Ligand-directed functional heterogeneity of histamine H1 receptors: Novel dual-function ligands selectively activate and block H 1-mediated phospholipase C and adenylyl cyclase signaling

Journal of Pharmacology and Experimental Therapeutics

Volumn 311, Issue 1, 2004, Pages 274-281

  Moniri, Nader H ^a   Covington Strachan, Dawn ^a   Booth, Raymond G ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 PHENYL 3 DIMETHYLAMINO 1,2,3,4 TETRAHYDRONAPHTHALENE; 5 PHENYL 7 DIMETHYLAMINO 5,6,7,8 TETRAHYDRO 9H BENZOCYCLOHEPTANE; ADENYLATE CYCLASE; COMPLEMENTARY DNA; CYCLIC AMP; HISTAMINE H1 RECEPTOR; HISTAMINERGIC RECEPTOR AFFECTING AGENT; LIGAND; MEPYRAMINE; PHOSPHOLIPASE C; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING ASSAY; CARDIOVASCULAR SYSTEM; CELL LINE; CHO CELL; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DESIGN; ENZYME ACTIVATION; ENZYME INHIBITION; GASTROINTESTINAL TRACT; GENETIC TRANSFECTION; GUINEA PIG; LIGAND BINDING; MAMMAL CELL; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY; RESPIRATORY SYSTEM; SIGNAL TRANSDUCTION; STEREOCHEMISTRY;

ADENYLATE CYCLASE; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; CYCLIC AMP; FEMALE; HISTAMINE H1 ANTAGONISTS; PHOSPHOLIPASE C; PYRILAMINE; RADIOLIGAND ASSAY; RECEPTORS, HISTAMINE H1; SIGNAL TRANSDUCTION;

EID: 4644266968     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.070086     Document Type: Article

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