Constitutive activity of G protein coupled receptors and drug action

Pharmaceutica Acta Helvetiae

Volumn 74, Issue 2-3, 2000, Pages 327-331

  Leurs, Rob ^a   Pena, Maria Sol Rodriguez ^a   Bakker, Remko A ^a   Alewijnse, Astrid E ^a   Timmerman, Henk ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Autoantibodies; Constitutive activity; Disease; Drug design; G protein coupled receptor (GPCR); Inverse agonist; Neutral antagonist

Indexed keywords

ADENYLATE CYCLASE; BETA 2 ADRENERGIC RECEPTOR; BURIMAMIDE; CIMETIDINE; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; HISTAMINE; HISTAMINE H1 RECEPTOR; HISTAMINE H2 RECEPTOR; MEPYRAMINE;

CONFERENCE PAPER; CONFORMATIONAL TRANSITION; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ANIMALS; GTP-BINDING PROTEINS; HUMANS; RECEPTORS, CELL SURFACE; RECEPTORS, CHEMOKINE;

EID: 0034028073     PISSN: 00316865     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-6865(99)00042-4     Document Type: Conference Paper

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