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Volumn 19, Issue 2, 2007, Pages 123-128

Early decisions in lymphoid development

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 7; NOTCH1 RECEPTOR; TRANSCRIPTION FACTOR;

EID: 33847678449     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2007.02.007     Document Type: Review
Times cited : (61)

References (51)
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    • Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors
    • This study shows that expression of the macrophage-associated transcription factors C/EBPα and PU.1 in fully committed pre-T cells converts the cells into functional macrophages or myeloid dendritic cells, respectively. The induced differentiation is inhibited by Notch signaling, indicating a reciprocal antagonism between C/EBPα and PU.1 on one hand and activated Notch on the other.
    • Laiosa C.V., Stadtfeld M., Xie H., de Andres-Aguayo L., and Graf T. Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors. Immunity 25 (2006) 731-744. This study shows that expression of the macrophage-associated transcription factors C/EBPα and PU.1 in fully committed pre-T cells converts the cells into functional macrophages or myeloid dendritic cells, respectively. The induced differentiation is inhibited by Notch signaling, indicating a reciprocal antagonism between C/EBPα and PU.1 on one hand and activated Notch on the other.
    • (2006) Immunity , vol.25 , pp. 731-744
    • Laiosa, C.V.1    Stadtfeld, M.2    Xie, H.3    de Andres-Aguayo, L.4    Graf, T.5


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