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The authors use adoptive transfer to demonstrate that positioning of ThFH cells in locations at the follicular borders required for the effective activation of B cells is caused by a balanced expression of CXCR5 and CCR7, which recruit T cells into B cell follicles or constrains them in the T-cell areas of the lymph node, respectively.
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••] demonstrate that Th17 cells differentiate by use of signaling molecules and transcription factors distinct from those required for Th1/Th2 differentiation. This justifies the recognition of this as the third distinct lineage capable of differentiation directly from naïve CD4 T cells.
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••] demonstrate that Th17 cells differentiate by use of signaling molecules and transcription factors distinct from those required for Th1/Th2 differentiation. This justifies the recognition of this as the third distinct lineage capable of differentiation directly from naïve CD4 T cells.
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The authors demonstrate that Itk phosphorylates T-bet on Tyr525 under Th1 conditions, thus facilitating an interaction between T-bet and GATA3 that diminishes binding of GATA3 to target DNA sequences. This study reveals previously unappreciated direct physical interactions between the Th subset master regulators.
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