Characterization of Api g 1.0201, a new member of the Api g 1 family of celery allergens

International Archives of Allergy and Immunology

Volumn 122, Issue 2, 2000, Pages 115-123

  Hoffmann Sommergruber, Karin ^a   Ferris, Rosemary ^a   Pec, Martina ^a   Radauer, Christian ^a   O'Riordain, Gabriel ^a   Laimer Da Camara Machado, Margit ^b   Scheiner, Otto ^a   Breiteneder, Heimo ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

Author keywords

Api g 1.0201; Food allergy; IgE binding; Isoforms; Major celery allergen

Indexed keywords

ALLERGENICITY; AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CROSS REACTION; FOOD ALLERGY; HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SEQUENCE HOMOLOGY;

EID: 0033919355     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000024367     Document Type: Article

References (49)

1. Sloan AE, Powers ME: A perspective on popular perceptions of adverse reactions to food. J Allergy Clin Immunol 1986;78:127-133.
2. Sampson HA: Epidemiology of food allergy. Pediatr Allergy Immunol 1996:7(suppl 9):42-50.
3. Bock SA: Prospective appraisal of complaints of adverse reactions to food in children during the first three years of life. Pediatrics 1987;79: 683-688.
4. Bruijnzeel-Koomen C, Ortolani C, Aas K, Bindslev-Jensen C, Björkstén B, Moneret-Vautrin D, Wüthrich B: Adverse reactions to food. European Academy of Allergology and Clinical Immunology Subcommittee. Allergy 1995;50: 623-635.
5. Sampson HA: Clinical manifestations of adverse food reactions. Pediatr Allergy Immunol 1995;6(suppl 8):29-37.
6. Ebner C, Hirschwehr R, Bauer L, Breiteneder H. Valenta R, Ebner H, Kraft D, Scheiner O: Identification of allergens in fruits and vegetables: IgE cross-reactivities with the important birch pollen allergens Bet v 1 and Bet v 2 (birch profilin). J Allergy Clin Immunol 1995;95: 962-969.
7. Bauer L, Ebner C, Hirschwehr R, Wüthrich B, Pichler C, Fritsch R, Scheiner O, Kraft D: IgE cross-reactivity between birch pollen, mugwort pollen and celery is due to at least three distinct cross-reacting allergens: Immunoblot investigation of the birch-mugwort-celery syndrome. Clin Exp Allergy 1996;26:1161-1170.
8. Hoffmann-Sommergruber K, Demoly P, Crameri R, Breiteneder H, Ebner C, Laimer Da Camara Machado M, Blaser K, Ismail C, Scheiner O, Bousquet J, Menz G: IgE reactivity to Api g 1, a major celery allergen, in a central European population is based on primary sensitization by Bet v 1. J Allergy Clin Immunol 1999;104:478-484.
9. Ortolani C, Ispano M, Ansaloni R, Rotondo F, Incorvaia C, Pastorello EA: Diagnostic problems due to cross-reactions in food allergy. Allergy 1998;53(suppl 46):58-61.
10. Wüthrich B: Zur Nahrungsmittelallergie: Häufigkeit der Symptome und der allergieauslösenden Nahrungsmittel bei 402 Patienten -Kuhmilchallergie - Nahrungsmittel und Neurodermitis atopica. Allergologie 1993;16:280-287.
11. Pauli G, Bessot JC, Dietermann-Molard A, Braun PA, Thierry R: Celery sensitivity: Clinical and immunological correlations with pollen allergy. Clin Allergy 1985;15:273-279.
12. Vallier P, Dechamp C, Vial O, Deviller P: A study of allergens in celery with cross-sensitivity to mugwort and birch pollens. Allergy 1988; 18:491-500.
13. Wuethrich B, Staeger J, Johansson SGO: Celery allergy associated with birch and mugwort pollinosis. Allergy 1991;45:566-571.
14. Valenta R, Duchene M, Ebner C, Valent P, Sillaber C, Deviller P, Ferreira F, Tejkl M, Edelmann H, Kraft D, Scheiner O: Profilins constitute a novel family of functional plant pan-allergens. J Exp Med 1992;175:377-385.
15. Vallier P, DeChamp C, Valenta R, Vial O, Deviller P: Purification and characterization of an allergen from celery immunochemically related to an allergen present in several other plant species. Identification as a profilin. Clin Exp Allergy 1992;22:774-782.
16. Breiteneder H, Hoffmann-Sommergruber K, O'Riordain G, Susani M, Ahorn H, Ebner C, Kraft D, Scheiner O: Molecular characterization of Api g 1, the major allergen of celery (Apium graveolens), and its immunological and structural relationships to a group of 17-kDa tree pollen allergens. Eur J Biochem 1995;233: 484-489.
17. Breiteneder H, Pettenburger K, Bito A, Valenta R, Kraft D, Rumpold H, Scheinen O, Breitenbach The gene coding for the major birch pollen allergen Bet v 1 is highly homologous to a pea disease resistance response gene. EMBO J 1989;8:1935-1938.
18. Ferreira F, Hirtenlehner K, Jilek A, Godnik-Cvar J, Breiteneder H, Grimm R, Hoffmann-Sommergruber K, Scheiner O, Kraft D, Breitenbach M, Rheinberger H-J, Ebner C: Dissection of IgE and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: Potential use of hypoallergenic isoforms for immunotherapy. J Exp Med 1996;183:1-11.
19. Muller W, Karamfilov T, Kahlert H, Stuwe H, Fahlbusch B, Cromwell O, Fiebig H, Jager L: Mapping of T-cell epitopes of Phl p 5: Evidence for crossreacting and non-crossreacting T-cell epitopes within Phl p 5 isoallergens. Clin Exp Allergy 1998;28:1538-1548.
20. Vanek-Krebitz M, Hoffmann-Sommergruber K, Laimer da Camara Machado M, Susani M, Ebner C, Kraft D, Scheiner O, Breiteneder H: Cloning and sequencing of Mal d 1, the major allergen from apple (Malus domestica), and its immunological relationship to Bet v 1, the major birch pollen allergen. Biochem Biophys Res Commun 1995;214:538-551.
21. Atkinson RG, Perry J, Matsui T, Ross SG, Macrae EA: A stress-, pathogenesis-, and allergen-related cDNA in apple fruit is also ripening-related. NZ J Crop Horticult Sci 1996;24: 103-107.
22. Vieths S, Jankiewicz A, Schöning B, Aulepp H: Apple allergy: The IgE-binding potency of apple strains is related to the occurrence of the 18-kDa allergen. Allergy 1994;49:262-271.
23. Son DY, Scheurer S, Hoffmann A, Haustein D, Vieths S: Pollen-related food allergy: Cloning and immunological analysis of isoforms and mutants of Mal d 1, the major apple allergen, and Bet v 1, the major birch pollen allergen. Eur J Nutr 1999;38:201-215.
24. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-159.
25. Sanger F, Nicklen S, Coulson AR: DNA sequencing with chain terminating inhibitors. Proc Natl Acad Sci USA 1977;74:5463-5467.
26. Stüber D, Matile H, Garota G: System for high level production in E. coli and rapid purification of recombinant proteins: Application to epitope mapping, preparation of antibodies and structure function analysis; in Lefkovits I, Pernis B (eds): Immunological Methods. New York, Academic Press, 1990, pp 121-152.
27. 27. Jacobs S: Determination of nitrogen in proteins by means of indanetrione hydrate. Nature 1959;183:262.
28. Jarolim E, Tejkl M, Rohac M, Schlerka G, Scheiner O, Kraft D, Breitenbach M, Rumpold H: Monoclonal antibodies against birch pollen allergens: Characterization by immunoblotting and use for single-step affinity purification of the major allergen Bet v 1. Int Arch Allergy Appl Immunol 1989;90:54-60.
29. Hoffmann-Sommergruber K, Susani M, Ferreira F, Jertschin P, Ahorn H, Steiner R, Kraft D, Scheiner O, Breiteneder H: High-level expression and purification of the major birch pollen allergen Bet v I. Protein Expr Purif 1997;9:33-39.
30. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-685.
31. Towbin H, Staehelin T. Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some appliances. Proc Natl Acad Sci USA 1979;76:4350-4354.
32. Larsen JN, Loewenstein H: Allergen nomenclature. J Allergy Clin Immunol 1996;97:577-578.
33. Guex N, Peitsch MC: SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling. Electrophoresis 1997;18:2714-2723.
34. Spangfort M, Larsen JN, Gajhede M: Crystallization and preliminary X-ray investigation at 2.0 A resolution of Bet v 1, a birch pollen protein causing IgE-mediated allergy. Proteins 1996;26:358-360.
35. Gajhede M, Osmark P, Flemming M, Poulsen M, Ipsen H, Larsen N, Joost van Neerven RJ, Schou C, Loewenstein H, Spangfort M: X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy. Nat Struct Biol 1996;3: 1040-1045.
36. Somssich I, Schmelzer E, Kawalleck P, Hahlbrock K: Gene structure and in situ transcript localization of pathogenesis-related protein 1 in parsley. Mol Gen Genet 1988;213:93-98.
37. Hoffmann-Sommergruber K, O'Riordain G, Ahorn H, Ebner C, Laimer Da Camara Machado M, Pühringer H, Scheiner O, Breitene-der H: Molecular characterization of Dau c 1, the Bet v 1 homologous protein from carrot and its cross-reactivity with Bet v 1 and Api g 1. Clin Exp Allergy 1999;29:480-484.
38. Swoboda I, Scheiner O, Heberle-Bors E, Vicente O: cDNA cloning and characterization of three genes in the Bet v 1 gene family that encode pathogenesis-related proteins. Plant Cell Environ 1995;18:865-874.
39. Ganglberger E, Grünberger K, Sponer B, Radauer C. Breiteneder H, Boltz-Nitulescu G, Scheiner O, Jensen-Jarolim E: Allergen mimotopes for 3 dimensional epitope search and induction of antibodies inhibiting human IgE binding. FASEB J, in press.
40. Laffer S, Vangelista L, Steinberger P, Kraft D, Pastore A, Valenta R: Molecular characterization of Bip 1, a monoclonal antibody that modulates IgE binding to birch pollen allergen Bet v 1. J Immunol 1996;157:4953-4962.
41. Breitwieser A, Mader A, Schocher I, Hoffmann-Sommergruber K, Aberer W, Scheiner O, Sleytr UB, Sara M: A novel dipstick developed for rapid Bet v 1-specific IgE detection: Recombinant allergen immobilized via a monoclonal antibody to crystalline bacterial cell-surface layers. Allergy 1998;53:786-793.
42. Scheurer S, Metzner K, Haustein D, Vieths S: Molecular cloning, expression and characterization of Pru a 1, the major cherry allergen. Mol Immunol 1997;34:619-629.
43. Scheurer S, Son DY, Boehm M, Karamloo F, Franke S, Hoffmann A, Haustein D, Vieths S: Cross-reactivity and epitope analysis of Pru a 1, the major cherry allergen. Mol Immunol 1999;36:155-167.
44. Moneo I, Gomez M, Sanchez-Monge R, Alday E, de las Heras M, Esteban I, Bootello A, Salcedo G: Lack of crossreaction with Bet v 1 in patients sensitized to Dau c 1, a carrot allergen. Ann Allergy Asthma Immunol 1999;83:71-75.
45. Asero R: Effects of birch pollen-specific immunotherapy on apple allergy in birch pollen-hypersensitive patients. Clin Exp Allergy 1998; 28:1368-1373.
46. Swoboda I, Jilek A, Ferreira F, Hoffmann-Sommergruber K, Scheiner O, Kraft D, Breiteneder H, Pittenauer E, Schmid E, Vicente O, Heberle-Bors E, Ahorn H, Breitenbach M: Isoforms of Bet v 1, the major birch pollen allergen, analyzed by liquid chromatography, mass spectrometry, and cDNA cloning. J Biol Chem 1995;270:6:2607-2613.
47. Weiss C, Kramer B, Ebner C, Susani M, Briza P, Hoffmann-Sommergruber K, Breiteneder H, Kraft D, Scheiner O, Breitenbach M, Ferreira F: High-level expression of tree pollen isoallergens in Escherichia coli. Int Arch Allergy Immunol 1996;110:282-287.
48. Ferreira F. Hebenstreit D, Kramer B, Himly M, Breiteneder H, Scheiner O, Briza P, Ebner C, Breitenbach M: Amino acid positions involved in the formation of IgE-binding epitopes of Api g 1 and Mal d 1 allergens (abstract). J Allergy Clin Immunol 2000;105:413.
49. Ferreira F, Ebner C, Kramer B, Casari G, Briza P, Kungl AJ, Grimm R, Jahn-Schmid B, Breiteneder H, Kraft D, Breitenbach M, Rheinberger HJ, Scheiner O: Modulation of IgE reactivity of allergens by site-directed mutagenesis: Potential use of hypoallergenic variants for immunotherapy. FASEB J 1998;12:231-242.