Classifying food allergens

Detecting Allergens in Food

Volumn , Issue , 2006, Pages 21-61

  Breiteneder, H ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 54249089105     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1533/9781845690557.1.21     Document Type: Chapter

References (262)

1. Murzin A.G., Brenner S.E., Hubbard T., Chothia C. SCOP: a structural classification of proteins database for the investigation of sequences and structures. J Mol Biol 1995, 247(4):536-540.
2. Van Loon L.C., Van Strien E.A. The families of pathogenesis-related proteins, their activities, and comparative analysis of PR-1 types proteins. Physiol Mol Plant Pathol 1999, 55(1):85-97.
3. Breiteneder H., Ebner C. Molecular and biochemical classification of plant-derived food allergens. Allergy Clin Immunol 2000, 106(1):27-36. Pt 1.
4. Hoffmann-Sommergruber K. Plant allergens and pathogenesis-related proteins. What do they have in common ?. Int Arch Allergy Immunol 2000, 122(3):155-166.
5. Dunwell J.M., Khuri S., Gane P.J. Microbial relatives of the seed storage proteins of higher plants: conservation of structure and diversification of function during evolution of the cupin superfamily. Microbiol Mol Biol Rev 2000, 64(1):153-179.
6. Dunwell J.M. Cupins: a new superfamily of functionally diverse proteins that include germins and plant storage proteins. Biotechnol Genet Eng Rev 1998, 15:1-32.
7. Dunwell J.M., Gane J.P. Microbial relatives of seed storage proteins: conservation of motifs in a functionally diverse superfamily of enzymes. J Mol Evol 1998, 46(2):147-154.
8. Thanh V.B., Shibasaki K. Major proteins of soybean seeds. Reversible and irreversible dissociation of beta-conglycinin. J Agric Food Chem 1979, 27(4):805-809.
9. Shewry P.R., Napier J.A., Tatham A.S. Seed storage proteins: structures and biosynthesis. Plant Cell 1995, 7(7):945-956.
10. Häger K.P., Fischer H. 'Molecular phylogenies and structural diversification of gymnosperm and angiosperm storage globulins', in Shewry, P R and Casey, R (eds) Seed Proteins 1999, 499-515. Kluwer Academic Publishers, Dordrecht.
11. Ko T.P., Day J., McPherson A. The refined structure of canavalin from jack bean in two crystal forms at 2.1 and 2.0A resolution. Acta Crystallogr D Biol Crystallogr 2000, 56:411-420. 4.
12. Ko T.P., Kuznetsov Y.G., Malkin A.J., Day J., McPherson A. X-ray diffraction and atomic force microscopy analysis of twinned crystals: rhombohedral canavalin. Acta Crystallogr D Biol Crystallogr 2001, 57(6):829-839.
13. Lawrence M.C., Izard T., Beuchat M., Blagrove R.J., Colman P.M. Structure of phaseolin at 2.2A resolution. Implications for a common vicilin/ legumin structure and the genetic engineering of seed storage proteins. J Mol Biol 1994, 23(5):748-776.
14. Maruyama N., Adachi M., Takahashi K., Yagasaki K., Kohno M., Takenaka Y., Okuda E., Nakagawa S., Mikami B., Utsumi S. Crystal structures of recombinant and native soybean beta-conglycinin beta homotrimers. Eur J Biochem 2001, 268(12):3595-3604.
15. Burks A.W., Williams L.W., Helm R.M., Connaughton C., Cockrell G., O'Brien Identification of a major peanut allergen, Ara h 1, in patients with atopic dermatitis and positive peanut challenge. J Allergy Clin Immunol 1991, 88(2):172-179.
16. Burks A.W., Shin D., Cockrell G., Stanley J.S., Helm R.M., Bannon G.A. Mapping and mutational analysis of the IgE-binding epitopes on Ara h 1, a legume vicilin protein and a major allergen in peanut hypersensitivity. Eur J Biochem 1997, 245(2):334-339.
17. Shin D.S., Compadre C.M., Maleki S.J., Kopper R.A., Sampson H., Huang S.K., Burks A.W., Bannon G.A. Biochemical and structural analysis of the IgE binding sites on Ara h1, an abundant and highly allergenic peanut protein. J Biol Chem 1998, 273(22):13753-13759.
18. Maleki S.J., Kopper R.A., Shin D.S., Park C.W., Compadre C.M., Sampson H., Burks A.W., Bannon G.A. Structure of the major peanut allergen Ara h 1 may protect IgE-binding epitopes from degradation. J Immunol 2000, 164(11):5844-5849.
19. Koppelman S.J., Bruijnzeel-Koomen C.A., Hessing M., de Jongh H.H. Heat-induced conformational changes of Ara h 1, a major peanut allergen, do not affect its allergenic properties. J Biol Chem 1999, 274(8):4770-4777.
20. Beyer K., Morrow E., Li X.M., Bardina L., Bannon G.A., Burks A.W., Sampson H.A. Effects of cooking methods on peanut allergenicity. J Allergy Clin Immunol 2001, 107(6):1077-1081.
21. Wensing M., Knulst A.C., Piersma S., O'Kane F., Knol E.F., Koppelman S.J. Patients with anaphylaxis to pea can have peanut allergy caused by cross-reactive IgE to vicilin (Ara h 1). J Allergy Clin Immunol 2003, 111(2):420-424.
22. Burks A.W., Brooks J.R., Sampson H.A. Allergenicity of major component proteins of soybean determined by enzyme-linked immunosorbent assay (ELISA) and immunoblotting in children with atopic dermatitis and positive soy challenges. J Allergy Clin Immunol 1988, 81(6):1135-1142.
23. Ogawa T., Bando N., Tsuji H., Nishikawa K., Kitamura K. Alpha-subunit of beta-conglycinin, an allergenic protein recognized by IgE antibodies of soybean-sensitive patients with atopic dermatitis. Biosci Biotechnol Biochem 1995, 5(5):831-833.
24. Teuber S.S., Jarvis K.C., Dandekar A.M., Peterson W.R., Ansari A.A. Identification and cloning of a complementary DNA encoding a vicilin-like proprotein, Jug r 2, from English walnut kernel (Juglans regia), a major food allergen. J Allergy Clin Immunol 1999, 104(6):1311-1320.
25. Sanchez-Monge R., Pascual C.Y., Diaz-Perales A., Fernandez-Crespo J., Martin-Esteban M., Salcedo G. Isolation and characterization of relevant allergens from boiled lentils. J Allergy Clin Immunol 2000, 106(5):955-961.
26. Wang F., Robotham J.M., Teuber S.S., Tawde P., Sathe S.K., Roux K.H. Ana o 1, a cashew (Anacardium occidental) allergen of the vicilin seed storage protein family. J Allergy Clin Immunol 2002, 110(1):160-166.
27. Beyer, K, Bardina, L, Grishina, G and Sampson, H A, 'Identification of sesame seed allergens by 2-dimensional proteomics and Edman sequencing: seed storage proteins as common food allergens', J Allergy Clin Immunol, 110(1), 154-159.
28. Müntz K., Jung R., Saalbach G. 'Synthesis, processing and targeting of legume seed proteins', in Shewry, P, Prand, W and Stobart, A K (eds) 1993, 128-146. Biosynthesis, Interactions, and Manipulation, Oxford University Press, Seed Storage Compounds.
29. Adachi M., Takenaka Y., Gidamis A.B., Mikami B., Utsumi S. Crystal structure of soybean proglycinin A1aB1b homotrimer. J Mol Biol 2001, 305(2):291-305.
30. Rabjohn P., Helm E.M., Stanley J.S., West C.M., Sampson H.A., Burks A.W., Bannon G.A. Molecular cloning and epitope analysis of the peanut allergen Ara h 3. J Clin Invest 1999, 103(4):535-542.
31. Rabjohn P., West C.M., Connaughton C., Sampson H.A., Helm R.M., Burks A.W., Bannon G.A. Modification of peanut allergen Ara h 3: effects on IgE binding and T cell stimulation. Int Arch Allergy Immunol 2002, 128(1):15-23.
32. Kleber-Janke T., Crameri R., Appenzeller U., Schlaak M., Becker W.M. Selective cloning of peanut allergens, including profilin and 2S albumins, by phage display technology. Int Arch Allergy Immunol 1999, 19(4):265-274.
33. Koppelman S.J., Knol E.F., Vlooswijk R.A., Wensing M., Knulst A.C., Hefle S.L., Gruppen H., Piersma S. Peanut allergen Ara h 3: isolation from peanuts and biochemical characterization. Allergy 2003, 58(11):1144-1151.
34. Beardslee T.A., Zeece M.G., Sarath G., Markwell J.P. Soybean glycinin G1 acidic chain shares IgE epitopes with peanut allergen Ara h 3. Int Arch Allergy Immunol 2000, 123(4):299-307.
35. Helm R.M., Cockrell G., Connaughton C., Sampson H.A., Bannon G.A., Beilinson V., Livingstone D., Nielsen N.C., Burks A.W. A soybean G2 glycinin allergen. 1. Identification and characterization. Int Arch Allergy Immunol 2000, 123(3):205-212.
36. Helm R.M., Cockrell G., Connaughton C., Sampson H.A., Bannon G.A., Beilinson V., Nielsen N.C., Burks A.W. A soybean G2 glycinin allergen. 2. Epitope mapping and three-dimensional modeling. Int Arch Allergy Immunol 2000, 123(3):213-219.
37. Beyer K., Grishina G., Bardina L., Grishin A., Sampson H.A. Identification of an 11S globulin as a major hazelnut food allergen in hazelnut-induced systemic reactions. J Allergy Clin Immunol 2002, 110(3):517-523.
38. Teuber S.S., Peterson W.R. Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens. J Allergy Clin Immunol 1999, 103(6):1180-1185.
39. Pasini G., Simonato B., Giannattasio M., Gemignani C., Curioni A. IgE binding to almond proteins in two CAP-FEIA-negative patients with allergic symptoms to almond as compared to three CAP-FEIA-false-positive subjects. Allergy 2000, 55(10):955-958.
40. Tatham A.S., Shewry P.R. Elastomeric proteins: biological roles, structuresand mechanisms. Trends Biochem Sci 2000, 25(11):567-571.
41. Green P.H., Jabri B. Coeliac disease. Lancet 2003, 362(9381):383-393.
42. Maruyama N., Ichise K., Katsube T., Kishimoto T., Kawase S., Matsumura Y., Takeuchi Y., Sawada T., Utsumi S. Identification of major wheat allergens by means of the Escherichia coli expression system. Eur J Biochem 1998, 255(3):739-745.
43. Tanabe S., Arai S., Yanagihara Y., Mita H., Takahashi K., Watanabe M. A major wheat allergen has a Gln-Gln-Gln-Pro-Pro motif identified as an IgE-binding epitope. Biochem Biophys Res Commun 1996, 219(2):290-293.
44. Codina R., Lockey R.F., Fernandez-Caldas E., Rama R. Purification and characterization of a soybean hull allergen responsible for the Barcelona asthma outbreaks. II. Purification and sequencing of the Gly m 2 allergen. Clin Exp Allergy 1997, 27(4):424-430.
45. Baud F., Pebay-Peyroula E., Cohen-Addad C., Odani S., Lehmann M.S. Crystal structure of hydrophobic protein from soybean; a member of a new cysteine-rich family. J Mol Biol 1993, 231(3):877-887.
46. Shewry P.R., Pandya M.J. The 2S albumin storage proteins. Shewry, P R 1999, 563-586. Dordrecht, Kluwer Academic Publishers, Seed Proteins. R. Casey (Ed.).
47. Shewry P.R., Napier J.A., Tatham A.S. Seed storage proteins: structures and biosynthesis. Plant Cell 1995, 7(7):945-956.
48. Terras F.R., Schoofs H., De Bolle M.F., Van Leuven F., Rees S.B., Vanderleyden J., Cammue B.P., Broekaert W.F. Analysis of two novel classes of plant antifungal proteins from radish (Raphanus sativus L.) seeds. J Biol Chem 1992, 267(22):15301-15309.
49. Menéndez-Arias L., Moneo I., Domínguez J., Rodríguez R. Primary structure of the major allergen from yellow mustard seeds, Sin a 1. Eur J Biochem 1988, 177(1):159-166.
50. Monsalve R.I., Gonzáles de la Peña M.A., Menéndez-Arias L., López-Otín C., Villalba M., Rodríguez R. Characterization of a new oriental-mustard (Brassica juncea) allergen, Bra j 1E: detection of an allergenic epitope. Biochem J 1993, 293:625-632. (Pt3).
51. Monsalve R.I., Gonzáles de la Peña M.A., López-Otín C., Fiandor A., Fernández C., Villalba M., Rodriguez R. Detection, isolation and complete amino acid sequence of an aeroallergenic protein from rapeseed flour. Clin Exp Allergy 1997, 27(7):833-841.
52. Nordlee J.A., Taylor S.L., Townsend J.A., Thomas L.A., Bush R.K. Identification of a Brazil-nut allergen in transgenic soybeans. New Engl J Med 1996, 334(11):688-692.
53. Teuber, S S, Jarvis, K C, Dandekar, A M, Peterson, W R and Ansari, A A, 'Identification and cloning of a complementary DNA encoding a vicilin-like proprotein, Jug r 2, from English walnut kernel (Juglans regia), a major food allergen', J Allergy Clin Immunol, 104(6), 1311-1320.
54. Kelly J.D., Hlywka J.J., Hefle S.L. Identification of sunflower seed IgE-binding proteins. Int Arch Allergy Immunol 2000, 121(1):19-24.
55. Robotham J.M., Teuber S.S., Sathe S.K., Roux K. Linear IgE epitope mapping of the English walnut (Juglans regia) major food allergen, Jug r 1. J Allergy Clin Immunol 2002, 109(1):143-149.
56. Teuber S.S., Sathe S.K., Peterson W.R., Roux K.H. Characterization of the soluble allergenic proteins of cashew nut (Anacardium occidentale L.). J Agric Food Chem 2002, 50(22):6543-6549.
57. Pastorello E.A., Varin E., Farioli L., Pravettoni V., Ortolani C., Trambaioli C., Fortunato D., Giuffrida M.G., Rivolta F., Robino A., Calamari A.M., Lacava L., Conti A. The major allergen of sesame seeds (Sesamum indicum) is a 2S albumin. J Chromatogr B Biomed Sci Appl 2001, 756(1-2):85-93.
58. Burks A.W., Williams L.W., Connaughton C., Cockrell G., O'Brien T., Helm R.M. Identification and characterization of a second major peanut allergen, Ara h II, with use of sera of patients with atopic dermatitis and positive peanut challenge 1992, 90:962-969. (6Pt1).
59. Maleki S.J., Viquez O., Jacks T., Dodo H., Champagne E.T., Chung S.Y., Landry S.J. The major peanut allergen, Ara h 2, functions as a trypsin inhibitor, and roasting enhances this function. J Allergy Clin Immunol 2003, 112(1):190-195.
60. Kunst L., Samuels A.L. Biosynthesis and secretion of plant cuticular wax. Prog Lipid Res 2003, 42(1):51-80.
61. Pastorello E.A., Pompei C., Pravettoni V., Brenna O., Farioli L., Trambaioli C., Conti A. Lipid transfer proteins and 2S albumins as allergens. Allergy 2001, 56(Suppl 67):45-57.
62. Asero R., Mistrello G., Roncarolo D., de Vries S.C., Gautier M.F., Ciurana C.L., Verbeek E., Mohammadi T., Knul-Brettlova V., Akkerdaas J.H., Bulder I., Aalberse R.C., van Ree R. Lipid transfer protein: a pan-allergen in plant-derived foods that is highly resistant to pepsin digestion. Int Arch Allergy Immunol 2001, 124(1-3):67-69.
63. Sanchez-Monge R., Lombardero M., Garcia-Selles F.J., Barber D., Salcedo G. Lipid-transfer proteins are relevant allergens in fruit allergy. J Allergy Clin Immunol 1999, 103:514-519. 103(3Pt1).
64. Pastorello E.A., Farioli L., Pravettoni V., Ortolani C., Ispano M., Monza M., Baroglio C., Scibola E., Ansaloni R., Incorvaia C., Conti A. The major allergen of peach (Prunus persica) is a lipid transfer protein. J Allergy Clin Immunol 1999, 103:520-526. (3Pt1).
65. Pastorello E.A., Pravettoni V., Farioli L., Ispano M., Fortunato D., Monza M., Giuffrida M.G., Rivolta F., Scibola E., Ansaloni R., Incorvaia C., Conti A., Ortolani C. Clinical role of a lipid transfer protein that acts as a new apple-specific allergen. J Allergy Clin Immunol 1999, 104(5):1099-1106.
66. Pastorello E.A., D'Ambrosio F.P., Pravettoni V., Farioli L., Giuffrida G., Monza M., Ansaloni R., Fortunato D., Scibola E., Rivolta F., Incorvaia C., Bengtsson A., Conti A., Ortolani C. Evidence for a lipid transfer protein as the major allergen of apricot. J Allergy Clin Immunol 2000, 105:371-377. (2Pt1).
67. Scheurer S., Pastorello E.A., Wangorsch A., Kastner M., Haustein D., Vieths S. Recombinant allergens Pru av 1 and Pru av 4 and a newly identified lipid transfer protein in the in vitro diagnosis of cherry allergy. J Allergy Clin Immunol 2001, 107(4):724-731.
68. Pastorello E.A., Farioli L., Pravettoni V., Giuffrida M.G., Ortolani C., Fortunato D., Trambaioli C., Scibola E., Calamari A.M., Robino A.M., Conti A. Characterization of the major allergen of plum as a lipid transfer protein. J Chromatogr B Biomed Sci Appl 2001, 756(1-2):95-103.
69. Pastorello E.A., Vieths S., Pravettoni V., Farioli L., Trambaioli C., Fortunato D., Luttkopf D., Calamari M., Ansaloni R., Scibilia J., Ballmer-Weber B.K., Poulsen L.K., Wutrich B., Hansen K.S., Robino A.M., Ortolani C., Conti A. Identification of hazelnut major allergens in sensitive patients with positive double-blind, placebo-controlled food challenge results. J Allergy Clin Immunol 2002, 109(3):563-570.
70. Diaz-Perales A., Lombardero M., Sanchez-Monge R., Garcia-Selles F.J., Pernas M., Fernandez-Rivas M., Barber D., Salcedo G. Lipid-transfer proteins as potential plant panallergens: cross-reactivity among proteins of Artemisia pollen, Castanea nut and Rosaceae fruits, with different IgE-binding capacities. Clin Exp Allergy 2000, 30(10):1403-1410.
71. Pastorello E.A., Farioli L., Pravettoni V., Ispano M., Scibola E., Trambaioli C., Giuffrida M.G., Ansaloni R., Godovac-Zimmermann J., Conti A., Fortunato D., Ortolani C. The maize major allergen, which is responsible for food-induced allergic reactions, is a lipid transfer protein. J Allergy Clin Immunol 2000, 106(4):744-751.
72. Diaz-Perales A., Tabar A.I., Sanchez-Monge R., Garcia B.E., Gomez B., Barber D., Salcedo G. Characterization of asparagus allergens: a relevant role of lipid transfer proteins. J Allergy Clin Immunol 2002, 110(5):790-796.
73. Pastorello E.A., Farioli L., Pravettoni V., Ortolani C., Fortunato D., Giuffrida M.G., Perono Garoffo L., Calamari A.M., Brenna O., Conti A. Identification of grape and wine allergens as an endochitinase 4, a lipid-transfer protein, and a thaumatin. J Allergy Clin Immunol 2003, 111(2):350-359.
74. San Miguel-Moncin M., Krail M., Scheurer S., Enrique E., Alonso R., Conti A., Cistero-Bahima A., Vieths S. Lettuce anaphylaxis: identification of a lipid transfer protein as the major allergen. Allergy 2003, 58(6):511-517.
75. García-Olmedo F., Salcedo G., Sanchez-Monge R., Gomez L., Royo J., Carbonero P. Plant proteinaceous inhibitors of proteinases and alpha-amylases. Oxford Surv Plant Mol Cell Biol 1987, 4(3):275-334.
76. James J.M., Sixbey J.P., Helm R.M., Bannon G.A., Burks A.W. Wheat alpha-amylase inhibitor: a second route of allergic sensitization. J Allergy Clin Immunol 1997, 99(2):239-244.
77. Sánchez-Monge R., Gomez L., Barber D., Lopez-Otín C., Armentia A., Salcedo G. Wheat and barley allergens associated with baker's asthma. Glycosylated subunits of the alpha-amylase-inhibitor family have enhanced IgE-binding capacity. Biochem J 1992, 281(3):401-405.
78. Mena M., Sanchez-Monge R., Gomez L., Salcedo G., Carbonero P. A major barley allergen associated with baker's asthma disease is a glycosylated monomeric inhibitor of insect alpha-amylase: cDNA cloning and chromosomal location of the gene. Plant Mol Biol 1992, 20(3):451-455.
79. García-Casado G., Armentia A., Sánchez-Monge R., Sánchez L.M., Lopez-Otín C., Salcedo G. A major baker's asthma allergen from rye flour is considerably more active than its barley counterpart. FEBS Lett 1996, 364(1):36-40.
80. García-Casado G., Armentia A., Sánchez-Monge R., Malpica J.M., Salcedo G. Rye flour allergens associated with baker's asthma. Correlation between in vivo and in vitro activities and comparison with their wheat and barley homologues. Clin Exp Allergy 1996, 26(4):428-435.
81. Nakase M., Usui Y., Alvarez-Nakase A.M., Adachi T., Urisu A., Nakamura R., Aoki N., Kitajima K., Matsuda T. Cereal allergens: rice-seed allergens with structural similarity to wheat and barley allergens. Allergy 1998, 53(46 Suppl):55-57.
82. Nakase M., Adachi T., Urisu A., Miyashita T., Alvarez A.M., Nagasaka S., Aoki N., Nakamura R., Matsuda T. Rice (Oryza sativa L.) alpha amylase inhibitors of 14-16kDa are potential allergens and products of a multi gene family. J Agric Food Chem 1996, 44(8):2624-2628.
83. Izumi H., Adachi T., Fujii N., Matsuda T., Nakamura R., Tanaka K., Urisu A., Kurosawa Y. Nucleotide sequence of a cDNA clone encoding a major allergenic protein in rice seeds. Homology of the deduced amino acid sequence with members of alpha-amylase/trypsin inhibitor family. FEBS Lett 1992, 302(3):213-216.
84. Adachi T., Izumi H., Yamada T., Tanaka K., Takeuchi S., Nakamura R., Matsuda T. Gene structure and expression of rice seed allergenic proteins belonging to the alpha-amylase/trypsin inhibitor family. Plant Mol Biol 1993, 21(2):239-248.
85. Alvarez A.M., Fukuhara E., Nakase M., Adachi T., Aoki N., Nakamura R., Matsuda T. Four rice seed cDNA clones belonging to the alpha-amylase/ trypsin inhibitor gene family encode potential rice allergens. Biosci Biotechnol Biochem 1995, 59(7):1304-1308.
86. Maruyama N., Ichise K., Katsube T., Kishimoto T., Kawase S., Matsumura Y., Takeuchi Y., Sawada T., Utsumi S. Identification of major wheat allergens by means of the Escherichia coli expression system. Eur J Biochem 1998, 255(3):739-745.
87. Tanabe S., Arai S., Yanagihara Y., Mita H., Takahashi K., Watanabe M. A major wheat allergen has a Gln-Gln-Gln-Pro-Pro motif identified as an IgE-binding epitope. Biochem Biophys Res Commun 1996, 219(2):290-293.
88. Palosuo K., Varjonen E., Kekki O.M., Klemola T., Kalkkinen N., Alenius H., Reunala T. Wheat omega-5 gliadin is a major allergen in children with immediate allergy to ingested wheat. J Allergy Clin Immunol 2001, 108(4):634-638.
89. Palosuo K., Alenius H., Varjonen E., Kalkkinen N., Reunala T. Rye gamma-70 and gamma-35 secalins and barley gamma-3 hordein cross-react with omega-5 gliadin, a major allergen in wheat-dependent, exercise-induced anaphylaxis. Clin Exp Allergy 2001, 31(3):466-473.
90. Berti P.J., Storer A.C. Alignment/phylogeny of the papain superfamily of cysteine proteases. J Mol Biol 1995, 246(2):273-283.
91. Barrett A.J., Rawlings N.D. Evolutionary lines of cysteine peptidases. Biol Chem 2001, 382(5):727-733.
92. Rawlings, N D and Barrett, A J 'Families of cysteine peptidases', Methods Enzymol 244, 461-486.
93. Pechan T., Cohen A., Williams W.P., Luthe D.S. Insect feeding mobilizes a unique plant defense protease that disrupts the peritrophic matrix of caterpillars. Proc Natl Acad Sci USA 2002, 99(20):13319-13323.
94. Gall H., Kalveram K.J., Forck G., Sterry W. Kiwi fruit allergy: a new birch pollen-associated food allergy. J Allergy Clin Immunol 1994, 94(1):70-76.
95. Diez-Gomez M.L., Quirce S., Aragoneses E., Cuevas M. Asthma caused by Ficus benjamina latex: evidence of cross-reactivity with fig fruit and papain. Ann Allergy Asthma Immunol 1998, 80(1):24-30.
96. Pastorello E.A., Conti A., Pravettoni V., Farioli L., Rivolta F., Ansaloni R., Ispano M., Incorvaia C., Giuffrida M.G., Ortolani C. Identification of actinidin as the major allergen of kiwi fruit. J Allergy Clin Immunol 1998, 101:531-537. (4Pt1).
97. Kalinski A., Weisemann J.M., Matthews B.F., Herman E.M. Molecular cloning of a protein associated with soybean seed oil bodies that is similar to thiol proteases of the papain family. J Biol Chem 1990, 265(23):13843-13848.
98. Ogawa T., Tsuji H., Bando N., Kitamura K., Zhu Y.L., Hirano H., Nishikawa K. Identification of the soybean allergenic protein, Gly m Bd 30K, with the soybean seed 34-kDa oil-body-associated protein. Biosci Biotechnol Biochem 1993, 57(6):1030-1033.
99. Ogawa T., Bando N., Tsuji H., Okajima H., Nishikawa K., Sasaoka K. Investigation of the IgE-binding proteins in soybeans by immunoblotting with the sera of the soybean-sensitive patients with atopic dermatitis. J Nutr Sci Vitaminol (Tokyo) 1991, 37(6):555-565.
100. Helm R., Cockrell G., Herman E., Burks A., Sampson H., Bannon G. Cellular and molecular characterization of a major soybean allergen. Int Arch Allergy Immunol 1998, 117(1):29-37.
101. Gonzalez R., Polo F., Zapatero L., Caravaca F., Carreira J. Purification and characterization of major inhalant allergens from soybean hulls. Clin Exp Allergy 1992, 22(8):748-755.
102. Gonzalez R., Varela J., Carreira J., Polo F. Soybean hydrophobic protein and soybean hull allergy. Lancet 1995, 346(8966):48-49.
103. Ji C., Boyd C., Slaymaker D., Okinaka Y., Takeuchi Y., Midland S.L., Sims J.J., Herman E., Keen N. Characterization of a 34-kDa soybean binding protein for the syringolide elicitors. Proc Natl Acad Sci USA 1998, 95(6):3306-3311.
104. Davies G., Henrissat B. Structures and mechanisms of glycosyl hydrolases. Structure 1995, 3(9):853-859.
105. Henrissat B. A classification of glycosyl hydrolases based on amino acid sequence similarities. Biochem J 1991, 280(Pt 2):309-316.
106. Brehler R., Theissen U., Mohr C., Luger T. Latex-fruit syndrome': frequency of cross-reacting IgE antibodies. Allergy 1997, 52(4):404-410.
107. Yagami T., Sato M., Nakamura A., Komiyama T., Kitagawa K., Akasawa A., Ikezawa Z. Plant defense-related enzymes as latex antigens. J Allergy Clin Immunol 1998, 101(3):379-385.
108. Yagami T., Osuna H., Kouno M., Haishima Y., Nakamura A., Ikezawa Z. Significance of carbohydrate epitopes in a latex allergen with beta-1,3-glucanase activity. Int Arch Allergy Immunol 2002, 129(1):27-37.
109. Peumans W.J., Barre A., Derycke V., Rouge P., Zhang W., May G.D., Delcour J.A., Va n Leuven F., Van Damme E.J. Purification, characterization and structural analysis of an abundant beta-1,3-glucanase from banana fruit. Eur J Biochem 2000, 267:1188-1195. 4.
110. Kasprzewska A. Plant chitinases - regulation and function. Cell Mol Biol Lett 2003, 8(3):809-824.
111. Beintema J.J. Structural features of plant chitinases and chitin-binding proteins. FEBS Lett 1994, 350(2-3):159-163.
112. Diaz-Perales A., Collada C., Blanco C., Sánchez-Monge R., Carrillo T., Aragoncillo C., Salcedo G. Class I chitinases with hevein-like domains, but not class II enzymes, are relevant chestnut and avocado allergens. J Allergy Clin Immunol 1998, 102(1):127-133.
113. Sowka S., Hsieh L.-S., Krebitz M., Akasawa A., Martin B., Starrett D., Peterbauer C.K., Scheiner O., Breiteneder H. Identification and cloning of Prs a 1, a 32kDa major allergen of avocado and its expression in Pichia pastoris. J Biol Chem 1998, 273(43):28091-28097.
114. Sanchez-Monge R., Blanco C., Díaz-Perales A., Collada C., Carrillo T., Aragoncillo C., Salcedo G. Isolation and characterization of major banana allergens: identification as fruit class I chitinases. Clin Exp Allergy 1999, 29(5):673-680.
115. Chen Z., Posch A., Cremer R., Raulf-Heimsoth M., Baur X. Identification of hevein (Hev b 6.02) in Hevea latex as a major cross-reacting allergen with avocado fruit in patients with latex allergy. J Allergy Clin Immunol 1998, 102(3):476-481.
116. Diaz-Perales A., Sanchez-Monge R., Blanco C., Lombardero M., Carillo T., Salcedo G. What is the role of the hevein-like domain of fruit class I chitinases in their allergenic capacity?. Clin Exp Allergy 2002, 32(3):448-454.
117. Karisola P., Alenius H., Mikkola J., Kalkkinen N., Helin J., Pentikainen O.T., Repo S., Reunala T., Turjanmaa K., Johnson M.S., Palosuo T., Kulomaa M.S. The major conformational IgE-binding epitopes of hevein (Hev b6.02) are identified by a novel chimera-based allergen epitope mapping strategy. J Biol Chem 2002, 277(25):22656-22661.
118. Stanford A., Bevan M., Northcote D. Differential expression within a family of novel wound-induced genes in potato. Mol Gen Genet 1989, 215(2):200-208.
119. Kauffmann S., Legrand M., Fritig B. Isolation and characterization of six pathogenesis-related (PR) proteins of Samsun NN tobacco. Plant Mol Biol 1990, 14(3):381-390.
120. Linthorst H.J.M., Danhash N., Brederode F.T., Van Kan J.A.L., De Wit P.J.G.M., Bol J.F. Tobacco and tomato PR proteins homologous to win and pro-hevein lack the 'hevein' domain. Mol Plant Microbe Inter 1991, 4(6):586-592.
121. Hanninen A.R., Mikkola J.H., Kalkkinen N., Turjanmaa K., Ylitalo L., Reunala T., Palosuo T. Increased allergen production in turnip (Brassica rapa) by treatments activating defense mechanisms. J Allergy Clin Immunol 1999, 104(1):194-201.
122. Van Damme E.J., Charels D., Roy S., Tierens K., Barre A., Martins J.C., Rouge P., Van Leuven F., Does M., Peumans W.J. A gene encoding a hevein-like protein from elderberry fruits is homologous to PR-4 and class V chitinase genes. Plant Physiol 1999, 119(4):1547-1556.
123. Dudler R., Mauch F., Reimmann C. Thaumatin-like proteins, in Witty, M, Higginbotham, J D (eds) 1994, 93-199. Boca Raton, FL, CRC Press Inc, Thaumatin.
124. Koiwa H., Kato H., Nakatsu T., Oda J., Yamada Y., Sato F. Crystal structure of tobacco PR-5d protein at 1.8A resolution reveals a conserved acidic cleft structure in antifungal thaumatin-like proteins. J Mol Biol 1999, 286(4):1137-1145.
125. Batalia M.A., Monzingo A.F., Ernst S., Roberts W., Robertus J.D. The crystal structure of the antifungal protein zeamatin, a member of the thaumatin-like, PR-5 protein family. Nat Struct Biol 1996, 3(1):19-23.
126. Ogata C.M., Gordon P.F., de Vos A.M., Kim S.H. Crystal structure of a sweet tasting protein thaumatin I, at 1.65A resolution. J Mol Biol 1992, 228(3):893-908.
127. Krebitz M., Wagner B., Ferreira F., Peterbauer C., Campillo N., Witty M., Kolarich D., Steinkellner H., Scheiner O., Breiteneder H. 'Plant-based heterologous expression of Mal d 2, a thaumatin-like protein and allergen of apple (Malus domestica), and its characterization as an antifungal protein. J Mol Biol 2003, 329(4):721-730.
128. Inschlag C., Hoffmann-Sommergruber K., O'Riordain G., Ahorn H., Ebner C., Scheiner O., Breiteneder H. Biochemical characterization of Pru a 2, a 23-kD thaumatin-like protein representing a potential major allergen in cherry (Prunus avium). Int Arch Allergy Immunol 1998, 116(1):22-28.
129. Jensen-Jarolim E., Santner B., Leitner A., Grimm R., Scheiner O., Ebner C., Breiteneder H. Bell peppers (Capsicum annuum) express allergens (profilin, pathogenesis-related protein P23 and Bet v 1) depending on the horticultural strain. Int Arch Allergy Immunol 1998, 116(2):103-109.
130. Fuchs H.C., Hoffmann-Sommergruber K., Wagner B., Krebitz M., Scheiner O., Breiteneder H. Heterologous expression in Nicotiana benthamiana of Cap a 1, a thaumatin-like protein and major allergen from bell pepper (Capsicum annuum). J Allergy Clin Immunol 2002, 109:134-135.
131. Pastorello E.A., Farioli L., Pravettoni V., Ortolani C., Fortunato D., Giuffrida M.G., Perono Garoffo L., Calamari A.M., Brenna O., Conti A. Identification of grape and wine allergens as an endochitinase 4, a lipid-transfer protein, and a thaumatin. J Allergy Clin Immunol 2003, 111(2):350-359.
132. Gavrovic-Jankulovic M., Cirkovic T., Vuckovic O., Atanaskovic-Markovic M., Petersen A., Gojgic G., Burazer L., Jankov R.M. Isolation and biochemical characterization of a thaumatin-like kiwi allergen. J Allergy Clin Immunol 2002, 110(5):805-810.
133. Welinder K.G. Superfamily of plant, fungal and bacterial peroxidases. Curr Opin Struct Biol 1992, 2(3):388-393.
134. Van Loon L.C., Pierpoint W.S., Boller T., Conejero V. Recommendations for naming plant pathogenesis-related proteins. Plant Mol Biol Rep 1994, 12(2):245-264.
135. Sánchez-Monge R., García-Casado G., López-Otín C., Armentia A., Salcedo G. Wheat flour peroxidase is a prominent allergen associated with baker's asthma. Clin Exp Allergy 1997, 27(10):1130-1137.
136. Yamashita H., Nanba Y., Onishi M., Kimoto M., Hiemori M., Tsuji H. Identification of a wheat allergen, Tri a Bd 36K, as a peroxidase. Biosci Biotechnol Biochem 2002, 66(11):2487-2490.
137. Weangsripanaval T., Nomura N., Moriyama T., Ohta N., Ogawa T. Identification of suberization-associated anionic peroxidase as a possible allergenic protein from tomato. Biosci Biotechnol Biochem 2003, 67(6):1299-1304.
138. Breiteneder H., Pettenburger K., Bito A., Valenta R., Kraft D., Rumpold H., Scheiner O., Breitenbach M. The gene coding for the major birch pollen allergen Betv1, is highly homologous to a pea disease resistance response gene. EMBO J 1989, 8(7):1935-1938.
139. Wen J., Vanek-Krebitz M., Hoffmann-Sommergruber K., Scheiner O., Breiteneder H. The potential of Betv1 homologues, a nuclear multigene family, as phylogenetic markers in flowering plants. Mol Phylogenet Evol 1997, 8(3):317-333.
140. Hoffmann-Sommergruber K., Ferris R., Pec M., Radauer C., O'Riordain G., Laimer Da Camara Machado M., Scheiner O., Breiteneder H. Characterization of Api g 1.0201, a new member of the Api g 1 family of celery allergens. Int Arch Allergy Immunol 2000, 122(2):115-123.
141. Arquint O., Helbling A., Crameri R., Ferreira F., Breitenbach M., Pichler W.J. Reduced in vivo allergenicity of Bet v 1d isoform, a natural component of birch pollen. J Allergy Clin Immunol 1999, 104(6):1239-1243.
142. Son D.Y., Scheurer S., Hoffmann A., Haustein D., Vieths S. Pollen-related food allergy: cloning and immunological analysis of isoforms and mutants of Mal d 1, the major apple allergen, and Bet v 1, the major birch pollen allergen. Eur J Nutr 1999, 38(4):201-215.
143. Gajhede M., Osmark P., Poulsen F.M., Ipsen H., Larsen J.N., Joost van Neerven R.J., Schou C., Lowenstein H., Spangfort M.D. X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy. Nat Struct Biol 1996, 3(12):1040-1045.
144. Markovic-Housley Z., Degano M., Lamba D., von Roepenack-Lahaye E., Clemens S., Susani M., Ferreira F., Scheiner O., Breiteneder H. Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier. J Mol Biol 2003, 325(1):123-133.
145. Neudecker P., Schweimer K., Nerkamp J., Scheurer S., Vieths S., Sticht H., Rosch P. Allergic cross-reactivity made visible: solution structure of the major cherry allergen Pru av 1. J Biol Chem 2001, 276(25):22756-27763.
146. Vanek-Krebitz M., Hoffmann-Sommergruber K., da Camara Laimer, Machado M., Susani M., Ebner C., Kraft D., Scheiner O., Breiteneder H. Cloning and sequencing of Mal d 1, the major allergen from apple (Malus domestica), and its immunological relationship to Bet v 1, the major birch pollen allergen. Biochem Biophys Res Comm 1995, 214(2):538-551.
147. Scheurer S., Metzner K., Haustein D., Vieths S. Molecular cloning, expression and characterization of Pru a 1, the major cherry allergen. Mol Immunol 1997, 34(8-9):619-629.
148. Scheurer S., Pastorello E.A., Wangorsch A., Kastner M., Haustein D., Vieths S. Recombinant allergens Pru av 1 and Pru av 4 and a newly identified lipid transfer protein in the in vitro diagnosis of cherry allergy. J Allergy Clin Immunol 2001, 107(4):724-731.
149. Karamloo F., Scheurer S., Wangorsch A., May S., Haustein D., Vieths S. Pyr c 1, the major allergen from pear (Pyrus communis), is a new member of the Bet v 1 allergen family. J Chromatogr B Biomed Sci Appl 2001, 756(1-2):281-293.
150. Breiteneder H., Hoffmann-Sommergruber K., O'Riordain G., Susani M., Ahorn H., Ebner C., Kraft D., Scheiner O. Molecular characterization of Api g 1, the major allergen of celery (Apium graveolens) and its immunological and structural relationships to a group of 17-kDa tree pollen allergens. Eur J Biochem 1995, 233(2):484-489.
151. Hoffmann-Sommergruber K., O'Riordain G., Ahorn H., Ebner C., da Camara Laimer, Machado M., Pühringer H., Scheiner O., Breiteneder H. Molecular characterization of Dau c 1, the Bet v 1 homologous protein from carrot and its cross-reactivity with Bet v 1 and Api g 1. Clin Exp Allergy 1999, 29(6):840-847.
152. Hoffmann-Sommergruber K., Vanek-Krebitz M., Radauer C., Wen J., Ferreira F., Scheiner O., Breitenender H. Genomic characterization of members of the Bet v 1 family: genes coding for allergens and pathogenesis-related proteins share intron positions. Gene 1997, 197(1-2):91-100.
153. Luttkopf D., Muller U., Skov P.S., Ballmer-Weber B.K., Wüthrich B., Skamstrup Hansen K., Poulsen L.K., Kastner M., Haustein D., Vieths S. Comparison of four variants of a major allergen in hazelnut (Corylus avellana) Cor a 1.04 with the major hazel pollen allergen Cor a 1.01. Mol Immunol 2002, 38(7):515-525.
154. Kleine-Tebbe J., Vogel L., Crowell D.N., Haustein U.F., Vieths S. Severe oral allergy syndrome and anaphylactic reactions caused by a Bet v 1-related PR-10 protein in soybean, SAM22. J Allergy Clin Immunol 2002, 110(5):797-804.
155. Valenta R., Duchene M., Pettenburger K., Sillaber C., Valent P., Bettelheim P., Breitenbach M., Rumpold H., Kraft D., Scheiner O. Identification of profilin as a novel pollen allergen; IgE autoreactivity in sensitized individuals. Science 1991, 253(5019):557-560.
156. Valenta R., Duchene M., Ebner C., Valent P., Sillaber C., Deviller P., Ferreira F., Tejkl M., Edelmann H., Kraft D., Scheiner O. Profilins constitute a novel family of functional plant pan-allergens. J Exp Med 1992, 175(2):377-385.
157. Ebner C., Jensen-Jarolim E., Leitner A., Breitender H. Characterization of allergens in plant-derived spices: Apiaceae spices, pepper (Piperaceae), and paprika (bell peppers, Solanaceae). Allergy 1998, 53(46 Suppl):52-54.
158. Hirschwehr R., Valenta R., Ebner C., Ferreira F., Sperr W.R., Valent P., Rohac M., Rumpold H., Scheiner O., Kraft D. Identification of common allergenic structures in hazel pollen and hazelnuts: a possible explanation for sensitivity to hazelnuts in patients allergic to tree pollen. J Allergy Clin Immunol 1992, 90:927-936. (6Pt1).
159. Van Ree R., Voitenko V., van Leeuwen W.A., Aalberse R.C. Profilin is a cross-reactive allergen in pollen and vegetable foods. Int Arch Allergy Immunol 1992, 98(2):97-104.
160. Fah J., Wüthrich B., Vieths S. Anaphylactic reaction to lychee fruit: evidence for sensitization to profilin. Clin Exp Allergy 1995, 25(10):1018-1023.
161. Petersen A., Vieths S., Aulepp H., Schlaak M., Becker W.M. Ubiquitous structures responsible for IgE cross-reactivity between tomato fruit and grass pollen allergens. J Allergy Clin Immunol 1996, 98(4):805-815.
162. Fritsch R., Ebner H., Kraft D., Ebner C. Food allergy to pumpkin seed -characterization of allergens. Allergy 1997, 52(3):335-337.
163. Rihs H.P., Chen Z., Rueff F., Petersen A., Rozynek P., Heimann H., Baur X. IgE binding of the recombinant allergen soybean profilin (rGly m 3) is mediated by conformational epitopes. J Allergy Clin Immunol 1999, 104(6):1293-1301.
164. Scheurer S., Wangorsch A., Haustein D., Vieths S. Cloning of the minorallergen Api g 4 profilin from celery (Apium graveolens) and its cross-reactivitywith birch pollen profilin Bet v 2. Clin Exp Allergy 2000, 30(7):962-971.
165. Scheurer S., Wangorsch A., Nerkamp J., Skov P.S., Ballmer-Weber B., Wuthrich B., Haustein D., Vieths S. Cross-reactivity within the profilin panallergen family investigated by comparison of recombinant profilins from pear (Pyr c 4), cherry (Pru av 4) and celery (Api g 4) with birch pollen profilin Bet v 2'. J Chromatogr B Biomed Sci Appl 2001, 756(1-2):315-325.
166. Reindl J., Rihs H.P., Scheurer S., Wangorsch A., Haustein D., Vieths S. IgE reactivity to profilin in pollen-sensitized subjects with adverse reactions to banana and pineapple. Int Arch Allergy Immunol 2002, 128(2):105-114.
167. Laskowski M., Kato I. Protein inhibitors of proteinases. Ann Rev Biochem 1980, 49:593-626.
168. Mazumdar-Leighton S., Broadway R.M. Identification of six chymotrypsin cDNAs from larval midguts of Helicoverpa zea and Agrotis ipsilon feeding on the soybean (Kunitz) trypsin inhibitor. Insect Biochem Mol Biol 2001, 31(6-7):633-644.
169. Burks A.W., Cockrell G., Connaughton C., Guin J., Allen W., Helm R.M. Identification of peanut agglutinin and soybean trypsin inhibitor as minor legume allergens. Int Arch Allergy Immunol 1994, 105(2):143-149.
170. Moroz L.A., Lang W.H. Kunitz soybean trypsin inhibitor. A specific allergen in food anaphylaxis. New Engl J Med 1980, 302(20):1126-1128.
171. Seppala U., Majamaa H., Turjanmaa K., Helin J., Reunala T., Kalkkinen N., Palosuo T. Identification of four novel potato (Solanum tuberosum) allergens belonging to the family of soybean trypsin inhibitors. Allergy 2001, 56(7):619-626.
172. Shibasaki M., Sumazaki R., Isoyama S., Takita H. Interaction of lectins with human IgE: IgE-binding property and histamine-releasing activity of twelve plant lectins. Int Arch Allergy Immunol 1992, 98(1):18-25.
173. Burks A.W., Cockrell G., Connaughton C., Guin J., Allen W., Helm R.M. 'Identification of peanut agglutinin and soybean trypsin inhibitor as minor legume allergens. Int Arch Allergy Immunol 1994, 105(2):143-149.
174. Seppala U., Alenius H., Turjanmaa K., Reunala T., Palosuo T., Kalkkinen N. Identification of patatin as a novel allergen for children with positive skin prick test responses to raw potato. J Allergy Clin Immunol 1999, 103:165-171. (1Pt1).
175. Karamloo F., Wangorsch A., Kasahara H., Davin L.B., Haustein D., Lewis N.G., Vieths S. Phenylcoumaran benzylic ether and isoflavonoid reductases are a new class of cross-reactive allergens in birch pollen, fruits and vegetables. Eur J Biochem 2001, 268(20):5310-5320.
176. Pons L., Chery C., Romano A., Namour F. Artesani, M C and Gueant, J L (2002) 'The 18kDa peanut oleosin is a candidate allergen for IgE-mediated reactions to peanuts'. Allergy 2002, 57(Suppl 72):88-93.
177. Westphal S., Kolarich D., Foetisch K., Lauer I., Altmann F., Conti A., Crespo J.F., Rodriguez J., Enrique E., Vieths S., Scheurer S. Molecular characterization and allergenic activity of Lyc e 2 (beta-fructofuranosidase), a glycosylated allergen of tomato. Eur J Biochem 2003, 270(6):1327-1337.
178. Cuesta-Herranz J., Pastor C., Figueredo E., Vidarte L., De las Heras M., Duran C., Fernandez-Caldas E., de Miguel J., Vivanco F. Identification of cucumisin (Cuc m 1), a subtilisin-like endopeptidase, as the major allergen of melon fruit. Clin Exp Allergy 2003, 33(6):827-833.
179. Bublin M., Radauer C., Wilson I.B.H., Kraft D., Scheiner O., Breiteneder H., Hoffmann-Sommergruber K. Cross-reactive N-glycans of Api g 5, a high molecular weight glycoprotein allergen from celery, are required for immunoglobulin E binding and activation of effector cells from allergic patients. FASEB J 2003, 17(12):1697-1699.
180. Lehrer S.B., Reese G. Recombinant proteins in newly developed foods: identification of allergenic activity. Int Arch Allergy Immunol 1997, 113(1-3):122-124.
181. Sampson H.A. Food anaphylaxis. Br Med Bull 2000, 56(4):925-935.
182. Reese G., Ayuso R., Lehrer S.B. Tropomyosin: an invertebrate pan-allergen. Int Arch Allergy Immunol 1999, 119(4):247-258.
183. Sicherer S.H. Clinical implications of cross-reactive food allergens. J Allergy Clin Immunol 2001, 108(6):881-890.
184. Bugajska-Schretter A., Grote M., Vangelista L., Valent P., Sperr W.R., Rumpold H., Pastore A., Reichelt R., Valenta R., Spitzauer S. Purification, biochemical, and immunological characterisation of a major food allergen: different immunoglobulin E recognition of the apo- and calcium-bound forms of carp parvalbumin. Gut 2000, 46(5):661-669.
185. Host A. Frequency of cow's milk allergy in childhood. Ann Allergy Asthma Immunol 2002, 89(6 Suppl 1):33-37.
186. Bordin G., Cordeiro Raposo F., de la Calle B., Rodriguez A.R. Identification and quantification of major bovine milk proteins by liquid chromatography. J Chromatogr A 2001, 928(1):63-76.
187. Werfel S.J., Cooke S.K., Sampson H.A. Clinical reactivity to beef in children allergic to cow's milk. J Allergy Clin Immunol 1997, 99(3):293-300.
188. Sampson H.A. Food sensitivity and the pathogenesis of atopic dermatitis. J R Soc Med 1997, 90(Suppl 30):2-8.
189. Cooke S.K., Sampson H.A. Allergenic properties of ovomucoid in man. J Immunol 1997, 159(4):2026-2032.
190. Bernhisel-Broadbent J., Dintzis H.M., Dintzis R.Z., Sampson H.A. Allergenicity and antigenicity of chicken egg ovomucoid (Gal d III) compared with ovalbumin (Gal d I) in children with egg allergy and in mice. J Allergy Clin Immunol 1994, 93(6):1047-1059.
191. Langland T. A clinical and immunological study of allergy to hen's egg white. VI. Occurrence of proteins cross-reacting with allergens in hen's egg white as studied in egg white from turkey, duck, goose, seagull, and in hen egg yolk, and hen and chicken sera and flesh. Allergy 1983, 38(7):399-412.
192. Anibarro B., Seoane F.J., Vila C., Lombardero M. Allergy to eggs from duck and goose without sensitization to hen egg proteins. J Allergy Clin Immunol 2000, 105(4):834-836.
193. Szepfalusi Z., Ebner C., Pandjaitan R., Orlicek F., Scheiner O., Boltz-Nitulescu G., Kraft D., Ebner H. Egg yolk alpha-livetin (chicken serum albumin) is a cross-reactive allergen in the bird-egg syndrome. J Allergy Clin Immunol 1994, 93(5):932-942.
194. Bausela B.A., Garcia-Ara M.C., Martin Esteban M., Boyano Martinez T.B., Diaz Pena J.M., Ojeda Casas J.A. Peculiarities of egg allergy in children with bird protein sensitization. Ann Allergy Asthma Immunol 1997, 78(2):213-216.
195. Kelso J.M., Cockrell G.E., Helm R.M., Burks A.W. Common allergens in avian meat. J Allergy Clin Immunol 1999, 104(1):202-204.
196. Lewit-Bentley A., Rety S. EF-hand calcium-binding proteins. Curr Opin Struct Biol 2000, 10(6):637-643.
197. Pauls T.L., Cox J.A., Berchtold M.W. The Ca2+(-)binding proteins parvalbumin and oncomodulin and their genes: new structural and functional findings. Biochim Biophys Acta 1996, 1306(1):39-54.
198. Elsayed S., Apold J. Immunochemical analysis of cod fish allergen M: locations of the immunoglobulin binding sites as demonstrated by the native and synthetic peptides. Allergy 1983, 38(7):449-459.
199. Van Do T., Hordvik I., Endresen C., Elsayed S. The major allergen (parvalbumin) of codfish is encoded by at least two isotypic genes: cDNA cloning, expression and antibody binding of the recombinant allergens. Mol Immunol 2003, 39(10):595-602.
200. Das Dores S., Chopin C., Villaume C., Fleurence J., Gueant J.L. A new oligomeric parvalbumin allergen of Atlantic cod (Gad m I) encoded by a gene distinct from that of Gad c I. Allergy 2002, 57:79-83. (Suppl72).
201. Lindstrom C.D., van Do T., Hordvik I., Endresen C., Elsayed S. Cloning of two distinct cDNAs encoding parvalbumin, the major allergen of Atlantic salmon (Salmo salar). Scand J Immunol 1996, 44(4):335-344.
202. Swoboda I., Bugajska-Schretter A., Verdino P., Keller W., Sperr W.R., Valent P., Valenta R., Spitzauer S. Recombinant carp parvalbumin, the major cross-reactive fish allergen: a tool for diagnosis and therapy of fish allergy. J Immunol 2002, 168(9):4576-4584.
203. Yamada S., Nolte H., Zychlinsky E. Identification and characterization of allergens in two species of tuna fish. Ann Allergy Asthma Immunol 1999, 82(4):395-400.
204. Hilger C., Grigioni F., Thill L., Mertens L., Hentges F. Severe IgE-mediated anaphylaxis following consumption of fried frog legs: definition of alpha-parvalbumin as the allergen in cause. Allergy 2002, 57(11):1053-1058.
205. Hamada Y., Tanaka H., Ishizaki S., Ishida M., Nagashima Y., Shiomi K. Purification, reactivity with IgE and cDNA cloning of parvalbumin as the major allergen of mackerels. Food Chem Toxicol 2003, 41(8):1149-1156.
206. MacLeod A.R. Genetic origin of diversity of human cytoskeletal tropomyosins. Bioessays 1987, 6(5):208-212.
207. Shanti K.N., Martin B.M., Nagpal S., Metcalfe D.D., Rao P.V. Identification of tropomyosin as the major shrimp allergen and characterization of its IgE-binding epitopes. J Immunol 1993, 151(10):5354-5363.
208. Lin R.Y., Shen H.D., Han S.H. Identification and characterization of a 30 kd major allergen from Parapenaeus fissurus. J Allergy Clin Immunol 1993, 92(6):837-845.
209. Daul C.B., Slattery M., Reese G., Lehrer S.B. Identification of the major brown shrimp (Penaeus aztecus) allergen as the muscle protein tropomyosin. Int Arch Allergy Immunol 1994, 105(1):49-55.
210. Leung P.S., Chu K.H., Chow W.K., Ansari A., Bandea C.I., Kwan H.S., Nagy S.M., Gershwin M.E. Cloning, expression, and primary structure of Metapenaeus ensis tropomyosin, the major heat-stable shrimp allergen. J Allergy Clin Immunol 1994, 94(5):882-890.
211. Leung P.S., Chen Y.C., Gershwin M.E., Wong S.H., Kwan H.S., Chu K.H. Identification and molecular characterization of Charybdis feriatus tropomyosin, the major crab allergen. J Allergy Clin Immunol 1998, 102(5):847-852.
212. Leung P.S., Chen Y.C., Mykles D.L., Chow W.K., Li C.P., Chu K.H. Molecular identification of the lobster muscle protein tropomyosin as a seafood allergen. Mol Mar Biol Biotechnol 1998, 7(1):12-20.
213. Mykles D.L., Cotton J.L., Taniguchi H., Sano K., Maeda Y. Cloning of tropomyosins from lobster (Homarus americanus) striated muscles: fast and slow isoforms may be generated from the same transcript. J Muscle Res Cell Motil 1998, 19(2):105-115.
214. Ishikawa M., Ishida M., Shimakura K., Nagashima Y., Shiomi K. Tropomyosin, the major oyster Crassostrea gigas allergen and its IgE-binding epitopes. J Food Sci 1998, 63:44-47.
215. Leung P.S., Chu K.H. cDNA cloning and molecular identification of the major oyster allergen from the Pacific oyster Crassostrea gigas. Clin Exp Allergy 2001, 31(8):1287-1294.
216. Ishikawa M., Nagashima Y., Shiomi K. Identification of the oyster allergen Cra g 2 as tropomyosin. Fish Sci 1998, 64(5):854-855.
217. Ishikawa M., Ishida M., Shimakura K., Nagashima Y., Shiomi K. Purification and IgE-binding epitopes of a major allergen in the gastropod Turbo cornutus. Biosci Biotechnol Biochem 1998, 62(7):1337-1343.
218. Miyazawa H., Fukamachi H., Inagaki Y., Reese G., Daul C.B., Lehrer S.B., Inouye S., Sakaguchi M. Identification of the first major allergen of a squid (Todarodes pacificus). J Allergy Clin Immunol 1996, 98:948-953. (5Pt1).
219. Chu K.H., Wong S.H., Leung P.S. Tropomyosin is the major mollusk allergen: reverse transcriptase polymerase chain reaction, expression and IgE reactivity. Mar Biotechnol 2000, 2(5):499-509.
220. Asturias J.A., Eraso E., Arilla M.C., Gomez-Bayon N., Inacio F., Martinez A. Cloning, isolation, and IgE-binding properties of Helix aspersa (brown garden snail) tropomyosin. Int Arch Allergy Immunol 2002, 128(2):90-96.
221. Chu K.H., Wong S.H., Leung P.S. Tropomyosin is the major mollusk allergen: reverse transcriptase polymerase chain reaction, expression and IgE reactivity. Mar Biotechnol (NY) 2000, 2(5):499-509.
222. Strong S.J., Ellington W.R. Isolation and sequence analysis of the gene for arginine kinase from the chelicerate arthropod, Limulus polyphemus: insights into catalytically important residues. Biochim Biophys Acta 1995, 1246(2):197-200.
223. Lin R.Y., Shen H., Han S.H. Identification and characterization of a 30 kd major allergen from Parapenaeus fissurus. J Allergy Clin Immunol 1993, 92(6):837-845.
224. Yu C.J., Lin Y.F., Chiang B.L., Chow L.P. Proteomics and immunological analysis of a novel shrimp allergen, Pen m 2. J Immunol 2003, 170(1):445-453.
225. Henrissat B., Bairoch A. New families in the classification of glycosyl hydrolases based on amino acid sequence similarities. Biochem J 1993, 293(Pt 3):781-788.
226. Henrissat B., Bairoch A. Updating the sequence-based classification of glycosyl hydrolases. Biochem J 1996, 316(Pt 2):695-696.
227. Shewale J.G., Sinha S.K., Brew K. Evolution of alpha-lactalbumins. The complete amino acid sequence of the alpha-lactalbumin from a marsupial (Macropus rufogriseus) and corrections to regions of sequence in bovine and goat alpha-lactalbumins. J Biol Chem 1984, 259(8):4947-4956.
228. Brew K., Castellino F.J., Vanaman T.C., Hill R.L. The complete amino acid sequence of bovine alpha-lactalbumin. J Biol Chem 1970, 245(17):4570-4582.
229. Nitta K., Sugai S. The evolution of lysozyme and alpha-lactalbumin. Eur J Biochem 1989, 182(1):111-118.
230. Anet J., Back J.F., Baker R.S., Barnett D., Burley R.W., Howden M.E. Allergens in the white and yolk of hen's egg. A study of IgE binding by egg proteins. Int Arch Allergy Appl Immunol 1985, 77(3):364-371.
231. Pervaiz S., Brew K. Homology of beta-lactoglobulin, serum retinol-binding protein, and protein HC. Science 1985, 228(4697):335-337.
232. Jamieson A.C., Vandeyar M.A., Kang Y.C., Kinsella J.E., Batt C.A. Cloning and nucleotide sequence of the bovine beta-lactoglobulin gene. Gene 1987, 61(1):85-90.
233. Brownlow S., Morais Cabral J.H., Cooper R., Flower D.R., Yewdall S.J., Polikarpov I., North A.C., Sawyer L. Bovine beta-lactoglobulin at 1.8A resolution - still an enigmatic lipocalin. Structure 1997, 5(4):481-495.
234. He X.M., Carter D.C. Atomic structure and chemistry of human serum albumin. Nature 1992, 358(6383):209-215.
235. Spuergin P., Walter M., Schiltz E., Deichmann K., Forster J., Mueller H. Allergenicity of alpha-caseins from cow, sheep, and goat. Allergy 1997, 52(3):293-298.
236. Bellioni-Businco B., Paganelli R., Lucenti P., Giampietro P.G., Perborn H., Businco L. Allergenicity of goat's milk in children with cow's milk allergy. J Allergy Clin Immunol 1999, 103(6):1191-1194.
237. Quirce S., Maranon F., Umpierrez A., de las Heras M., Fernandez-Caldas E., Sastre J. Chicken serum albumin (Gal d 5) is a partially heat-labile inhalant and food allergen implicated in the bird-egg syndrome. Allergy 2001, 56(8):754-762.
238. Ayuso R., Lehrer S.B., Lopez M., Reese G., Ibanez M.D., Esteban M.M., Ownby D.R., Schwartz H. Identification of bovine IgG as a major cross-reactive vertebrate meat allergen. Allergy 2000, 55(4):348-354.
239. Holt C., Sawyer L. Primary and predicted secondary structures of the caseins in relation to their biological functions. Protein Eng 1988, 2(4):251-259.
240. Wal J.M. Structure and function of milk allergens. Allergy 2001, 56:35-38. (Suppl67).
241. Wal J.M. Cow's milk allergens. Allergy 1998, 53(11):1013-1022.
242. Restani P., Gaiaschi A., Plebani A., Beretta B., Cavagni G., Fiocchi A., Poiesi C., Velona T., Ugazio A.G., Galli C.L. Cross-reactivity between milk proteins from different animal species. Clin Exp Allergy 1999, 29(7):997-1004.
243. Businco L., Giampietro P.G., Lucenti P., Lucaroni F., Pini C., Di Felice G., Iacovacci P., Curadi C., Orlandi M. Allergenicity of mare's milk in children with cow's milk allergy. J Allergy Clin Immunol 2000, 105(5):1031-1034.
244. Sharma S., Kumar P., Betzel C., Singh T.P. Structure and function of proteins involved in milk allergies. J Chromatogr B Biomed Sci Appl 2001, 756(1-2):183-187.
245. Holen E., Elsayed S. Characterization of four major allergens of hen egg-white by IEF/SDS-PAGE combined with electrophoretic transfer and IgE-immunoautoradiography. Int Arch Allergy Appl Immunol 1990, 91(2):136-141.
246. Laskowski M., Kato I., Ardelt W., Cook J., Denton A., Empie M.W., Kohr W.J., Park S.J., Parks K., Schatzley B.L., Schoenberger O.L., Tashiro M., Vichot G., Whatley H.A., Wieczorek A., Wieczorek M. 'Ovomucoid third domains from 100 avian species: isolation, sequences, and hypervariability of enzyme-inhibitor contact residues. Biochemistry 1987, 26(1):202-221.
247. Williamson M.P., Marion D., Wuthrich K. Secondary structure in the solution conformation of the proteinase inhibitor IIA from bull seminal plasma by nuclear magnetic resonance. J Mol Biol 1984, 173(3):341-359.
248. Kato I., Schrode J., Kohr W.J., Laskowski M. Chicken ovomucoid: determination of its amino acid sequence, determination of the trypsin reactive site, and preparation of all three of its domains. Biochemistry 1987, 26(1):193-201.
249. Hunt L.T., Dayhoff M.O. A surprising new protein superfamily containing ovalbumin, antithrombin-III, and alpha 1-proteinase inhibitor. Biochem Biophys Res Commun 1980, 95(2):864-871.
250. Remold-O'Donnell E. The ovalbumin family of serpin proteins. FEBS Lett 1993, 315(2):105-108.
251. Tada Y., Nakase M., Adachi T., Nakamura R., Shimada H., Takahashi M., Fujimura T., Matsuda T. Reduction of 14-16kDa allergenic proteins in transgenic rice plants by antisense gene. FEBS Lett 1996, 391(3):341-345.
252. Herman E.M., Helm R.M., Jung R., Kinney A.J. Genetic modification removes an immunodominant allergen from soybean. Plant Physiol 2003, 132(1):36-43.
253. Vieths S., Hoffmann A., Holzhauser T., Muller U., Reindl J., Haustein D. Factors influencing the quality of food extracts for in vitro and in vivo diagnosis. Allergy 1998, 53(46 Suppl):65-71.
254. Ballmer-Weber B.K., Hoffmann A., Wüthrich B., Lüttkopf D., Pompei C., Wangorsch A., Kastner M., Vieths S. Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and allergy. Allergy 2002, 57(3):228-235.
255. Asero R., Mistrello G., Roncarolo D., de Vries S.C., Gautier M.F., Ciurana C.L., Verbeek E., Mohammadi T., Knul-Brettlova V., Akkerdaas J.H., Bulder I., Aalberse R.C., van Ree R. Lipid transfer protein: a pan-allergen in plant-derived foods that is highly resistant to pepsin digestion. Int Arch Allergy Immunol 2000, 122(1):20-32.
256. Sen M., Kopper R., Pons L., Abraham E.C., Burks A.W., Bannon G.A. Protein structure plays a critical role in peanut allergen stability and may determine immunodominant IgE-binding epitopes. J Immunol 2002, 169(2):882-887.
257. Ferreira F., Wallner M., Breiteneder H., Hartl A., Thalhamer J., Ebner C. Genetic engineering of allergens: future therapeutic products. Int Arch Allergy Immunol 2002, 128(3):171-178.
258. Bannon G.A., Cockrell G., Connaughton C., West C.M., Helm R., Stanley J.S., King N., Rabjohn P., Sampson H.A., Burks A.W. Engineering, characterization and in vitro efficacy of the major peanut allergens for use in immunotherapy. Int Arch Allergy Immunol 2001, 124(1-3):70-72.
259. Rabjohn P., West C.M., Connaughton C., Sampson H.A., Helm R.M., Burks A.W., Bannon G.A. Modification of peanut allergen Ara h 3: effects on IgE binding and T cell stimulation. Int Arch Allergy Immunol 2002, 128(1):15-23.
260. Cocco R.R., Jarvinen K.M., Sampson H.A., Beyer K. Mutational analysis of major, sequential IgE-binding epitopes in alpha-s1-casein, a major cow's milk allergen. J Allergy Clin Immunol 2003, 112(2):433-437.
261. Valenta R., Kraft D. From allergen structure to new forms of allergen-specific immunotherapy. Curr Opin Immunol 2002, 14(6):718-727.
262. Brusic V., Millot M., Petrovsky N., Gendel S.M., Gigonzac O., Stelman S.J. Allergen databases. Allergy 2003, 58(11):1093-1100.