluation of prodrugs of 9-[2-(phosphonomethoxy) ethoxy]adenine
-
Serafinowska, H. T., Ashton, R. J., Bailey, S., Harnden, M. R., Jackson, S. M., Sutton, D. (1995). Synthesis and in vivo evaluation of prodrugs of 9-[2-(phosphonomethoxy) ethoxy]adenine. J. Med. Chem., 38, 1372-1379.
-
(1995)
J. Med. Chem
, vol.38
, pp. 1372-1379
-
-
Serafinowska, H.T.1
Ashton, R.J.2
Bailey, S.3
Harnden, M.R.4
Jackson, S.M.5
Sutton, D.6
-
34
-
-
0028306517
-
Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy) ethyl]adenine (PMEA)
-
Starrett, J. E. Jr, Tortolani, D. R., Russell, J., Hitchcock, M. J., Whiterock, V., Martin, J. C., Mansuri, M. M. (1994). Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy) ethyl]adenine (PMEA). J. Med. Chem., 37, 1857-1864.
-
(1994)
J. Med. Chem
, vol.37
, pp. 1857-1864
-
-
Starrett Jr., J.E.1
Tortolani, D.R.2
Russell, J.3
Hitchcock, M.J.4
Whiterock, V.5
Martin, J.C.6
Mansuri, M.M.7
-
35
-
-
0028269336
-
N-Phosphonomethyl dipeptides and their phosphonate prodrugs, a new-generation of neutral endopeptidase (Nep, Ec-3.4.24.11) inhibitors
-
Delombaert, S., Erion, M. D., Tan, J., Blanchard, L., Elchehabi, L., Ghai, R. D., Sakane, Y., Berry, C., Trapani, A. J. (1994). N-Phosphonomethyl dipeptides and their phosphonate prodrugs, a new-generation of neutral endopeptidase (Nep, Ec-3.4.24.11) inhibitors. J. Med. Chem., 37, 498-511.
-
(1994)
J. Med. Chem
, vol.37
, pp. 498-511
-
-
Delombaert, S.1
Erion, M.D.2
Tan, J.3
Blanchard, L.4
Elchehabi, L.5
Ghai, R.D.6
Sakane, Y.7
Berry, C.8
Trapani, A.J.9
-
36
-
-
0345669115
-
Bisphosphonate prodrugs: Synthesis and in vitro evaluation of novel acyloxyalkyl esters of clodronic acid
-
Niemi, R., Vepsäläinen, J., Taipale, H., Järvinen, T. (1999). Bisphosphonate prodrugs: Synthesis and in vitro evaluation of novel acyloxyalkyl esters of clodronic acid. J. Med. Chem., 42, 5053-5058.
-
(1999)
J. Med. Chem
, vol.42
, pp. 5053-5058
-
-
Niemi, R.1
Vepsäläinen, J.2
Taipale, H.3
Järvinen, T.4
-
37
-
-
0031767154
-
Bisphosphonate prodrugs: Synthesis and in vitro evaluation of novel partial amides of clodronic acid
-
Niemi, R., Pennanen, H.,Vepsäläinen, J., Taipale, H., Järvinen, T. (1998). Bisphosphonate prodrugs: Synthesis and in vitro evaluation of novel partial amides of clodronic acid. Int. J. Pharm., 174, 111-115.
-
(1998)
Int. J. Pharm
, vol.174
, pp. 111-115
-
-
Niemi, R.1
Pennanen, H.2
Vepsäläinen, J.3
Taipale, H.4
Järvinen, T.5
-
38
-
-
0023153468
-
Macromolecular prodrugs. 4. Kinetics of hydrolysis of metronidazole monosuccinate dextran ester conjugates in aqueoussolution and in plasma-Sequential release of metronidazole from the conjugates at physiological pH
-
Larsen, C., Johansen, M. (1987). Macromolecular prodrugs. 4. Kinetics of hydrolysis of metronidazole monosuccinate dextran ester conjugates in aqueoussolution and in plasma-Sequential release of metronidazole from the conjugates at physiological pH. Int. J. Pharm., 35, 39-45.
-
(1987)
Int. J. Pharm
, vol.35
, pp. 39-45
-
-
Larsen, C.1
Johansen, M.2
-
39
-
-
0023726234
-
Comparative pharmacokinetics of methylprednisolone phosphate and hemisuccinate in high-doses
-
Mollmann, H., Rohdewald, P., Barth, J., Mollmann, C., Verho, M., Derendorf, H. (1988). Comparative pharmacokinetics of methylprednisolone phosphate and hemisuccinate in high-doses. Pharm. Res., 5, 509-513.
-
(1988)
Pharm. Res
, vol.5
, pp. 509-513
-
-
Mollmann, H.1
Rohdewald, P.2
Barth, J.3
Mollmann, C.4
Verho, M.5
Derendorf, H.6
-
40
-
-
0026091717
-
Disposition of methylprednisolone and its sodium succinate prodrug in vivo and in perfused liver of rats-Nonlinear and sequential 1st-pass elimination
-
Kong,A. N., Jusko,W. J. (1991). Disposition of methylprednisolone and its sodium succinate prodrug in vivo and in perfused liver of rats-Nonlinear and sequential 1st-pass elimination. J. Pharm. Sci., 80, 409-415.
-
(1991)
J. Pharm. Sci
, vol.80
, pp. 409-415
-
-
Kong, A.N.1
Jusko, W.J.2
-
41
-
-
0021346784
-
Prodrugs as drug delivery systems. 26. Preparation and enzymatic-hydrolysis of various water-soluble amino-acid esters of metronidazole
-
Bundgaard, H., Larsen, C.,Thorbek, P. (1984). Prodrugs as drug delivery systems. 26. Preparation and enzymatic-hydrolysis of various water-soluble amino-acid esters of metronidazole. Int. J. Pharm., 18, 67-77.
-
(1984)
Int. J. Pharm
, vol.18
, pp. 67-77
-
-
Bundgaard, H.1
Larsen, C.2
Thorbek, P.3
-
42
-
-
0034993669
-
Synthesis, chemical and enzymatic hydrolysis, and bioavailability evaluation in rabbits of metronidazole amino acid ester prodrugs with enhanced water solubility
-
Mahfouz, N. M., Hassan, M. A. (2001). Synthesis, chemical and enzymatic hydrolysis, and bioavailability evaluation in rabbits of metronidazole amino acid ester prodrugs with enhanced water solubility. J. Pharm. Pharm., 53, 841-848.
-
(2001)
J. Pharm. Pharm.
, vol.53
, pp. 841-848
-
-
Mahfouz, N.M.1
Hassan, M.A.2
-
43
-
-
0342264395
-
Lipophilic metronidazole derivatives and their absoprtion through hairless mouse skin
-
Másson, M., Thorsteinsson, T., Sigurdsson, T. H., Loftsson, T. (2000). Lipophilic metronidazole derivatives and their absoprtion through hairless mouse skin. Die Pharmazie, 55, 369-371.
-
(2000)
Die Pharmazie
, vol.55
, pp. 369-371
-
-
Másson, M.1
Thorsteinsson, T.2
Sigurdsson, T.H.3
Loftsson, T.4
-
44
-
-
0028896858
-
Novel, water-soluble phosphate derivatives of 2¢-ethoxy carbonylpaclitaxel as potential prodrugs of paclitaxel-Synthesis and antitumor evaluation
-
Ueda,Y., Matiskella, J. D., Mikkilineni, A. B., Farina,V., Knipe, J. O., Rose,W. C., Casazza, A. M., Vyas,D. M. (1995). Novel, water-soluble phosphate derivatives of 2¢-ethoxy carbonylpaclitaxel as potential prodrugs of paclitaxel-Synthesis and antitumor evaluation. Bioorganic Med. Chem. Lett., 5, 247-252.
-
(1995)
Bioorganic Med. Chem. Lett
, vol.5
, pp. 247-252
-
-
Ueda, Y.1
Matiskella, J.D.2
Mikkilineni, A.B.3
Farina, V.4
Knipe, J.O.5
Rose, W.C.6
Casazza, A.M.7
Vyas, D.M.8
-
45
-
-
0027173188
-
Chemical modification of an antitumor alkaloid, 20(S)-camptothecin-E-lactone ringmodified water-soluble derivatives of 7-ethylcamptothecin
-
Sawada, S., Yaegashi, T., Furuta, T., Yokokura, T., Miyasaka, T. (1993). Chemical modification of an antitumor alkaloid, 20(S)-camptothecin-E-lactone ringmodified water-soluble derivatives of 7-ethylcamptothecin. Chem. Pharm. Bull., 41, 310-313.
-
(1993)
Chem. Pharm. Bull
, vol.41
, pp. 310-313
-
-
Sawada, S.1
Yaegashi, T.2
Furuta, T.3
Yokokura, T.4
Miyasaka, T.5
-
46
-
-
0028609069
-
Synthesis and antitumor-activity of 20(S)-camptothecin derivatives-A-ringsubstituted 7-ethylcamptothecins and their E-ring-modified water-soluble derivatives
-
Yaegashi,T., Sawada, S., Nagata, H., Furuta,T.,Yokokura,T., Miyasaka,T. (1994). Synthesis and antitumor-activity of 20(S)-camptothecin derivatives-A-ringsubstituted 7-ethylcamptothecins and their E-ring-modified water-soluble derivatives. Chem. Pharm. Bull., 42, 2518-2525.
-
(1994)
Chem. Pharm. Bull
, vol.42
, pp. 2518-2525
-
-
Yaegashi, T.1
Sawada, S.2
Nagata, H.3
Furuta, T.4
Yokokura, T.5
Miyasaka, T.6
-
47
-
-
0017703270
-
Improved delivery through biological-membranes
-
Bodor, N., Sloan, K. B., Higuchi, T., Sasahara, K. (1977). Improved delivery through biological-membranes. 4. Prodrugs of L-dopa. J. Med. Chem., 20, 1435-1445.
-
(1977)
4. Prodrugs of L-dopa. J. Med. Chem
, vol.20
, pp. 1435-1445
-
-
Bodor, N.1
Sloan, K.B.2
Higuchi, T.3
Sasahara, K.4
-
48
-
-
0019122255
-
Pro-drugs as drug delivery systems. 13. Kinetics of decomposition of N-Mannich bases of salicylamide and assessment of their suitability as possible pro-drugs for amines
-
Johansen, M., Bundgaard, H. (1980). Pro-drugs as drug delivery systems. 13. Kinetics of decomposition of N-Mannich bases of salicylamide and assessment of their suitability as possible pro-drugs for amines. Int. J. Pharm., 7, 119-127.
-
(1980)
Int. J. Pharm
, vol.7
, pp. 119-127
-
-
Johansen, M.1
Bundgaard, H.2
-
49
-
-
0020053363
-
Pro-drugs as drug delivery systems. 21. Preparation, physicochemical properties and bioavailability of a novel water-soluble pro-drug type for carbamazepine
-
Bundgaard, H., Johansen, M., Stella, V., Cortese, M. (1982). Pro-drugs as drug delivery systems. 21. Preparation, physicochemical properties and bioavailability of a novel water-soluble pro-drug type for carbamazepine. Int. J. Pharm., 10, 181-192.
-
(1982)
Int. J. Pharm
, vol.10
, pp. 181-192
-
-
Bundgaard, H.1
Johansen, M.2
Stella, V.3
Cortese, M.4
-
50
-
-
0032550320
-
Vitro hydrolysis of polyunsaturated fatty acid N-acyloxymethyl derivatives of theophylline
-
Redden, R., Douglas, J. E., Burke, M. J., Horrobin, D. F. (1998). In vitro hydrolysis of polyunsaturated fatty acid N-acyloxymethyl derivatives of theophylline. Int. J. Pharm., 165, 87.
-
(1998)
Int. J. Pharm
, vol.165
, pp. 87
-
-
Redden, R.1
Douglas, J.E.2
Burke, M.J.3
Horrobin, D.F.4
-
51
-
-
0024367481
-
A novel solution-stable, water-soluble prodrug type for drugs containing a hydroxyl or an NH-acidic group
-
Bundgaard, H., Falch, E., Jensen, E. (1989). A novel solution-stable, water-soluble prodrug type for drugs containing a hydroxyl or an NH-acidic group. J. Med. Chem., 32, 2503-2507.
-
(1989)
J. Med. Chem
, vol.32
, pp. 2503-2507
-
-
Bundgaard, H.1
Falch, E.2
Jensen, E.3
-
52
-
-
0020533024
-
Prodrugs of 6-thiopurines-Enhanced delivery through the skin
-
Sloan, K. B., Hashida, M., Alexander, J., Bodor, N., Higuchi, T. (1983). Prodrugs of 6-thiopurines-Enhanced delivery through the skin. J. Pharm. Sci., 72, 372-378.
-
(1983)
J. Pharm. Sci.
, vol.72
, pp. 372-378
-
-
Sloan, K.B.1
Hashida, M.2
Alexander, J.3
Bodor, N.4
Higuchi, T.5
-
53
-
-
0019959158
-
Pro-drugs as drug delivery systems. 23. Improved dermal delivery of 5-fluorouracil through human-skin via N-acyloxymethyl pro-drug derivatives
-
Mollgaard, B., Hoelgaard, A., Bundgaard, H. (1982). Pro-drugs as drug delivery systems. 23. Improved dermal delivery of 5-fluorouracil through human-skin via N-acyloxymethyl pro-drug derivatives. Int. J. Pharm., 12, 153-162.
-
(1982)
Int. J. Pharm
, vol.12
, pp. 153-162
-
-
Mollgaard, B.1
Hoelgaard, A.2
Bundgaard, H.3
-
54
-
-
0035289188
-
Prodrug based optimal drug delivery via membrane transporter/receptor
-
Yang, C.,Tirucherai,G. S., Mitra, A. K. (2001). Prodrug based optimal drug delivery via membrane transporter/receptor. Expert Opin. Biol. Ther., 1, 159-175.
-
(2001)
Expert Opin. Biol. Ther
, vol.1
, pp. 159-175
-
-
Yang, C.1
Tirucherai, G.S.2
Mitra, A.K.3
-
55
-
-
0031430945
-
Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs
-
Shaw, J. P., Sueoka,C. M., Oliyai, R., Lee,W. A., Arimilli, M. N., Kim,C. U., Cundy, K. C. (1997). Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs. Pharm. Res., 14, 1824-1829.
-
(1997)
Pharm. Res
, vol.14
, pp. 1824-1829
-
-
Shaw, J.P.1
Sueoka, C.M.2
Oliyai, R.3
Lee, W.A.4
Arimilli, M.N.5
Kim, C.U.6
Cundy, K.C.7
-
57
-
-
0028792567
-
Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients
-
Cundy, K. C., Barditch-Crovo, P.,Walker, R. E., Collier, A. C., Ebeling, D., Toole, J., Jaffe, H. S. (1995). Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients. Antimicrob. Agents Chemother., 39, 2401-2405.
-
(1995)
Antimicrob. Agents Chemother
, vol.39
, pp. 2401-2405
-
-
Cundy, K.C.1
Barditch-Crovo, P.2
Walker, R.E.3
Collier, A.C.4
Ebeling, D.5
Toole, J.6
Jaffe, H.S.7
-
58
-
-
0141750717
-
Oral direct thrombin inhibitors in clinical development
-
Gustafsson, D. (2003). Oral direct thrombin inhibitors in clinical development. J. Internal Med., 254, 322-334.
-
(2003)
J. Internal Med
, vol.254
, pp. 322-334
-
-
Gustafsson, D.1
-
59
-
-
0042143281
-
Targeted prodrug design to optimize drug delivery
-
Han, H. K., Amidon, G. L. (2000). Targeted prodrug design to optimize drug delivery. AAPS PharmSci, 2, E6.
-
(2000)
AAPS PharmSci
, vol.2
-
-
Han, H.K.1
Amidon, G.L.2
-
60
-
-
0347359134
-
Intestinal solute carriers: An overview of trends and strategies for improving oral drug absorption
-
Steffansen, B., Nielsen, C. U., Brodin, B., Eriksson, A. H., Andersen, R., Frokjaer, S. (2004). Intestinal solute carriers: An overview of trends and strategies for improving oral drug absorption. Eur. J. Pharm. Sci., 21, 3-16
-
(2004)
Eur. J. Pharm. Sci.
, vol.21
, pp. 3-16
-
-
Steffansen, B.1
Nielsen, C.U.2
Brodin, B.3
Eriksson, A.H.4
Andersen, R.5
Frokjaer, S.6
-
61
-
-
0026541051
-
Species differences in the metabolism and disposition of antiviral nucleoside analogues: 1
-
de Miranda, P., Good, S. S. (1992). Species differences in the metabolism and disposition of antiviral nucleoside analogues: 1. Acyclovir. Antiviral Chem. Chemother., 3, 1-8.
-
(1992)
Acyclovir. Antiviral Chem. Chemother
, vol.3
, pp. 1-8
-
-
de Miranda, P.1
Good, S.S.2
-
62
-
-
0027768955
-
Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single-and multiple-dose administration to normal volunteers
-
Weller, S., Blum, M. R., Doucette, M., Burnette,T., Cederberg,D. M., De Miranda, P., Smiley, M. L. (1993). Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single-and multiple-dose administration to normal volunteers. Clin. Pharm. Ther., 54, 595-605.
-
(1993)
Clin. Pharm. Ther
, vol.54
, pp. 595-605
-
-
Weller, S.1
Blum, M.R.2
Doucette, M.3
Burnette, T.4
Cederberg, D.M.5
De Miranda, P.6
Smiley, M.L.7
-
63
-
-
0029062086
-
Valaciclovir compared with acyclovir for improved therapy for herpes zoster in immunocompetent adults
-
Beutner, K. R., Friedman, D. J., Forszpaniak, C., Andersen, P. L., Wood, M. J. (1995). Valaciclovir compared with acyclovir for improved therapy for herpes zoster in immunocompetent adults. Antimicrob. Agents Chemother., 39, 1546-1553.
-
(1995)
Antimicrob. Agents Chemother
, vol.39
, pp. 1546-1553
-
-
Beutner, K.R.1
Friedman, D.J.2
Forszpaniak, C.3
Andersen, P.L.4
Wood, M.J.5
-
64
-
-
0032916827
-
Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line
-
Guo, A., Hu, P., Balimane, P. V., Leibach, F. H., Sinko, P. J. (1999). Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line. J. Pharmcol. Exper. Ther., 289, 448-454.
-
(1999)
J. Pharmcol. Exper. Ther
, vol.289
, pp. 448-454
-
-
Guo, A.1
Hu, P.2
Balimane, P.V.3
Leibach, F.H.4
Sinko, P.J.5
-
65
-
-
0031662109
-
5¢-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter
-
Han, H., De Vrueh, R. L., Rhie, J. K., Covitz, K. M., Smith, P. L., Lee, C. P., Oh, D. M., Sadee, W., Amidon, G. L. (1998). 5¢-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter. Pharm. Res., 15, 1154-1159.
-
(1998)
Pharm. Res
, vol.15
, pp. 1154-1159
-
-
Han, H.1
De Vrueh, R.L.2
Rhie, J.K.3
Covitz, K.M.4
Smith, P.L.5
Lee, C.P.6
Oh, D.M.7
Sadee, W.8
Amidon, G.L.9
-
66
-
-
0033812228
-
Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2
-
Sugawara, M., Huang, W., Fei, Y. J., Leibach, F. H., Ganapathy, V., Ganapathy, M. E. (2000). Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2. J. Pharm. Sci., 89, 781-789.
-
(2000)
J. Pharm. Sci
, vol.89
, pp. 781-789
-
-
Sugawara, M.1
Huang, W.2
Fei, Y.J.3
Leibach, F.H.4
Ganapathy, V.5
Ganapathy, M.E.6
-
67
-
-
0038692005
-
Absorption rate limit considerations for oral phosphate prodrugs
-
Heimbach, T., Oh, D. M., Li, L. Y., Forsberg, M., Savolainen, J., Leppanen, J., Matsunaga,Y., Flynn,G., Fleisher,D. (2003). Absorption rate limit considerations for oral phosphate prodrugs. Pharm. Res., 20, 848-856.
-
(2003)
Pharm. Res
, vol.20
, pp. 848-856
-
-
Heimbach, T.1
Oh, D.M.2
Li, L.Y.3
Forsberg, M.4
Savolainen, J.5
Leppanen, J.6
Matsunaga, Y.7
Flynn, G.8
Fleisher, D.9
-
68
-
-
0032810558
-
Mechanism of intestinal absorption of an orally active beta-lactam prodrug: Uptake and transport of carindacillin in Caco-2 cells
-
Li, Y. H., Ito, K., Tsuda, Y., Kohda, R., Yamada, H., Itoh, T. (1999). Mechanism of intestinal absorption of an orally active beta-lactam prodrug: Uptake and transport of carindacillin in Caco-2 cells. J. Pharmcol. Exper. Ther., 290, 958-964.
-
(1999)
J. Pharmcol. Exper. Ther.
, vol.290
, pp. 958-964
-
-
Li, Y.H.1
Ito, K.2
Tsuda, Y.3
Kohda, R.4
Yamada, H.5
Itoh, T.6
-
69
-
-
0142139248
-
Designing for topical delivery: Prodrugs can make the difference
-
Sloan, K. B.,Wasdo, S. (2003). Designing for topical delivery: Prodrugs can make the difference. Med. Res. Rev., 23, 763-793.
-
(2003)
Med. Res. Rev
, vol.23
, pp. 763-793
-
-
Sloan, K.B.1
Wasdo, S.2
-
70
-
-
0024553048
-
Prodrugs for dermal delivery
-
Sloan, K. B. (1989). Prodrugs for dermal delivery. Adv. Drug Delivery Rev., 3, 67-101.
-
(1989)
Adv. Drug Delivery Rev
, vol.3
, pp. 67-101
-
-
Sloan, K.B.1
-
71
-
-
0002387624
-
Functional group considerations in the development of prodrugs approaches to solving topical delivery problems
-
K. B. Sloan (Ed.), Marcel Dekker, New York
-
Sloan, K. B. (1992). Functional group considerations in the development of prodrugs approaches to solving topical delivery problems. In K. B. Sloan (Ed.), Prodrugs; Topical and Ocular Drug Delivery. Marcel Dekker, New York, pp. 17-116.
-
(1992)
Prodrugs; Topical and Ocular Drug Delivery.
, pp. 17-116
-
-
Sloan, K.B.1
-
72
-
-
0020608682
-
Logics of transdermal controlled drug administration
-
Chien, Y. W. (1983). Logics of transdermal controlled drug administration. Drug Devel. Ind. Pharm., 9, 497-520.
-
(1983)
Drug Devel. Ind. Pharm
, vol.9
, pp. 497-520
-
-
Chien, Y.W.1
-
73
-
-
0032803081
-
Synthesis and in vitro evaluation of aminoacyloxyalkyl esters of 2-(6-methoxy-2-naphthyl)propionic acid as novel naproxen prodrugs for dermal drug delivery
-
Rautio, J., Nevalainen, T., Taipale, H., Vepsäläinen, J., Gynther, J., Pedersen, T., Järvinen, T. (1999). Synthesis and in vitro evaluation of aminoacyloxyalkyl esters of 2-(6-methoxy-2-naphthyl)propionic acid as novel naproxen prodrugs for dermal drug delivery. Pharm. Res., 16, 1172-1178.
-
(1999)
Pharm. Res
, vol.16
, pp. 1172-1178
-
-
Rautio, J.1
Nevalainen, T.2
Taipale, H.3
Vepsäläinen, J.4
Gynther, J.5
Pedersen, T.6
Järvinen, T.7
-
74
-
-
0034692169
-
Synthesis and in vitro evaluation of novel morpholinyl-and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery
-
Rautio, J., Nevalainen, T., Taipale, H., Vepsäläinen, J., Gynther, J., Laine, K., Järvinen, T. (2000). Synthesis and in vitro evaluation of novel morpholinyl-and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery. J. Med. Chem., 43, 1489-1494.
-
(2000)
J. Med. Chem
, vol.43
, pp. 1489-1494
-
-
Rautio, J.1
Nevalainen, T.2
Taipale, H.3
Vepsäläinen, J.4
Gynther, J.5
Laine, K.6
Järvinen, T.7
-
75
-
-
0033911293
-
Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation
-
Rautio, J., Nevalainen, T., Taipale, H., Vepsäläinen, J., Gynther, J., Laine, K., Järvinen, T. (2000). Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation. Eur. J. Pharm. Sci., 11, 157-163.
-
(2000)
Eur. J. Pharm. Sci
, vol.11
, pp. 157-163
-
-
Rautio, J.1
Nevalainen, T.2
Taipale, H.3
Vepsäläinen, J.4
Gynther, J.5
Laine, K.6
Järvinen, T.7
-
76
-
-
0032920847
-
Synthesis, stereoselective enzymatic hydrolysis, and skin permeation of diastereomeric propranolol ester prodrugs
-
Udata, C.,Tirucherai,G., Mitra, A. K. (1999). Synthesis, stereoselective enzymatic hydrolysis, and skin permeation of diastereomeric propranolol ester prodrugs. J. Pharm. Sci., 88, 544-550.
-
(1999)
J. Pharm. Sci
, vol.88
, pp. 544-550
-
-
Udata, C.1
Tirucherai, G.2
Mitra, A.K.3
-
77
-
-
0017872741
-
Penetration routes of topically applied eye medications
-
Doane, M. G., Jensen, A. D., Dohlman, C. H. (1978). Penetration routes of topically applied eye medications. Am. J. Ophthalmol., 85, 383-386.
-
(1978)
Am. J. Ophthalmol
, vol.85
, pp. 383-386
-
-
Doane, M.G.1
Jensen, A.D.2
Dohlman, C.H.3
-
78
-
-
0026666843
-
The transport barrier of epithelia:A comparative study on membrane permeability and charge selectivity in the rabbit
-
Rojanasakul, Y., Wang, L-Y., Bhat, M., Glover, D. D., Malanga, C. J., Ma, K. H. (1992). The transport barrier of epithelia:A comparative study on membrane permeability and charge selectivity in the rabbit. Pharm. Res., 9, 1029-1034.
-
(1992)
Pharm. Res
, vol.9
, pp. 1029-1034
-
-
Rojanasakul, Y.1
Wang, L.-Y.2
Bhat, M.3
Glover, D.D.4
Malanga, C.J.5
Ma, K.H.6
-
79
-
-
0025752584
-
Role of enzymatic lability in the corneal and conjunctival penetration on timolol ester prodrugs in the pigmented rabbit
-
Chien, D-S., Sasaki, H., Bundgaard, H., Buur, A., Lee, V. H. L. (1991). Role of enzymatic lability in the corneal and conjunctival penetration on timolol ester prodrugs in the pigmented rabbit. Pharm. Res., 8, 728-733.
-
(1991)
Pharm. Res
, vol.8
, pp. 728-733
-
-
Chien, D.-S.1
Sasaki, H.2
Bundgaard, H.3
Buur, A.4
Lee, V.H.L.5
-
80
-
-
0025775370
-
Lipophilicity influence on conjunctival drug penetration in the pigmented rabbit:A comparison with corneal penetration
-
Wang,W., Sasaki, H., Chien,D.-S., Lee,V. H., L. (1991). Lipophilicity influence on conjunctival drug penetration in the pigmented rabbit:A comparison with corneal penetration. Curr. Eye Res., 10, 571-579.
-
(1991)
Curr. Eye Res
, vol.10
, pp. 571-579
-
-
Wang, W.1
Sasaki, H.2
Chien, D.-S.3
Lee, V.H.L.4
-
81
-
-
0021052458
-
Corneal penetration behavior of betablocking agents I: Physicochemical factors
-
Schoenwald, R. D., Huang, H.-S. (1983). Corneal penetration behavior of betablocking agents I: Physicochemical factors. J. Pharm. Sci., 72, 1266-1272.
-
(1983)
J. Pharm. Sci
, vol.72
, pp. 1266-1272
-
-
Schoenwald, R.D.1
Huang, H.-S.2
-
82
-
-
0017806197
-
Relationship between steroid permeability across excised rabbit cornea and octanol-water partition coefficients
-
Schoenwald, R. D.,Ward, R. L. (1978). Relationship between steroid permeability across excised rabbit cornea and octanol-water partition coefficients. J. Pharm. Sci., 67, 787-789.
-
(1978)
J. Pharm. Sci
, vol.67
, pp. 787-789
-
-
Schoenwald, R.D.1
Ward, R.L.2
-
83
-
-
0032941568
-
Enhancement of ocular drug penetration
-
Sasaki, H., Yamamura, M., Mukai, T., Nishida, K., Nakamura, J., Nakashima, M., Ichikawa, M. (1999). Enhancement of ocular drug penetration. Crit. Rev. Ther. Drug Carrier Syst., 16, 85-146.
-
(1999)
Crit. Rev. Ther. Drug Carrier Syst
, vol.16
, pp. 85-146
-
-
Sasaki, H.1
Yamamura, M.2
Mukai, T.3
Nishida, K.4
Nakamura, J.5
Nakashima, M.6
Ichikawa, M.7
-
84
-
-
0017137343
-
Prodrug approaches to enhancement of physicochemical properties of drugs IV: Novel epinephrine prodrug
-
Hussain,A.,Truelove, J. E. (1976). Prodrug approaches to enhancement of physicochemical properties of drugs IV: Novel epinephrine prodrug. J. Pharm. Sci., 65, 1510-1512.
-
(1976)
J. Pharm. Sci
, vol.65
, pp. 1510-1512
-
-
Hussain, A.1
Truelove, J.E.2
-
85
-
-
0018874141
-
Systemic absorption of topical ocularly applied epinephrine and dipivefrin
-
Anderson, J. A. (1980). Systemic absorption of topical ocularly applied epinephrine and dipivefrin. Arch. Ophthalmol., 98, 350-353.
-
(1980)
Arch. Ophthalmol
, vol.98
, pp. 350-353
-
-
Anderson, J.A.1
-
86
-
-
0017940245
-
Dipivalyl epinephrine: A new pro-drug in the treatment of glaucoma
-
Mandell, A. I., Stentz, F. (1978). Dipivalyl epinephrine: A new pro-drug in the treatment of glaucoma. Ophthalmology, 85, 268-275.
-
(1978)
Ophthalmology
, vol.85
, pp. 268-275
-
-
Mandell, A.I.1
Stentz, F.2
-
87
-
-
0017809651
-
Ocular absorption and metabolism of topically applied epinephrine and a dipivalyl ester of epinephrine
-
Wei, C., Anderson, J. A., Leopold, I. (1978). Ocular absorption and metabolism of topically applied epinephrine and a dipivalyl ester of epinephrine. Investigative Ophthalmol. Vis. Sci., 17, 315-321.
-
(1978)
Investigative Ophthalmol. Vis. Sci
, vol.17
, pp. 315-321
-
-
Wei, C.1
Anderson, J.A.2
Leopold, I.3
-
88
-
-
0017129552
-
The effects of dipivalyl epinephrine on the eye
-
Kaback, M. B., Podos, S. M., Harbin, Jr. T. S., Mandell, A., Becker, B. (1976). The effects of dipivalyl epinephrine on the eye. Am. J. Ophthalmol., 81, 768-772.
-
(1976)
Am. J. Ophthalmol
, vol.81
, pp. 768-772
-
-
Kaback, M.B.1
Podos, S.M.2
Harbin Jr., T.S.3
Mandell, A.4
Becker, B.5
-
89
-
-
0018386680
-
Clinical comparison of dipivalyl epinephrine and epinephrine in the treatment of glaucoma
-
Kohn, A. N., Moss, A. P., Hargett, N. A., Ritch, R., Smith, H., Podos, S. M. (1979). Clinical comparison of dipivalyl epinephrine and epinephrine in the treatment of glaucoma. Am. J. Ophthalmol., 87, 196-201.
-
(1979)
Am. J. Ophthalmol
, vol.87
, pp. 196-201
-
-
Kohn, A.N.1
Moss, A.P.2
Hargett, N.A.3
Ritch, R.4
Smith, H.5
Podos, S.M.6
-
90
-
-
0036669549
-
Current status of prostaglandin therapy; Latanoprost and unoprostone
-
Susanna, R., Chew, P., Kitazawa, Y. (2002). Current status of prostaglandin therapy; Latanoprost and unoprostone. Surv. Ophthalmol., 47, S97-S104.
-
(2002)
Surv. Ophthalmol.
, vol.47
-
-
Susanna, R.1
Chew, P.2
Kitazawa, Y.3
-
91
-
-
0034810344
-
Travoprost compared with latanoprost and timolol in patients with open-angle glaucoma or ocular hypertension
-
Netlans,P. A., Landry,T., Sullivan, E. K.,Andrew, R., Silver, L.,Weiner,A., Mallick, S., Dickerson, J., Bergamini,W.V.W., Robertson, S. M., Davis,A. D. (2001). Travoprost compared with latanoprost and timolol in patients with open-angle glaucoma or ocular hypertension. Am. J. Ophthalmol., 132, 472-484.
-
(2001)
Am. J. Ophthalmol
, vol.132
, pp. 472-484
-
-
Netlans, P.A.1
Landry, T.2
Sullivan, E.K.3
Andrew, R.4
Silver, L.5
Weiner, A.6
Mallick, S.7
Dickerson, J.8
Bergamini, W.V.W.9
Robertson, S.M.10
Davis, A.D.11
-
92
-
-
0343867170
-
Rate control of ocular pilocarpine delivery with bispilocarpic acid diesters
-
Suhonen, P., Järvinen, T., Lehmussaari, K., Reunamäki, T., Urtti A. (1996). Rate control of ocular pilocarpine delivery with bispilocarpic acid diesters. Int. J. Pharm., 127, 85-94.
-
(1996)
Int. J. Pharm
, vol.127
, pp. 85-94
-
-
Suhonen, P.1
Järvinen, T.2
Lehmussaari, K.3
Reunamäki, T.4
Urtti, A.5
-
93
-
-
0023885078
-
Low dose O-butyryl timolol improves the therapeutic index of timolol in the pigmented rabbit
-
Chang, S.-C., Bundgaard, H., Buur, A., Lee, V. H. L. (1988). Low dose O-butyryl timolol improves the therapeutic index of timolol in the pigmented rabbit. Investigative Ophthalmol. Vis. Sci., 29, 626-629.
-
(1988)
Investigative Ophthalmol. Vis. Sci
, vol.29
, pp. 626-629
-
-
Chang, S.-C.1
Bundgaard, H.2
Buur, A.3
Lee, V.H.L.4
-
94
-
-
0027264829
-
Ocular delivery of the b-blocker, tilisolol, through the prodrug approach
-
Sasaki, H., Igarashi, Y., Nishida, K., Nakamura, J. (1993). Ocular delivery of the b-blocker, tilisolol, through the prodrug approach. Int. J. Pharm., 93, 49-60.
-
(1993)
Int. J. Pharm
, vol.93
, pp. 49-60
-
-
Sasaki, H.1
Igarashi, Y.2
Nishida, K.3
Nakamura, J.4
-
95
-
-
0036689265
-
Mechanism of corneal permeation of l-valyl ester of acyclovir: Targeting the oligopeptide transporter on the rabbit cornea
-
Anand, B. S., Mitra, A. K. (2002). Mechanism of corneal permeation of l-valyl ester of acyclovir: Targeting the oligopeptide transporter on the rabbit cornea. Pharm. Res., 19, 1194-1202.
-
(2002)
Pharm. Res
, vol.19
, pp. 1194-1202
-
-
Anand, B.S.1
Mitra, A.K.2
-
96
-
-
0346825138
-
Nasal drug delivery. Physiological Pharmaceutics. Barriers to Drug Absorption
-
2nd ed., Taylor & Francis, London
-
Washington,N.,Washington,C.,Wilson,C. G. (2001). Nasal drug delivery. In Physiological Pharmaceutics. Barriers to Drug Absorption, 2nd ed., Taylor & Francis, London, pp. 199-220.
-
(2001)
-
-
Washington, N.1
Washington, C.2
Wilson, C.G.3
-
97
-
-
0036121337
-
Prodrug strategies in nasal drug delivery
-
Pezron, I.,Tirucherai, G. S., Duvvuri, S., Mitra, A. K. (2002). Prodrug strategies in nasal drug delivery. Expert Opin. Ther. Patents, 12, 331-340.
-
(2002)
Expert Opin. Ther. Patents
, vol.12
, pp. 331-340
-
-
Pezron, I.1
Tirucherai, G.S.2
Duvvuri, S.3
Mitra, A.K.4
-
98
-
-
0036016980
-
Testosterone 17b-N,N-dimethylglycinate hydrochloride: A prodrug with a potential for nasal delivery of testosterone
-
Hussain, A. A., Al-Bayatti, A. A., Dakkuri, A., Okochi, K., Hussain, M. A. (2002). Testosterone 17b-N,N-dimethylglycinate hydrochloride: A prodrug with a potential for nasal delivery of testosterone. J. Pharm. Sci., 91, 785-789.
-
(2002)
J. Pharm. Sci
, vol.91
, pp. 785-789
-
-
Hussain, A.A.1
Al-Bayatti, A.A.2
Dakkuri, A.3
Okochi, K.4
Hussain, M.A.5
-
99
-
-
0035808275
-
Cyclodextrin solubilization of benzodiazepines: Formulation of midazolam nasal spray
-
Loftsson, T., Gudmundsdottir, H., Sigurjonsdottir, J. F., Sigurdsson, H. H., Sigfusson, S. D., Masson, M., Stefansson, E. (2001). Cyclodextrin solubilization of benzodiazepines: Formulation of midazolam nasal spray. Int. J. Pharm., 212, 29-40.
-
(2001)
Int. J. Pharm
, vol.212
, pp. 29-40
-
-
Loftsson, T.1
Gudmundsdottir, H.2
Sigurjonsdottir, J.F.3
Sigurdsson, H.H.4
Sigfusson, S.D.5
Masson, M.6
Stefansson, E.7
-
100
-
-
0035663585
-
Intranasal administration of midazolam in a cyclodextrin based formulation: Bioavailability and clinical evaluation in humans
-
Gudmundsdottir, H., Sigurjonsdottir, J. F., Masson, M., Fjalldal,O., Stefansson, E., Loftsson, T. (2001). Intranasal administration of midazolam in a cyclodextrin based formulation: Bioavailability and clinical evaluation in humans. Pharmazie, 56, 963-966.
-
(2001)
Pharmazie
, vol.56
, pp. 963-966
-
-
Gudmundsdottir, H.1
Sigurjonsdottir, J.F.2
Masson, M.3
Fjalldal, O.4
Stefansson, E.5
Loftsson, T.6
-
101
-
-
0036846813
-
Enhanced permeability of molecular weight markers and poorly bioavailable compounds across Caco-2 cell monolayers using the absorption enhancer, zonula occludens toxin
-
Cox, D. S., Raje, S., Gao, H. L., Salama, N. N., Eddington, N. D. (2002). Enhanced permeability of molecular weight markers and poorly bioavailable compounds across Caco-2 cell monolayers using the absorption enhancer, zonula occludens toxin. Pharm. Res., 19, 1680-1688.
-
(2002)
Pharm. Res
, vol.19
, pp. 1680-1688
-
-
Cox, D.S.1
Raje, S.2
Gao, H.L.3
Salama, N.N.4
Eddington, N.D.5
-
102
-
-
0028108056
-
Biodegradation characteristics of acyclovir 2¢-esters by respiratory carboxylesterases: Implications in prodrug design for intranasal and pulmonary drug delivery
-
Shao, Z., Hoffman, A. J., Mitra, A. K. (1994). Biodegradation characteristics of acyclovir 2¢-esters by respiratory carboxylesterases: Implications in prodrug design for intranasal and pulmonary drug delivery. Int. J. Pharm., 112, 181-190.
-
(1994)
Int. J. Pharm
, vol.112
, pp. 181-190
-
-
Shao, Z.1
Hoffman, A.J.2
Mitra, A.K.3
-
103
-
-
0028316205
-
The physicochemical properties, plasma enzymatic hydrolysis, and nasal absorption of acyclovir and its 2¢-ester prodrugs
-
Shao, Z., Park, G.-B., Krishnamoorthy, R., Mitra, A. K. (1994). The physicochemical properties, plasma enzymatic hydrolysis, and nasal absorption of acyclovir and its 2¢-ester prodrugs. Pharm. Res., 11, 237-242.
-
(1994)
Pharm. Res
, vol.11
, pp. 237-242
-
-
Shao, Z.1
Park, G.-B.2
Krishnamoorthy, R.3
Mitra, A.K.4
-
104
-
-
0032484626
-
Intranasal drug delivery
-
Hussain, A. A. (1998). Intranasal drug delivery. Adv. Drug Delivery Rev., 29, 39-49.
-
(1998)
Adv. Drug Delivery Rev
, vol.29
, pp. 39-49
-
-
Hussain, A.A.1
-
105
-
-
0033795553
-
Enhancement of systemic and CNS specific delivery of L-dopa by the nasal administration of its water soluble prodrugs
-
Kao,H. D.,Traboulsi, A., Itoh, S., Dittert, L., Hussain, A. (2000). Enhancement of systemic and CNS specific delivery of L-dopa by the nasal administration of its water soluble prodrugs. Pharm. Res., 17, 978-984.
-
(2000)
Pharm. Res
, vol.17
, pp. 978-984
-
-
Kao, H.D.1
Traboulsi, A.2
Itoh, S.3
Dittert, L.4
Hussain, A.5
-
106
-
-
0035090504
-
Nasal absorption of tyrosine-linked model compounds
-
Yang, C., Mitra, A. K. (2001). Nasal absorption of tyrosine-linked model compounds. J. Pharm. Sci., 90, 340-347.
-
(2001)
J. Pharm. Sci
, vol.90
, pp. 340-347
-
-
Yang, C.1
Mitra, A.K.2
-
107
-
-
0035042563
-
Chemical stability, enzymatic hydrolysis, and nasal uptake of amino acid ester prodrugs of acyclovir
-
Yang, C., Gao, H., Mitra, A. K. (2001). Chemical stability, enzymatic hydrolysis, and nasal uptake of amino acid ester prodrugs of acyclovir. J. Pharm. Sci., 90, 617-624.
-
(2001)
J. Pharm. Sci
, vol.90
, pp. 617-624
-
-
Yang, C.1
Gao, H.2
Mitra, A.K.3
-
108
-
-
0025949443
-
Prodrugs of peptides. 15. 4-Imidazolidinone prodrug derivatives of enkephalins to prevent aminopeptidasecatalyzed metabolism in plasma and absorptive mucosae
-
Rasmussen, G. J., Bundgaard, H. (1991). Prodrugs of peptides. 15. 4-Imidazolidinone prodrug derivatives of enkephalins to prevent aminopeptidasecatalyzed metabolism in plasma and absorptive mucosae. Int. J. Pharm., 76, 113-122.
-
(1991)
Int. J. Pharm
, vol.76
, pp. 113-122
-
-
Rasmussen, G.J.1
Bundgaard, H.2
-
109
-
-
0036148739
-
Novel approaches to nasal delivery of peptides and proteins
-
Tirucherai, G. S., Pezron, I., Mitra, A. K. (2002). Novel approaches to nasal delivery of peptides and proteins. S. T.P. Pharma Sci., 12, 3-12.
-
(2002)
S. T.P. Pharma Sci
, vol.12
, pp. 3-12
-
-
Tirucherai, G.S.1
Pezron, I.2
Mitra, A.K.3
-
110
-
-
0029856304
-
Etoposide phosphate, the water soluble prodrug of etoposide
-
Witterland, A. H. I., Koks, C. H. W., Beijnen, J. H. (1996). Etoposide phosphate, the water soluble prodrug of etoposide. Pharm.World Sci., 18, 163-170.
-
(1996)
Pharm.World Sci
, vol.18
, pp. 163-170
-
-
Witterland, A.H.I.1
Koks, C.H.W.2
Beijnen, J.H.3
-
111
-
-
0032820005
-
A novel prodrug approach for tertiary amines. 2. Physicochemical and in vitro enzymatic evaluation of selected Nphosphonooxymethyl prodrugs
-
Krise, J. P., Narisawa, S., Stella,V. J. (1999). A novel prodrug approach for tertiary amines. 2. Physicochemical and in vitro enzymatic evaluation of selected Nphosphonooxymethyl prodrugs. J. Pharm. Sci., 88, 922-927.
-
(1999)
J. Pharm. Sci
, vol.88
, pp. 922-927
-
-
Krise, J.P.1
Narisawa, S.2
Stella, V.J.3
-
112
-
-
0032840753
-
A novel prodrug approach for tertiary amines. 3. vivo evaluation of two N-phosphonooxymethyl prodrugs in rats and dogs
-
Krise, J. P., Charman,W. N., Charman, S. A., Stella, V. J. (1999). A novel prodrug approach for tertiary amines. 3. In vivo evaluation of two N-phosphonooxymethyl prodrugs in rats and dogs. J. Pharm. Sci., 88, 928-932.
-
(1999)
J. Pharm. Sci
, vol.88
, pp. 928-932
-
-
Krise, J.P.1
Charman, W.N.2
Charman, S.A.3
Stella, V.J.4
-
113
-
-
0033549849
-
Novel prodrug approach for tertiary amines: Synthesis and preliminary evaluation of Nphosphonooxymethyl prodrugs
-
Krise, J. P., Zygmunt, J., Georg, G. I., Stella, V. J. (1999). Novel prodrug approach for tertiary amines: Synthesis and preliminary evaluation of Nphosphonooxymethyl prodrugs. J. Med. Chem., 42, 3094-3100.
-
(1999)
J. Med. Chem
, vol.42
, pp. 3094-3100
-
-
Krise, J.P.1
Zygmunt, J.2
Georg, G.I.3
Stella, V.J.4
-
114
-
-
0023852518
-
Kinetics of regeneration of metronidazole from hemiesters of maleic acid, succinic acid and glutaric acid in aqueous buffer, human plasma and pig liver homogenate
-
Larsen, C.,Kurtzhals, P., Johansen, M. (1988). Kinetics of regeneration of metronidazole from hemiesters of maleic acid, succinic acid and glutaric acid in aqueous buffer, human plasma and pig liver homogenate. Int. J. Pharm., 41, 121-129.
-
(1988)
Int. J. Pharm
, vol.41
, pp. 121-129
-
-
Larsen, C.1
Kurtzhals, P.2
Johansen, M.3
-
115
-
-
13344261987
-
Discovery of the hemifumarate and (alpha-l-alanyloxy)methyl ether as prodrugs of an antirheumatic oxindole: Prodrugs for the enolic OH group
-
Robinson, R. P., Reiter, L. A., Barth,W. E., Campeta, A. M., Cooper, K., Cronin, B. J., Destito, R., Donahue, K. M., Falkner, F. C., Fiese, E. F., Johnson, D. L., Kuperman, A. V., Liston, T. E., Malloy, D., Martin, J. J., Mitchell, D. Y., Rusek, F. W., Shamblin, S. L., Wright, C. F. (1996). Discovery of the hemifumarate and (alpha-l-alanyloxy)methyl ether as prodrugs of an antirheumatic oxindole: Prodrugs for the enolic OH group. J. Med. Chem., 39, 10-18.
-
(1996)
J. Med. Chem
, vol.39
, pp. 10-18
-
-
Robinson, R.P.1
Reiter, L.A.2
Barth, W.E.3
Campeta, A.M.4
Cooper, K.5
Cronin, B.J.6
Destito, R.7
Donahue, K.M.8
Falkner, F.C.9
Fiese, E.F.10
Johnson, D.L.11
Kuperman, A.V.12
Liston, T.E.13
Malloy, D.14
Martin, J.J.15
Mitchell, D.Y.16
Rusek, F.W.17
Shamblin, S.L.18
Wright, C.F.19
-
116
-
-
84889857366
-
Water soluble pro-drugs of propofol
-
U. S. Patent 6,254,853
-
Hendler, S. S., Sanchez, R. A., Zielinski, J. (2001). Water soluble pro-drugs of propofol. U. S. Patent 6,254,853 B1.
-
(2001)
-
-
Hendler, S.S.1
Sanchez, R.A.2
Zielinski, J.3
-
117
-
-
0032555191
-
Prodrug esters of the indolocarbazole CEP-751 (KT-6587)
-
Hudkins, R. L., Iqbal, M., Park, C. H., Goldstein, J., Herman, J. L., Shek, E., Murakata, C., Mallamo, J. P. (1998). Prodrug esters of the indolocarbazole CEP-751 (KT-6587). Bioorganic Med. Chem. Lett., 8, 1873-1876.
-
(1998)
Bioorganic Med. Chem. Lett
, vol.8
, pp. 1873-1876
-
-
Hudkins, R.L.1
Iqbal, M.2
Park, C.H.3
Goldstein, J.4
Herman, J.L.5
Shek, E.6
Murakata, C.7
Mallamo, J.P.8
-
118
-
-
0037156957
-
Vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles
-
Bradshaw, T. D., Chua, M. S., Browne, H. L., Trapani,V., Sausville, E. A., Stevens, M. F. (2002). In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles. Br. J. Cancer, 86, 1348-1354.
-
(2002)
Br. J. Cancer
, vol.86
, pp. 1348-1354
-
-
Bradshaw, T.D.1
Chua, M.S.2
Browne, H.L.3
Trapani, V.4
Sausville, E.A.5
Stevens, M.F.6
-
119
-
-
0037333833
-
Water soluble prodrugs of the antitumor agent 3-(3-amino-4-methoxy)phenyl]-2-(3,4,5-trimethoxyphenyl)cyclopent-2-ene-1-one
-
Nam, N. H., Kim,Y.,You,Y. J., Hong, D. H., Kim, H. M., Ahn, B. Z. (2003).Water soluble prodrugs of the antitumor agent 3-(3-amino-4-methoxy)phenyl]-2-(3,4,5-trimethoxyphenyl)cyclopent-2-ene-1-one. Bioorganic Med. Chem., 11, 1021-1029.
-
(2003)
Bioorganic Med. Chem.
, vol.11
, pp. 1021-1029
-
-
Nam, N.H.1
Kim, Y.2
You, Y.J.3
Hong, D.H.4
Kim, H.M.5
Ahn, B.Z.6
-
120
-
-
0036132925
-
Fluphenazine plasma level monitoring for patients receiving fluphenazine decanoate
-
Marder, S. R., Aravagiri, M.,Wirshing,W. C.,Wirshing, D. A., Lebell, M., Mintz, J. (2002). Fluphenazine plasma level monitoring for patients receiving fluphenazine decanoate. Schizophr. Res., 53, 25-30.
-
(2002)
Schizophr. Res
, vol.53
, pp. 25-30
-
-
Marder, S.R.1
Aravagiri, M.2
Wirshing, W.C.3
Wirshing, D.A.4
Lebell, M.5
Mintz, J.6
-
121
-
-
0038690338
-
Suspensions of pro-drug insulin greatly prolong normoglycemic patterns in diabetic rats
-
Shechter, Y., Tsubery, H., Fridkin, M. (2003). Suspensions of pro-drug insulin greatly prolong normoglycemic patterns in diabetic rats. Biochem. Biophys. Res. Commun., 307, 315-321.
-
(2003)
Biochem. Biophys. Res. Commun
, vol.307
, pp. 315-321
-
-
Shechter, Y.1
Tsubery, H.2
Fridkin, M.3
-
122
-
-
0024166436
-
The design and bioactivation of presystemically stable prodrugs
-
Svensson, L. A.,Tunek,A. (1988). The design and bioactivation of presystemically stable prodrugs. Drug Metabolism Rev., 19, 165-194.
-
(1988)
Drug Metabolism Rev
, vol.19
, pp. 165-194
-
-
Svensson, L.A.1
Tunek, A.2
-
123
-
-
0023820851
-
Hydrolysis of 3H-bambuterol, a carbamate prodrug of terbutaline, in blood from humans and laboratory animals in vitro
-
Tunek, A., Levin, E., Svensson, L. A. (1988). Hydrolysis of 3H-bambuterol, a carbamate prodrug of terbutaline, in blood from humans and laboratory animals in vitro. Biochem. Pharmcol., 37, 3867-3876.
-
(1988)
Biochem. Pharmcol
, vol.37
, pp. 3867-3876
-
-
Tunek, A.1
Levin, E.2
Svensson, L.A.3
-
125
-
-
0032053823
-
The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
-
Brown, J. M., Giaccia,A. J. (1998). The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy. Cancer Res., 58, 408-416.
-
(1998)
Cancer Res
, vol.58
, pp. 408-416
-
-
Brown, J.M.1
Giaccia, A.J.2
-
126
-
-
0035352723
-
Recent advances in bioreductive drug targeting
-
Naylor, M. A., Thomson, P. (2001). Recent advances in bioreductive drug targeting. Mini Rev. Med. Chem., 1, 17-29.
-
(2001)
Mini Rev. Med. Chem
, vol.1
, pp. 17-29
-
-
Naylor, M.A.1
Thomson, P.2
-
127
-
-
0029439313
-
Radicals from one-electron reduction of nitro compounds, aromatic Noxides and quinones: The kinetic basis for hypoxia-selective, bioreductive drugs
-
Wardman, P., Dennis, M. F., Everett, S. A., Patel, K. B., Stratford, M. R., Tracy, M. (1995). Radicals from one-electron reduction of nitro compounds, aromatic Noxides and quinones: The kinetic basis for hypoxia-selective, bioreductive drugs. Biochem. Soc. Symp., 61, 171-194.
-
(1995)
Biochem. Soc. Symp
, vol.61
, pp. 171-194
-
-
Wardman, P.1
Dennis, M.F.2
Everett, S.A.3
Patel, K.B.4
Stratford, M.R.5
Tracy, M.6
-
128
-
-
0035181464
-
Strategies for enzyme/prodrug cancer therapy
-
Xu,G., McLeod, H. L. (2001). Strategies for enzyme/prodrug cancer therapy. Clin. Cancer Res., 7, 3314-3324.
-
(2001)
Clin. Cancer Res
, vol.7
, pp. 3314-3324
-
-
Xu, G.1
McLeod, H.L.2
-
129
-
-
0035523154
-
Antibody directed enzyme prodrug therapy (ADEPT) and related approaches for anticancer therapy
-
Jung, M. (2001). Antibody directed enzyme prodrug therapy (ADEPT) and related approaches for anticancer therapy. Mini Rev. Med. Chem., 1, 399-407.
-
(2001)
Mini Rev. Med. Chem
, vol.1
, pp. 399-407
-
-
Jung, M.1
-
130
-
-
0034186366
-
Prodrug activation enzymes in cancer gene therapy
-
Aghi, M., Hochberg, F., Breakefield, X. O. (2000). Prodrug activation enzymes in cancer gene therapy. J. Gene Med., 2, 148-164.
-
(2000)
J. Gene Med
, vol.2
, pp. 148-164
-
-
Aghi, M.1
Hochberg, F.2
Breakefield, X.O.3
-
131
-
-
0036015567
-
Cytochrome P450 gene-directed enzyme prodrug therapy (GDEPT) for cancer
-
Chen, L.,Waxman,D. J. (2002). Cytochrome P450 gene-directed enzyme prodrug therapy (GDEPT) for cancer. Curr. Pharm. Des., 8, 1405-1416.
-
(2002)
Curr. Pharm. Des
, vol.8
, pp. 1405-1416
-
-
Chen, L.1
Waxman, D.J.2
-
132
-
-
0031983448
-
Gene-directed enzyme prodrug therapy
-
Niculescu-Duvaz, I., Spooner, R., Marais, R., Springer, C. J. (1998). Gene-directed enzyme prodrug therapy. Bioconjugate Chem., 9, 4-22.
-
(1998)
Bioconjugate Chem
, vol.9
, pp. 4-22
-
-
Niculescu-Duvaz, I.1
Spooner, R.2
Marais, R.3
Springer, C.J.4
-
133
-
-
0034478186
-
Approaches to gene-directed enzyme prodrug therapy (GDEPT)
-
Springer, C. J., Niculescu-Duvaz, I. (2000). Approaches to gene-directed enzyme prodrug therapy (GDEPT). Adv. Exper. Med. Biol., 465, 403-409.
-
(2000)
Adv. Exper. Med. Biol
, vol.465
, pp. 403-409
-
-
Springer, C.J.1
Niculescu-Duvaz, I.2
-
134
-
-
0027412117
-
Development of lipophilic anticancer agents for the treatment of brain tumors by the esterification of water-soluble chlorambucil
-
Genka, S., Deutsch, J., Shetty, U. H., Stahle, P. L., John, V., Lieberburg, I. M., Ali-Osman, F., Rapoport, S. I, Greig, N. H. (1993). Development of lipophilic anticancer agents for the treatment of brain tumors by the esterification of water-soluble chlorambucil. Clin. Exper. Metastasis, 11, 131-140.
-
(1993)
Clin. Exper. Metastasis
, vol.11
, pp. 131-140
-
-
Genka, S.1
Deutsch, J.2
Shetty, U.H.3
Stahle, P.L.4
John, V.5
Lieberburg, I.M.6
Ali-Osman, F.7
Rapoport, S.I.8
Greig, N.H.9
-
135
-
-
0025165113
-
Physicochemical and pharmacokinetic parameters of seven lipophilic chlorambucil esters designed for brain penetration
-
Greig, N. H., Genka, S., Daly, E. M., Sweeney,D. J., Rapoport, S. I. (1990). Physicochemical and pharmacokinetic parameters of seven lipophilic chlorambucil esters designed for brain penetration. Cancer Chemother. Pharmcol., 25, 311-319.
-
(1990)
Cancer Chemother. Pharmcol
, vol.25
, pp. 311-319
-
-
Greig, N.H.1
Genka, S.2
Daly, E.M.3
Sweeney, D.J.4
Rapoport, S.I.5
-
136
-
-
0033526158
-
Recent advances in the brain targeting of neuropharmaceuticals by chemical delivery systems
-
Bodor, N., Buchwald, P. (1999). Recent advances in the brain targeting of neuropharmaceuticals by chemical delivery systems. Adv. Drug Delivery Rev., 36, 229-254.
-
(1999)
Adv. Drug Delivery Rev
, vol.36
, pp. 229-254
-
-
Bodor, N.1
Buchwald, P.2
-
137
-
-
0036629267
-
Barriers to remember: Brain-targeting chemical delivery systems and Alzheimeŕs disease
-
Bodor, N., Buchwald, P. (2002). Barriers to remember: Brain-targeting chemical delivery systems and Alzheimeŕs disease. Drug Discov. Today, 7, 766-774.
-
(2002)
Drug Discov. Today
, vol.7
, pp. 766-774
-
-
Bodor, N.1
Buchwald, P.2
-
138
-
-
0033526179
-
Carrier-mediated or specialized transport of drugs across the blood-brain barrier
-
Tsuji, A., Tamai, I. I. (1999). Carrier-mediated or specialized transport of drugs across the blood-brain barrier. Adv. Drug Delivery Rev., 5, 277-290.
-
(1999)
Adv. Drug Delivery Rev
, vol.5
, pp. 277-290
-
-
Tsuji, A.1
Tamai, I.I.2
-
139
-
-
0033756459
-
Transporter-mediated permeation of drugs across the blood-brain barrier
-
Tamai, I., Tsuji, A.(2000). Transporter-mediated permeation of drugs across the blood-brain barrier. J. Pharm. Sci., 89, 1371-1388.
-
(2000)
J. Pharm. Sci.
, vol.89
, pp. 1371-1388
-
-
Tamai, I.1
Tsuji, A.2
-
140
-
-
0030607725
-
Synthesis of glucose-chlorambucil derivatives and their recognition by the human GLUT1 glucose transporter
-
Halmos, T., Santarromana, M., Antonakis, K., Scherman, D. (1996). Synthesis of glucose-chlorambucil derivatives and their recognition by the human GLUT1 glucose transporter. Eur. J. Pharmcol., 318, 477-484.
-
(1996)
Eur. J. Pharmcol
, vol.318
, pp. 477-484
-
-
Halmos, T.1
Santarromana, M.2
Antonakis, K.3
Scherman, D.4
-
141
-
-
0032897670
-
Synthesis, stability, and pharmacological evaluation of nipecotic acid prodrugs
-
Bonina, F. P., Arenare, L., Palagiano, F., Saija, A., Nava, F., Trombetta, D., De Caprariis, P. (1999). Synthesis, stability, and pharmacological evaluation of nipecotic acid prodrugs. J. Pharm. Sci., 88, 561-567.
-
(1999)
J. Pharm. Sci
, vol.88
, pp. 561-567
-
-
Bonina, F.P.1
Arenare, L.2
Palagiano, F.3
Saija, A.4
Nava, F.5
Trombetta, D.6
De Caprariis, P.7
-
142
-
-
0034737759
-
Systemically administered d-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents
-
Battaglia,G., La Russa, M., Bruno,V.,Arenare, L., Ippolito, R., Copani,A., Bonina, F., Nicoletti, F. (2000). Systemically administered d-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents. Brain Res., 860, 149-156.
-
(2000)
Brain Res
, vol.860
, pp. 149-156
-
-
Battaglia, G.1
La Russa, M.2
Bruno, V.3
Arenare, L.4
Ippolito, R.5
Copani, A.6
Bonina, F.7
Nicoletti, F.8
-
143
-
-
0037203976
-
Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activity
-
Manfredini, S., Pavan, B.,Vertuani, S., Scaglianti, M., Compagnone,D., Biondi, C., Scatturin, A., Tanganelli, S., Ferraro, L., Prasad, P., Dalpiaz, A. (2002). Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activity. J. Med. Chem., 45, 559-562.
-
(2002)
J. Med. Chem
, vol.45
, pp. 559-562
-
-
Manfredini, S.1
Pavan, B.2
Vertuani, S.3
Scaglianti, M.4
Compagnone, D.5
Biondi, C.6
Scatturin, A.7
Tanganelli, S.8
Ferraro, L.9
Prasad, P.10
Dalpiaz, A.11
-
144
-
-
0343462226
-
Prodrugs and targeted drug delivery
-
Kearney, A. S. (1996). Prodrugs and targeted drug delivery. Adv. Drug Delivery Rev., 19, 225-239.
-
(1996)
Adv. Drug Delivery Rev
, vol.19
, pp. 225-239
-
-
Kearney, A.S.1
-
145
-
-
0038725720
-
Pharmaceutical approaches to colon targeted drug delivery systems
-
Chourasia, M. K., Jain, S. K. (2003). Pharmaceutical approaches to colon targeted drug delivery systems. J. Pharm. Pharm. Sci., 6, 33-66.
-
(2003)
J. Pharm. Pharm. Sci
, vol.6
, pp. 33-66
-
-
Chourasia, M.K.1
Jain, S.K.2
-
146
-
-
0242668404
-
Specific drug delivery to the kidney
-
Haas, M., Moolenaar, F., Meijer, D. K., De Zeeuw, D. (2002). Specific drug delivery to the kidney. Cardiovasc. Drugs Ther., 16, 489-496.
-
(2002)
Cardiovasc. Drugs Ther
, vol.16
, pp. 489-496
-
-
Haas, M.1
Moolenaar, F.2
Meijer, D.K.3
De Zeeuw, D.4
-
147
-
-
0018117844
-
G-Glutamyl dopa: A kidney-specific dopamine precursor
-
Wilk, S., Mizoguchi, H., Orlowski, M. (1978). g-Glutamyl dopa: A kidney-specific dopamine precursor. J. Pharmcol. Exper. Ther., 206, 227-232.
-
(1978)
J. Pharmcol. Exper. Ther
, vol.206
, pp. 227-232
-
-
Wilk, S.1
Mizoguchi, H.2
Orlowski, M.3
-
148
-
-
0018833881
-
N-acyl-gamma-glutamyl derivatives of sulfamethoxazole as models of kidney-selective prodrugs
-
Orlowski, M., Mizoguchi, H.,Wilk, S. (1980). N-acyl-gamma-glutamyl derivatives of sulfamethoxazole as models of kidney-selective prodrugs. J. Pharmcol. Exper. Ther., 212, 167-172.
-
(1980)
J. Pharmcol. Exper. Ther
, vol.212
, pp. 167-172
-
-
Orlowski, M.1
Mizoguchi, H.2
Wilk, S.3
-
149
-
-
0026015884
-
Five years' experience with gamma-l-glutamyl-l-dopa: A relatively renally specific dopaminergic prodrug in man
-
Lee, M. R. (1990). Five years' experience with gamma-l-glutamyl-l-dopa: A relatively renally specific dopaminergic prodrug in man. J.Autonomic Pharmcol., 10, 103-108.
-
(1990)
J.Autonomic Pharmcol
, vol.10
, pp. 103-108
-
-
Lee, M.R.1
-
150
-
-
0031126947
-
Prodrug strategies to enhance the intestinal absorption of peptides
-
Gangwar, S., Pauletti, G. M.,Wang, B. H., Siahaan, T. J., Stella, V. J., Borchardt, R. T. (1997). Prodrug strategies to enhance the intestinal absorption of peptides. Drug Discov. Today, 2, 148-155.
-
(1997)
Drug Discov. Today
, vol.2
, pp. 148-155
-
-
Gangwar, S.1
Pauletti, G.M.2
Wang, B.H.3
Siahaan, T.J.4
Stella, V.J.5
Borchardt, R.T.6
-
151
-
-
0032827971
-
Optimizing oral absorption of peptides using prodrug strategies
-
Borchardt, R. T. (1999). Optimizing oral absorption of peptides using prodrug strategies. J. Controlled Release, 62, 231-238.
-
(1999)
J. Controlled Release
, vol.62
, pp. 231-238
-
-
Borchardt, R.T.1
-
153
-
-
0343026460
-
Prodrugs of peptides and peptidomimetics for improved formulation and delivery
-
Oliyai, R. (1996). Prodrugs of peptides and peptidomimetics for improved formulation and delivery. Adv. Drug Delivery Rev., 19, 275-286.
-
(1996)
Adv. Drug Delivery Rev
, vol.19
, pp. 275-286
-
-
Oliyai, R.1
-
154
-
-
0026524913
-
Kinetics and mechanism of isomerization of cyclosporine-A
-
Oliyai, R., Stella, V. J. (1992). Kinetics and mechanism of isomerization of cyclosporine-A. Pharm. Res., 9, 617-622.
-
(1992)
Pharm. Res
, vol.9
, pp. 617-622
-
-
Oliyai, R.1
Stella, V.J.2
-
155
-
-
0037811300
-
Effect of the acyl groups on O ÆN acyl migration in the water-soluble prodrugs of HIV-1 protease inhibitor
-
Hamada,Y.,Matsumoto, H., Kimura,T., Hayashi,Y., Kiso,Y. (2003). Effect of the acyl groups on O ÆN acyl migration in the water-soluble prodrugs of HIV-1 protease inhibitor. Bioorganic Med. Chem. Lett., 13, 2727-2730.
-
(2003)
Bioorganic Med. Chem. Lett
, vol.13
, pp. 2727-2730
-
-
Hamada, Y.1
Matsumoto, H.2
Kimura, T.3
Hayashi, Y.4
Kiso, Y.5
-
156
-
-
0036973331
-
New water-soluble prodrugs of HIV protease inhibitors based on O Æ N intramolecular acyl migration
-
Hamada, Y., Ohtake, J., Sohma, Y., Kimura, T., Hayashi, Y., Kiso, Y. (2002). New water-soluble prodrugs of HIV protease inhibitors based on O Æ N intramolecular acyl migration. Bioorganic Med. Chem., 10, 4155-4167.
-
(2002)
Bioorganic Med. Chem
, vol.10
, pp. 4155-4167
-
-
Hamada, Y.1
Ohtake, J.2
Sohma, Y.3
Kimura, T.4
Hayashi, Y.5
Kiso, Y.6
-
157
-
-
0026650180
-
The utility of the prodrug approach to improve peptide absorption
-
Bundgaard, H. (1992). The utility of the prodrug approach to improve peptide absorption. J. Controlled Release, 21, 63-72.
-
(1992)
J. Controlled Release
, vol.21
, pp. 63-72
-
-
Bundgaard, H.1
-
158
-
-
0028147094
-
Synthesis and in-vitro study of a diglyceride prodrug of a peptide
-
Delie, F., Couvreur, P., Nisato,D., Michel, J. B., Puisieux, F., Letourneux,Y. (1994). Synthesis and in-vitro study of a diglyceride prodrug of a peptide. Pharm. Res., 11, 1082-1087.
-
(1994)
Pharm. Res
, vol.11
, pp. 1082-1087
-
-
Delie, F.1
Couvreur, P.2
Nisato, D.3
Michel, J.B.4
Puisieux, F.5
Letourneux, Y.6
-
159
-
-
84889856830
-
Peptide and protein derivatives
-
S. Frokjaer and L. Hovgaard (Eds.), Taylor & Francis, London
-
Friis,G. J. (2000). Peptide and protein derivatives. In S. Frokjaer and L. Hovgaard (Eds.), Pharmaceutical. Formulation Development of Peptides and Proteins.Taylor & Francis, London, pp. 206-219.
-
(2000)
Pharmaceutical. Formulation Development of Peptides and Proteins.
, pp. 206-219
-
-
Friis, G.J.1
-
160
-
-
0027472110
-
Prodrugs of peptides. 18. Synthesis and evaluation of various esters of desmopressin (Ddavp)
-
Kahns, A. H., Buur, A., Bundgaard, H. (1993). Prodrugs of peptides. 18. Synthesis and evaluation of various esters of desmopressin (Ddavp). Pharm. Res., 10, 68-74.
-
(1993)
Pharm. Res
, vol.10
, pp. 68-74
-
-
Kahns, A.H.1
Buur, A.2
Bundgaard, H.3
-
161
-
-
0033067843
-
The effect of conformation on the membrane permeation of coumarinic acid-, and phenylpropionic acid-based cyclic prodrugs of opioid peptides
-
Gudmundsson, O. S., Jois, S. D. S., Vander Velde, D. G., Siahaan, T. J.,Wang, B., Borchardt, R. T. (1999). The effect of conformation on the membrane permeation of coumarinic acid-, and phenylpropionic acid-based cyclic prodrugs of opioid peptides. J. Peptide Res., 53, 383-392.
-
(1999)
J. Peptide Res
, vol.53
, pp. 383-392
-
-
Gudmundsson, O.S.1
Jois, S.D.S.2
Vander Velde, D.G.3
Siahaan, T.J.4
Wang, B.5
Borchardt, R.T.6
-
162
-
-
0032908281
-
Acyloxyalkoxy-based cyclic prodrugs of opioid peptides: Evaluation of the chemical and enzymatic stability as well as their transport properties across Caco-2 cell monolayers
-
Bak, A., Gudmundsson, O. S., Friis, G. J., Siahaan, T. J., Borchardt, R. T. (1999). Acyloxyalkoxy-based cyclic prodrugs of opioid peptides: Evaluation of the chemical and enzymatic stability as well as their transport properties across Caco-2 cell monolayers. Pharm. Res., 16, 24-29.
-
(1999)
Pharm. Res
, vol.16
, pp. 24-29
-
-
Bak, A.1
Gudmundsson, O.S.2
Friis, G.J.3
Siahaan, T.J.4
Borchardt, R.T.5
-
163
-
-
0032930316
-
Phenylpropionic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeation
-
Gudmundsson,O. S.,Nimkar, K., Gangwar, S., Siahaan,T., Borchardt, R. T. (1999). Phenylpropionic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeation. Pharm. Res., 16, 16-23.
-
(1999)
Pharm. Res
, vol.16
, pp. 16-23
-
-
Gudmundsson, O.S.1
Nimkar, K.2
Gangwar, S.3
Siahaan, T.4
Borchardt, R.T.5
-
164
-
-
0023134061
-
Improved corneal penetration of timolol by prodrugs as a means to reduce systemic drug load
-
Chang, S.-C., Bundgaard, H., Buur,A., Lee,V. H. L. (1987). Improved corneal penetration of timolol by prodrugs as a means to reduce systemic drug load. Investigative Ophthalmol. Vis. Sci., 29, 487-491.
-
(1987)
Investigative Ophthalmol. Vis. Sci
, vol.29
, pp. 487-491
-
-
Chang, S.-C.1
Bundgaard, H.2
Buur, A.3
Lee, V.H.L.4
-
165
-
-
0030447091
-
Nonsteroidal antiiflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation
-
Mahmud,T., Rafi, S. S., Scott,D. L., Wriilesworth, J. M., Bjarnason, I. (1996). Nonsteroidal antiiflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation. Arthritis Rheum., 39, 1998-2003.
-
(1996)
Arthritis Rheum
, vol.39
, pp. 1998-2003
-
-
Mahmud, T.1
Rafi, S.S.2
Scott, D.L.3
Wriilesworth, J.M.4
Bjarnason, I.5
-
166
-
-
0029804639
-
Pharmacokinetics of indomethacin ester prodrugs: Gastrointestinal and hepatic toxicity and the hydrolytic capacity of various tissues in rats
-
Ogiso,T., Iwaki, M.,Tanino,T., Nagai,T., Ueda,Y., Muraoka,O.,Tanabe,G. (1996). Pharmacokinetics of indomethacin ester prodrugs: Gastrointestinal and hepatic toxicity and the hydrolytic capacity of various tissues in rats. Biol. Pharm. Bull., 19, 1178-1183.
-
(1996)
Biol. Pharm. Bull
, vol.19
, pp. 1178-1183
-
-
Ogiso, T.1
Iwaki, M.2
Tanino, T.3
Nagai, T.4
Ueda, Y.5
Muraoka, O.6
Tanabe, G.7
-
167
-
-
0028961924
-
Pharmacokinetic analysis of diethylcarbonate prodrugs of ibuprofen and naproxen
-
Samara, E.,Avnir, D., Ladkani, D., Bialer, M. (1995). Pharmacokinetic analysis of diethylcarbonate prodrugs of ibuprofen and naproxen. Biopharm. Drug Disposition, 16, 201-210.
-
(1995)
Biopharm. Drug Disposition
, vol.16
, pp. 201-210
-
-
Samara, E.1
Avnir, D.2
Ladkani, D.3
Bialer, M.4
-
168
-
-
0030822089
-
1-Ethylazacycloalkan-2-one indomethacin esters as new oral prodrugs: Chemical stability, enzymatic hydrolysis, anti-inflammatory activity and gastrointestinal toxicity
-
Bonina, F., Trombetta, D., Borzi, A., De Pasquale, A., Saija, A. (1997). 1-Ethylazacycloalkan-2-one indomethacin esters as new oral prodrugs: Chemical stability, enzymatic hydrolysis, anti-inflammatory activity and gastrointestinal toxicity. Int. J. Pharm., 156, 245-250.
-
(1997)
Int. J. Pharm
, vol.156
, pp. 245-250
-
-
Bonina, F.1
Trombetta, D.2
Borzi, A.3
De Pasquale, A.4
Saija, A.5
-
169
-
-
0030591420
-
Macromolecular prodrugs. VI. Kinetic study of poly[a,b-(N-2-hydroxyethyl-dl-aspartamide]-ketoprofen hydrolysis
-
Jaksic, P., Mlinaric-Majerski, K., Zorc, B., Dumic, M. (1996). Macromolecular prodrugs. VI. Kinetic study of poly[a,b-(N-2-hydroxyethyl-dl-aspartamide]-ketoprofen hydrolysis. Int. J. Pharm., 135, 177-182.
-
(1996)
Int. J. Pharm
, vol.135
, pp. 177-182
-
-
Jaksic, P.1
Mlinaric-Majerski, K.2
Zorc, B.3
Dumic, M.4
-
170
-
-
0032710426
-
Cyclic amide derivatives as potential prodrugs II: N-hydroxymethylsuccinimide-/istatin esters of some NSAIDs as prodrugs with an improved therapeutic index
-
Mahfouz, N. M., Omar, F. A., Aboul-Fadl, T. (1999). Cyclic amide derivatives as potential prodrugs II: N-hydroxymethylsuccinimide-/istatin esters of some NSAIDs as prodrugs with an improved therapeutic index. Eur. J. Med. Chem., 34, 551-562.
-
(1999)
Eur. J. Med. Chem
, vol.34
, pp. 551-562
-
-
Mahfouz, N.M.1
Omar, F.A.2
Aboul-Fadl, T.3
-
171
-
-
0035816143
-
Polymer-drug conjugates, PDEPT and PELT: Basic principles for design and transfer from the laboratory to clinic
-
Duncan, R., Gac-Breton, S., Keane, R., Musila, R., Sat,Y. N., Satchi, R., Searle, F. (2001). Polymer-drug conjugates, PDEPT and PELT: Basic principles for design and transfer from the laboratory to clinic. J. Controlled Release, 74, 135-146.
-
(2001)
J. Controlled Release
, vol.74
, pp. 135-146
-
-
Duncan, R.1
Gac-Breton, S.2
Keane, R.3
Musila, R.4
Sat, Y.N.5
Satchi, R.6
Searle, F.7
-
172
-
-
0035292828
-
Delivery of peptides and proteins through the blood-brain barrier
-
Bickel, U.,Yoshikawa, T., Pardridge,W. M. (2001). Delivery of peptides and proteins through the blood-brain barrier. Adv. Drug Delivery Rev., 46, 247-279.
-
(2001)
Adv. Drug Delivery Rev
, vol.46
, pp. 247-279
-
-
Bickel, U.1
Yoshikawa, T.2
Pardridge, W.M.3
-
173
-
-
0034601881
-
Dextrans for targeted and sustained delivery of therapeutic and imaging agents
-
Mehvar, R. (2000). Dextrans for targeted and sustained delivery of therapeutic and imaging agents. J. Controlled Release, 69, 1-25.
-
(2000)
J. Controlled Release
, vol.69
, pp. 1-25
-
-
Mehvar, R.1
-
174
-
-
0034712820
-
Macromolecular prodrugs. VIII. Synthesis of polymer-gemfibrozil conjugates
-
Lovrek, M., Zorc, B., Boneschans, B., Butula, I. (2000). Macromolecular prodrugs. VIII. Synthesis of polymer-gemfibrozil conjugates. Int. J. Pharm., 200, 59-66
-
(2000)
Int. J. Pharm.
, vol.200
, pp. 59-66
-
-
Lovrek, M.1
Zorc, B.2
Boneschans, B.3
Butula, I.4
-
175
-
-
0037173537
-
Macromolecular prodrugs: X. Kinetics of fenoprofen release from PHEAfenoprofen conjugate. Kinetics of fenoprofen release from PHEAfenoprofen conjugate
-
Van Der Merwe, T., Boneschans, B., Zorc, B., Breytenbach, J., Zovko, M. (2002). Macromolecular prodrugs: X. Kinetics of fenoprofen release from PHEAfenoprofen conjugate. Int. J. Pharm., 241, 223-230.
-
(2002)
Int. J. Pharm
, vol.241
, pp. 223-230
-
-
Van Der Merwe, T.1
Boneschans, B.2
Zorc, B.3
Breytenbach, J.4
Zovko, M.5
-
176
-
-
0037072529
-
Poly(l-glutamic acid)-Anticancer drug conjugates
-
Li, C. (2002). Poly(l-glutamic acid)-Anticancer drug conjugates. Adv. Drug Delivery Rev., 54, 695-713.
-
(2002)
Adv. Drug Delivery Rev
, vol.54
, pp. 695-713
-
-
Li, C.1
-
177
-
-
0041181628
-
HPMA copolymer-anticancer drug conjugates: Design, activity, and mechanism of action
-
Kopecek, J.,Kopeckova, P.,Minko,T., Lu, Z. (2000). HPMA copolymer-anticancer drug conjugates: Design, activity, and mechanism of action. Eur. J. Pharm. Biopharm., 50, 61-81.
-
(2000)
Eur. J. Pharm. Biopharm
, vol.50
, pp. 61-81
-
-
Kopecek, J.1
Kopeckova, P.2
Minko, T.3
Lu, Z.4
-
178
-
-
0035816204
-
Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS
-
Maeda, H., Sawa, T., Konno, T. (2001). Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS. J. Controlled Release, 74, 47-61.
-
(2001)
J. Controlled Release
, vol.74
, pp. 47-61
-
-
Maeda, H.1
Sawa, T.2
Konno, T.3
-
179
-
-
0035291191
-
SMANCS and polymer-conjugated macromolecular drugs: Advantages in cancer chemotherapy
-
Maeda, H. (2001). SMANCS and polymer-conjugated macromolecular drugs: Advantages in cancer chemotherapy. Adv. Drug Delivery Rev., 46, 169-185.
-
(2001)
Adv. Drug Delivery Rev
, vol.46
, pp. 169-185
-
-
Maeda, H.1
-
180
-
-
0034060544
-
Poly(ethylene glycol) conjugated drugs and prodrugs:A comprehensive review
-
Greenwald, R. B., Conover, C. D., Choe,Y. H. (2000). Poly(ethylene glycol) conjugated drugs and prodrugs:A comprehensive review. Crit. Rev.Ther. Drug Carrier Sys., 17, 101-161.
-
(2000)
Crit. Rev.Ther. Drug Carrier Sys
, vol.17
, pp. 101-161
-
-
Greenwald, R.B.1
Conover, C.D.2
Choe, Y.H.3
-
181
-
-
0035816168
-
PEG drugs: An overview
-
Greenwald, R. B. (2001). PEG drugs: An overview. J. Controlled Release, 74, 159-171.
-
(2001)
J. Controlled Release
, vol.74
, pp. 159-171
-
-
Greenwald, R.B.1
-
182
-
-
0037428969
-
Effective drug delivery by PEGylated drug conjugates
-
Greenwald, R. B., Choe,Y. H., McGuire, J., Conover, C. D. (2003). Effective drug delivery by PEGylated drug conjugates. Adv. Drug Delivery Rev., 55, 217-250.
-
(2003)
Adv. Drug Delivery Rev
, vol.55
, pp. 217-250
-
-
Greenwald, R.B.1
Choe, Y.H.2
McGuire, J.3
Conover, C.D.4
|