Reduced in vivo allergenicity of Bet v 1d isoform, a natural component of birch pollen

Journal of Allergy and Clinical Immunology

Volumn 104, Issue 6, 1999, Pages 1239-1243

  Arquint, Oliver ^a   Helbling, Arthur ^a   Crameri, Reto ^b   Ferreira, Fátima ^c   Breitenbach, Michael ^c   Pichler, Werner J ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b SWISS INSTITUTE OF ALLERGY AND ASTHMA RESEARCH SIAF   (Switzerland)

^c UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Conjunctival provocation test; Intradermal test; Recombinant Bet v 1; Recombinant isoforms; Skin prick test; Type I allergy

Indexed keywords

IMMUNOGLOBULIN E; POLLEN ANTIGEN; RECOMBINANT PROTEIN;

ADULT; ALLERGENICITY; ANTIGEN SPECIFICITY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HUMAN; HUMAN CELL; IMMUNOGENICITY; IMMUNOGLOBULIN PRODUCTION; INTRACUTANEOUS TEST; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; POLLEN; POLLEN ALLERGY; PRICK TEST; PRIORITY JOURNAL; PROVOCATION TEST; T LYMPHOCYTE ACTIVATION;

EID: 0033408326     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(99)70019-9     Document Type: Article

References (17)

1. 1. Jarolim E, Rumpold H, Endler AT, Ebner H, Breitenbach M, Scheiner O, et al. IgE and IgG antibodies of patients with allergy to birch pollen as tools to define the allergen profile of Betula verrucosa. Allergy 1989;44:385-95.
2. 2. Breiteneder H, Pettenburger K, Bito A, Valenta R, Kraft D, Rumpold H, et al. The gene coding for the major birch pollen allergen Bet v 1 is highly homologous to a pea disease resistance response gene. EMBO J 1989;8:1935-8.
3. 3. Hoffmann-Sommergruber K, Susani M, Ferreira F, Jertschin P, Ahorn R, Steiner D, et al. High level expression and purification of the major birch pollen allergen, Bet v 1. J Prot Express Purif 1997;9:33-9.
4. 4. Gaijhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, van Neerven RJJ, et al. X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy. Nat Struct Biol 1996;3:1040-5.
5. 5. Swoboda I, Jilek A, Ferreira F, Engel E, Hoffmann-Sommergruber K, Scheiner O, et al. Isoforms of Bet v 1, the major birch pollen allergen, analyzed by liquid chromatography, mass spectrometry, and cDNA cloning. J Biol Chemistry 1995;270:2607-13.
6. 6. Ferreira F, Hirthenlehner K, Briza P, Breiteneder H, Scheiner O, Kraft D, et al. Isoforms of atopic allergens with reduced allergenicity but conserved T cell antigenicity: possible use for specific immunotherapy. Int Arch Allergy Immunol 1997;113:125-7.
7. 7. Ferreira F, Hirtenlehner K, Jilek A, Godnik-Cvar J, Breiteneder H, Grimm R, et al. Dissection of immunoglobulin E and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: potential use of hypoallergenic isoforms for immunotherapy. J Exp Med 1996;183:599-609.
8. 8. Ferreira FD, Hoffmann-Sommergruber K, Breiteneder H, Pettenburger K, Ebner C, Sommergruber W, et al. Purification and characterization of recomhinant Bet v 1, the major birch pollen allergen: immunological equivalence to natural Bet v 1. J Biol Chem 1993;268:19574-80.
9. 9. Boehm M, Rosch P. Expression in Escherichia coli, purification and spectroscopic characterization of two mutant Bet v 1 proteins. Biol Chem 1997;378:687-95.
10. 10. Ferreira F, Ebner C, Kramer B, Casari G, Briza P, Kungl AJ, et al. Modulation of IgE reactivity of allergens by site-directed mutagenesis: potential use of hypoallergenic variants for immunotherapy. FASEB J 1998;12:231-42.
11. 11. Menz G, Dolecek C, Schönheit-Kenn U, Ferreira F, Moser M, Schneider T, et al. Serological and skin-test diagnosis of birch pollen allergy with recombinant Bet v 1, the major birch pollen allergen. Clin Exp Allergy 1996;26:50-60.
12. 12. Dreborg S. Skin prick test. Allergy 1984;40:55-9.
13. 13. Müller U, Fricker M, Wymann D, Blaser K, Crameri R. Increased specificity of diagnostic tests with recombinant major bee venom allergen phospholipase A2. Clin Exp Allergy 1997;27:915-20.
14. 14. Möller Ch, Björksten B, Nilsson G, Dreborg S. The precision of the conjunctival provocation test. Allergy 1984;39:37-41.
15. 15. Abelson MB, Chambers WA, Smith LM. Conjunctival allergen challenge: a clinical approach to studying allergic conjuctivitis. Arch Ophthalmol 1990;109:84-8.
16. 16. Nyfeler B, Pichler WJ. The lymphocyte transformation test for the diagnosis of drug allergy: sensitivity and specificity. Clin Exp Allergy 1997;27:175-81.
17. 17. Haugaard L, Dahl R, Jacobsen L. A controlled dose-response study of immunotherapy with standardized, partially purified extract of house dust mite: clinical efficacy and side effects. J Allergy Clin Immunol 1993;91:709-42.