Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes

Drug Metabolism and Disposition

Volumn 27, Issue 4, 1999, Pages 533-541

  Granvil, Camille P ^a,b   Madan, Ajay ^c   Sharkawi, Mahmoud ^a   Parkinson, Andrew ^c   Wainer, Irving W ^b,d  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^d GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; COMPLEMENTARY DNA; CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; DRUG METABOLITE; IFOSFAMIDE; TESTOSTERONE DERIVATIVE;

ARTICLE; DRUG METABOLISM; DRUG TRANSFORMATION; ENANTIOMER; ENZYME ACTIVITY; ENZYME KINETICS; HUMAN; HUMAN CELL; LIVER METABOLISM; LIVER MICROSOME; NEUROTOXICITY; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME SYSTEM; DNA, COMPLEMENTARY; HUMANS; IFOSFAMIDE; ISOENZYMES; KINETICS; MALE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; OXIDOREDUCTASES, N-DEMETHYLATING; RABBITS; RATS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 0032946502     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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