Hepatic, extrahepatic, microsomal, and mitochondrial activation of the N-hydroxylated prodrugs benzamidoxime, guanoxabenz, and Ro-3656 ([[1-[(2S)-2-[[4[(hydroxyamino)iminomethyl]benzoyl]amino]-1-oxopropyl] -4-piperidinyl]oxy]-acetic acid)

Drug Metabolism and Disposition

Volumn 33, Issue 11, 2005, Pages 1740-1747

  Clement, Bernd ^a   Mau, Sabine ^a   Deters, Stephanie ^a   Havemeyer, Antje ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

[[1 [2 [[4 (AMINOIMINOMETHYL)BENZOYL]AMINO] 1 OXOPROPYL] 4 PIPERIDINYL]OXY]ACETIC ACID; [[1 [2 [[4 [(HYDROXYAMIN)IMINOMETHYL]BENZOYL]AMINO] 1 OXOPROPYL] 4 PIPERIDINYL]OXY]ACETIC ACID; ACETIC ACID DERIVATIVE; BENZAMIDINE; BENZAMIDOXIME; GLYCOLIC ACID DERIVATIVE; GUANABENZ; GUANOXABENZ; PRODRUG; RO 443888; RO 483656; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN MICROSOME; CELL ISOLATION; CELL ORGANELLE; CONTROLLED STUDY; DRUG HYDROXYLATION; ENZYME ACTIVATION; ENZYME ACTIVITY; INTESTINE; KIDNEY MICROSOME; LIVER MICROSOME; LIVER MITOCHONDRION; LUNG; MICROSOME; NONHUMAN; PRIORITY JOURNAL; SWINE;

ANIMALS; BENZAMIDINES; CYTOCHROME P-450 ENZYME SYSTEM; CYTOCHROME-B(5) REDUCTASE; CYTOCHROMES B5; GUANABENZ; HETEROCYCLIC COMPOUNDS; HUMANS; KIDNEY; KINETICS; LIVER; MICROSOMES, LIVER; MITOCHONDRIA; OXIMES; PRODRUGS; SWINE;

ANIMALIA; ORYCTOLAGUS CUNICULUS; SUIDAE; SUS SCROFA;

EID: 27544492348     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.005249     Document Type: Article

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