-
1
-
-
3242793327
-
Historical review: A brief history and personal retrospective of seven-transmembrane receptors
-
R.J. Lefkowitz Historical review: A brief history and personal retrospective of seven-transmembrane receptors Trends Pharmacol. Sci. 25 2004 413 422
-
(2004)
Trends Pharmacol. Sci.
, vol.25
, pp. 413-422
-
-
Lefkowitz, R.J.1
-
2
-
-
1942517868
-
Principles: Receptor theory in pharmacology
-
T. Kenakin Principles: Receptor theory in pharmacology Trends Pharmacol. Sci. 25 2004 186 192
-
(2004)
Trends Pharmacol. Sci.
, vol.25
, pp. 186-192
-
-
Kenakin, T.1
-
3
-
-
1642495639
-
Efficacy as a vector: The relative prevalence and paucity of inverse agonism
-
T. Kenakin Efficacy as a vector: the relative prevalence and paucity of inverse agonism Mol. Pharmacol. 65 2004 2 11
-
(2004)
Mol. Pharmacol.
, vol.65
, pp. 2-11
-
-
Kenakin, T.1
-
4
-
-
0000114679
-
Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors
-
C. Braestrup Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors Proc. Natl. Acad. Sci. U. S. A. 77 1980 2288 2292
-
(1980)
Proc. Natl. Acad. Sci. U. S. A.
, vol.77
, pp. 2288-2292
-
-
Braestrup, C.1
-
5
-
-
0019996866
-
Interaction of convulsive ligands with benzodiazepine receptors
-
C. Braestrup Interaction of convulsive ligands with benzodiazepine receptors Science 216 1982 1241 1243
-
(1982)
Science
, vol.216
, pp. 1241-1243
-
-
Braestrup, C.1
-
7
-
-
0030693304
-
The benzodiazepine binding site of GABAA receptors
-
E. Sigel, and A. Buhr The benzodiazepine binding site of GABAA receptors Trends Pharmacol. Sci. 18 1997 425 429
-
(1997)
Trends Pharmacol. Sci.
, vol.18
, pp. 425-429
-
-
Sigel, E.1
Buhr, A.2
-
8
-
-
0031799363
-
International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: Classification on the basis of subunit structure and receptor function
-
E.A. Barnard International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function Pharmacol. Rev. 50 1998 291 313
-
(1998)
Pharmacol. Rev.
, vol.50
, pp. 291-313
-
-
Barnard, E.A.1
-
9
-
-
0016412390
-
Energetics of ligand binding to proteins
-
G. Weber Energetics of ligand binding to proteins Adv. Protein Chem. 29 1975 1 83
-
(1975)
Adv. Protein Chem.
, vol.29
, pp. 1-83
-
-
Weber, G.1
-
10
-
-
0000977357
-
Allosteric linkage
-
J. Wyman Allosteric linkage J. Am. Chem. Soc. 89 1967 2202 2218
-
(1967)
J. Am. Chem. Soc.
, vol.89
, pp. 2202-2218
-
-
Wyman, J.1
-
12
-
-
0001158926
-
A look at receptor efficacy. from the signaling network of the cell to the intramolecular motion of the receptor
-
T.P. Kenakin J.A. Angus Springer
-
H.O. Onaran A look at receptor efficacy. From the signaling network of the cell to the intramolecular motion of the receptor T.P. Kenakin J.A. Angus The Pharmacology of Functional, Biochemical, and Recombinant Systems 2000 Springer 217 280
-
(2000)
The Pharmacology of Functional, Biochemical, and Recombinant Systems
, pp. 217-280
-
-
Onaran, H.O.1
-
13
-
-
85056068477
-
Intramolecular dynamics and ligand-induced conformational changes: A stochastic model of receptor action
-
A. Christopoulos CRC Press
-
H.O. Onaran, and T. Costa Intramolecular dynamics and ligand-induced conformational changes: a stochastic model of receptor action A. Christopoulos Biomedical Applications of Computer Modeling 2001 CRC Press 109 134
-
(2001)
Biomedical Applications of Computer Modeling
, pp. 109-134
-
-
Onaran, H.O.1
Costa, T.2
-
14
-
-
0000164734
-
Site-specific thermodynamics: Understanding cooperativity in molecular recognition
-
E. Di Cera Site-specific thermodynamics: understanding cooperativity in molecular recognition Chem. Rev. 98 1998 1563 1592
-
(1998)
Chem. Rev.
, vol.98
, pp. 1563-1592
-
-
Di Cera, E.1
-
15
-
-
0010673662
-
A modification of receptor theory
-
R.P. Stephenson A modification of receptor theory Br. J. Pharmacol. 11 1956 379 393
-
(1956)
Br. J. Pharmacol.
, vol.11
, pp. 379-393
-
-
Stephenson, R.P.1
-
16
-
-
0002355204
-
The use of b-haloalkylamines in the differentiation of receptors and in the determination of dissociation constants of receptor-agonist complexes
-
N.J. Harper A.B. Simmonds Academic Press
-
R.F. Furchgott The use of b-haloalkylamines in the differentiation of receptors and in the determination of dissociation constants of receptor-agonist complexes N.J. Harper A.B. Simmonds Advances in Drug Research 1966 Academic Press 21 55
-
(1966)
Advances in Drug Research
, pp. 21-55
-
-
Furchgott, R.F.1
-
18
-
-
0002060353
-
The relationship between classical and cooperative models for drug action
-
H.P. Rang University Park Press
-
D. Colquhoun The relationship between classical and cooperative models for drug action H.P. Rang Drug Receptors 1973 University Park Press 149 182
-
(1973)
Drug Receptors
, pp. 149-182
-
-
Colquhoun, D.1
-
19
-
-
0032199006
-
Binding, gating, affinity and efficacy: The interpretation of structure-activity relationships for agonists and of the effects of mutating receptors
-
D. Colquhoun Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors Br. J. Pharmacol. 125 1998 924 947
-
(1998)
Br. J. Pharmacol.
, vol.125
, pp. 924-947
-
-
Colquhoun, D.1
-
20
-
-
70449143838
-
Interaction at end-plate receptors between different choline derivatives
-
J. Del Castillo, and B. Katz Interaction at end-plate receptors between different choline derivatives Proc. R. Soc. Lond. B. Biol. Sci. 146 1957 369 381
-
(1957)
Proc. R. Soc. Lond. B. Biol. Sci.
, vol.146
, pp. 369-381
-
-
Del Castillo, J.1
Katz, B.2
-
21
-
-
0015239283
-
The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. IV. Effects of guanylnucleotides on binding of 125I-glucagon
-
M. Rodbell The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. IV. Effects of guanylnucleotides on binding of 125I-glucagon J. Biol. Chem. 246 1971 1872 1876
-
(1971)
J. Biol. Chem.
, vol.246
, pp. 1872-1876
-
-
Rodbell, M.1
-
22
-
-
0019137579
-
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor
-
A. De Lean A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor J. Biol. Chem. 255 1980 7108 7117
-
(1980)
J. Biol. Chem.
, vol.255
, pp. 7108-7117
-
-
De Lean, A.1
-
23
-
-
0018862848
-
A quantitative analysis of beta-adrenergic receptor interactions: Resolution of high and low affinity states of the receptor by computer modeling of ligand binding data
-
R.S. Kent A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data Mol. Pharmacol. 17 1980 14 23
-
(1980)
Mol. Pharmacol.
, vol.17
, pp. 14-23
-
-
Kent, R.S.1
-
24
-
-
0021193681
-
The mammalian beta 2-adrenergic receptor: Reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system
-
R.A. Cerione The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system Biochemistry 23 1984 4519 4525
-
(1984)
Biochemistry
, vol.23
, pp. 4519-4525
-
-
Cerione, R.A.1
-
25
-
-
0022356539
-
Functional activation of beta-adrenergic receptors by thiols in the presence or absence of agonists
-
S.E. Pedersen, and E.M. Ross Functional activation of beta-adrenergic receptors by thiols in the presence or absence of agonists J. Biol. Chem. 260 1985 14150 14157
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 14150-14157
-
-
Pedersen, S.E.1
Ross, E.M.2
-
26
-
-
0001169515
-
Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins
-
T. Costa, and A. Herz Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins Proc. Natl. Acad. Sci. U. S. A. 86 1989 7321 7325
-
(1989)
Proc. Natl. Acad. Sci. U. S. A.
, vol.86
, pp. 7321-7325
-
-
Costa, T.1
Herz, A.2
-
27
-
-
0025238655
-
Spontaneous association between opioid receptors and GTP-binding regulatory proteins in native membranes: Specific regulation by antagonists and sodium ions
-
T. Costa Spontaneous association between opioid receptors and GTP-binding regulatory proteins in native membranes: specific regulation by antagonists and sodium ions Mol. Pharmacol. 37 1990 383 394
-
(1990)
Mol. Pharmacol.
, vol.37
, pp. 383-394
-
-
Costa, T.1
-
28
-
-
0026509982
-
Agonist-independent inhibition of G protein activation by muscarinic acetylcholine receptor antagonists in cardiac membranes
-
G. Hilf, and K.H. Jakobs Agonist-independent inhibition of G protein activation by muscarinic acetylcholine receptor antagonists in cardiac membranes Eur. J. Pharmacol. 225 1992 245 252
-
(1992)
Eur. J. Pharmacol.
, vol.225
, pp. 245-252
-
-
Hilf, G.1
Jakobs, K.H.2
-
29
-
-
0028169068
-
Unoccupied beta-adrenoceptor-induced adenylyl cyclase stimulation in turkey erythrocyte membranes
-
K. Gotze, and K.H. Jakobs Unoccupied beta-adrenoceptor-induced adenylyl cyclase stimulation in turkey erythrocyte membranes Eur. J. Pharmacol. 268 1994 151 158
-
(1994)
Eur. J. Pharmacol.
, vol.268
, pp. 151-158
-
-
Gotze, K.1
Jakobs, K.H.2
-
30
-
-
0027462281
-
Agonist-independent effects of muscarinic antagonists on Ca2+ and K+ currents in frog and rat cardiac cells
-
R. Hanf Agonist-independent effects of muscarinic antagonists on Ca2+ and K+ currents in frog and rat cardiac cells J. Physiol. 461 1993 743 765
-
(1993)
J. Physiol.
, vol.461
, pp. 743-765
-
-
Hanf, R.1
-
31
-
-
0025212680
-
Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function
-
S. Cotecchia Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function Proc. Natl. Acad. Sci. U. S. A. 87 1990 2896 2900
-
(1990)
Proc. Natl. Acad. Sci. U. S. A.
, vol.87
, pp. 2896-2900
-
-
Cotecchia, S.1
-
32
-
-
0026592357
-
Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation
-
M.A. Kjelsberg Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation J. Biol. Chem. 267 1992 1430 1433
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 1430-1433
-
-
Kjelsberg, M.A.1
-
33
-
-
0027513982
-
A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model
-
P. Samama A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model J. Biol. Chem. 268 1993 4625 4636
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 4625-4636
-
-
Samama, P.1
-
34
-
-
0027296623
-
Constitutively active mutants of the alpha 2-adrenergic receptor
-
Q. Ren Constitutively active mutants of the alpha 2-adrenergic receptor J. Biol. Chem. 268 1993 16483 16487
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 16483-16487
-
-
Ren, Q.1
-
35
-
-
0026318020
-
G-protein-coupled receptor genes as protooncogenes: Constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity
-
L.F. Allen G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity Proc. Natl. Acad. Sci. U. S. A. 88 1991 11354 11358
-
(1991)
Proc. Natl. Acad. Sci. U. S. A.
, vol.88
, pp. 11354-11358
-
-
Allen, L.F.1
-
36
-
-
0027369421
-
Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas
-
J. Parma Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas Nature 365 1993 649 651
-
(1993)
Nature
, vol.365
, pp. 649-651
-
-
Parma, J.1
-
37
-
-
0027372340
-
A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty
-
A. Shenker A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty Nature 365 1993 652 654
-
(1993)
Nature
, vol.365
, pp. 652-654
-
-
Shenker, A.1
-
38
-
-
0026608113
-
Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: Thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand
-
T. Costa Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand Mol. Pharmacol. 41 1992 549 560
-
(1992)
Mol. Pharmacol.
, vol.41
, pp. 549-560
-
-
Costa, T.1
-
39
-
-
0027297275
-
Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins
-
R.J. Lefkowitz Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins Trends Pharmacol. Sci. 14 1993 303 307
-
(1993)
Trends Pharmacol. Sci.
, vol.14
, pp. 303-307
-
-
Lefkowitz, R.J.1
-
40
-
-
0030596736
-
The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy
-
J.M. Weiss The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy J. Theor. Biol. 181 1996 381 397
-
(1996)
J. Theor. Biol.
, vol.181
, pp. 381-397
-
-
Weiss, J.M.1
-
41
-
-
0030826705
-
A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions
-
M. Bouaboula A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions J. Biol. Chem. 272 1997 22330 22339
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 22330-22339
-
-
Bouaboula, M.1
-
42
-
-
0042343718
-
Tiotidine, a histamine H2 receptor inverse agonist that binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model
-
F. Monczor Tiotidine, a histamine H2 receptor inverse agonist that binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model Mol. Pharmacol. 64 2003 512 520
-
(2003)
Mol. Pharmacol.
, vol.64
, pp. 512-520
-
-
Monczor, F.1
-
43
-
-
1242294511
-
Constitutively active Gq/11-coupled receptors enable signaling by co-expressed G(i/o)-coupled receptors
-
R.A. Bakker Constitutively active Gq/11-coupled receptors enable signaling by co-expressed G(i/o)-coupled receptors J. Biol. Chem. 279 2004 5152 5161
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 5152-5161
-
-
Bakker, R.A.1
-
44
-
-
0026767427
-
Reverse intrinsic activity of antagonists on G protein-coupled receptors
-
W. Schutz, and M. Freissmuth Reverse intrinsic activity of antagonists on G protein-coupled receptors Trends Pharmacol. Sci. 13 1992 376 380
-
(1992)
Trends Pharmacol. Sci.
, vol.13
, pp. 376-380
-
-
Schutz, W.1
Freissmuth, M.2
-
45
-
-
0031794526
-
Agonist-independent regulation of constitutively active G-protein-coupled receptors
-
R. Leurs Agonist-independent regulation of constitutively active G-protein-coupled receptors Trends Biochem. Sci. 23 1998 418 422
-
(1998)
Trends Biochem. Sci.
, vol.23
, pp. 418-422
-
-
Leurs, R.1
-
46
-
-
0033303167
-
Constitutive receptor systems for drug discovery
-
G. Chen Constitutive receptor systems for drug discovery J. Pharmacol. Toxicol. Methods 42 1999 199 206
-
(1999)
J. Pharmacol. Toxicol. Methods
, vol.42
, pp. 199-206
-
-
Chen, G.1
-
47
-
-
0032818914
-
Inverse agonists and serotonergic transmission: From recombinant, human serotonin (5-HT)1B receptors to G-protein coupling and function in corticolimbic structures in vivo
-
M.J. Millan Inverse agonists and serotonergic transmission: from recombinant, human serotonin (5-HT)1B receptors to G-protein coupling and function in corticolimbic structures in vivo Neuropsychopharmacology 21 1999 61S 67S
-
(1999)
Neuropsychopharmacology
, vol.21
-
-
Millan, M.J.1
-
48
-
-
0034016295
-
Inverse agonism at G protein-coupled receptors: (Patho)physiological relevance and implications for drug discovery
-
R.A. de Ligt Inverse agonism at G protein-coupled receptors: (patho)physiological relevance and implications for drug discovery Br. J. Pharmacol. 130 2000 1 12
-
(2000)
Br. J. Pharmacol.
, vol.130
, pp. 1-12
-
-
De Ligt, R.A.1
-
49
-
-
0036783213
-
Lessons from constitutively active mutants of G protein-coupled receptors
-
C. Parnot Lessons from constitutively active mutants of G protein-coupled receptors Trends Endocrinol. Metab. 13 2002 336 343
-
(2002)
Trends Endocrinol. Metab.
, vol.13
, pp. 336-343
-
-
Parnot, C.1
-
50
-
-
0036033424
-
Constitutive activity of G-protein-coupled receptors: Cause of disease and common property of wild-type receptors
-
R. Seifert, and K. Wenzel-Seifert Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors Naunyn Schmiedebergs Arch. Pharmacol. 366 2002 381 416
-
(2002)
Naunyn Schmiedebergs Arch. Pharmacol.
, vol.366
, pp. 381-416
-
-
Seifert, R.1
Wenzel-Seifert, K.2
-
51
-
-
0036468505
-
Mechanisms of inverse agonism at G-protein-coupled receptors
-
P.G. Strange Mechanisms of inverse agonism at G-protein-coupled receptors Trends Pharmacol. Sci. 23 2002 89 95
-
(2002)
Trends Pharmacol. Sci.
, vol.23
, pp. 89-95
-
-
Strange, P.G.1
-
52
-
-
0347627709
-
Constitutive activity and inverse agonists of G protein-coupled receptors: A current perspective
-
G. Milligan Constitutive activity and inverse agonists of G protein-coupled receptors: a current perspective Mol. Pharmacol. 64 2003 1271 1276
-
(2003)
Mol. Pharmacol.
, vol.64
, pp. 1271-1276
-
-
Milligan, G.1
-
54
-
-
0028933842
-
Mutations and diseases of G protein coupled receptors
-
M. Birnbaumer Mutations and diseases of G protein coupled receptors J. Recept. Signal Transduct. Res. 15 1995 131 160
-
(1995)
J. Recept. Signal Transduct. Res.
, vol.15
, pp. 131-160
-
-
Birnbaumer, M.1
-
55
-
-
0035952635
-
Virally encoded 7TM receptors
-
M.M. Rosenkilde Virally encoded 7TM receptors Oncogene 20 2001 1582 1593
-
(2001)
Oncogene
, vol.20
, pp. 1582-1593
-
-
Rosenkilde, M.M.1
-
56
-
-
0037867964
-
Virally encoded G protein-coupled receptors: Targets for potentially innovative anti-viral drug development
-
M.J. Smit Virally encoded G protein-coupled receptors: targets for potentially innovative anti-viral drug development Curr. Drug Targets 4 2003 431 441
-
(2003)
Curr. Drug Targets
, vol.4
, pp. 431-441
-
-
Smit, M.J.1
-
57
-
-
2942751868
-
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
-
Y. Zou Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II Nat. Cell Biol. 6 2004 499 506
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 499-506
-
-
Zou, Y.1
-
58
-
-
4444324531
-
Allosteric modulators: The new generation of receptor antagonist
-
T. Kenakin Allosteric modulators: the new generation of receptor antagonist Mol. Interv. 4 2004 222 229
-
(2004)
Mol. Interv.
, vol.4
, pp. 222-229
-
-
Kenakin, T.1
-
59
-
-
0034649481
-
High constitutive activity of native H3 receptors regulates histamine neurons in brain
-
S. Morisset High constitutive activity of native H3 receptors regulates histamine neurons in brain Nature 408 2000 860 864
-
(2000)
Nature
, vol.408
, pp. 860-864
-
-
Morisset, S.1
-
60
-
-
0027940368
-
Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy
-
C.A. Milano Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy Proc. Natl. Acad. Sci. U. S. A. 91 1994 10109 10113
-
(1994)
Proc. Natl. Acad. Sci. U. S. A.
, vol.91
, pp. 10109-10113
-
-
Milano, C.A.1
-
61
-
-
0031442990
-
Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide
-
E. Schipani Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide Proc. Natl. Acad. Sci. U. S. A. 94 1997 13689 13694
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 13689-13694
-
-
Schipani, E.1
-
62
-
-
1342264249
-
Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation
-
B. Holst, and T.W. Schwartz Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation Trends Pharmacol. Sci. 25 2004 113 117
-
(2004)
Trends Pharmacol. Sci.
, vol.25
, pp. 113-117
-
-
Holst, B.1
Schwartz, T.W.2
-
64
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
D. Huszar Targeted disruption of the melanocortin-4 receptor results in obesity in mice Cell 88 1997 131 141
-
(1997)
Cell
, vol.88
, pp. 131-141
-
-
Huszar, D.1
-
65
-
-
0030764741
-
Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
-
M.M. Ollmann Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein Science 278 1997 135 138
-
(1997)
Science
, vol.278
, pp. 135-138
-
-
Ollmann, M.M.1
-
66
-
-
0035130843
-
AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor
-
W.A. Nijenhuis AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor Mol. Endocrinol. 15 2001 164 171
-
(2001)
Mol. Endocrinol.
, vol.15
, pp. 164-171
-
-
Nijenhuis, W.A.1
-
67
-
-
0032563291
-
G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization
-
R.J. Lefkowitz G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization J. Biol. Chem. 273 1998 18677 18680
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 18677-18680
-
-
Lefkowitz, R.J.1
-
68
-
-
0141593597
-
Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
-
M. Azzi Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors Proc. Natl. Acad. Sci. U. S. A. 100 2003 11406 11411
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 11406-11411
-
-
Azzi, M.1
-
69
-
-
14844333116
-
Internalization and Src activity regulate the time course of ERK activation by delta opioid receptor ligands
-
N. Audet Internalization and Src activity regulate the time course of ERK activation by delta opioid receptor ligands J. Biol. Chem. 280 2005 7808 7816
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 7808-7816
-
-
Audet, N.1
-
70
-
-
13444291851
-
Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling
-
J. Kim Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling Proc. Natl. Acad. Sci. U. S. A. 102 2005 1442 1447
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 1442-1447
-
-
Kim, J.1
-
71
-
-
13444270337
-
Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor
-
X.R. Ren Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor Proc. Natl. Acad. Sci. U. S. A. 102 2005 1448 1453
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 1448-1453
-
-
Ren, X.R.1
-
72
-
-
0029897495
-
Constitutively active mutants of the alpha 1B-adrenergic receptor: Role of highly conserved polar amino acids in receptor activation
-
A. Scheer Constitutively active mutants of the alpha 1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation EMBO J. 15 1996 3566 3578
-
(1996)
EMBO J.
, vol.15
, pp. 3566-3578
-
-
Scheer, A.1
-
73
-
-
0030614337
-
The activation process of the alpha1B-adrenergic receptor: Potential role of protonation and hydrophobicity of a highly conserved aspartate
-
A. Scheer The activation process of the alpha1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate Proc. Natl. Acad. Sci. U. S. A. 94 1997 808 813
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 808-813
-
-
Scheer, A.1
-
74
-
-
0035824582
-
Mutational and computational analysis of the alpha(1b)-adrenergic receptor. Involvement of basic and hydrophobic residues in receptor activation and G protein coupling
-
P.J. Greasley Mutational and computational analysis of the alpha(1b)-adrenergic receptor. Involvement of basic and hydrophobic residues in receptor activation and G protein coupling J. Biol. Chem. 276 2001 46485 46494
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 46485-46494
-
-
Greasley, P.J.1
-
75
-
-
0036239236
-
Mutagenesis and modelling of the alpha(1b)-adrenergic receptor highlight the role of the helix 3/helix 6 interface in receptor activation
-
P.J. Greasley Mutagenesis and modelling of the alpha(1b)-adrenergic receptor highlight the role of the helix 3/helix 6 interface in receptor activation Mol. Pharmacol. 61 2002 1025 1032
-
(2002)
Mol. Pharmacol.
, vol.61
, pp. 1025-1032
-
-
Greasley, P.J.1
-
76
-
-
0030859541
-
Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor
-
U. Gether Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor EMBO J. 16 1997 6737 6747
-
(1997)
EMBO J.
, vol.16
, pp. 6737-6747
-
-
Gether, U.1
-
77
-
-
0030611331
-
Constitutive activation of the beta2 adrenergic receptor alters the orientation of its sixth membrane-spanning segment
-
J.A. Javitch Constitutive activation of the beta2 adrenergic receptor alters the orientation of its sixth membrane-spanning segment J. Biol. Chem. 272 1997 18546 18549
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 18546-18549
-
-
Javitch, J.A.1
-
78
-
-
0033061256
-
Mutation of a highly conserved aspartic acid in the beta2 adrenergic receptor: Constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6
-
S.G. Rasmussen Mutation of a highly conserved aspartic acid in the beta2 adrenergic receptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6 Mol. Pharmacol. 56 1999 175 184
-
(1999)
Mol. Pharmacol.
, vol.56
, pp. 175-184
-
-
Rasmussen, S.G.1
-
79
-
-
0031018485
-
Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility
-
U. Gether Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility J. Biol. Chem. 272 1997 2587 2590
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 2587-2590
-
-
Gether, U.1
-
80
-
-
0035397917
-
Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders
-
W.P. Spooren Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders Trends Pharmacol. Sci. 22 2001 331 337
-
(2001)
Trends Pharmacol. Sci.
, vol.22
, pp. 331-337
-
-
Spooren, W.P.1
-
81
-
-
0036591659
-
A model for the functioning of family 3 GPCRs
-
M.L. Parmentier A model for the functioning of family 3 GPCRs Trends Pharmacol. Sci. 23 2002 268 274
-
(2002)
Trends Pharmacol. Sci.
, vol.23
, pp. 268-274
-
-
Parmentier, M.L.1
-
82
-
-
0037424518
-
Mutational analysis and molecular modeling of the allosteric binding site of a novel, selective, noncompetitive antagonist of the metabotropic glutamate 1 receptor
-
P. Malherbe Mutational analysis and molecular modeling of the allosteric binding site of a novel, selective, noncompetitive antagonist of the metabotropic glutamate 1 receptor J. Biol. Chem. 278 2003 8340 8347
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 8340-8347
-
-
Malherbe, P.1
-
83
-
-
0346458626
-
Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors
-
C. Goudet Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors Proc. Natl. Acad. Sci. U. S. A. 101 2004 378 383
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 378-383
-
-
Goudet, C.1
-
84
-
-
0036259109
-
Discovery of an ectopic activation site on the M(1) muscarinic receptor
-
T.A. Spalding Discovery of an ectopic activation site on the M(1) muscarinic receptor Mol. Pharmacol. 61 2002 1297 1302
-
(2002)
Mol. Pharmacol.
, vol.61
, pp. 1297-1302
-
-
Spalding, T.A.1
-
85
-
-
0035529012
-
Agonist Trapping by GABAA Receptor Channels
-
M.T. Bianchi, and R.L. Macdonald Agonist Trapping by GABAA Receptor Channels J. Neurosci. 21 2001 9083 9091
-
(2001)
J. Neurosci.
, vol.21
, pp. 9083-9091
-
-
Bianchi, M.T.1
MacDonald, R.L.2
-
86
-
-
0028181698
-
Benzodiazepine and beta-carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture
-
C. Rogers Benzodiazepine and beta-carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture J. Physiol. 475 1994 69 82
-
(1994)
J. Physiol.
, vol.475
, pp. 69-82
-
-
Rogers, C.1
-
87
-
-
0031011984
-
Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor
-
S. Ueno Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor J. Neurosci. 17 1997 625 634
-
(1997)
J. Neurosci.
, vol.17
, pp. 625-634
-
-
Ueno, S.1
-
88
-
-
0029055030
-
Allosteric modulation of muscarinic acetylcholine receptors
-
S. Tucek, and J. Proska Allosteric modulation of muscarinic acetylcholine receptors Trends Pharmacol. Sci. 16 1995 205 212
-
(1995)
Trends Pharmacol. Sci.
, vol.16
, pp. 205-212
-
-
Tucek, S.1
Proska, J.2
-
89
-
-
4344603756
-
Allosteric modulation of G protein-coupled receptors: Perspectives and recent developments
-
W. Soudijn Allosteric modulation of G protein-coupled receptors: perspectives and recent developments Drug Discov. Today 9 2004 752 758
-
(2004)
Drug Discov. Today
, vol.9
, pp. 752-758
-
-
Soudijn, W.1
-
90
-
-
0036258990
-
G protein-coupled receptor allosterism and complexing
-
A. Christopoulos, and T. Kenakin G protein-coupled receptor allosterism and complexing Pharmacol. Rev. 54 2002 323 374
-
(2002)
Pharmacol. Rev.
, vol.54
, pp. 323-374
-
-
Christopoulos, A.1
Kenakin, T.2
|