RNA Editing of the Human Serotonin 5-HT2C Receptor Alters Receptor-mediated Activation of G13 Protein

Journal of Biological Chemistry

Volumn 276, Issue 48, 2001, Pages 44663-44668

  Price, Raymond D ^a   Weiner, David M ^b   Chang, Mike S S ^a   Sanders Bush, Elaine ^a  

^a VANDERBILT UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; GENES; RNA;

SIGNALING PATHWAYS;

PROTEINS;

ACTIN; CELL SURFACE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPROTEIN; PROTEIN G 13; SEROTONIN 2C RECEPTOR; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; DNA BINDING PROTEINS; G13 PROTEIN; GTP BINDING PROTEINS; PEPTIDE; PHOSPHATIDYLINOSITOL; RITANSERIN; SEROTONIN; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL CELL; ARTICLE; CELL SURFACE; CYTOSKELETON; GENOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA EDITING; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CELL STRAIN 3T3; CHEMISTRY; DOSE RESPONSE; HUMAN; HYDROLYSIS; KINETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; MOUSE; RNA PROCESSING;

ANIMALIA;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMAL; BINDING SITES; CLONING, MOLECULAR; CYTOSKELETON; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEINS; HUMAN; HYDROLYSIS; KINETICS; MICE; MOLECULAR SEQUENCE DATA; PEPTIDES; PHOSPHATIDYLINOSITOLS; PROTEIN ISOFORMS; RECEPTORS, SEROTONIN; RITANSERIN; RNA EDITING; RNA PROCESSING, POST-TRANSCRIPTIONAL; SEROTONIN; SEROTONIN ANTAGONISTS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0035977070     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106745200     Document Type: Article

References (45)

1. Sanders-Bush, E., and Canton, H. (1995) in Psychopharmacology: The Fourth Generation of Progress (Bloom, F. E., and Kupfer, D. J., eds) pp. 431-41, Raven Press, New York
2. Chang, M., Zhang, L., Tam, J. P., and Sanders-Bush, E. (2000) J. Biol. Chem. 275, 7021-7029
3. Burns, C. M., Chu, H., Rueter, S. M., Hutchinson, L. K., Canton, H., Sanders-Bush, E., and Emeson, R. B. (1997) Nature 387, 303-308
4. Niswender, C. M., Sanders-Bush, E., and Emeson, R. B. (1998) Ann. N. Y. Acad. Sci. 861, 38-48
5. Niswender, C. M., Copeland, S. C., Herrick-Davis, K., Emeson, R. B., and Sanders-Bush, E. (1999) J. Biol. Chem. 274, 9472-9478
6. Fitzgerald, L. W., Iyer, G., Conklin, D. S., Krause, C. M., Marshall, A., Patterson, J. P., Tran, D. P., Jonak, G. J., and Hartig, P. R. (1999) Neuropsychopharmacology 21, 82S-90S
7. Price, R. D., and Sanders-Bush, E. (2000) Mol. Pharmacol. 58, 859-862
8. Arora, K. K., Sakai, A., and Catt, K. J. (1995) J. Biol. Chem. 270, 22820-22826
9. Blin, N., Yun, J., and Wess, J. (1995) J. Biol. Chem. 270, 17741-17748
10. Liu, J., and Wess, J. (1996) J. Biol. Chem. 271, 8772-8778
11. Gomeza, J., Joly, C., Kuhn, R., Knopfel, T., Bockaert, J., and Pin, J. P. (1996) J. Biol. Chem. 271, 2199-2205
12. Iida-Klein, A., Guo, J., Takemura, M., Drake, M. T., Potts, J. T., Jr., Abou-Samra, A., Bringhurst, F. R., and Segre, G. V. (1997) J. Biol. Chem. 272, 6882-6889
13. Arora, K. K., Cheng, Z., and Catt, K. J. (1997) Mol. Endocrinol. 11, 1203-1212
14. Verrall, S., Ishii, M., Chen, M., Wang, L., Tram, T., and Coughlin, S. R. (1997) J. Biol. Chem. 272, 6898-6902
15. Ballesteros, J., Kitanovic, S., Guarnieri, F., Davies, P., Fromme, B. J., Konvicka, K., Chi, L., Millar, R. P., Davidson, J. S., Weinstein, H., and Sealfon, S. C. (1998) J. Biol. Chem. 273, 10445-10453
16. Burstein, E. S., Spalding, T. A., and Brann, M. R. (1998) J. Biol. Chem. 273, 24322-24327
17. Burstein, E. S., Spalding, T. A., Brauner-Osborne, H., and Brann, M. R. (1995) FEBS Lett. 363, 261-263
18. Burstein, E. S., Brauner-Osborne, H., Spalding, T. A., Conklin, B. R., and Brann, M. R. (1997) J. Neurochem. 68, 525-533
19. Messier, T. L., Dorman, C. M., Brauner-Osborne, H., Eubanks, D., and Brann, M. R. (1995) Pharmacol. Toxicol. 76, 308-311
20. Brauner-Osborne, H., and Brann, M. R. (1996) Eur. J. Pharmacol. 295, 93-102
21. Wurch, T., and Pauwels, P. J. (2000) J. Neurochem. 75, 1180-1189
22. Amatruda, T. T., III, Dragas-Graonic, S., Holmes, R., and Perez, H. D. (1995) J. Biol. Chem. 270, 28010-28013
23. Barker, E. L., Westphal, R. S., Schmidt, D., and Sanders-Bush, E. (1994) J. Biol. Chem. 269, 11687-11690
24. Hamm, H. E., and Rarick, H. M. (1994) Methods Enzymol. 237, 423-436
25. Taylor, J. M., and Neubig, R. R. (1994) Cell. Signal. 6, 841-849
26. Kenakin, T. (1995) Trends Pharmacol. Sci. 16, 232-238
27. Samama, P., Cotecchia, S., Costa, T., and Lefkowitz, R. J. (1993) J. Biol. Chem. 268, 4625-4636
28. Offermanns, S., Toombs, C. F., Hu, Y. H., and Simon, M. I. (1997) Nature 389, 183-186
29. Buhl, A. M., Johnson, N. L., Dhanasekaran, N., and Johnson, G. L. (1995) J. Biol. Chem. 270, 24631-24634
30. Katoh, H., Aoki, J., Yamaguchi, Y., Kitano, Y., Ichikawa, A., and Negishi, M. (1998) J. Biol. Chem. 273, 28700-28707
31. Gohla, A., Offermanns, S., Wilkie, T. M., and Schultz, G. (1999) J. Biol. Chem. 274, 17901-17907
32. Egan, C., Grinde, E., Dupre, A., Roth, B. L., Hake, M., Teitler, M., and Herrick-Davis, K. (2000) Synapse 35, 144-150
33. Grotewiel, M. S., and Sanders-Bush, E. (1999) Naunyn-Schmiedeberg's Arch. Pharmacol. 359, 21-27
34. Weiner, D. M., Burstein, E. S., Nash, N., Croston, G. E., Currier, E. A., Vanover, K. E., Harvey, S. C., Donohue, E., Hansen, H. C., Andersson, C. M., Spalding, T. A., Gibson, D. F., Krebs-Thomson, K., Powell, S. B., Geyer, M. A., Hacksell, U., and Brann, M. R. (2001) J. Pharmacol. Exp. Ther. 299, 268-276
35. Herrick-Davis, K., Grinde, E., and Niswender, C. M. (1999) J. Neurochem. 73, 1711-1717
36. Niswender, C. M., Herrick-Davis, K., Dilley, G. E., Meltzer, H. Y., Overholser, J. C., Stockmeier, C. A., Emeson, R. B., and Sanders-Bush, E. (2001) Neuropsychopharmacology 24, 478-491
37. Sodhi, M., Burnet, P., Makoff, A., Kerwin, R., and Harrison, P. (2001) Mol. Psychiatry, 373-379
38. Herrick-Davis, K., Grinde, E., and Teitler, M. (2000) J. Pharmacol. Exp. Ther. 295, 226-232
39. Dhanasekaran, N., and Dermott, J. M. (1996) Cell. Signal. 8, 235-245
40. Zohn, I. M., Campbell, S. L., Khosravi-Far, R., Rossman, K. L., and Der, C. J. (1998) Oncogene 17, 1415-1438
41. Wang, Y., Gu, Q., and Cynader, M. S. (1997) Exp. Brain Res. 114, 321-328
42. Tecott, L. H., Sun, L. M., Akana, S. F., Strack, A. M., Lowenstein, D. H., Dallman, M. F., and Julius, D. (1995) Nature 374, 542-546
43. Higuchi, M., Maas, S., Single, F. N., Hartner, J., Rozov, A., Burnashev, N., Feldmeyer, D., Sprengel, R., and Seeburg, P. H. (2000) Nature 406, 78-81
44. Melcher, T., Maas, S., Herb, A., Sprengel, R., Seeburg, P. H., and Higuchi, M. (1996) Nature 379, 460-464
45. Rueter, S. M., Dawson, T. R., and Emeson, R. B. (1999) Nature 399, 75-80