Building better mouse models of asthma

Current Allergy and Asthma Reports

Volumn 7, Issue 3, 2007, Pages 231-236

  Lloyd, Clare M ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; ALUMINUM HYDROXIDE; ALUMINUM POTASSIUM SULFATE; CYTOKINE; EOTAXIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 11; INTERLEUKIN 13; INTERLEUKIN 5; INTERLEUKIN 9; OVALBUMIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; VASCULOTROPIN;

ALLERGIC ASTHMA; CHEMOSENSITIZATION; CYTOKINE PRODUCTION; DERMATOPHAGOIDES; EOSINOPHIL; EXPERIMENTAL MODEL; GENE OVEREXPRESSION; HUMAN; LUNG FUNCTION; LUNG INJURY; LUNG STRUCTURE; MAST CELL; NONHUMAN; PATHOGENESIS; PHENOTYPE; PROTEIN EXPRESSION; RESPIRATORY TRACT INFLAMMATION; REVIEW; TH2 CELL; TRANSGENIC MOUSE;

EID: 34249025784     PISSN: 15297322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11882-007-0077-0     Document Type: Review

References (39)

1. Lloyd CM, Gonzalo JA, Coyle AJ, Gutierrez-Ramos JC: Mouse models of allergic airway disease. Adv Immunol 2001, 77:263-295.
2. Elias J: The relationship between asthma and COPD: lessons from transgenic mice. Chest 2004, 126:111S-116S.
3. Lee JJ, McGarry MP, Farmer SC, et al.: Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. J Exp Med 1997, 185:2143-2156.
4. Zhu Z, Homer RJ, Wang Z, et al.: Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999, 103:779-788.
5. Temann UA, Geba GP, Rankin JA, Flavell RA: Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness. J Exp Med 1998, 188:1307-1320.
6. Tang W, Geba GP, Zheng T, et al.: Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction. J Clin Invest 1996, 98:2845-2853.
7. Ray P, Tang W, Wang P, et al.: Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes. J Clin Invest 1997, 100:2501-2511.
8. Lee CG, Link H, Baluk P, et al.: Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med 2004, 10:1095-1103.
9. Zhu Z, Zheng T, Lee CG, et al.: Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling. Semin Cell Dev Biol 2002, 13:121-128.
10. Lee CG, Kang HR, Homer RJ, et al.: Transgenic modeling of transforming growth factor-1: role of apoptosis in fibrosis and alveolar remodeling. Proc Am Thorac Soc 2006, 3:418-423.
11. Finotto S, Neurath MF, Glickman JN, et al.: Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 2002, 295:336-338.
12. Temelkovski J, Hogan SP, Shepherd DP, et al.: An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen. Thorax 1998, 53:849-856.
13. McMillan S, Lloyd C: Prolonged allergen challenge in mice leads to persistent airway remodeling. Clin Exp Allergy 2004, 34:497-507.
14. Henderson WRJ, Tang LO, Chu SJ, et al.: A role for cystemyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med 2002, 165:108-116.
15. Leigh R, Ellis R, Wattie J, et al.: Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation. Am J Respir Cell Mol Biol 2002, 27:526-535.
16. Cho JY, Miller M, Back KJ, et al.: Inhibition of airway remodeling in IL-5-deficient mice. J Clin invest 2004, 113:551-560.
17. Kumar RK, Herbert C, Yang M, et al.: Role of interleukin-13 in eosinophil accumulation and airway remodeling in a mouse model of chronic asthma. Clin Exp Allergy 2002, 32:1104-1111.
18. Foster PS, Webb DC, Yang M, et al.: Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthma. Clin Exp Allergy 2003, 33:688-695.
19. Yang C, Li L, Volk A, et al.: Therapeutic dosing with anti-interleukin-13 monoclonal antibody inhibits asthma progression in mice. J Pharmacol Exp Ther 2005, 313:8-15.
20. Kumar RK, Herbert C, Webb DC, et al.: Effects of anticytokine therapy in a mouse model of chronic asthma. Am J Respir Crit Care Med 2004, 170:1043-1048.
21. Humbles AA, Lloyd CM, McMillan SJ, et al.: A critical role for eosinophils in allergic airways remodeling. Science 2004, 305:1776-1779.
22. Ikeda RK, Miller M, Nayar J, et al.: Accumulation of peribronchial mast cells in a mouse model of ovalbumin allergen induced chronic airway inflammation: modulation by immunostimulatory DNA sequences. J Immunol 2003, 171:4860-4867.
23. Kumar RK, Herbert C, Kasper M: Reversibility of airway inflammation and remodeling following cessation of antigenic challenge in a model of chronic asthma. Clin Exp Allergy 2004, 34:1796-1802.
24. Wegmann M, Fehrenbach H, Fehrenbach A, et al.: Involvement of distal airways in a chronic model of experimental asthma. Clin Expl Allergy 2005, 35:1263-1274.
25. Henderson WR Jr, Lewis DD, Albert RK, et al.: The importance of leukotrienes in airway inflammation in a mouse model of asthma. J Exp Med 1996, 184:1483-1494.
26. Tanaka H, Masuda T, Tokuoka S, et al.: The effect of allergen-induced airway inflammation on airway remodeling in a murine model of allergic asthma. Inflamm Res 2001, 50:616-624.
27. Johnson JR, Wiley RE, Fattouh R, et al.: Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling. Am J Respir Crit Care Med 2004, 169:378-385.
28. Leigh R, Ellis R, Wattie JN, et al.: Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodeling in mice. Am J Respir Crit Care Med 2004, 169:860-867.
29. Masuda T, Tanaka H, Komai M, et al.: Mast cells play a partial role in allergen-induced subepithelial fibrosis in a murine model of allergic asthma. Clin Exp Allergy 2003, 33:705-713.
30. McMillan SJ, Xanthou C, Lloyd CM: Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-β antibody: effect on the SMAD signaling pathway. J Immunol 2005, 174:5774-5780.
31. Broide DH, Lawrence T, Doherty T, et al.: Allergen-induced peribronchial fibrosis and mucus production mediated by I B kinase beta-dependent genes in airway epithelium. Proc Natl Acad Sci U S A 2005, 102:17723-17728.
32. McMillan SJ, Xanthou C, Lloyd CM: Therapeutic administration of Budesonide ameliorates allergen-induced airway remodeling. Clin Exp Allergy 2005, 35:388-396.
33. McMenamin C, Holt PG: The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production. J Exp Med 1993, 178:889-899.
34. McMenamin C, Pimm C, McKersey M, Holt PG: Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cells. Science 1994, 265:1869-1871.
35. van Halteren AG, van der Cammen MJ, Cooper D, et al.: Regulation of antigen-specific IgE, IgG1, and mast cell responses to ingested allergen by mucosal tolerance induction. J Immunol 1997, 159:3009-3015.
36. Stampfli MR, Wiley RE, Neigh GS, et al.: GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice. J Clin Invest 1998, 102:1704-1714.
37. Shinagawa K, Kojima M: Mouse model of airway remodeling: strain differences. Am J Respir Crit Care Med 2003, 168:959-967.
38. Cates EC, Fattouh R, Wattie J, et al.: Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GM-CSF-mediated mechanism. J Immunol 2004, 173:6384-6392.
39. Fattouh R, Pouladi MA, Alvarez D, et al.: House dust mite facilitates ovalbumin-specific allergic sensitization and airway inflammation. Am J Respir Crit Care Med 2005, 172:314-321.