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Volumn 90, Issue , 2006, Pages 65-81

Mechanisms underlying helminth-induced Th2 polarization: Default, negative or positive pathways?

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; ANTIGEN; CD4 ANTIGEN; CYTOKINE; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR;

EID: 33144468736     PISSN: 16602242     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review
Times cited : (51)

References (66)
  • 1
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL: Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-2357.
    • (1986) J Immunol , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 2
    • 0036885067 scopus 로고    scopus 로고
    • The lineage decisions of helper T cells
    • Murphy KM, Reiner SL: The lineage decisions of helper T cells. Nat Rev Immunol 2002;2:933-944.
    • (2002) Nat Rev Immunol , vol.2 , pp. 933-944
    • Murphy, K.M.1    Reiner, S.L.2
  • 3
    • 0026708718 scopus 로고
    • Regulation of immunity to parasites by T cells and T cell-derived cytokines
    • Sher A, Coffman RL: Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu Rev Immunol 1992;10:385-409.
    • (1992) Annu Rev Immunol , vol.10 , pp. 385-409
    • Sher, A.1    Coffman, R.L.2
  • 4
    • 0028288179 scopus 로고
    • Lymphokine production by human T cells ill disease states
    • Romagnani S: Lymphokine production by human T cells ill disease states. Annu Rev Immunol 1994;12:227-257.
    • (1994) Annu Rev Immunol , vol.12 , pp. 227-257
    • Romagnani, S.1
  • 5
    • 0028065540 scopus 로고
    • Human Th1 and Th2 cells: Functional properties, regulation of development and role in autoimmunity
    • De Carli M, D'Elios MM, Zancuoghi G, Romagnani S, Del Prete G: Human Th1 and Th2 cells: Functional properties, regulation of development and role in autoimmunity. Autoimmunity 1994;18:301-308.
    • (1994) Autoimmunity , vol.18 , pp. 301-308
    • De Carli, M.1    D'Elios, M.M.2    Zancuoghi, G.3    Romagnani, S.4    Del Prete, G.5
  • 6
  • 7
    • 0036636093 scopus 로고    scopus 로고
    • The immunobiology of schistosomiasis
    • Pearce EJ, MacDonald AS: The immunobiology of schistosomiasis. Nat Rev Immunol 2002;2:499-511.
    • (2002) Nat Rev Immunol , vol.2 , pp. 499-511
    • Pearce, E.J.1    MacDonald, A.S.2
  • 11
    • 1642362240 scopus 로고    scopus 로고
    • Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production
    • Voehringer D, Shinkai K, Locksley RM: Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity 2004;20:267-277.
    • (2004) Immunity , vol.20 , pp. 267-277
    • Voehringer, D.1    Shinkai, K.2    Locksley, R.M.3
  • 14
    • 0029826972 scopus 로고    scopus 로고
    • Schistosoma mansoni egg-induced early IL-4 production is dependent upon IL-5 and eosinophils
    • Sabin EA, Kopf MA, Pearce EJ: Schistosoma mansoni egg-induced early IL-4 production is dependent upon IL-5 and eosinophils. J Exp Med 1996;184:1871-1878.
    • (1996) J Exp Med , vol.184 , pp. 1871-1878
    • Sabin, E.A.1    Kopf, M.A.2    Pearce, E.J.3
  • 15
    • 0032983440 scopus 로고    scopus 로고
    • Interleukin 5 (IL-5) is not required for expression of a Th2 response or host resistance mechanisms during murine schistosomiasis mansoni but does play a role in development of IL-4-producing non-T, non-B cells
    • Brunet LR, Sabin EA, Cheever AW, Kopf MA, Pearce EJ: Interleukin 5 (IL-5) is not required for expression of a Th2 response or host resistance mechanisms during murine schistosomiasis mansoni but does play a role in development of IL-4-producing non-T, non-B cells. Infect Immun 1999;67:3014-3018.
    • (1999) Infect Immun , vol.67 , pp. 3014-3018
    • Brunet, L.R.1    Sabin, E.A.2    Cheever, A.W.3    Kopf, M.A.4    Pearce, E.J.5
  • 18
    • 0028346887 scopus 로고
    • Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells
    • Schmitz J, Thiel A, Kuhn R, Rajewsky K, Muller W, Assenmacher M, Radbruch A: Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells. J Exp Med 1994;179:1349-1353.
    • (1994) J Exp Med , vol.179 , pp. 1349-1353
    • Schmitz, J.1    Thiel, A.2    Kuhn, R.3    Rajewsky, K.4    Muller, W.5    Assenmacher, M.6    Radbruch, A.7
  • 20
    • 0034292396 scopus 로고    scopus 로고
    • Conventional, naive CD4+ T cells provide an initial source of very vast IL-4 during Th2 differentiation
    • Noben-Trauth N, Hu-Li J, Paul WE: Conventional, naive CD4+ T cells provide an initial source of very vast IL-4 during Th2 differentiation. J Immunol 2000;165:3620-3625.
    • (2000) J Immunol , vol.165 , pp. 3620-3625
    • Noben-Trauth, N.1    Hu-Li, J.2    Paul, W.E.3
  • 21
    • 0034653932 scopus 로고    scopus 로고
    • Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile
    • Jankovic D, Kullberg MC, Noben-Trauth N, Caspar P, Paul WE, Sher A: Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile. J Immunol 2000;164:3047-3055.
    • (2000) J Immunol , vol.164 , pp. 3047-3055
    • Jankovic, D.1    Kullberg, M.C.2    Noben-Trauth, N.3    Caspar, P.4    Paul, W.E.5    Sher, A.6
  • 22
    • 0033168893 scopus 로고    scopus 로고
    • Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile
    • Jankovic D, Kullberg MC, Noben-Trauth N, Caspar P, Ward JM, Cheever AW, Paul WE, Sher A: Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile. J Immunol 1999;163:337-342.
    • (1999) J Immunol , vol.163 , pp. 337-342
    • Jankovic, D.1    Kullberg, M.C.2    Noben-Trauth, N.3    Caspar, P.4    Ward, J.M.5    Cheever, A.W.6    Paul, W.E.7    Sher, A.8
  • 23
    • 0032145438 scopus 로고    scopus 로고
    • A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5
    • Hogan SP, Matthaei KI, Young JM, Koskinen A, Young IG, Foster PS: A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5. J Immunol 1998;161:1501-1509.
    • (1998) J Immunol , vol.161 , pp. 1501-1509
    • Hogan, S.P.1    Matthaei, K.I.2    Young, J.M.3    Koskinen, A.4    Young, I.G.5    Foster, P.S.6
  • 24
    • 0025133974 scopus 로고
    • Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism
    • Sadick MD, Heinzel FP, Holaday BJ, Pu RT, Dawkins RS, Locksley RM: Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism. J Exp Med 1990;171:115-127.
    • (1990) J Exp Med , vol.171 , pp. 115-127
    • Sadick, M.D.1    Heinzel, F.P.2    Holaday, B.J.3    Pu, R.T.4    Dawkins, R.S.5    Locksley, R.M.6
  • 26
    • 0028069831 scopus 로고
    • IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni
    • Oswald IP, Caspar P, Jankovic D, Wynn TA, Pearce EJ, Sher A: IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni. J Immunol 1994;153:1707-1713.
    • (1994) J Immunol , vol.153 , pp. 1707-1713
    • Oswald, I.P.1    Caspar, P.2    Jankovic, D.3    Wynn, T.A.4    Pearce, E.J.5    Sher, A.6
  • 27
    • 0034660408 scopus 로고    scopus 로고
    • A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells
    • Whelan M, Harnett MM, Houston KM, Patel V, Harnett W, Rigley KP: A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells. J Immunol 2000;164:6453-6460.
    • (2000) J Immunol , vol.164 , pp. 6453-6460
    • Whelan, M.1    Harnett, M.M.2    Houston, K.M.3    Patel, V.4    Harnett, W.5    Rigley, K.P.6
  • 28
    • 0035882012 scopus 로고    scopus 로고
    • - dendritic cell activation status plays an integral role in influencing Th2 response development
    • - dendritic cell activation status plays an integral role in influencing Th2 response development. J Immunol 2001;167:1982-1988.
    • (2001) J Immunol , vol.167 , pp. 1982-1988
    • MacDonald, A.S.1    Straw, A.D.2    Bauman, B.3    Pearce, E.J.4
  • 29
    • 4043140752 scopus 로고    scopus 로고
    • Parasite-induced Th2 polarization is associated with down-regulated dendritic cell responsiveness to Th1 stimuli and a transient delay in T lymphocyte cycling
    • Jankovic D, Kullberg MC, Caspar P, Sher A: Parasite-induced Th2 polarization is associated with down-regulated dendritic cell responsiveness to Th1 stimuli and a transient delay in T lymphocyte cycling. J Immunol 2004;173:2419-2427.
    • (2004) J Immunol , vol.173 , pp. 2419-2427
    • Jankovic, D.1    Kullberg, M.C.2    Caspar, P.3    Sher, A.4
  • 30
    • 0036533626 scopus 로고    scopus 로고
    • Cutting edge: Polarized Th cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cells
    • MacDonald AS, Pearce EJ: Cutting edge: Polarized Th cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cells. J Immunol 2002;168:3127-3130.
    • (2002) J Immunol , vol.168 , pp. 3127-3130
    • MacDonald, A.S.1    Pearce, E.J.2
  • 33
    • 0037083298 scopus 로고    scopus 로고
    • Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse Th cell-polarizing signals
    • de Jong EC, Vieira PL, Kalinski P, Schuitemaker JH, Tanaka Y, Wierenga EA, Yazdanbakhsh M, Kapsenberg ML: Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse Th cell-polarizing signals. J Immunol 2002;168:1704-1709.
    • (2002) J Immunol , vol.168 , pp. 1704-1709
    • De Jong, E.C.1    Vieira, P.L.2    Kalinski, P.3    Schuitemaker, J.H.4    Tanaka, Y.5    Wierenga, E.A.6    Yazdanbakhsh, M.7    Kapsenberg, M.L.8
  • 34
    • 1042290501 scopus 로고    scopus 로고
    • Activation of dendritic cells: Translating innate into adaptive immunity
    • Reis e Sousa C: Activation of dendritic cells: Translating innate into adaptive immunity. Curr Opin Immunol 2004;16:21-25.
    • (2004) Curr Opin Immunol , vol.16 , pp. 21-25
    • Reis E Sousa, C.1
  • 35
    • 0038342438 scopus 로고    scopus 로고
    • Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites
    • Chaussabel D, Semnani RT, McDowell MA, Sacks D, Sher A, Nutman TB: Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites. Blood 2003;102:672-681.
    • (2003) Blood , vol.102 , pp. 672-681
    • Chaussabel, D.1    Semnani, R.T.2    McDowell, M.A.3    Sacks, D.4    Sher, A.5    Nutman, T.B.6
  • 37
    • 9244249137 scopus 로고    scopus 로고
    • Selective maturation of dendritic cells by Nippostrongylus brasiliensis-secreted proteins drives Th2 immune responses
    • Balic A, Harcus Y, Holland MJ, Maizels RM: Selective maturation of dendritic cells by Nippostrongylus brasiliensis-secreted proteins drives Th2 immune responses. Eur J Immunol 2004;34:3047-3059.
    • (2004) Eur J Immunol , vol.34 , pp. 3047-3059
    • Balic, A.1    Harcus, Y.2    Holland, M.J.3    Maizels, R.M.4
  • 40
    • 2442615981 scopus 로고    scopus 로고
    • Filaria-induced immune evasion: Suppression by the infective stage of Brugia malayi at the earliest host-parasite interface
    • Semnani RT, Law M, Kubofcik J, Nutman TB: Filaria-induced immune evasion: Suppression by the infective stage of Brugia malayi at the earliest host-parasite interface. J Immunol 2004;172:6229-6238.
    • (2004) J Immunol , vol.172 , pp. 6229-6238
    • Semnani, R.T.1    Law, M.2    Kubofcik, J.3    Nutman, T.B.4
  • 42
    • 0030809617 scopus 로고    scopus 로고
    • Dendritic cells, obtained from peripheral blood precursors in the presence of PGE2, promote Th2 responses
    • Kalinski P, Hilkens CM, Snijders A, Snijdewint FG, Kapsenberg ML: Dendritic cells, obtained from peripheral blood precursors in the presence of PGE2, promote Th2 responses. Adv Exp Med Biol 1997;417:363-367.
    • (1997) Adv Exp Med Biol , vol.417 , pp. 363-367
    • Kalinski, P.1    Hilkens, C.M.2    Snijders, A.3    Snijdewint, F.G.4    Kapsenberg, M.L.5
  • 43
    • 0036413568 scopus 로고    scopus 로고
    • The proteolytic activity of the major dust mite allergen Der p 1 conditions dendritic cells to produce less interleukin-12: Allergen-induced Th2 bias determined at the dendritic cell level
    • Ghaemmaghami AM, Gough L, Sewell HF, Shakib F: The proteolytic activity of the major dust mite allergen Der p 1 conditions dendritic cells to produce less interleukin-12: Allergen-induced Th2 bias determined at the dendritic cell level. Clin Exp Allergy 2002;32:1468-1475.
    • (2002) Clin Exp Allergy , vol.32 , pp. 1468-1475
    • Ghaemmaghami, A.M.1    Gough, L.2    Sewell, H.F.3    Shakib, F.4
  • 44
  • 45
    • 0037080199 scopus 로고    scopus 로고
    • Cutting edge: Th2 response induction by dendritic cells: A role for CD40
    • MacDonald AS, Straw AD, Dalton NM, Pearce EJ: Cutting edge: Th2 response induction by dendritic cells: A role for CD40. J Immunol 2002;168:537-540.
    • (2002) J Immunol , vol.168 , pp. 537-540
    • MacDonald, A.S.1    Straw, A.D.2    Dalton, N.M.3    Pearce, E.J.4
  • 46
    • 0036569444 scopus 로고    scopus 로고
    • Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interaction
    • MacDonald AS, Patton EA, La Flamme AC, Araujo MI, Huxtable CR, Bauman B, Pearce EJ: Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interaction. J Immunol 2002;168:4643-4649.
    • (2002) J Immunol , vol.168 , pp. 4643-4649
    • MacDonald, A.S.1    Patton, E.A.2    La Flamme, A.C.3    Araujo, M.I.4    Huxtable, C.R.5    Bauman, B.6    Pearce, E.J.7
  • 48
    • 0344153910 scopus 로고    scopus 로고
    • Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-like receptor 4-dependent mechanism
    • Thomas PG, Carter MR, Atochina O, Da'Dara AA, Piskorska D, McGuire E, Harn DA: Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-like receptor 4-dependent mechanism. J Immunol 2003;171:5837-5841.
    • (2003) J Immunol , vol.171 , pp. 5837-5841
    • Thomas, P.G.1    Carter, M.R.2    Atochina, O.3    Da'Dara, A.A.4    Piskorska, D.5    McGuire, E.6    Harn, D.A.7
  • 49
    • 4043082787 scopus 로고    scopus 로고
    • Molecular basis of the differences in binding properties of the highly related C-type lectins DC-SIGN and L-SIGN to Lewis X trisaccharide and Schistosoma mansoni egg antigens
    • Van Liempt E, Imberty A, Bank CM, Van Vliet SJ, Van Kooyk Y, Geijtenbeek TB, Van Die I: Molecular basis of the differences in binding properties of the highly related C-type lectins DC-SIGN and L-SIGN to Lewis X trisaccharide and Schistosoma mansoni egg antigens. J Biol Chem 2004;279:33161-33167.
    • (2004) J Biol Chem , vol.279 , pp. 33161-33167
    • Van Liempt, E.1    Imberty, A.2    Bank, C.M.3    Van Vliet, S.J.4    Van Kooyk, Y.5    Geijtenbeek, T.B.6    Van Die, I.7
  • 50
    • 0037121946 scopus 로고    scopus 로고
    • Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen
    • Eisenbarth SC, Piggott DA, Huleatt JW, Visintin I, Herrick CA, Bottomly K: Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med 2002;196:1645-1651.
    • (2002) J Exp Med , vol.196 , pp. 1645-1651
    • Eisenbarth, S.C.1    Piggott, D.A.2    Huleatt, J.W.3    Visintin, I.4    Herrick, C.A.5    Bottomly, K.6
  • 54
    • 0035500862 scopus 로고    scopus 로고
    • Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo
    • Pulendran B, Kumar P, Cutler CW, Mohamadzadeh M, Van Dyke T, Banchereau J: Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J Immunol 2001;167:5067-5076.
    • (2001) J Immunol , vol.167 , pp. 5067-5076
    • Pulendran, B.1    Kumar, P.2    Cutler, C.W.3    Mohamadzadeh, M.4    Van Dyke, T.5    Banchereau, J.6
  • 56
    • 2342496710 scopus 로고    scopus 로고
    • Instruction of distinct CD4 T helper cell fates by different Notch ligands on antigen-presenting cells
    • Amsen D, Blander JM, Lee GR, Tanigaki K, Honjo T, Flavell RA: Instruction of distinct CD4 T helper cell fates by different Notch ligands on antigen-presenting cells. Cell 2004;117:515-526.
    • (2004) Cell , vol.117 , pp. 515-526
    • Amsen, D.1    Blander, J.M.2    Lee, G.R.3    Tanigaki, K.4    Honjo, T.5    Flavell, R.A.6
  • 57
    • 0037868111 scopus 로고    scopus 로고
    • Investigating the impact of helminth products on immune responsiveness using a TCR transgenic adoptive transfer system
    • Boitelle A, Scales HE, Di Lorenzo C, Devaney E, Kennedy MW, Garside P, Lawrence CE: Investigating the impact of helminth products on immune responsiveness using a TCR transgenic adoptive transfer system. J Immunol 2003;171:447-454.
    • (2003) J Immunol , vol.171 , pp. 447-454
    • Boitelle, A.1    Scales, H.E.2    Di Lorenzo, C.3    Devaney, E.4    Kennedy, M.W.5    Garside, P.6    Lawrence, C.E.7
  • 58
    • 0034618067 scopus 로고    scopus 로고
    • Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors. Role of stimulator/responder ratio
    • Tanaka H, Demeure CE, Rubio M, Delespesse G, Sarfati M: Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors. Role of stimulator/responder ratio. J Exp Med 2000;192:405-412.
    • (2000) J Exp Med , vol.192 , pp. 405-412
    • Tanaka, H.1    Demeure, C.E.2    Rubio, M.3    Delespesse, G.4    Sarfati, M.5
  • 59
    • 0037237628 scopus 로고    scopus 로고
    • Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: Dependency on antigen dose and differential toll-like receptor ligation
    • Boonstra A, Asselin-Paturel C, Gilliet M, Crain C, Trinchieri G, Liu YJ, O'Garra A: Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: Dependency on antigen dose and differential toll-like receptor ligation. J Exp Med 2003;197:101-109.
    • (2003) J Exp Med , vol.197 , pp. 101-109
    • Boonstra, A.1    Asselin-Paturel, C.2    Gilliet, M.3    Crain, C.4    Trinchieri, G.5    Liu, Y.J.6    O'Garra, A.7
  • 61
    • 0038638583 scopus 로고    scopus 로고
    • An epigenetic view of helper T cell differentiation
    • Ansel KM, Lee DU, Rao A: An epigenetic view of helper T cell differentiation. Nat Immunol 2003;4:616-623.
    • (2003) Nat Immunol , vol.4 , pp. 616-623
    • Ansel, K.M.1    Lee, D.U.2    Rao, A.3
  • 63
    • 9644262463 scopus 로고    scopus 로고
    • Signaling pathways in Th2 development
    • Mowen KA, Glimcher LH: Signaling pathways in Th2 development. Immunol Rev 2004;202:203-222.
    • (2004) Immunol Rev , vol.202 , pp. 203-222
    • Mowen, K.A.1    Glimcher, L.H.2
  • 64
    • 12344269852 scopus 로고    scopus 로고
    • T helper cell fate specified by kinase-mediated interaction of T-bet with GALA-3
    • Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH: T helper cell fate specified by kinase-mediated interaction of T-bet with GALA-3. Science 2005;307:430-433.
    • (2005) Science , vol.307 , pp. 430-433
    • Hwang, E.S.1    Szabo, S.J.2    Schwartzberg, P.L.3    Glimcher, L.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.