Constitutive Activity of the Serotonin2C Receptor Inhibits In Vivo Dopamine Release in the Rat Striatum and Nucleus Accumbens

Journal of Neuroscience

Volumn 24, Issue 13, 2004, Pages 3235-3241

  De Deurwaerdère, Philippe ^a   Navailles, Sylvia ^a   Berg, Kelly A ^b   Clarke, William P ^b   Spampinato, Umberto ^a  

^a CNRS   (France)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

5 HT2C receptor; Constitutive activity; DA release; Nucleus accumbens; Rat; Striatum

Indexed keywords

1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; 2 (6 CHLORO 5 FLUORO 1 INDOLYL) 1 METHYLETHYLAMINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 5,7 DIHYDROXYTRYPTAMINE; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; ARACHIDONIC ACID; DOPAMINE; G PROTEIN COUPLED RECEPTOR; INOSITOL PHOSPHATE; LIGAND; SEROTONIN; SEROTONIN 2C RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHO CELL; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

5,7-DIHYDROXYTRYPTAMINE; AMINOPYRIDINES; ANIMALS; CHO CELLS; CRICETINAE; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLAMINES; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; INDOLES; LIGANDS; MALE; MICRODIALYSIS; NEOSTRIATUM; NEURAL INHIBITION; NEURAL PATHWAYS; NUCLEUS ACCUMBENS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2C; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 1842610940     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0112-04.2004     Document Type: Article

References (45)

1. Andersson JL, Nomikos GG, Marcus M, Hertel P, Mathe JM, Svensson TH (1995) Ritanserin potentiates the stimulatory effects of raclopride on neuronal activity and dopamine release selectivity in the mesolimbic dopaminergic system. Naunyn Schmiedebergs Arch Pharmacol 352:374-385.
2. Barker EL, Westphal RS, Schmidt D, Sanders-Bush E (1994) Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands. J Biol Chem 269:11687-11690.
3. Barnes NM, Sharp T (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38:1083-1152.
4. Baumgarten HC, Bjorklund A, Lackenmayer L, Nobin A (1973) Evaluation of the effects of 5,7-dihydroxytryptamine on serotonin and catecholamine neurones in the rat CNS. Acta Physiol Scand 391:1-19.
5. 2C receptor agonists. Ann NY Acad Sci 861:104-110.
6. 2C receptor systems. Mol Pharmacol 55:863-872.
7. Burns CM, Chu H, Reuter SM, Hutchinson LK, Canton H, Sanders-Bush E, Emeson RB (1997) Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature 387:303-308.
8. Clarke WP, Bond RA (1998) The elusive nature of intrinsic efficacy. Trends Pharmacol Sci 19:270-276.
9. De Deurwaerdère P, Chesselet M-F (2000) Nigrostriatal lesions alter oral dyskinesia and c-Fos expression induced by the serotonin agonist 1-(m-chlorophenyl)piperazine in adult rats. J Neurosci 20:5170-5178.
10. 2C receptors. Trends Pharmacol Sci 22:502-504.
11. 3 receptors. J Neurosci 18:6528-6538.
12. Di Chiara G (2002) Nucleus accumbens shell and core dopamine: differential role in behavior and addiction. Behav Brain Res 137:75-114.
13. Di Giovanni G, De Deurwaerdère P, Di Mascio M, Di Matteo V, Esposito E, Spampinato U (1999) Selective blockade of serotonin-2C/2B receptors enhances mesolimbic and mesostriatal dopaminergic function: a combined in vivo electrophysiological and microdialysis study. Neuroscience 91:587-597.
14. 2C receptors in the control of central dopamine function. Trends Pharmacol Sci 22:229-232.
15. Dunnett SB, Robbins TW (1992) The functional role of mesotelencephalic dopamine systems. Biol Rev Camb Philos Soc 67:491-518.
16. Eberle-Wang K, Mikeladze Z, Uryu K, Chesselet MF (1997) Pattern of expression of the serotonin2C receptor messenger RNA in the basal ganglia of adult rats. J Comp Neurol 384:233-247.
17. Evans KL, Cropper JD, Berg KA, Clarke WP (2001) Visualizing differences in ligand-induced beta-arrestin-GFP interactions and trafficking between three recently characterized G protein-coupled receptors. J Pharmacol Exp Ther 297:1025-1035.
18. 2C receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: a combined dialysis and electrophysiological analysis in the rat. Synapse 36:205-221.
19. Grottick AJ, Fletcher PJ, Higgins GA (2000) Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior. J Pharmacol Exp Ther 295:1183-1191.
20. Harvey JA, Welsh SE, Hood H, Romano AG (1999) Effect of 5-HT2 receptor antagonists on a cranial nerve reflex in the rabbit: evidence for inverse agonism. Psychopharmacology 141:162-168.
21. 2C receptor RNA editing alters receptor basal activity: implications for serotonergic signal transduction. J Neurochem 73:1711-1717.
22. Kapur S, Remington G (1996) Serotonin-dopamine interaction and its relevance to schizophrenia. Am J Psychiatry 153:466-476.
23. Kenakin T (1995) Agonist-receptor efficacy II: agonist trafficking of receptor signals. Trends Pharmacol Sci 16:232-238.
24. Kenakin T (2001) Inverse, protean, and ligand-selective agonism: matters of receptor conformation. FASEB J 15:598-611.
25. 2B receptor antagonist with anxiolytic-like properties. Br J Pharmacol 117:427-434.
26. 2C receptor antagonist. Neuropharmacology 36:609-620.
27. Kirby LG, Kreiss DS, Singh A, Lucki I (1995) Effect of destruction of serotonin neurons on basal and fenfluramine-induced serotonin release in striatum. Synapse 20:99-105.
28. Lefkowitz RJ, Cotecchia S, Samama P, Costa T (1993) Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. Trends Pharmacol Sci 14:303-307.
29. 2C receptor agonists: pharmacological characteristics and therapeutic potential. J Pharmacol Exp Ther 286:913-924.
30. Meltzer HY (1999) The role of serotonin in antipsychotic drug action. Neuropsychopharmacology 21:106S-115S.
31. Morisset S, Rouleau A, Ligneau X, Gbahou F, Tardivel-Lacombe J, Stark H, Schunack W, Ganellin CR, Schwartz J-C, Arrang J-M (2000) High constitutive activity of native H3 receptors regulates histamine neurons in brain. Nature 408:860-864.
32. Niswender CM, Copeland SC, Herrick-Davis K, Emeson RB, Sanders-Bush E (1999) RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity. J Biol Chem 274:9472-9478.
33. 2C receptor alterations in suicide and implications for serotonergic pharmacotherapy. Neuropsychopharmacology 24:478-491.
34. Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. New York: Academic.
35. Pellegrino LJ, Cushman AJ (1967) A stereotaxic atlas of the rat brain. New York: Meredith.
36. 2C/2B receptor subtypes modulate dopamine release induced in vivo by amphetamine and morphine in both the rat nucleus accumbens and striatum. Neuropsychopharmacology 26:311-324.
37. 2C receptor alters receptor-mediated activation of G13 protein. J Biol Chem 276:44663-44668.
38. Rauser L, Savage JE, Meltzer HY, Roth BL (2001) Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor. J Pharmacol Exp Ther 299:83-89.
39. Rocha BA, Goulding EH, O'Dell LE, Mead AN, Coufal NG, Parsons LH, Tecott LH (2002) Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice. J Neurosci 22:10039-10045.
40. Sharp T, Bramwell SR, Clark D, Grahame-Smith DG (1989a) In vivo measurement of extracellular 5-hydroxytryptamine in hippocampus of the anesthetized rat using microdialysis: changes in relation to 5-hydroxytryptaminergic neuronal activity. J Neurochem 53:234-240.
41. Sharp T, Bramwell SR, Grahame-Smith DG (1989b) 5-HT1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis. Br J Pharmacol 96:283-290.
42. Soubrié P, Reisine TD, Glowinski J (1984) Functional aspects of serotonin transmission in the basal ganglia: a review and in vivo approach using the push-pull cannula technique. Neuroscience 13:605-625.
43. Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF, Julius D (1995) Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors. Nature 374:542-546.
44. 2C agonists selectively inhibit morphine-induced dopamine efflux in the nucleus accumbens. Brain Res 781:291-299.
45. Wood MD, Heidbreder C, Reavill C, Ashby Jr CR, Middlemiss DN (2001) 5-HT2C receptor antagonists: potential in schizophrenia. Drug Dev Res 54:88-94.