메뉴 건너뛰기




Volumn 116, Issue 3, 2005, Pages 477-486

Airway remodeling contributes to the progressive loss of lung function in asthma: An overview

Author keywords

Airway; Asthma; Inflammation; Remodeling

Indexed keywords

CD4 ANTIGEN;

EID: 24644520068     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2005.07.011     Document Type: Review
Times cited : (298)

References (87)
  • 2
    • 0033432660 scopus 로고    scopus 로고
    • Risk factors for growth and decline of lung function in asthmatic individuals up to age 42 years. a 30-year follow-up study
    • M.H. Grol, J. Gerritsen, J.M. Vonk, J.P. Schouten, G.H. Koeter, and B. Rijcken Risk factors for growth and decline of lung function in asthmatic individuals up to age 42 years. A 30-year follow-up study Am J Respir Crit Care Med 160 1999 1830 1837
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1830-1837
    • Grol, M.H.1    Gerritsen, J.2    Vonk, J.M.3    Schouten, J.P.4    Koeter, G.H.5    Rijcken, B.6
  • 3
    • 0032558685 scopus 로고    scopus 로고
    • A 15-year follow-up study of ventilatory function in adults with asthma
    • P. Lange, J. Parner, J. Vestbo, P. Schnohr, and G. Jensen A 15-year follow-up study of ventilatory function in adults with asthma N Engl J Med 339 1998 1194 1200
    • (1998) N Engl J Med , vol.339 , pp. 1194-1200
    • Lange, P.1    Parner, J.2    Vestbo, J.3    Schnohr, P.4    Jensen, G.5
  • 4
    • 4143109103 scopus 로고    scopus 로고
    • Similarities and differences in asthma and COPD. the Dutch hypothesis
    • E.R. Bleecker Similarities and differences in asthma and COPD. The Dutch hypothesis Chest 126 suppl 2004 93S 95S
    • (2004) Chest , vol.126 , Issue.SUPPL.
    • Bleecker, E.R.1
  • 6
    • 0024828192 scopus 로고
    • Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity
    • P.K. Jeffery, A.J. Wardlaw, F.C. Nelson, J.V. Collins, and A.B. Kay Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity Am Rev Respir Dis 140 1989 1745 1753
    • (1989) Am Rev Respir Dis , vol.140 , pp. 1745-1753
    • Jeffery, P.K.1    Wardlaw, A.J.2    Nelson, F.C.3    Collins, J.V.4    Kay, A.B.5
  • 7
    • 0035891664 scopus 로고    scopus 로고
    • Remodeling in asthma and chronic obstructive lung disease
    • P.K. Jeffery Remodeling in asthma and chronic obstructive lung disease Am J Respir Crit Care Med 164 suppl 2001 S28 S38
    • (2001) Am J Respir Crit Care Med , vol.164 , Issue.SUPPL.
    • Jeffery, P.K.1
  • 8
    • 0031052842 scopus 로고    scopus 로고
    • Kinetics of the development and recovery of the lung from IgE-mediated inflammation: Dissociation of pulmonary eosinophilia, lung injury, and eosinophil-active cytokines
    • J.R. Shaver, J.G. Zangrilli, S.K. Cho, R.A. Cirelli, M. Pollice, and A.T. Hastie Kinetics of the development and recovery of the lung from IgE-mediated inflammation: dissociation of pulmonary eosinophilia, lung injury, and eosinophil-active cytokines Am J Respir Crit Care Med 155 1997 442 448
    • (1997) Am J Respir Crit Care Med , vol.155 , pp. 442-448
    • Shaver, J.R.1    Zangrilli, J.G.2    Cho, S.K.3    Cirelli, R.A.4    Pollice, M.5    Hastie, A.T.6
  • 9
    • 1642372399 scopus 로고    scopus 로고
    • Prolonged allergen challenge in mice leads to persistent airway remodelling
    • S.J. McMillan, and C.M. Lloyd Prolonged allergen challenge in mice leads to persistent airway remodelling Clin Exp Allergy 34 2004 497 507
    • (2004) Clin Exp Allergy , vol.34 , pp. 497-507
    • McMillan, S.J.1    Lloyd, C.M.2
  • 10
    • 0027181166 scopus 로고
    • Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. a 3-D morphometric study
    • M. Ebina, T. Takahashi, T. Chiba, and M. Motomiya Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study Am Rev Respir Dis 148 1993 720 726
    • (1993) Am Rev Respir Dis , vol.148 , pp. 720-726
    • Ebina, M.1    Takahashi, T.2    Chiba, T.3    Motomiya, M.4
  • 11
    • 0027365905 scopus 로고
    • Small airways dimensions in asthma and in chronic obstructive pulmonary disease
    • K. Kuwano, C.H. Bosken, P.D. Pare, T.R. Bai, B.R. Wiggs, and J.C. Hogg Small airways dimensions in asthma and in chronic obstructive pulmonary disease Am Rev Respir Dis 148 1993 1220 1225
    • (1993) Am Rev Respir Dis , vol.148 , pp. 1220-1225
    • Kuwano, K.1    Bosken, C.H.2    Pare, P.D.3    Bai, T.R.4    Wiggs, B.R.5    Hogg, J.C.6
  • 14
    • 0035185240 scopus 로고    scopus 로고
    • Effects of growth factors and extracellular matrix on survival of human airway smooth muscle cells
    • A.M. Freyer, S.R. Johnson, and I.P. Hall Effects of growth factors and extracellular matrix on survival of human airway smooth muscle cells Am J Respir Cell Mol Biol 25 2001 569 576
    • (2001) Am J Respir Cell Mol Biol , vol.25 , pp. 569-576
    • Freyer, A.M.1    Johnson, S.R.2    Hall, I.P.3
  • 15
    • 0033791846 scopus 로고    scopus 로고
    • Regulation of cyclin D(1) expression and DNA synthesis by phosphatidylinositol 3-kinase in airway smooth muscle cells
    • K. Page, J. Li, Y. Wang, S. Kartha, R.G. Pestell, and M.B. Hershenson Regulation of cyclin D(1) expression and DNA synthesis by phosphatidylinositol 3-kinase in airway smooth muscle cells Am J Respir Cell Mol Biol 23 2000 436 443
    • (2000) Am J Respir Cell Mol Biol , vol.23 , pp. 436-443
    • Page, K.1    Li, J.2    Wang, Y.3    Kartha, S.4    Pestell, R.G.5    Hershenson, M.B.6
  • 17
    • 0033787918 scopus 로고    scopus 로고
    • Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle
    • V.P. Krymskaya, M.J. Orsini, A.J. Eszterhas, K.C. Brodbeck, J.L. Benovic, and R.A. Panettieri Jr. Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle Am J Respir Cell Mol Biol 23 2000 546 554
    • (2000) Am J Respir Cell Mol Biol , vol.23 , pp. 546-554
    • Krymskaya, V.P.1    Orsini, M.J.2    Eszterhas, A.J.3    Brodbeck, K.C.4    Benovic, J.L.5    Panettieri Jr., R.A.6
  • 18
    • 0028812421 scopus 로고
    • VIP inhibits basal and histamine-stimulated proliferation of human airway smooth muscle cells
    • K. Maruno, A. Absood, and S.I. Said VIP inhibits basal and histamine-stimulated proliferation of human airway smooth muscle cells Am J Physiol Lung Cell Mol Physiol 268 1995 L1047 L1051
    • (1995) Am J Physiol Lung Cell Mol Physiol , vol.268
    • Maruno, K.1    Absood, A.2    Said, S.I.3
  • 20
    • 85047694597 scopus 로고    scopus 로고
    • Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox
    • D.W. McGraw, K.F. Almoosa, R.J. Paul, B.K. Kobilka, and S.B. Liggett Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox J Clin Invest 112 2003 619 626
    • (2003) J Clin Invest , vol.112 , pp. 619-626
    • McGraw, D.W.1    Almoosa, K.F.2    Paul, R.J.3    Kobilka, B.K.4    Liggett, S.B.5
  • 23
    • 0035888675 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor gamma expression in human asthmatic airways: Relationship with proliferation, apoptosis, and airway remodeling
    • L. Benayoun, S. Letuve, A. Druilhe, J. Boczkowski, M.C. Dombret, and P. Mechighel Regulation of peroxisome proliferator-activated receptor gamma expression in human asthmatic airways: relationship with proliferation, apoptosis, and airway remodeling Am J Respir Crit Care Med 164 2001 1487 1494
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1487-1494
    • Benayoun, L.1    Letuve, S.2    Druilhe, A.3    Boczkowski, J.4    Dombret, M.C.5    Mechighel, P.6
  • 24
    • 0025977594 scopus 로고
    • Abnormalities in airway smooth muscle in fatal asthma. a comparison between trachea and bronchus
    • T.R. Bai Abnormalities in airway smooth muscle in fatal asthma. A comparison between trachea and bronchus Am Rev Respir Dis 143 1991 441 443
    • (1991) Am Rev Respir Dis , vol.143 , pp. 441-443
    • Bai, T.R.1
  • 25
    • 0024123412 scopus 로고
    • Responsiveness of bronchial smooth muscle from asthmatic patients to relaxant and contractile agonists
    • S.D. Whicker, C.L. Armour, and J.L. Black Responsiveness of bronchial smooth muscle from asthmatic patients to relaxant and contractile agonists Pulm Pharmacol 1 1988 25 31
    • (1988) Pulm Pharmacol , vol.1 , pp. 25-31
    • Whicker, S.D.1    Armour, C.L.2    Black, J.L.3
  • 26
    • 0028353880 scopus 로고
    • Hypothesis: Excessive bronchoconstriction in asthma is due to decreased airway elastance
    • A.M. Bramley, R.J. Thomson, C.R. Roberts, and R.R. Schellenberg Hypothesis: excessive bronchoconstriction in asthma is due to decreased airway elastance Eur Respir J 7 1994 337 341
    • (1994) Eur Respir J , vol.7 , pp. 337-341
    • Bramley, A.M.1    Thomson, R.J.2    Roberts, C.R.3    Schellenberg, R.R.4
  • 27
    • 0024677522 scopus 로고
    • Mechanical factors determining maximum bronchoconstriction
    • P.T. Macklem Mechanical factors determining maximum bronchoconstriction Eur Respir J Suppl 6 1989 516s 519s
    • (1989) Eur Respir J Suppl , vol.6
    • MacKlem, P.T.1
  • 28
    • 0030047379 scopus 로고    scopus 로고
    • A theoretical analysis of the effect of airway smooth muscle load on airway narrowing
    • P.T. Macklem A theoretical analysis of the effect of airway smooth muscle load on airway narrowing Am J Respir Crit Care Med 153 1996 83 89
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 83-89
    • MacKlem, P.T.1
  • 29
    • 0031201731 scopus 로고    scopus 로고
    • Perhaps airway smooth muscle dysfunction contributes to asthmatic bronchial hyperresponsiveness after all
    • J. Solway, and J.J. Fredberg Perhaps airway smooth muscle dysfunction contributes to asthmatic bronchial hyperresponsiveness after all Am J Respir Cell Mol Biol 17 1997 144 146
    • (1997) Am J Respir Cell Mol Biol , vol.17 , pp. 144-146
    • Solway, J.1    Fredberg, J.J.2
  • 30
    • 0024578295 scopus 로고
    • The mechanics of airway narrowing in asthma
    • A.L. James, P.D. Pare, and J.C. Hogg The mechanics of airway narrowing in asthma Am Rev Respir Dis 139 1989 242 246
    • (1989) Am Rev Respir Dis , vol.139 , pp. 242-246
    • James, A.L.1    Pare, P.D.2    Hogg, J.C.3
  • 31
    • 2442715233 scopus 로고    scopus 로고
    • The allergic mouse model of asthma: Normal smooth muscle in an abnormal lung?
    • S. Wagers, L.K. Lundblad, M. Ekman, C.G. Irvin, and J.H. Bates The allergic mouse model of asthma: normal smooth muscle in an abnormal lung? J Appl Physiol 96 2004 2019 2027
    • (2004) J Appl Physiol , vol.96 , pp. 2019-2027
    • Wagers, S.1    Lundblad, L.K.2    Ekman, M.3    Irvin, C.G.4    Bates, J.H.5
  • 32
    • 0019457138 scopus 로고
    • Regulation of bronchomotor tone by lung inflation in asthmatic and nonasthmatic subjects
    • J.E. Fish, M.G. Ankin, J.F. Kelly, and Peterman VI Regulation of bronchomotor tone by lung inflation in asthmatic and nonasthmatic subjects J Appl Physiol 50 1981 1079 1086
    • (1981) J Appl Physiol , vol.50 , pp. 1079-1086
    • Fish, J.E.1    Ankin, M.G.2    Kelly, J.F.3    Peterman, V.I.4
  • 33
    • 0028817013 scopus 로고
    • Airway hyperresponsiveness in asthma: A problem of limited smooth muscle relaxation with inspiration
    • G. Skloot, S. Permutt, and A. Togias Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration J Clin Invest 96 1995 2393 2403
    • (1995) J Clin Invest , vol.96 , pp. 2393-2403
    • Skloot, G.1    Permutt, S.2    Togias, A.3
  • 34
    • 0036893225 scopus 로고    scopus 로고
    • Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects
    • X. Ma, Z. Cheng, H. Kong, Y. Wang, H. Unruh, and N.L. Stephens Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects Am J Physiol Lung Cell Mol Physiol 283 2002 L1181 L1189
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.283
    • Ma, X.1    Cheng, Z.2    Kong, H.3    Wang, Y.4    Unruh, H.5    Stephens, N.L.6
  • 36
    • 0141792242 scopus 로고    scopus 로고
    • Airway smooth muscle: Immunomodulatory cells that modulate airway remodeling?
    • R.A. Panettieri Jr. Airway smooth muscle: immunomodulatory cells that modulate airway remodeling? Respir Physiol Neurobiol 137 2003 277 293
    • (2003) Respir Physiol Neurobiol , vol.137 , pp. 277-293
    • Panettieri Jr., R.A.1
  • 37
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • Z. Zhu, R.J. Homer, Z. Wang, Q. Chen, G.P. Geba, and J. Wang Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production J Clin Invest 103 1999 779 788
    • (1999) J Clin Invest , vol.103 , pp. 779-788
    • Zhu, Z.1    Homer, R.J.2    Wang, Z.3    Chen, Q.4    Geba, G.P.5    Wang, J.6
  • 38
    • 2542486456 scopus 로고    scopus 로고
    • Asthma: Mechanisms of disease persistence and progression
    • L. Cohn, J.A. Elias, and G.L. Chupp Asthma: mechanisms of disease persistence and progression Annu Rev Immunol 22 2004 789 815
    • (2004) Annu Rev Immunol , vol.22 , pp. 789-815
    • Cohn, L.1    Elias, J.A.2    Chupp, G.L.3
  • 39
    • 9644281044 scopus 로고    scopus 로고
    • Interleukin-13 in asthma pathogenesis
    • M. Wills-Karp Interleukin-13 in asthma pathogenesis Immunol Rev 202 2004 175 190
    • (2004) Immunol Rev , vol.202 , pp. 175-190
    • Wills-Karp, M.1
  • 40
    • 0033840582 scopus 로고    scopus 로고
    • Airway subepithelial fibrosis in a murine model of atopic asthma: Suppression by dexamethasone or anti-interleukin-5 antibody
    • D.I. Blyth, T.F. Wharton, M.S. Pedrick, T.J. Savage, and S. Sanjar Airway subepithelial fibrosis in a murine model of atopic asthma: suppression by dexamethasone or anti-interleukin-5 antibody Am J Respir Cell Mol Biol 23 2000 241 246
    • (2000) Am J Respir Cell Mol Biol , vol.23 , pp. 241-246
    • Blyth, D.I.1    Wharton, T.F.2    Pedrick, M.S.3    Savage, T.J.4    Sanjar, S.5
  • 41
    • 0031803208 scopus 로고    scopus 로고
    • Transforming growth factor-beta (TGF-beta)
    • D.A. Clark, and R. Coker Transforming growth factor-beta (TGF-beta) Int J Biochem Cell Biol 30 1998 293 298
    • (1998) Int J Biochem Cell Biol , vol.30 , pp. 293-298
    • Clark, D.A.1    Coker, R.2
  • 42
    • 0037246364 scopus 로고    scopus 로고
    • Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling
    • S.T. Holgate, M. Peters-Golden, R.A. Panettieri, and W.R. Henderson Jr. Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling J Allergy Clin Immunol 111 suppl 2003 S18 S34
    • (2003) J Allergy Clin Immunol , vol.111 , Issue.SUPPL.
    • Holgate, S.T.1    Peters-Golden, M.2    Panettieri, R.A.3    Henderson Jr., W.R.4
  • 43
    • 0042388120 scopus 로고    scopus 로고
    • Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway
    • M.R. Blackburn, C.G. Lee, H.W. Young, Z. Zhu, J.L. Chunn, and M.J. Kang Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway J Clin Invest 112 2003 332 344
    • (2003) J Clin Invest , vol.112 , pp. 332-344
    • Blackburn, M.R.1    Lee, C.G.2    Young, H.W.3    Zhu, Z.4    Chunn, J.L.5    Kang, M.J.6
  • 44
    • 0032859197 scopus 로고    scopus 로고
    • Balance in asthma between matrix metalloproteinases and their inhibitors
    • G. Mautino, F. Capony, J. Bousquet, and A.M. Vignola Balance in asthma between matrix metalloproteinases and their inhibitors J Allergy Clin Immunol 104 1999 530 533
    • (1999) J Allergy Clin Immunol , vol.104 , pp. 530-533
    • Mautino, G.1    Capony, F.2    Bousquet, J.3    Vignola, A.M.4
  • 45
    • 17444454662 scopus 로고    scopus 로고
    • Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma
    • J.J. Lee, M.P. McGarry, S.C. Farmer, K.L. Denzler, K.A. Larson, and P.E. Carrigan Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma J Exp Med 185 1997 2143 2156
    • (1997) J Exp Med , vol.185 , pp. 2143-2156
    • Lee, J.J.1    McGarry, M.P.2    Farmer, S.C.3    Denzler, K.L.4    Larson, K.A.5    Carrigan, P.E.6
  • 47
    • 0037059509 scopus 로고    scopus 로고
    • Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    • S. Finotto, M.F. Neurath, J.N. Glickman, S. Qin, H.A. Lehr, and F.H. Green Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet Science 295 2002 336 338
    • (2002) Science , vol.295 , pp. 336-338
    • Finotto, S.1    Neurath, M.F.2    Glickman, J.N.3    Qin, S.4    Lehr, H.A.5    Green, F.H.6
  • 48
    • 0035821221 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation
    • A. Mathew, J.A. MacLean, E. DeHaan, A.M. Tager, F.H. Green, and A.D. Luster Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation J Exp Med 193 2001 1087 1096
    • (2001) J Exp Med , vol.193 , pp. 1087-1096
    • Mathew, A.1    MacLean, J.A.2    Dehaan, E.3    Tager, A.M.4    Green, F.H.5    Luster, A.D.6
  • 49
    • 7044260960 scopus 로고    scopus 로고
    • The interplay of dendritic cells, Th2 cells and regulatory T cells in asthma
    • H. Kuipers, and B.N. Lambrecht The interplay of dendritic cells, Th2 cells and regulatory T cells in asthma Curr Opin Immunol 16 2004 702 708
    • (2004) Curr Opin Immunol , vol.16 , pp. 702-708
    • Kuipers, H.1    Lambrecht, B.N.2
  • 50
    • 17144367365 scopus 로고    scopus 로고
    • In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma
    • L.S. van Rijt, S. Jung, A. Kleinjan, N. Vos, M. Willart, and C. Duez In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma J Exp Med 201 2005 981 991
    • (2005) J Exp Med , vol.201 , pp. 981-991
    • Van Rijt, L.S.1    Jung, S.2    Kleinjan, A.3    Vos, N.4    Willart, M.5    Duez, C.6
  • 52
    • 0030068235 scopus 로고    scopus 로고
    • Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity
    • D.B. Corry, H.G. Folkesson, M.L. Warnock, D.J. Erle, M.A. Matthay, and J.P. Wiener-Kronish Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity J Exp Med 183 1996 109 117
    • (1996) J Exp Med , vol.183 , pp. 109-117
    • Corry, D.B.1    Folkesson, H.G.2    Warnock, M.L.3    Erle, D.J.4    Matthay, M.A.5    Wiener-Kronish, J.P.6
  • 53
    • 0030028768 scopus 로고    scopus 로고
    • Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
    • P.S. Foster, S.P. Hogan, A.J. Ramsay, K.I. Matthaei, and I.G. Young Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model J Exp Med 183 1996 195 201
    • (1996) J Exp Med , vol.183 , pp. 195-201
    • Foster, P.S.1    Hogan, S.P.2    Ramsay, A.J.3    Matthaei, K.I.4    Young, I.G.5
  • 55
  • 56
    • 0037438409 scopus 로고    scopus 로고
    • Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway
    • P.T. Flood-Page, A.N. Menzies-Gow, A.B. Kay, and D.S. Robinson Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway Am J Respir Crit Care Med 167 2003 199 204
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 199-204
    • Flood-Page, P.T.1    Menzies-Gow, A.N.2    Kay, A.B.3    Robinson, D.S.4
  • 58
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • M.J. Leckie, A. ten Brinke, J. Khan, Z. Diamant, B.J. O'Connor, and C.M. Walls Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response Lancet 356 2000 2144 2148
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1    Ten Brinke, A.2    Khan, J.3    Diamant, Z.4    O'Connor, B.J.5    Walls, C.M.6
  • 59
    • 0032875377 scopus 로고    scopus 로고
    • Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
    • S.E. Wenzel, L.B. Schwartz, E.L. Langmack, J.L. Halliday, J.B. Trudeau, and R.L. Gibbs Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics Am J Respir Crit Care Med 160 1999 1001 1008
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1001-1008
    • Wenzel, S.E.1    Schwartz, L.B.2    Langmack, E.L.3    Halliday, J.L.4    Trudeau, J.B.5    Gibbs, R.L.6
  • 61
    • 0037385864 scopus 로고    scopus 로고
    • Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13
    • B.B. Vargaftig, and M. Singer Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13 Am J Respir Cell Mol Biol 28 2003 410 419
    • (2003) Am J Respir Cell Mol Biol , vol.28 , pp. 410-419
    • Vargaftig, B.B.1    Singer, M.2
  • 62
    • 0034867321 scopus 로고    scopus 로고
    • Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells
    • P. Berger, D.W. Perng, H. Thabrew, S.J. Compton, J.A. Cairns, and A.R. McEuen Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells J Appl Physiol 91 2001 1372 1379
    • (2001) J Appl Physiol , vol.91 , pp. 1372-1379
    • Berger, P.1    Perng, D.W.2    Thabrew, H.3    Compton, S.J.4    Cairns, J.A.5    McEuen, A.R.6
  • 64
    • 0034665101 scopus 로고    scopus 로고
    • Production of plasminogen activator inhibitor-1 by human mast cells and its possible role in asthma
    • S.H. Cho, S.W. Tam, S. Demissie-Sanders, S.A. Filler, and C.K. Oh Production of plasminogen activator inhibitor-1 by human mast cells and its possible role in asthma J Immunol 165 2000 3154 3161
    • (2000) J Immunol , vol.165 , pp. 3154-3161
    • Cho, S.H.1    Tam, S.W.2    Demissie-Sanders, S.3    Filler, S.A.4    Oh, C.K.5
  • 65
    • 0742305248 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 in the pathogenesis of asthma
    • S.H. Cho, C.H. Ryu, and C.K. Oh Plasminogen activator inhibitor-1 in the pathogenesis of asthma Exp Biol Med (Maywood) 229 2004 138 146
    • (2004) Exp Biol Med (Maywood) , vol.229 , pp. 138-146
    • Cho, S.H.1    Ryu, C.H.2    Oh, C.K.3
  • 66
    • 0028958224 scopus 로고
    • Evaluation of airway inflammation by endobronchial and transbronchial biopsy in nocturnal and nonnocturnal asthma
    • M. Kraft, R. Djukanovic, J. Torvik, L. Cunningham, J. Henson, and S. Wilson Evaluation of airway inflammation by endobronchial and transbronchial biopsy in nocturnal and nonnocturnal asthma Chest 107 suppl 1995 162S
    • (1995) Chest , vol.107 , Issue.SUPPL.
    • Kraft, M.1    Djukanovic, R.2    Torvik, J.3    Cunningham, L.4    Henson, J.5    Wilson, S.6
  • 69
    • 0036933504 scopus 로고    scopus 로고
    • Goblet cell and mucin gene abnormalities in asthma
    • J.V. Fahy Goblet cell and mucin gene abnormalities in asthma Chest 122 suppl 2002 320S 326S
    • (2002) Chest , vol.122 , Issue.SUPPL.
    • Fahy, J.V.1
  • 70
    • 0036079897 scopus 로고    scopus 로고
    • Immunity, inflammation, and remodeling in the airway epithelial barrier: Epithelial-viral-allergic paradigm
    • M.J. Holtzman, J.D. Morton, L.P. Shornick, J.W. Tyner, M.P. O'Sullivan, and A. Antao Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm Physiol Rev 82 2002 19 46
    • (2002) Physiol Rev , vol.82 , pp. 19-46
    • Holtzman, M.J.1    Morton, J.D.2    Shornick, L.P.3    Tyner, J.W.4    O'Sullivan, M.P.5    Antao, A.6
  • 71
    • 0033135134 scopus 로고    scopus 로고
    • Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma
    • D. Sampath, M. Castro, D.C. Look, and M.J. Holtzman Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma J Clin Invest 103 1999 1353 1361
    • (1999) J Clin Invest , vol.103 , pp. 1353-1361
    • Sampath, D.1    Castro, M.2    Look, D.C.3    Holtzman, M.J.4
  • 72
    • 0035132115 scopus 로고    scopus 로고
    • Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression
    • C.L. Ordonez, R. Khashayar, H.H. Wong, R. Ferrando, R. Wu, and D.M. Hyde Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression Am J Respir Crit Care Med 163 2001 517 523
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 517-523
    • Ordonez, C.L.1    Khashayar, R.2    Wong, H.H.3    Ferrando, R.4    Wu, R.5    Hyde, D.M.6
  • 73
    • 0032531571 scopus 로고    scopus 로고
    • IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells
    • L. Cohn, J.S. Tepper, and K. Bottomly IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells J Immunol 161 1998 3813 3816
    • (1998) J Immunol , vol.161 , pp. 3813-3816
    • Cohn, L.1    Tepper, J.S.2    Bottomly, K.3
  • 74
    • 0035667908 scopus 로고    scopus 로고
    • IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells
    • J. Laoukili, E. Perret, T. Willems, A. Minty, E. Parthoens, and O. Houcine IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells J Clin Invest 108 2001 1817 1824
    • (2001) J Clin Invest , vol.108 , pp. 1817-1824
    • Laoukili, J.1    Perret, E.2    Willems, T.3    Minty, A.4    Parthoens, E.5    Houcine, O.6
  • 76
    • 0038240988 scopus 로고    scopus 로고
    • Mucosal and systemic inflammatory changes in allergic rhinitis and asthma: A comparison between upper and lower airways
    • G.J. Braunstahl, W.J. Fokkens, S.E. Overbeek, A. Kleinjan, H.C. Hoogsteden, and J.B. Prins Mucosal and systemic inflammatory changes in allergic rhinitis and asthma: a comparison between upper and lower airways Clin Exp Allergy 33 2003 579 587
    • (2003) Clin Exp Allergy , vol.33 , pp. 579-587
    • Braunstahl, G.J.1    Fokkens, W.J.2    Overbeek, S.E.3    Kleinjan, A.4    Hoogsteden, H.C.5    Prins, J.B.6
  • 81
    • 1642370744 scopus 로고    scopus 로고
    • Bronchoalveolar lavage fluid concentrations of transforming growth factor (TGF)-beta1, TGF-beta2, interleukin (IL)-4 and IL-13 after segmental allergen challenge and their effects on alpha-smooth muscle actin and collagen III synthesis by primary human lung fibroblasts
    • V. Batra, A.I. Musani, A.T. Hastie, S. Khurana, K.A. Carpenter, and J.G. Zangrilli Bronchoalveolar lavage fluid concentrations of transforming growth factor (TGF)-beta1, TGF-beta2, interleukin (IL)-4 and IL-13 after segmental allergen challenge and their effects on alpha-smooth muscle actin and collagen III synthesis by primary human lung fibroblasts Clin Exp Allergy 34 2004 437 444
    • (2004) Clin Exp Allergy , vol.34 , pp. 437-444
    • Batra, V.1    Musani, A.I.2    Hastie, A.T.3    Khurana, S.4    Carpenter, K.A.5    Zangrilli, J.G.6
  • 82
    • 0037212314 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases in asthma
    • E.A. Kelly, and N.N. Jarjour Role of matrix metalloproteinases in asthma Curr Opin Pulm Med 9 2003 28 33
    • (2003) Curr Opin Pulm Med , vol.9 , pp. 28-33
    • Kelly, E.A.1    Jarjour, N.N.2
  • 83
    • 10444273257 scopus 로고    scopus 로고
    • Airway remodelling assessed by sputum and high-resolution computed tomography in asthma and COPD
    • A.M. Vignola, F. Paganin, L. Capieu, N. Scichilone, M. Bellia, and L. Maakel Airway remodelling assessed by sputum and high-resolution computed tomography in asthma and COPD Eur Respir J 24 2004 910 917
    • (2004) Eur Respir J , vol.24 , pp. 910-917
    • Vignola, A.M.1    Paganin, F.2    Capieu, L.3    Scichilone, N.4    Bellia, M.5    Maakel, L.6
  • 84
    • 0035903306 scopus 로고    scopus 로고
    • Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1)
    • C.G. Lee, R.J. Homer, Z. Zhu, S. Lanone, X. Wang, and V. Koteliansky Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1) J Exp Med 194 2001 809 821
    • (2001) J Exp Med , vol.194 , pp. 809-821
    • Lee, C.G.1    Homer, R.J.2    Zhu, Z.3    Lanone, S.4    Wang, X.5    Koteliansky, V.6
  • 85
    • 0035186301 scopus 로고    scopus 로고
    • Quantitative and morphological analysis of the vascular bed in bronchial biopsy specimens from asthmatic and non-asthmatic subjects
    • G. Salvato Quantitative and morphological analysis of the vascular bed in bronchial biopsy specimens from asthmatic and non-asthmatic subjects Thorax 56 2001 902 906
    • (2001) Thorax , vol.56 , pp. 902-906
    • Salvato, G.1
  • 86
    • 7044260315 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung
    • C.G. Lee, H. Link, P. Baluk, R.J. Homer, S. Chapoval, and V. Bhandari Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung Nat Med 10 2004 1095 1103
    • (2004) Nat Med , vol.10 , pp. 1095-1103
    • Lee, C.G.1    Link, H.2    Baluk, P.3    Homer, R.J.4    Chapoval, S.5    Bhandari, V.6
  • 87
    • 0035117286 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis
    • M. Hoshino, M. Takahashi, and N. Aoike Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis J Allergy Clin Immunol 107 2001 295 301
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 295-301
    • Hoshino, M.1    Takahashi, M.2    Aoike, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.