Cutting edge: GATA-3-dependent enhancer activity in IL-4 gene regulation

Journal of Immunology

Volumn 161, Issue 8, 1998, Pages 3822-3826

  Ranganath, Sheila ^a   Ouyang, Wenjun ^a   Bhattarcharya, Deepta ^b   Sha, William C ^b   Grupe, Andrew ^c   Peltz, Gary ^c   Murphy, Kenneth M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ROCHE BIOSCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 3; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; GATA3 PROTEIN, HUMAN; GATA3 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; ENHANCER REGION; GENE EXPRESSION REGULATION; GENETIC TRANSDUCTION; HELPER CELL; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RETROVIRUS; TRANSGENIC MOUSE; ANIMAL; GENETICS; HUMAN; IMMUNOLOGY; LEUKEMIA CELL LINE; TH2 CELL;

ANIMALS; DNA-BINDING PROTEINS; ENHANCER ELEMENTS (GENETICS); GATA3 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-4; JURKAT CELLS; MICE; TH2 CELLS; TRANS-ACTIVATORS;

EID: 0032531544     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. + T cells. Annu. Rev. Immunol. 12:635.
2. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of T helper lymphocytes. Nature 383:787.
3. Zheng, W., and R. A. Flavell. 1997. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89:587.
4. Ho, I. C., M. R. Hodge, J. W. Rooney, and L. H. Glimcher. 1996. The protooncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell 85:973.
5. Pandolfi, P. P., M. E. Roth, A. Karis, M. W. Leonard, E. Dzierzak, F. G. Grosveld, J. D. Engel, and M. H. Lindenbaum. 1995. Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis. Nat. Genet. 11:40.
6. Ting, C. N., M. C. Olson, K. P. Barton, and J. M. Leiden. 1996. Transcription factor GATA-3 is required for development of the T-cell lineage. Nature 384: 474.
7. Zhang, D. H., L. Cohn, P. Ray, K. Bottomly, and A. Ray. 1997. Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. J. Biol. Chem. 272:21597.
8. Szabo, S. J., J. S. Gold, T. L. Murphy, and K. M. Murphy. 1993. Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc. Mol. Cell. Biol. 13:4793.
9. Bruhn, K. W., K. Nelms, J. L. Boulay, W. E. Paul, and M. J. Lenardo. 1993. Molecular dissection of the mouse interleukin-4 promoter. Proc. Natl. Acad. Sci. USA 90:9707.
10. Hodge, M. R., J. W. Rooney, and L. H Glimcher. 1995. The proximal promoter of the IL-4 gene is composed of multiple essential regulatory sites that bind at least two distinct factors. J. Immunol. 154:6397.
11. Rooney, J. W., M. R. Hodge, P. G. McCaffrey, A. Rao, and L. H. Glimcher. 1994. A common factor regulates both Th1- and Th2-specific cytokine gene expression. EMBO J. 13:625.
12. Li-Weber, M., A. Eder, H. Krafft-Czepa, and P. H. Krammer. 1992. T cell-specific negative regulation of transcription of the human cytokine IL-4. J. Immunol. 148:1913.
13. Li-Weber, M., H. Krafft, and P. H. Krammer. 1993. A novel enhancer element in the human IL-4 promoter is suppressed by a position-independent silencer. J. Immunol. 151:1371.
14. Henkel, G., and M. A. Brown. 1994. PU. 1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer. Proc. Natl. Acad. Sci. USA 91:7737.
15. Henkel, G., D. L. Weiss, R. McCoy, T. Deloughery, D. Tara, and M. A. Brown. 1992. A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer. J. Immunol. 149:3239.
16. Wenner, C. A., S. J. Szabo, and K. M. Murphy. 1997. Identification of IL-4 promoter elements conferring Th2-restricted expression during T helper cell subset development. J. Immunol. 158:765.
17. Fujita, T., G. P. Nolan, Ghosh S., and D. Baltimore. 1998. Independent modes of transcriptional activation by the p50 and p65 subunits of NF-κB. Genes Dev. 6:775.
18. Pedone, P. V., J. G. Omichinski, P. Nony, C. Trainor, A. M. Gronenborn, G. M. Clore, and G. Felsenfeld. 1997. The N-terminal fingers of chicken GATA-2 and GATA-3 are independent sequence-specific DNA binding domains. EMBO J. 16:2874.
19. Stamatoyannopoulos, J. A., A. Goodwin, T. Joyce, and C. H. Lowrey. 1995. NF-E2 and GATA binding motifs are required for the formation of DNase I hypersensitive site 4 of the human β-globin locus control region. EMBO J. 14:106.
20. Tripp, C. S., M. K. Gately, J. Hakimi, P. Ling, and E. R. Unanue. 1994. Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice: reversal by IFN-γ. J. Immunol. 152:1883.
21. Ohara, J., and W. E. Paul. 1985. Production of a monoclonal antibody to ana molecular characterization of B-cell stimulatory factor-1. Nature 315:333.