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Volumn 533, Issue 1-3, 2006, Pages 110-117

Phosphodiesterase inhibitors in airways disease

Author keywords

Asthma; Chronic obstructive pulmonary disease; Cilomilast; Phosphodiesterase; Phosphodiesterase inhibitor; Roflumilast; Rolipram

Indexed keywords

2 [4 [6,7 DIETHOXY 2,3 BIS(HYDROXYMETHYL) 1 NAPHTHYL] 2 PYRIDYL] 4 (3 PYRIDYL) 1(2H) PHTHALAZINONE; 3 (3 CYCLOPENTYLOXY 4 METHOXYBENZYL) 6 ETHYLAMINO 8 ISOPROPYL 3H PURINE; 4 (3 CHLOROPHENYL) 1,7 DIETHYLPYRIDO[2,3 D]PYRIMIDIN 2(1H) ONE; 6 (4 ACETAMIDOPHENYL) 1,2,3,4,4A,10B HEXAHYDRO 8,9 DIMETHOXY 2 METHYLBENZO[C][1,6]NAPHTHYRIDINE; 7 METHOXYBENZOFURAN 4 CARBOXAMIDE DERIVATIVE; BAY 198004; BECLOMETASONE; C 3885; CC 7075; CC 7085; CI 1044; CILOMILAST; ISOPRENALINE; KW 4490; MOTAPIZONE; N (3,5 DICHLORO 4 PYRIDYL) [1 (4 FLUOROBENZYL) 5 HYDROXY 3 INDOLYL]GLYOXYLIC ACID AMIDE; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; PHOSPHODIESTERASE VII INHIBITOR; PHTALAZINE DERIVATIVE; PICLAMILAST; ROFLUMILAST; ROLIPRAM; SIGUAZODAN; SILDENAFIL; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZAPRINAST; ZARDAVERINE;

EID: 33644811309     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.12.059     Document Type: Review
Times cited : (254)

References (81)
  • 1
    • 0242312410 scopus 로고    scopus 로고
    • A new orally active, selective phosphodiesterase inhibitor, with beclomethasone propionate in asthma control
    • A. Albrecht, S. Leichtl, D. Bredenbroker, T.D. Bethke, and W. Wurst A new orally active, selective phosphodiesterase inhibitor, with beclomethasone propionate in asthma control Eur. Respir. J. 20 suppl 38 2002 304S
    • (2002) Eur. Respir. J. , vol.20 , Issue.SUPPL. 38
    • Albrecht, A.1    Leichtl, S.2    Bredenbroker, D.3    Bethke, T.D.4    Wurst, W.5
  • 2
    • 10344242415 scopus 로고    scopus 로고
    • Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation
    • M. Ariga, B. Neitzert, S. Nakae, G. Mottin, C. Bertrand, M.P. Pruniaux, S.L. Jin, and M. Conti Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation J. Immunol. 173 2004 7531 7538
    • (2004) J. Immunol. , vol.173 , pp. 7531-7538
    • Ariga, M.1    Neitzert, B.2    Nakae, S.3    Mottin, G.4    Bertrand, C.5    Pruniaux, M.P.6    Jin, S.L.7    Conti, M.8
  • 4
    • 0029939872 scopus 로고    scopus 로고
    • Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [3H]rolipram binding
    • M.S. Barnette, J.O. Bartus, M. Burman, S.B. Christensen, L.B. Cieslinski, K.M. Esser, U.S. Prabhakar, J.A. Rush, and T.J. Torphy Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [3H]rolipram binding Biochem. Pharmacol. 51 1996 949 956
    • (1996) Biochem. Pharmacol. , vol.51 , pp. 949-956
    • Barnette, M.S.1    Bartus, J.O.2    Burman, M.3    Christensen, S.B.4    Cieslinski, L.B.5    Esser, K.M.6    Prabhakar, U.S.7    Rush, J.A.8    Torphy, T.J.9
  • 5
    • 0028802726 scopus 로고
    • Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
    • J.A. Beavo Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms Physiol. Rev. 75 1995 725 748
    • (1995) Physiol. Rev. , vol.75 , pp. 725-748
    • Beavo, J.A.1
  • 6
    • 0028136159 scopus 로고
    • Multiple cyclic nucleotide phosphodiesterases
    • J.A. Beavo, M. Conti, and R.J. Heaslip Multiple cyclic nucleotide phosphodiesterases Mol. Pharmacol. 46 1994 399 405
    • (1994) Mol. Pharmacol. , vol.46 , pp. 399-405
    • Beavo, J.A.1    Conti, M.2    Heaslip, R.J.3
  • 7
    • 0034703546 scopus 로고    scopus 로고
    • Reduction of matrix metalloproteinase-9 activity by the selective phosphodiesterase 4 inhibitor, RP 73-401 in sensitized mice
    • C. Belleguic, M. Corbel, N. Germain, E. Boichot, P. Delaval, and V. Lagente Reduction of matrix metalloproteinase-9 activity by the selective phosphodiesterase 4 inhibitor, RP 73-401 in sensitized mice Eur. J. Pharmacol. 404 2000 369 373
    • (2000) Eur. J. Pharmacol. , vol.404 , pp. 369-373
    • Belleguic, C.1    Corbel, M.2    Germain, N.3    Boichot, E.4    Delaval, P.5    Lagente, V.6
  • 8
    • 0030459832 scopus 로고    scopus 로고
    • Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants
    • T.J. Bloom, and J.A. Beavo Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants Proc. Natl. Acad. Sci. U. S. A. 93 1996 14188 14192
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 14188-14192
    • Bloom, T.J.1    Beavo, J.A.2
  • 9
    • 0026688301 scopus 로고
    • Bronchodilatory effect of inhaled zardaverine, a phosphodiesterase III and IV inhibitor, in patients with asthma
    • T. Brunnee, R. Engelstatter, V.W. Steinijans, and G. Kunkel Bronchodilatory effect of inhaled zardaverine, a phosphodiesterase III and IV inhibitor, in patients with asthma Eur. Respir. J. 5 1992 982 985
    • (1992) Eur. Respir. J. , vol.5 , pp. 982-985
    • Brunnee, T.1    Engelstatter, R.2    Steinijans, V.W.3    Kunkel, G.4
  • 11
    • 0036265607 scopus 로고    scopus 로고
    • Recent advances in PDE4 inhibitors as immunoregulators and anti-inflammatory drugs
    • C. Burnouf, and M.P. Pruniaux Recent advances in PDE4 inhibitors as immunoregulators and anti-inflammatory drugs Curr. Pharm. Des 8 2002 1255 1296
    • (2002) Curr. Pharm. des , vol.8 , pp. 1255-1296
    • Burnouf, C.1    Pruniaux, M.P.2
  • 12
    • 14544272401 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: Advances in the development of specific phosphodiesterase inhibitors
    • A. Castro, M.J. Jerez, C. Gil, and A. Martinez Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: advances in the development of specific phosphodiesterase inhibitors Med. Res. Rev. 25 2005 229 244
    • (2005) Med. Res. Rev. , vol.25 , pp. 229-244
    • Castro, A.1    Jerez, M.J.2    Gil, C.3    Martinez, A.4
  • 13
    • 0034881183 scopus 로고    scopus 로고
    • Does sildenafil also improve breathing?
    • N.B. Charan Does sildenafil also improve breathing? Chest 120 2001 305 306
    • (2001) Chest , vol.120 , pp. 305-306
    • Charan, N.B.1
  • 14
    • 0000006097 scopus 로고    scopus 로고
    • Ariflo improves pulmonary function in patients with asthma: Results of a study in patients taking inhaled corticosteroids
    • C. Compton, E. Cedar, R.B. Nieman, O. Omit, S.J. Langley, and M. Sapene Ariflo improves pulmonary function in patients with asthma: results of a study in patients taking inhaled corticosteroids Am. J. Respir. Crit. Care Med. 195 1999 A624
    • (1999) Am. J. Respir. Crit. Care Med. , vol.195 , pp. 624
    • Compton, C.1    Cedar, E.2    Nieman, R.B.3    Omit, O.4    Langley, S.J.5    Sapene, M.6
  • 16
    • 0001349046 scopus 로고    scopus 로고
    • Cilomilast (Ariflo) 15 mg bid safety in a 6 month clinical trial programme
    • C.H. Compton, J.D. Eddlestone, and E. Cedar Cilomilast (Ariflo) 15 mg bid safety in a 6 month clinical trial programme Am. J. Respir. Crit. Care Med. 163 2001 A909
    • (2001) Am. J. Respir. Crit. Care Med. , vol.163 , pp. 909
    • Compton, C.H.1    Eddlestone, J.D.2    Cedar, E.3
  • 18
    • 0029009878 scopus 로고
    • Recent progress in understanding the hormonal regulation of phosphodiesterases
    • M. Conti, G. Nemoz, C. Sette, and E. Vicini Recent progress in understanding the hormonal regulation of phosphodiesterases Endocr. Rev. 16 1995 370 389
    • (1995) Endocr. Rev. , vol.16 , pp. 370-389
    • Conti, M.1    Nemoz, G.2    Sette, C.3    Vicini, E.4
  • 19
    • 0036200951 scopus 로고    scopus 로고
    • The selective phosphodiesterase 4 inhibitor RP 73-401 reduced matrix metalloproteinase 9 activity and transforming growth factor-beta release during acute lung injury in mice: The role of the balance between tumor necrosis factor-alpha and interleukin-10
    • M. Corbel, N. Germain, J. Lanchou, S. Molet, P.M. Silva, M.A. Martins, E. Boichot, and V. Lagente The selective phosphodiesterase 4 inhibitor RP 73-401 reduced matrix metalloproteinase 9 activity and transforming growth factor-beta release during acute lung injury in mice: the role of the balance between tumor necrosis factor-alpha and interleukin-10 J. Pharmacol. Exp. Ther. 301 2002 258 265
    • (2002) J. Pharmacol. Exp. Ther. , vol.301 , pp. 258-265
    • Corbel, M.1    Germain, N.2    Lanchou, J.3    Molet, S.4    Silva, P.M.5    Martins, M.A.6    Boichot, E.7    Lagente, V.8
  • 20
    • 0001689418 scopus 로고    scopus 로고
    • Cilomilast (ariflo) a potent selective inhibitor of phosphodiesterase 4 improves lung functions in patients with COPD: Results of a six month trial
    • J.D Eddleston, C.H. Compton, and R. Nieman Cilomilast (ariflo) a potent selective inhibitor of phosphodiesterase 4 improves lung functions in patients with COPD: results of a six month trial Am. J. Respir. Crit. Care Med. 163 2001 A277
    • (2001) Am. J. Respir. Crit. Care Med. , vol.163 , pp. 277
    • Eddleston, J.D.1    Compton, C.H.2    Nieman, R.3
  • 21
    • 0001689419 scopus 로고    scopus 로고
    • Cilomilast (ariflo) a potent selective inhibitor of phosphodiesterase 4 inhibitor reduces exacerbations in COPD patients: Results of a six month trial
    • J.D. Eddleston, C.H. Compton, and R. Nieman Cilomilast (ariflo) a potent selective inhibitor of phosphodiesterase 4 inhibitor reduces exacerbations in COPD patients: results of a six month trial Am. J. Respir. Crit. Care Med. 163 2001 A771
    • (2001) Am. J. Respir. Crit. Care Med. , vol.163 , pp. 771
    • Eddleston, J.D.1    Compton, C.H.2    Nieman, R.3
  • 23
    • 0030441056 scopus 로고    scopus 로고
    • In vitro down-regulation of antigen-induced IL-5 gene expression and protein production by cAMP-specific phosphodiesterase type 4 inhibitor
    • L. Foissier, M. Lonchampt, F. Coge, and E. Canet In vitro down-regulation of antigen-induced IL-5 gene expression and protein production by cAMP-specific phosphodiesterase type 4 inhibitor J. Pharmacol. Exp. Ther. 278 1996 1484 1490
    • (1996) J. Pharmacol. Exp. Ther. , vol.278 , pp. 1484-1490
    • Foissier, L.1    Lonchampt, M.2    Coge, F.3    Canet, E.4
  • 24
    • 4243900778 scopus 로고
    • Bronchodilator potency, effectiveness and time course of inhaled nebulised AH 21-132 in normal human subjects
    • R.W. Foster, and K. Rakshi Bronchodilator potency, effectiveness and time course of inhaled nebulised AH 21-132 in normal human subjects Br. J. Pharmacol. 99 1990 193P
    • (1990) Br. J. Pharmacol. , vol.99
    • Foster, R.W.1    Rakshi, K.2
  • 29
    • 0031989117 scopus 로고    scopus 로고
    • Effects of rolipram on cyclic AMP levels in alveolar macrophages and lipopolysaccharide-induced inflammation in mouse lung
    • V. Goncalves, d.M., M. Singer, B.B. Vargaftig, and M. Chignard Effects of rolipram on cyclic AMP levels in alveolar macrophages and lipopolysaccharide- induced inflammation in mouse lung Br. J. Pharmacol. 123 1998 631 636
    • (1998) Br. J. Pharmacol. , vol.123 , pp. 631-636
    • Goncalves, V.D.M.1    Singer, M.2    Vargaftig, B.B.3    Chignard, M.4
  • 31
    • 0034612334 scopus 로고    scopus 로고
    • Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D
    • G. Hansen, S. Jin, D.T. Umetsu, and M. Conti Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D Proc. Natl. Acad. Sci. U. S. A. 97 2000 6751 6756
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 6751-6756
    • Hansen, G.1    Jin, S.2    Umetsu, D.T.3    Conti, M.4
  • 32
    • 33644809210 scopus 로고    scopus 로고
    • Phthalazinone derivatives useful as PDE4/7 inhibitors (WO02085906).
    • Hatzelmann, A., Marx, D., Steinhilber, W., and Altana Pharma AG., 2002. Phthalazinone derivatives useful as PDE4/7 inhibitors (WO02085906).
    • (2002)
    • Hatzelmann, A.1    Marx, D.2    Steinhilber, W.3
  • 33
    • 0037443097 scopus 로고    scopus 로고
    • PDE4 cAMP phosphodiesterases: Modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization
    • M.D. Houslay, and D.R. Adams PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization Biochem. J. 370 2003 1 18
    • (2003) Biochem. J. , vol.370 , pp. 1-18
    • Houslay, M.D.1    Adams, D.R.2
  • 35
    • 0037188511 scopus 로고    scopus 로고
    • Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses
    • S.L. Jin, and M. Conti Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses Proc. Natl. Acad. Sci. U. S.A. 99 2002 7628 7633
    • (2002) Proc. Natl. Acad. Sci. U. S .A. , vol.99 , pp. 7628-7633
    • Jin, S.L.1    Conti, M.2
  • 37
    • 0036787848 scopus 로고    scopus 로고
    • Phosphodiesterase 4 inhibitor cilomilast inhibits fibroblast-mediated collagen gel degradation induced by tumor necrosis factor-alpha and neutrophil elastase
    • T. Kohyama, X. Liu, Y.K. Zhu, F.Q. Wen, H.J. Wang, Q. Fang, T. Kobayashi, and S.I. Rennard Phosphodiesterase 4 inhibitor cilomilast inhibits fibroblast-mediated collagen gel degradation induced by tumor necrosis factor-alpha and neutrophil elastase Am. J. Respir. Crit. Care Med. 27 2002 487 494
    • (2002) Am. J. Respir. Crit. Care Med. , vol.27 , pp. 487-494
    • Kohyama, T.1    Liu, X.2    Zhu, Y.K.3    Wen, F.Q.4    Wang, H.J.5    Fang, Q.6    Kobayashi, T.7    Rennard, S.I.8
  • 39
    • 0141630489 scopus 로고    scopus 로고
    • In vivo efficacy in airway disease models of N-(3,5-dichloropyrid-4-yl)- [1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyo xylic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration
    • H. Kuss, N. Hoefgen, S. Johanssen, T. Kronbach, and C. Rundfeldt In vivo efficacy in airway disease models of N-(3,5-dichloropyrid-4-yl)-[1-(4- fluorobenzyl)-5-hydroxy-indole-3-yl]-glyo xylic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration J. Pharmacol. Exp. Ther. 307 2003 373 385
    • (2003) J. Pharmacol. Exp. Ther. , vol.307 , pp. 373-385
    • Kuss, H.1    Hoefgen, N.2    Johanssen, S.3    Kronbach, T.4    Rundfeldt, C.5
  • 40
    • 0028258454 scopus 로고
    • Effects of isozyme-selective phosphodiesterase inhibitors on eosinophil infiltration in the guinea-pig lung
    • V. Lagente, I. Moodley, S. Perrin, G. Mottin, and J.L. Junien Effects of isozyme-selective phosphodiesterase inhibitors on eosinophil infiltration in the guinea-pig lung Eur. J. Pharmacol. 255 1994 253 256
    • (1994) Eur. J. Pharmacol. , vol.255 , pp. 253-256
    • Lagente, V.1    Moodley, I.2    Perrin, S.3    Mottin, G.4    Junien, J.L.5
  • 41
    • 0029011921 scopus 로고
    • Modulation of cytokine-induced eosinophil infiltration by phosphodiesterase inhibitors
    • V. Lagente, M.P. Pruniaux, J.L. Junien, and I. Moodley Modulation of cytokine-induced eosinophil infiltration by phosphodiesterase inhibitors Am. J. Respir. Crit. Care Med. 151 1995 1720 1724
    • (1995) Am. J. Respir. Crit. Care Med. , vol.151 , pp. 1720-1724
    • Lagente, V.1    Pruniaux, M.P.2    Junien, J.L.3    Moodley, I.4
  • 42
    • 18844426222 scopus 로고    scopus 로고
    • Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases
    • V. Lagente, C. Martin-Chouly, E. Boichot, M.A. Martins, and P.M. Silva Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases Mem. Inst. Oswaldo Cruz 100 Suppl 1 2005 131 136
    • (2005) Mem. Inst. Oswaldo Cruz , vol.100 , Issue.SUPPL. 1 , pp. 131-136
    • Lagente, V.1    Martin-Chouly, C.2    Boichot, E.3    Martins, M.A.4    Silva, P.M.5
  • 43
    • 0034746479 scopus 로고    scopus 로고
    • Effects of prostaglandin E2 and cAMP elevating drugs on GM-CSF release by cultured human airway smooth muscle cells. Relevance to asthma therapy
    • N. Lazzeri, M.G. Belvisi, H.J. Patel, M.H. Yacoub, K.F. Chung, and J.A. Mitchell Effects of prostaglandin E2 and cAMP elevating drugs on GM-CSF release by cultured human airway smooth muscle cells. Relevance to asthma therapy Am. J. Respir. Cell Mol. Biol. 24 2001 44 48
    • (2001) Am. J. Respir. Cell Mol. Biol. , vol.24 , pp. 44-48
    • Lazzeri, N.1    Belvisi, M.G.2    Patel, H.J.3    Yacoub, M.H.4    Chung, K.F.5    Mitchell, J.A.6
  • 44
    • 0242312410 scopus 로고    scopus 로고
    • Roflumilast, a new orally active, selective phosphodiesterase 4 inhibitor is effective in the treatment of asthma
    • S. Leichtl, C. Schmid-Wirlitsch, D. Bredenbroker, F. Rathgeb, and W. Wurst Roflumilast, a new orally active, selective phosphodiesterase 4 inhibitor is effective in the treatment of asthma Eur. Respir. J. 20 Suppl 38 2002 303S
    • (2002) Eur. Respir. J. , vol.20 , Issue.SUPPL. 38
    • Leichtl, S.1    Schmid-Wirlitsch, C.2    Bredenbroker, D.3    Rathgeb, F.4    Wurst, W.5
  • 45
    • 0033524977 scopus 로고    scopus 로고
    • CD3- and CD28-dependent induction of PDE7 required for T cell activation
    • L. Li, C. Yee, and J.A. Beavo CD3- and CD28-dependent induction of PDE7 required for T cell activation Science 283 1999 848 851
    • (1999) Science , vol.283 , pp. 848-851
    • Li, L.1    Yee, C.2    Beavo, J.A.3
  • 46
    • 2942618507 scopus 로고    scopus 로고
    • Modulation of matrix metalloproteinase production from human lung fibroblasts by type 4 phosphodiesterase inhibitors
    • C.A. Martin-Chouly, A. Astier, C. Jacob, M.P. Pruniaux, C. Bertrand, and V. Lagente Modulation of matrix metalloproteinase production from human lung fibroblasts by type 4 phosphodiesterase inhibitors Life Sci. 75 2004 823 840
    • (2004) Life Sci. , vol.75 , pp. 823-840
    • Martin-Chouly, C.A.1    Astier, A.2    Jacob, C.3    Pruniaux, M.P.4    Bertrand, C.5    Lagente, V.6
  • 48
    • 13544273183 scopus 로고    scopus 로고
    • Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells
    • M. Mata, B. Sarria, A. Buenestado, J. Cortijo, M. Cerda, and E.J. Morcillo Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells Thorax 60 2005 144 152
    • (2005) Thorax , vol.60 , pp. 144-152
    • Mata, M.1    Sarria, B.2    Buenestado, A.3    Cortijo, J.4    Cerda, M.5    Morcillo, E.J.6
  • 50
    • 0035372036 scopus 로고    scopus 로고
    • Differential distribution of cAMP-specific phosphodiesterase 7A mRNA in rat brain and peripheral organs
    • X. Miro, S. Perez-Torres, J.M. Palacios, P. Puigdomenech, and G. Mengod Differential distribution of cAMP-specific phosphodiesterase 7A mRNA in rat brain and peripheral organs Synapse 40 2001 201 214
    • (2001) Synapse , vol.40 , pp. 201-214
    • Miro, X.1    Perez-Torres, S.2    Palacios, J.M.3    Puigdomenech, P.4    Mengod, G.5
  • 51
    • 0025881348 scopus 로고
    • Granulocyte-macrophage colony-stimulating factor promotes the proliferation of human alveolar macrophages in vitro
    • K. Nakata, K.S. Akagawa, M. Fukayama, Y. Hayashi, M. Kadokura, and T. Tokunaga Granulocyte-macrophage colony-stimulating factor promotes the proliferation of human alveolar macrophages in vitro J. Immunol. 147 1991 1266 1272
    • (1991) J. Immunol. , vol.147 , pp. 1266-1272
    • Nakata, K.1    Akagawa, K.S.2    Fukayama, M.3    Hayashi, Y.4    Kadokura, M.5    Tokunaga, T.6
  • 52
    • 0030051755 scopus 로고    scopus 로고
    • Effects of selective phosphodiesterase inhibitors on platelet-activating factor- and antigen-induced airway hyperreactivity, eosinophil accumulation, and microvascular leakage in guinea pigs
    • J.L. Ortiz, J.M. Valles, M. Marti-Cabrera, J. Cortijo, and E.J. Morcillo Effects of selective phosphodiesterase inhibitors on platelet-activating factor- and antigen-induced airway hyperreactivity, eosinophil accumulation, and microvascular leakage in guinea pigs Naunyn-Schmiedeberg's Arch. Pharmacol. 353 1996 200 206
    • (1996) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.353 , pp. 200-206
    • Ortiz, J.L.1    Valles, J.M.2    Marti-Cabrera, M.3    Cortijo, J.4    Morcillo, E.J.5
  • 54
    • 33644790362 scopus 로고    scopus 로고
    • Dual inhibitors of PDE7 and PDE4. World patent (WO 02088079).
    • Pitts, W. J., Watson, A. J., Dodd, J. H., and Bristol Myers Squibb., 2002. Dual inhibitors of PDE7 and PDE4. World patent (WO 02088079).
    • (2002)
    • Pitts, W.J.1    Watson, A.J.2    Dodd, J.H.3
  • 56
    • 23744451716 scopus 로고    scopus 로고
    • Roflumilast - An oral anti-inflammatory treatment for chronic obstructive pulmonary disease: A randomised controlled trial
    • K.F. Rabe, E.D. Bateman, D. O'Donnell, S. Witte, D. Bredenbroeker, and T.D. Bethke Roflumilast - an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial Lancet 366 2005 563 571
    • (2005) Lancet , vol.366 , pp. 563-571
    • Rabe, K.F.1    Bateman, E.D.2    O'Donnell, D.3    Witte, S.4    Bredenbroeker, D.5    Bethke, T.D.6
  • 57
    • 0028949423 scopus 로고
    • Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases
    • R.R. Reinhardt, E. Chin, J. Zhou, M. Taira, T. Murata, V.C. Manganiello, and C.A. Bondy Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases J. Clin. Invest. 95 1995 1528 1538
    • (1995) J. Clin. Invest. , vol.95 , pp. 1528-1538
    • Reinhardt, R.R.1    Chin, E.2    Zhou, J.3    Taira, M.4    Murata, T.5    Manganiello, V.C.6    Bondy, C.A.7
  • 61
    • 19444363467 scopus 로고    scopus 로고
    • PDE4 inhibitors as new anti-inflammatory drugs: Effects on cell trafficking and cell adhesion molecules expression
    • M.J. Sanz, J. Cortijo, and E.J. Morcillo PDE4 inhibitors as new anti-inflammatory drugs: effects on cell trafficking and cell adhesion molecules expression Pharmacol. Ther. 106 2005 269 297
    • (2005) Pharmacol. Ther. , vol.106 , pp. 269-297
    • Sanz, M.J.1    Cortijo, J.2    Morcillo, E.J.3
  • 62
    • 19444363467 scopus 로고    scopus 로고
    • PDE4 inhibitors as new anti-inflammatory drugs: Effects on cell trafficking and cell adhesion molecules expression
    • M.J. Sanz, J. Cortijo, and E.J. Morcillo PDE4 inhibitors as new anti-inflammatory drugs: effects on cell trafficking and cell adhesion molecules expression Pharmacol. Ther. 106 2005 269 297
    • (2005) Pharmacol. Ther. , vol.106 , pp. 269-297
    • Sanz, M.J.1    Cortijo, J.2    Morcillo, E.J.3
  • 63
    • 1842530387 scopus 로고    scopus 로고
    • Clinical efficacy of sildenafil in primary pulmonary hypertension: A randomized, placebo-controlled, double-blind, crossover study
    • B.K. Sastry, C. Narasimhan, N.K. Reddy, and B.S. Raju Clinical efficacy of sildenafil in primary pulmonary hypertension: a randomized, placebo-controlled, double-blind, crossover study J. Am. Coll. Cardiol. 43 2004 1149 1153
    • (2004) J. Am. Coll. Cardiol. , vol.43 , pp. 1149-1153
    • Sastry, B.K.1    Narasimhan, C.2    Reddy, N.K.3    Raju, B.S.4
  • 64
    • 0029165312 scopus 로고
    • PDE isoenzymes as targets for anti-asthma drugs
    • C. Schudt, H. Tenor, and A. Hatzelmann PDE isoenzymes as targets for anti-asthma drugs Eur. Respir. J. 8 1995 1179 1183
    • (1995) Eur. Respir. J. , vol.8 , pp. 1179-1183
    • Schudt, C.1    Tenor, H.2    Hatzelmann, A.3
  • 65
    • 0037741441 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 as a target for the treatment of hypoxia-induced pulmonary hypertension
    • A. Sebkhi, J.W. Strange, S.C. Phillips, J. Wharton, and M.R. Wilkins Phosphodiesterase type 5 as a target for the treatment of hypoxia-induced pulmonary hypertension Circulation 107 2003 3230 3235
    • (2003) Circulation , vol.107 , pp. 3230-3235
    • Sebkhi, A.1    Strange, J.W.2    Phillips, S.C.3    Wharton, J.4    Wilkins, M.R.5
  • 69
    • 0029982516 scopus 로고    scopus 로고
    • Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNF alpha generation from human monocytes by interacting with a 'low-affinity' phosphodiesterase 4 conformer
    • J.E. Souness, M. Griffin, C. Maslen, K. Ebsworth, L.C. Scott, K. Pollock, M.N. Palfreyman, and J.A. Karlsson Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNF alpha generation from human monocytes by interacting with a 'low-affinity' phosphodiesterase 4 conformer Br. J. Pharmacol. 118 1996 649 658
    • (1996) Br. J. Pharmacol. , vol.118 , pp. 649-658
    • Souness, J.E.1    Griffin, M.2    Maslen, C.3    Ebsworth, K.4    Scott, L.C.5    Pollock, K.6    Palfreyman, M.N.7    Karlsson, J.A.8
  • 70
    • 0036264724 scopus 로고    scopus 로고
    • Phosphodiesterase 4 inhibitors for the treatment of COPD
    • G. Sturton, and M. Fitzgerald Phosphodiesterase 4 inhibitors for the treatment of COPD Chest 121 2002 192S 196S
    • (2002) Chest , vol.121
    • Sturton, G.1    Fitzgerald, M.2
  • 71
    • 0036179542 scopus 로고    scopus 로고
    • The new phosphodiesterase 4 inhibitor roflumilast is efficacious in exercise-induced asthma and leads to suppression of LPS-stimulated TNF-alpha ex vivo
    • W. Timmer, V. Leclerc, G. Birraux, M. Neuhauser, A. Hatzelmann, T. Bethke, and W. Wurst The new phosphodiesterase 4 inhibitor roflumilast is efficacious in exercise-induced asthma and leads to suppression of LPS-stimulated TNF-alpha ex vivo J. Clin. Pharmacol. 42 2002 297 303
    • (2002) J. Clin. Pharmacol. , vol.42 , pp. 297-303
    • Timmer, W.1    Leclerc, V.2    Birraux, G.3    Neuhauser, M.4    Hatzelmann, A.5    Bethke, T.6    Wurst, W.7
  • 72
    • 0031914520 scopus 로고    scopus 로고
    • Phosphodiesterase isozymes: Molecular targets for novel antiasthma agents
    • T.J. Torphy Phosphodiesterase isozymes: molecular targets for novel antiasthma agents Am. J. Respir. Crit. Care Med. 157 1998 351 370
    • (1998) Am. J. Respir. Crit. Care Med. , vol.157 , pp. 351-370
    • Torphy, T.J.1
  • 74
    • 0034975826 scopus 로고    scopus 로고
    • Chronic lipopolysaccharide exposure on airway function, cell infiltration, and nitric oxide generation in conscious guinea pigs: Effect of rolipram and dexamethasone
    • T.J. Toward, and K.J. Broadley Chronic lipopolysaccharide exposure on airway function, cell infiltration, and nitric oxide generation in conscious guinea pigs: effect of rolipram and dexamethasone J. Pharmacol. Exp. Ther. 298 2001 298 306
    • (2001) J. Pharmacol. Exp. Ther. , vol.298 , pp. 298-306
    • Toward, T.J.1    Broadley, K.J.2
  • 75
    • 1642493925 scopus 로고    scopus 로고
    • Effect of phosphodiesterase-5 inhibitor, sildenafil (Viagra), in animal models of airways disease
    • T.J. Toward, N. Smith, and K.J. Broadley Effect of phosphodiesterase-5 inhibitor, sildenafil (Viagra), in animal models of airways disease Am. J. Respir. Crit. Care Med. 169 2004 227 234
    • (2004) Am. J. Respir. Crit. Care Med. , vol.169 , pp. 227-234
    • Toward, T.J.1    Smith, N.2    Broadley, K.J.3
  • 76
    • 0029067986 scopus 로고
    • Effects of the mixed phosphodiesterase III/IV inhibitor, zardaverine, on airway function in patients with chronic airflow obstruction
    • D. Ukena, K. Rentz, C. Reiber, and G.W. Sybrecht Effects of the mixed phosphodiesterase III/IV inhibitor, zardaverine, on airway function in patients with chronic airflow obstruction Respir. Med. 89 1995 441 444
    • (1995) Respir. Med. , vol.89 , pp. 441-444
    • Ukena, D.1    Rentz, K.2    Reiber, C.3    Sybrecht, G.W.4
  • 77
    • 2942638301 scopus 로고    scopus 로고
    • Dose-dependent inhibitory effect of roflumilast, new orally active, selective phosphodiesterase 4 inhibitor on allergen-induced early and late asthmatic reactions
    • E.M. van Schalkwyk, K. van Heerden, and D. Bredenbroker Dose-dependent inhibitory effect of roflumilast, new orally active, selective phosphodiesterase 4 inhibitor on allergen-induced early and late asthmatic reactions Eur. Respir. J. 20 Suppl 38 2002 1105
    • (2002) Eur. Respir. J. , vol.20 , Issue.SUPPL. 38 , pp. 1105
    • Van Schalkwyk, E.M.1    Van Heerden, K.2    Bredenbroker, D.3


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