β2-Adrenergic receptor desensitization, internalization, and phosphorylation in response to full and partial agonists

Journal of Biological Chemistry

Volumn 272, Issue 38, 1997, Pages 23871-23879

  January, Bridgette ^a   Seibold, Anita ^a   Whaley, Brenda ^a   Hipkin, R William ^a   Lin, Doris ^a   Schonbrunn, Agnes ^a   Barber, Roger ^a   Clark, Richard B ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; PARTIAL AGONIST; ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR KINASE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE;

ARTICLE; CONTROLLED STUDY; GENE OVEREXPRESSION; HORMONE RECEPTOR INTERACTION; HORMONE RECEPTOR TRANSLOCATION; HUMAN; HUMAN CELL; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; CELL LINE; ENDOCYTOSIS; ENZYME ACTIVATION; METABOLISM; PHOSPHORYLATION;

ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; BETA-ADRENERGIC RECEPTOR KINASE; CELL LINE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDOCYTOSIS; ENZYME ACTIVATION; HUMANS; PHOSPHORYLATION; RECEPTORS, ADRENERGIC, BETA-2;

EID: 0030612652     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.38.23871     Document Type: Article

References (38)

1. Perkins, J. P., Hausdorff, W. P., and Lefkowitz, R. J. (1991) The β-Adrenergic Receptors (Perkins, J., P., ed) pp. 73-124, The Humana Press Inc., Clifton, NJ
2. Dixon, R. A. F., Sigal. I. S., and Strader, C. D. (1988) Cold Spring Harbor Symp. Quant. Biol. 53, 487-489
3. Palczewski, K., and Benovic, J. L. (1990) Trends Biol. Sci. 16, 387-392
4. Clark, R. B. (1986) J. Cyclic Nucleotide and Protein Phosphor. Res. 20, 151-209
5. Premont, R. T., Inglese, J., and Lefkowitz, R. J. (1995) FASEB J. 9, 175-182
6. Yuan, N., Friedman, J., Whaley, B. S., and Clark, R. B. (1994) J. Biol. Chem. 269, 23032-23038
7. Whaley, B. S., Yuan, N., Birnbaumer, L., Clark, R. B., and Barber, R. (1994) Mol. Pharmacol. 45, 481-489
8. Clark, R. B., Friedman, J., Dixon, R. A. F., and Strader, C. D. (1989) Mol. Pharmacol. 36, 343-348
9. Clark, R. B., Kunkel, M. W., Friedman, J., Goka, T. J., and Johnson, J. A. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 1442-1446
10. Hausdorff, W. P., Bouvier, M., O'Dowd, B. F., Irons, G. P., Caron, M. G., and Lefkowitz, R. J. (1989) J Biol. Chem. 264, 12657-12665
11. Proll. M. A., Clark, R. B., Goka, T. J., Barber, R., and Butcher, R. W. (1992) Mol. Pharmacol. 42, 116-122
12. Su, Y.-F., Harden, T. K., and Perkins, J. P. (1980) J. Biol. Chem. 255, 7410-7419
13. Clark, R. B., Allal, C., Friedman, J., Johnson, M., and Barber, R. (1996) Mol. Pharmacol. 49, 182-189
14. Morrison, K. J., Moore, R. H., Carsrud, N. D. V., Trial, J., Millman, E. E., Tuvim, M., Clark, R. B., Barber, R., Dickey, B. F., and Knoll, B. J., (1996) Mol. Pharmacol. 50, 692-699
15. Hipkin, R. W., Friedman, J., Clark, R. B., Eppler, C. M., and Schonbruun, A. (1997) J. Biol. Chem. 272, 13869-13876
16. Barovsky, K., and Brooker, G., (1980) J. Cyclic Nucleotide Res. 6, 297-307
17. Hoyer, D. E., Reynolds, E., and Molinoff, P. B. (1984) Mol. Pharmacol. 25, 209-218
18. von Zastrow, M., and Kobilka, B. K. (1992) J. Biol. Chem. 267, 3530-3538
19. Slowiejko, D. M., Levey, A., I., and Fisher, S. K. (1994) J. Neurochem. 62, 1795-1803
20. Whaley, B. S., Yuan, N., Barber, R., and Clark, R. B. (1995) Pharmacol. Commun. 6, 203-210
21. Pippig, S., Andexinger, S., Daniel, K., Puzicha, M., Caron, M. G., Lefkowitz, R. J., and Lohse, M. J. (1993) J. Biol. Chem. 268, 3201-3208
22. Towes, M. L., and Perkins, J. P. (1984) J. Biol. Chem. 259, 2227-2235
23. Benovic, J. L., Staniszewski, C., Mayor, F., Jr., Caron, M. G., and Lefkowitz, R. J., (1988) J. Biol. Chem. 263, 3893-3897
24. Ohguro, H., Van Hooser, J. P., Milam, A. H., and Palczewski, K. (1995) J. Biol. Chem. 270, 14259-14262
25. Fredericks, Z. L., Pitcher, J. A., and Lefkowitz, R. J. (1996) J. Biol. Chem. 271, 13796-13803
26. Strasser, R. H., Sibley, D. R., and Lefkowitz, R. J. (1986) Biochemistry 25, 1371-1377
27. Roth, N. S., Cambell, P. T., Caron, M. G., Lefkowitz, R. J., and Lhose, M. J. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 6201-6204
28. Barak, L. S., Tiberi, M., Freeman, N. J., Kwatra, M. M., Lefkowitz, R. J., and Caron, M. G. (1994) J. Biol. Chem. 269, 2790-2795
29. Yu., S. S., Lefkowitz, R. J., and Hausdorff, W. P., (1993) J. Biol. Chem. 268, 337-341
30. Cheung, A. H., Sigal, I. S., Dixon, R. A. F., and Strader, C. D. (1988) Mol. Pharmacol. 34, 132-138
31. Bouvier, M., Hausdorff, W. P., De Blasi, A., O'Dowd, B. F., Kobilka, B. K., Caron, M. G., and Lefkowitz, R. J. (1988) Nature 33, 370-373
32. Goodman, O. B., Krupnick, J. G., Santini, F., Gurevich, V. V., Penn, R. B., Gagnon, A. W., Keen, J. H., and Benovic, J. L. (1996) Nature 383, 447-450
33. Waldo, G. L., Northup, J. K., Perkins, J. P., and Harden, T. K. (1983) J. Biol. Chem. 258, 13900-13908
34. Kenakin, T. (1995) Trends Pharmacol. Sci. 16, 232-238
35. Samama, P., Cotecchia, S., Costa, T., and Lefkowitz, R. J. (1993) J. Biol Chem. 268, 4625-4636
36. Barnes, P. J. (1995) Am. J. Respir. Crit. Care Med. 152, 838-860
37. Ferguson, S. S. G., Downey, W. E., Colapietro, A.-M., Barak, L. S., Menard, L., and Caron, M. G. (1996) Science 271, 363-366
38. Krumins, A. J., and Barber, R. (1997) Mol. Pharmacol. 52, 144-154