Unusual dehydroxylation of antimicrobial amidoxime prodrugs by cytochrome b5 and NADH cytochrome b5 reductase

Drug Metabolism and Disposition

Volumn 33, Issue 12, 2005, Pages 1886-1893

  Saulter, Janelle Y ^a   Kurian, Joseph R ^b   Trepanier, Lauren A ^b   Tidwell, Richard R ^a   Bridges, Arlene S ^a   Boykin, David W ^c   Stephens, Chad E ^c   Anbazhagan, Mariappan ^c   Hall, James Edwin ^a,d  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c GEORGIA STATE UNIVERSITY   (United States)

^d CB#7360 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 HYDROXYAMIDINOPHENYL) 5 (4 METHOXYAMIDINOPHENYL)FURAN; 2,5 BIS(4 AMIDINOPHENYL)FURAN BIS O AMIDOXIME; AMIDINE; ANTIBODY; ANTIINFECTIVE AGENT; CYTOCHROME B5 REDUCTASE; DB 289; DB 290; DB 775; ENZYME INHIBITOR; FURAMIDINE; OXIME DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; HUMAN; HUMAN CELL; HYDROXYLATION; KINEMATICS; LIVER CYTOSOL; LIVER MICROSOME; LIVER MITOCHONDRION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN EXPRESSION; REDUCTION; STATISTICAL SIGNIFICANCE;

BENZAMIDINES; CYTOCHROME-B(5) REDUCTASE; CYTOCHROMES B5; CYTOSOL; HUMANS; MICROSOMES, LIVER;

ESCHERICHIA COLI;

EID: 28144457470     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.005017     Document Type: Article

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