메뉴 건너뛰기




Volumn 8, Issue 1, 2008, Pages 19-26

AKT signaling in regulating angiogenesis

Author keywords

AKT; Angiogenesis; HIF 1; Tumor growth; Vascularization; VEGF

Indexed keywords

ANGIOPOIETIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN MDM2; RAS PROTEIN; VASCULOTROPIN;

EID: 39049112846     PISSN: 15680096     EISSN: None     Source Type: Journal    
DOI: 10.2174/156800908783497122     Document Type: Review
Times cited : (169)

References (141)
  • 1
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta, S. R.; Brunet, A.; Greenberg, M. E. Cellular survival: a play in three Akts. Genes Dev. 1999, 13, 2905-2927.
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 2
    • 0031903015 scopus 로고    scopus 로고
    • Downstream signalling events regulated by phosphatidylinositol 3-kinase activity
    • Duronio, V.; Scheid, M. P.; Ettinger, S. Downstream signalling events regulated by phosphatidylinositol 3-kinase activity. Cell Signal. 1998, 10, 233-239.
    • (1998) Cell Signal , vol.10 , pp. 233-239
    • Duronio, V.1    Scheid, M.P.2    Ettinger, S.3
  • 3
    • 0032881288 scopus 로고    scopus 로고
    • Chan, T. O.; Rittenhouse, S. E.; Tsichlis, P. N. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide- dependent phosphorylation. Annu. Rev. Biochem. 1999, 68, 965-1014.
    • Chan, T. O.; Rittenhouse, S. E.; Tsichlis, P. N. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide- dependent phosphorylation. Annu. Rev. Biochem. 1999, 68, 965-1014.
  • 4
    • 0033604585 scopus 로고    scopus 로고
    • The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
    • Kandel, E. S.; Hay, N. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp. Cell Res. 1999, 253, 210-229.
    • (1999) Exp. Cell Res , vol.253 , pp. 210-229
    • Kandel, E.S.1    Hay, N.2
  • 5
    • 0034652392 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
    • Jiang, B. H.; Zheng, J. Z.; Aoki, M.; Vogt, P. K. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc. Natl. Acad. Sci. USA 2000, 97, 1749-1753.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1749-1753
    • Jiang, B.H.1    Zheng, J.Z.2    Aoki, M.3    Vogt, P.K.4
  • 7
    • 0031913246 scopus 로고    scopus 로고
    • Mechanism of activation and function of protein kinase B
    • Alessi, D. R.; Cohen, P. Mechanism of activation and function of protein kinase B. Curr. Opin. Genet. Dev. 1998, 8, 55-62.
    • (1998) Curr. Opin. Genet. Dev , vol.8 , pp. 55-62
    • Alessi, D.R.1    Cohen, P.2
  • 9
    • 0027938974 scopus 로고
    • Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase
    • Chen, H. C.; Guan, J. L. Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. USA 1994, 91, 10148-10152.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10148-10152
    • Chen, H.C.1    Guan, J.L.2
  • 10
    • 0029849027 scopus 로고    scopus 로고
    • Interleukin-4 induces association of the c-fes proto-oncogene product with phosphatidylinositol-3 kinase
    • Izuhara, K.; Feldman, R. A.; Greer, P.; Harada, N. Interleukin-4 induces association of the c-fes proto-oncogene product with phosphatidylinositol-3 kinase. Blood 1996, 88, 3910-3918.
    • (1996) Blood , vol.88 , pp. 3910-3918
    • Izuhara, K.1    Feldman, R.A.2    Greer, P.3    Harada, N.4
  • 11
    • 0028308191 scopus 로고
    • The Src-family kinase, Fyn, regulates the activation of phosphatidylinositol 3-kinase in an interleukin 2-responsive T cell line
    • Karnitz, L. M.; Sutor, S. L.; Abraham, R. T. The Src-family kinase, Fyn, regulates the activation of phosphatidylinositol 3-kinase in an interleukin 2-responsive T cell line. J. Exp. Med. 1994, 179, 1799-1808.
    • (1994) J. Exp. Med , vol.179 , pp. 1799-1808
    • Karnitz, L.M.1    Sutor, S.L.2    Abraham, R.T.3
  • 12
    • 0001582482 scopus 로고
    • Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma
    • Staal, S. P. Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc. Natl. Acad. Sci. USA 1987, 84, 5034-5037.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 5034-5037
    • Staal, S.P.1
  • 13
    • 0001457668 scopus 로고    scopus 로고
    • Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
    • Cheng, J. Q.; Ruggeri, B.; Klein, W. M.; Sonoda, G.; Altomare, D. A.; Watson, D. K.; Testa, J. R. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc. Natl. Acad. Sci. USA 1996, 93, 3636-3641.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3636-3641
    • Cheng, J.Q.1    Ruggeri, B.2    Klein, W.M.3    Sonoda, G.4    Altomare, D.A.5    Watson, D.K.6    Testa, J.R.7
  • 14
  • 15
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • Dimmeler, S.; Fleming, I.; Fisslthaler, B.; Hermann, C.; Busse, R.; Zeiher, A. M. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999, 399, 601-605.
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 17
    • 0033517190 scopus 로고    scopus 로고
    • NF-kappaB is a target of AKT in antiapoptotic PDGF signalling
    • Romashkova, J. A.; Makarov, S. S. NF-kappaB is a target of AKT in antiapoptotic PDGF signalling. Nature 1999, 401, 86-90.
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 18
    • 0033517189 scopus 로고    scopus 로고
    • NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
    • Ozes, O. N.; Mayo, L. D.; Gustin, J. A.; Pfeffer, S. R.; Pfeffer, L. M.; Donner, D. B. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 1999, 401, 82-85.
    • (1999) Nature , vol.401 , pp. 82-85
    • Ozes, O.N.1    Mayo, L.D.2    Gustin, J.A.3    Pfeffer, S.R.4    Pfeffer, L.M.5    Donner, D.B.6
  • 19
    • 0033519453 scopus 로고    scopus 로고
    • Induction of NF-kappaB by the Akt/PKB kinase
    • Kane, L. P.; Shapiro, V. S.; Stokoe, D.; Weiss, A. Induction of NF-kappaB by the Akt/PKB kinase. Curr. Biol. 1999, 9, 601-604.
    • (1999) Curr. Biol , vol.9 , pp. 601-604
    • Kane, L.P.1    Shapiro, V.S.2    Stokoe, D.3    Weiss, A.4
  • 20
    • 1842333237 scopus 로고    scopus 로고
    • Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
    • del Peso, L.; Gonzalez-Garcia, M.; Page, C.; Herrera, R.; Nunez, G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 1997, 278, 687-689.
    • (1997) Science , vol.278 , pp. 687-689
    • del Peso, L.1    Gonzalez-Garcia, M.2    Page, C.3    Herrera, R.4    Nunez, G.5
  • 21
    • 0028308412 scopus 로고
    • Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation
    • Cheatham, B.; Vlahos, C. J.; Cheatham, L.; Wang, L.; Blenis, J.; Kahn, C. R. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol. Cell Biol. 1994, 14, 4902-4911.
    • (1994) Mol. Cell Biol , vol.14 , pp. 4902-4911
    • Cheatham, B.1    Vlahos, C.J.2    Cheatham, L.3    Wang, L.4    Blenis, J.5    Kahn, C.R.6
  • 22
    • 0028908804 scopus 로고
    • Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP
    • Monfar, M.; Lemon, K. P.; Grammer, T. C.; Cheatham, L.; Chung, J.; Vlahos, C. J.; Blenis, J. Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP. Mol. Cell Biol. 1995, 15, 326-337.
    • (1995) Mol. Cell Biol , vol.15 , pp. 326-337
    • Monfar, M.1    Lemon, K.P.2    Grammer, T.C.3    Cheatham, L.4    Chung, J.5    Vlahos, C.J.6    Blenis, J.7
  • 23
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross, D. A.; Alessi, D. R.; Cohen, P.; Andjelkovich, M.; Hemmings, B. A. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995, 378, 785-789.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 24
    • 0029943605 scopus 로고    scopus 로고
    • Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
    • Klippel, A.; Reinhard, C.; Kavanaugh, W. M.; Apell, G.; Escobedo, M. A.; Williams, L. T. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol. Cell Biol. 1996, 16, 4117-4127.
    • (1996) Mol. Cell Biol , vol.16 , pp. 4117-4127
    • Klippel, A.1    Reinhard, C.2    Kavanaugh, W.M.3    Apell, G.4    Escobedo, M.A.5    Williams, L.T.6
  • 25
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • Cantley, L. C.; Neel, B. G. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. USA 1999, 96, 4240-4245.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 26
    • 0033597718 scopus 로고    scopus 로고
    • Carmeliet, P.; Lampugnani, M. G.; Moons, L.; Breviario, F.; Compernolle, V.; Bono, F.; Balconi, G.; Spagnuolo, R.; Oostuyse, B.; Dewerchin, M.; Zanetti, A.; Angellilo, A.; Mattot, V.; Nuyens, D.; Lutgens, E.; Clotman, F.; de Ruiter, M. C.; Gittenberger-de Groot, A.; Poelmann, R.; Lupu, F.; Herbert, J. M.; Collen, D.; Dejana, E. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell 1999, 98, 147-157.
    • Carmeliet, P.; Lampugnani, M. G.; Moons, L.; Breviario, F.; Compernolle, V.; Bono, F.; Balconi, G.; Spagnuolo, R.; Oostuyse, B.; Dewerchin, M.; Zanetti, A.; Angellilo, A.; Mattot, V.; Nuyens, D.; Lutgens, E.; Clotman, F.; de Ruiter, M. C.; Gittenberger-de Groot, A.; Poelmann, R.; Lupu, F.; Herbert, J. M.; Collen, D.; Dejana, E. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell 1999, 98, 147-157.
  • 27
    • 0035933094 scopus 로고    scopus 로고
    • Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins
    • Ong, S. H.; Hadari, Y. R.; Gotoh, N.; Guy, G. R.; Schlessinger, J.; Lax, I. Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. Proc. Natl. Acad. Sci. USA 2001, 98, 6074-6079.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6074-6079
    • Ong, S.H.1    Hadari, Y.R.2    Gotoh, N.3    Guy, G.R.4    Schlessinger, J.5    Lax, I.6
  • 28
    • 0035932346 scopus 로고    scopus 로고
    • Two distinct signalling pathways are involved in FGF2-stimulated proliferation of choriocapillary endothelial cells: A comparative study with VEGF
    • Zubilewicz, A.; Hecquet, C.; Jeanny, J. C.; Soubrane, G.; Courtois, Y.; Mascarelli, F. Two distinct signalling pathways are involved in FGF2-stimulated proliferation of choriocapillary endothelial cells: a comparative study with VEGF. Oncogene 2001, 20, 1403-1413.
    • (2001) Oncogene , vol.20 , pp. 1403-1413
    • Zubilewicz, A.1    Hecquet, C.2    Jeanny, J.C.3    Soubrane, G.4    Courtois, Y.5    Mascarelli, F.6
  • 29
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
    • Burgering, B. M.; Coffer, P. J. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 1995, 376, 599-602.
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2
  • 30
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong, H.; Chiles, K.; Feldser, D.; Laughner, E.; Hanrahan, C.; Georgescu, M. M.; Simons, J. W.; Semenza, G. L. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res. 2000, 60, 1541-1545.
    • (2000) Cancer Res , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6    Simons, J.W.7    Semenza, G.L.8
  • 31
    • 0035421326 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma
    • Dong, G.; Chen, Z.; Li, Z. Y.; Yeh, N. T.; Bancroft, C. C.; Van Waes, C. Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma. Cancer Res. 2001, 61, 5911-5918.
    • (2001) Cancer Res , vol.61 , pp. 5911-5918
    • Dong, G.1    Chen, Z.2    Li, Z.Y.3    Yeh, N.T.4    Bancroft, C.C.5    Van Waes, C.6
  • 32
    • 0032563207 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway
    • Khwaja, A.; Lehmann, K.; Marte, B. M.; Downward, J. Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway. J. Biol. Chem. 1998, 273, 18793-18801.
    • (1998) J. Biol. Chem , vol.273 , pp. 18793-18801
    • Khwaja, A.1    Lehmann, K.2    Marte, B.M.3    Downward, J.4
  • 33
    • 0031034574 scopus 로고    scopus 로고
    • Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
    • Kulik, G.; Klippel, A.; Weber, M. J. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell Biol. 1997, 17, 1595-1606.
    • (1997) Mol. Cell Biol , vol.17 , pp. 1595-1606
    • Kulik, G.1    Klippel, A.2    Weber, M.J.3
  • 34
  • 38
    • 25444482837 scopus 로고    scopus 로고
    • Mutated PI 3-kinases: Cancer targets on a silver platter
    • Kang, S.; Bader, A. G.; Zhao, L.; Vogt, P. K. Mutated PI 3-kinases: cancer targets on a silver platter. Cell Cycle 2005, 4, 578-581.
    • (2005) Cell Cycle , vol.4 , pp. 578-581
    • Kang, S.1    Bader, A.G.2    Zhao, L.3    Vogt, P.K.4
  • 39
    • 0242499482 scopus 로고    scopus 로고
    • Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3′-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas
    • Knobbe, C. B.; Reifenberger, G. Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3′-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas. Brain Pathol. 2003, 13, 507-518.
    • (2003) Brain Pathol , vol.13 , pp. 507-518
    • Knobbe, C.B.1    Reifenberger, G.2
  • 41
    • 0033618371 scopus 로고    scopus 로고
    • Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
    • Nakatani, K.; Thompson, D. A.; Barthel, A.; Sakaue, H.; Liu, W.; Weigel, R. J.; Roth, R. A. Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J. Biol. Chem. 1999, 274, 21528-21532.
    • (1999) J. Biol. Chem , vol.274 , pp. 21528-21532
    • Nakatani, K.1    Thompson, D.A.2    Barthel, A.3    Sakaue, H.4    Liu, W.5    Weigel, R.J.6    Roth, R.A.7
  • 42
    • 0030669894 scopus 로고    scopus 로고
    • Quantitative angiogenesis assays: Progress and problems
    • Jain, R. K.; Schlenger, K.; Hockel, M.; Yuan, F. Quantitative angiogenesis assays: progress and problems. Nat. Med. 1997, 3, 1203-1208.
    • (1997) Nat. Med , vol.3 , pp. 1203-1208
    • Jain, R.K.1    Schlenger, K.2    Hockel, M.3    Yuan, F.4
  • 43
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau, W. Mechanisms of angiogenesis. Nature 1997, 386, 671-674.
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 44
    • 32944463899 scopus 로고    scopus 로고
    • Angiogenesis
    • Folkman, J. Angiogenesis. Annu. Rev. Med. 2006, 57, 1-18.
    • (2006) Annu. Rev. Med , vol.57 , pp. 1-18
    • Folkman, J.1
  • 45
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet, P.; Jain, R. K. Angiogenesis in cancer and other diseases. Nature 2000, 407, 249-257.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 46
    • 0032852528 scopus 로고    scopus 로고
    • Molecular and biological properties of vascular endothelial growth factor
    • Ferrara, N. Molecular and biological properties of vascular endothelial growth factor. J. Mol. Med. 1999, 77, 527-543.
    • (1999) J. Mol. Med , vol.77 , pp. 527-543
    • Ferrara, N.1
  • 47
    • 0033135876 scopus 로고    scopus 로고
    • Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development
    • Gale, N. W.; Yancopoulos, G. D. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev. 1999, 13, 1055-1066.
    • (1999) Genes Dev , vol.13 , pp. 1055-1066
    • Gale, N.W.1    Yancopoulos, G.D.2
  • 48
    • 0032577571 scopus 로고    scopus 로고
    • Vasculogenesis, angiogenesis, and growth factors: Ephrins enter the fray at the border
    • Yancopoulos, G. D.; Klagsbrun, M.; Folkman, J. Vasculogenesis, angiogenesis, and growth factors: ephrins enter the fray at the border. Cell 1998, 93, 661-664.
    • (1998) Cell , vol.93 , pp. 661-664
    • Yancopoulos, G.D.1    Klagsbrun, M.2    Folkman, J.3
  • 49
    • 84975525035 scopus 로고
    • Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis
    • Folkman, J. Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. N. Engl. J. Med. 1995, 333, 1757-1763.
    • (1995) N. Engl. J. Med , vol.333 , pp. 1757-1763
    • Folkman, J.1
  • 50
    • 0033914013 scopus 로고    scopus 로고
    • Angiogenesis and cancer metastasis
    • Fidler, I. J. Angiogenesis and cancer metastasis. Cancer J. 2000, 6(Suppl. 2), S134-S141.
    • (2000) Cancer J , vol.6 , Issue.SUPPL. 2
    • Fidler, I.J.1
  • 51
    • 17444374974 scopus 로고    scopus 로고
    • Angiogenesis: A curse or cure?
    • Gupta, K.; Zhang J. Angiogenesis: a curse or cure? Postgrad. Med. J. 2005, 81, 236-242.
    • (2005) Postgrad. Med. J , vol.81 , pp. 236-242
    • Gupta, K.1    Zhang, J.2
  • 53
    • 10344220521 scopus 로고    scopus 로고
    • Endogenous angiogenesis inhibitors
    • Folkman, J. Endogenous angiogenesis inhibitors. APMIS 2004, 112, 496-507.
    • (2004) APMIS , vol.112 , pp. 496-507
    • Folkman, J.1
  • 54
    • 0025343230 scopus 로고
    • Signal transduction by receptors with tyrosine kinase activity
    • Ullrich, A.; Schlessinger, J. Signal transduction by receptors with tyrosine kinase activity. Cell 1990, 61, 203-212.
    • (1990) Cell , vol.61 , pp. 203-212
    • Ullrich, A.1    Schlessinger, J.2
  • 55
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1995, 1, 27-31.
    • (1995) Nat. Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 56
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong, G. H.; Rossant, J.; Gertsenstein, M.; Breitman, M. L. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995, 376, 66-70.
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 57
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
    • Plate, K. H.; Breier, G.; Weich, H. A.; Risau, W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 1992, 359, 845-848.
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3    Risau, W.4
  • 59
    • 0032515047 scopus 로고    scopus 로고
    • Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
    • Gerber, H. P.; McMurtrey, A.; Kowalski, J.; Yan, M.; Keyt, B. A.; Dixit, V.; Ferrara, N. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J. Biol. Chem. 1998, 273, 30336-30343.
    • (1998) J. Biol. Chem , vol.273 , pp. 30336-30343
    • Gerber, H.P.1    McMurtrey, A.2    Kowalski, J.3    Yan, M.4    Keyt, B.A.5    Dixit, V.6    Ferrara, N.7
  • 60
    • 0032440723 scopus 로고    scopus 로고
    • Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis
    • Ilan, N.; Mahooti, S.; Madri, J. A. Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis. J. Cell Sci. 1998, 111(Pt 24), 3621-3631.
    • (1998) J. Cell Sci , vol.111 , Issue.PART 24 , pp. 3621-3631
    • Ilan, N.1    Mahooti, S.2    Madri, J.A.3
  • 61
    • 0033522927 scopus 로고    scopus 로고
    • Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner
    • Fujio, Y.; Walsh, K. Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner. J. Biol. Chem. 1999, 274, 16349-16354.
    • (1999) J. Biol. Chem , vol.274 , pp. 16349-16354
    • Fujio, Y.1    Walsh, K.2
  • 62
    • 0028122465 scopus 로고
    • Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo
    • Dumont, D. J.; Gradwohl, G.; Fong, G. H.; Puri, M. C.; Gertsenstein, M.; Auerbach, A.; Breitman, M. L. Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev. 1994, 8, 1897-1909.
    • (1994) Genes Dev , vol.8 , pp. 1897-1909
    • Dumont, D.J.1    Gradwohl, G.2    Fong, G.H.3    Puri, M.C.4    Gertsenstein, M.5    Auerbach, A.6    Breitman, M.L.7
  • 64
    • 0032714316 scopus 로고    scopus 로고
    • Angiopoietin-1 and its receptor Tie-2 participate in the regulation of capillary-like tubule formation and survival of endothelial cells
    • Hayes, A. J.; Huang, W. Q.; Mallah, J.; Yang, D.; Lippman, M. E.; Li, L. Y. Angiopoietin-1 and its receptor Tie-2 participate in the regulation of capillary-like tubule formation and survival of endothelial cells. Microvasc. Res. 1999, 58, 224-237.
    • (1999) Microvasc. Res , vol.58 , pp. 224-237
    • Hayes, A.J.1    Huang, W.Q.2    Mallah, J.3    Yang, D.4    Lippman, M.E.5    Li, L.Y.6
  • 65
    • 0030726988 scopus 로고    scopus 로고
    • Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth
    • Lin, P.; Polverini, P.; Dewhirst, M.; Shan, S.; Rao, P. S.; Peters, K. Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth. J. Clin. Invest. 1997, 100, 2072-2078.
    • (1997) J. Clin. Invest , vol.100 , pp. 2072-2078
    • Lin, P.1    Polverini, P.2    Dewhirst, M.3    Shan, S.4    Rao, P.S.5    Peters, K.6
  • 71
    • 0006677050 scopus 로고    scopus 로고
    • Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3′-Kinase/Akt signal transduction pathway
    • Kim, I.; Kim, H. G.; So, J. N.; Kim, J. H.; Kwak, H. J.; Koh, G. Y. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3′-Kinase/Akt signal transduction pathway. Circ. Res. 2000, 86, 24-29.
    • (2000) Circ. Res , vol.86 , pp. 24-29
    • Kim, I.1    Kim, H.G.2    So, J.N.3    Kim, J.H.4    Kwak, H.J.5    Koh, G.Y.6
  • 72
    • 0342657703 scopus 로고    scopus 로고
    • Angiopoietin-1 induces endothelial cell sprouting through the activation of focal adhesion kinase and plasmin secretion
    • Kim, I.; Kim, H. G.; Moon, S. O.; Chae, S. W.; So, J. N.; Koh, K. N.; Ahn, B. C.; Koh, G. Y. Angiopoietin-1 induces endothelial cell sprouting through the activation of focal adhesion kinase and plasmin secretion. Circ. Res. 2000, 86, 952-959.
    • (2000) Circ. Res , vol.86 , pp. 952-959
    • Kim, I.1    Kim, H.G.2    Moon, S.O.3    Chae, S.W.4    So, J.N.5    Koh, K.N.6    Ahn, B.C.7    Koh, G.Y.8
  • 73
    • 0033573099 scopus 로고    scopus 로고
    • Role of PI 3-kinase in angiopoietin-1- mediated migration and attachment-dependent survival of endothelial cells
    • Fujikawa, K.; de Aos Scherpenseel, I.; Jain, S. K.; Presman, E.; Christensen, R. A.; Varticovski, L. Role of PI 3-kinase in angiopoietin-1- mediated migration and attachment-dependent survival of endothelial cells. Exp. Cell Res. 1999, 253, 663-672.
    • (1999) Exp. Cell Res , vol.253 , pp. 663-672
    • Fujikawa, K.1    de Aos Scherpenseel, I.2    Jain, S.K.3    Presman, E.4    Christensen, R.A.5    Varticovski, L.6
  • 74
    • 0034648666 scopus 로고    scopus 로고
    • Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway
    • Kim, I.; Kim, J. H.; Moon, S. O.; Kwak, H. J.; Kim, N. G.; Koh, G. Y. Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Oncogene 2000, 19, 4549-4552.
    • (2000) Oncogene , vol.19 , pp. 4549-4552
    • Kim, I.1    Kim, J.H.2    Moon, S.O.3    Kwak, H.J.4    Kim, N.G.5    Koh, G.Y.6
  • 77
    • 33744802895 scopus 로고    scopus 로고
    • Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure
    • Olsen, M. W.; Ley, C. D.; Junker, N.; Hansen, A. J.; Lund, E. L.; Kristjansen, P. E. Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure. Neoplasia. 2006, 8, 364-372.
    • (2006) Neoplasia , vol.8 , pp. 364-372
    • Olsen, M.W.1    Ley, C.D.2    Junker, N.3    Hansen, A.J.4    Lund, E.L.5    Kristjansen, P.E.6
  • 78
    • 13844273087 scopus 로고    scopus 로고
    • PI3K-Akt pathway: Its functions and alterations in human cancer
    • Osaki, M.; Oshimura, M.; Ito, H. PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis. 2004, 9, 667-676.
    • (2004) Apoptosis , vol.9 , pp. 667-676
    • Osaki, M.1    Oshimura, M.2    Ito, H.3
  • 79
    • 33748284463 scopus 로고    scopus 로고
    • Regulation of angiogenesis and tumor growth by p110 alpha and AKT1 via VEGF expression
    • Xia, C.; Meng, Q.; Cao, Z.; Shi, X.; Jiang, B. H. Regulation of angiogenesis and tumor growth by p110 alpha and AKT1 via VEGF expression. J. Cell Physiol 2006, 209, 56-66.
    • (2006) J. Cell Physiol , vol.209 , pp. 56-66
    • Xia, C.1    Meng, Q.2    Cao, Z.3    Shi, X.4    Jiang, B.H.5
  • 80
    • 0038756445 scopus 로고    scopus 로고
    • PTEN and phosphatidylinositol 3′-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: Evidence for an effect on the tumor and endothelial compartment
    • Su, J. D.; Mayo, L. D.; Donner, D. B.; Durden, D. L. PTEN and phosphatidylinositol 3′-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment. Cancer Res. 2003, 63, 3585-3592.
    • (2003) Cancer Res , vol.63 , pp. 3585-3592
    • Su, J.D.1    Mayo, L.D.2    Donner, D.B.3    Durden, D.L.4
  • 81
    • 23944521126 scopus 로고    scopus 로고
    • Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: Implication of chemoprevention of lung cancer
    • Liu, L. Z.; Fang, J.; Zhou, Q.; Hu, X.; Shi, X.; Jiang, B. H. Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer. Mol. Pharmacol. 2005, 68, 635-643.
    • (2005) Mol. Pharmacol , vol.68 , pp. 635-643
    • Liu, L.Z.1    Fang, J.2    Zhou, Q.3    Hu, X.4    Shi, X.5    Jiang, B.H.6
  • 84
    • 5144220019 scopus 로고    scopus 로고
    • SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway
    • Zhong, X. S.; Zheng, J. Z.; Reed, E.; Jiang, B. H. SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway. Biochem. Biophys. Res. Commun. 2004, 324, 471-480.
    • (2004) Biochem. Biophys. Res. Commun , vol.324 , pp. 471-480
    • Zhong, X.S.1    Zheng, J.Z.2    Reed, E.3    Jiang, B.H.4
  • 85
    • 17844405853 scopus 로고    scopus 로고
    • Blockade of vascular endothelial growth factor receptor signal pathway and antitumor activity of ON-III (2′,4′-dihydroxy-6′-methoxy-3′,5′- dimethylchalcone), a component from Chinese herbal medicine
    • Zhu, X. F.; Xie, B. F.; Zhou, J. M.; Feng, G. K.; Liu, Z. C.; Wei, X. Y.; Zhang, F. X.; Liu, M. F.; Zeng, Y. X. Blockade of vascular endothelial growth factor receptor signal pathway and antitumor activity of ON-III (2′,4′-dihydroxy-6′-methoxy-3′,5′- dimethylchalcone), a component from Chinese herbal medicine. Mol. Pharmacol. 2005, 67, 1444-1450.
    • (2005) Mol. Pharmacol , vol.67 , pp. 1444-1450
    • Zhu, X.F.1    Xie, B.F.2    Zhou, J.M.3    Feng, G.K.4    Liu, Z.C.5    Wei, X.Y.6    Zhang, F.X.7    Liu, M.F.8    Zeng, Y.X.9
  • 87
    • 0032189381 scopus 로고    scopus 로고
    • Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
    • Coffer, P. J.; Jin, J.; Woodgett, J. R. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem. J. 1998, 335(Pt 1), 1-13.
    • (1998) Biochem. J , vol.335 , Issue.PART 1 , pp. 1-13
    • Coffer, P.J.1    Jin, J.2    Woodgett, J.R.3
  • 89
    • 0035914388 scopus 로고    scopus 로고
    • Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
    • Cho, H.; Thorvaldsen, J. L.; Chu, Q.; Feng, F.; Birnbaum, M. J. Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J. Biol. Chem. 2001, 276, 38349-38352.
    • (2001) J. Biol. Chem , vol.276 , pp. 38349-38352
    • Cho, H.1    Thorvaldsen, J.L.2    Chu, Q.3    Feng, F.4    Birnbaum, M.J.5
  • 91
    • 30744432102 scopus 로고    scopus 로고
    • Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo
    • Chen, J.; Somanath, P. R.; Razorenova, O.; Chen, W. S.; Hay, N.; Bornstein, P.; Byzova, T. V. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nat. Med. 2005, 11, 1188-1196.
    • (2005) Nat. Med , vol.11 , pp. 1188-1196
    • Chen, J.1    Somanath, P.R.2    Razorenova, O.3    Chen, W.S.4    Hay, N.5    Bornstein, P.6    Byzova, T.V.7
  • 95
    • 0027482251 scopus 로고
    • Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract
    • Brown, L. F.; Berse, B.; Jackman, R. W.; Tognazzi, K.; Manseau, E. J.; Senger, D. R.; Dvorak, H. F. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract. Cancer Res. 1993, 53, 4727-4735.
    • (1993) Cancer Res , vol.53 , pp. 4727-4735
    • Brown, L.F.1    Berse, B.2    Jackman, R.W.3    Tognazzi, K.4    Manseau, E.J.5    Senger, D.R.6    Dvorak, H.F.7
  • 96
    • 30944440262 scopus 로고    scopus 로고
    • Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF)
    • Byrne, A. M.; Bouchier-Hayes, D. J.; Harmey, J. H. Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF). J. Cell Mol. Med. 2005, 9, 777-794.
    • (2005) J. Cell Mol. Med , vol.9 , pp. 777-794
    • Byrne, A.M.1    Bouchier-Hayes, D.J.2    Harmey, J.H.3
  • 97
    • 0030869787 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element
    • Mazure, N. M.; Chen, E. Y.; Laderoute, K. R.; Giaccia, A. J. Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood 1997, 90, 3322-3331.
    • (1997) Blood , vol.90 , pp. 3322-3331
    • Mazure, N.M.1    Chen, E.Y.2    Laderoute, K.R.3    Giaccia, A.J.4
  • 98
    • 4143140856 scopus 로고    scopus 로고
    • Cao, Z.; Fang, J.; Xia, C.; Shi, X.; Jiang, B. H. trans-3,4,5′- Trihydroxystibene inhibits hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in human ovarian cancer cells. Clin. Cancer Res. 2004, 10, 5253-5263.
    • Cao, Z.; Fang, J.; Xia, C.; Shi, X.; Jiang, B. H. trans-3,4,5′- Trihydroxystibene inhibits hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in human ovarian cancer cells. Clin. Cancer Res. 2004, 10, 5253-5263.
  • 99
    • 14644432362 scopus 로고    scopus 로고
    • Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways
    • Fang, J.; Xia, C.; Cao, Z.; Zheng, J. Z.; Reed, E.; Jiang, B. H. Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. FASEB J. 2005, 19, 342-353.
    • (2005) FASEB J , vol.19 , pp. 342-353
    • Fang, J.1    Xia, C.2    Cao, Z.3    Zheng, J.Z.4    Reed, E.5    Jiang, B.H.6
  • 100
    • 8544273759 scopus 로고    scopus 로고
    • Vascular endothelial growth factor transcriptional activation is mediated by hypoxiainducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling
    • Skinner, H. D.; Zheng, J. Z.; Fang, J.; Agani, F.; Jiang, B. H. Vascular endothelial growth factor transcriptional activation is mediated by hypoxiainducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling. J. Biol. Chem. 2004, 279, 45643-45651.
    • (2004) J. Biol. Chem , vol.279 , pp. 45643-45651
    • Skinner, H.D.1    Zheng, J.Z.2    Fang, J.3    Agani, F.4    Jiang, B.H.5
  • 101
    • 31544436674 scopus 로고    scopus 로고
    • Black raspberry extracts inhibit benzo(a)pyrene diolepoxide-induced activator protein 1 activation and VEGF transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway
    • Huang, C.; Li, J.; Song, L.; Zhang, D.; Tong, Q.; Ding, M.; Bowman, L.; Aziz, R.; Stoner, G. D. Black raspberry extracts inhibit benzo(a)pyrene diolepoxide-induced activator protein 1 activation and VEGF transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway. Cancer Res. 2006, 66, 581-587.
    • (2006) Cancer Res , vol.66 , pp. 581-587
    • Huang, C.1    Li, J.2    Song, L.3    Zhang, D.4    Tong, Q.5    Ding, M.6    Bowman, L.7    Aziz, R.8    Stoner, G.D.9
  • 102
    • 33748752709 scopus 로고    scopus 로고
    • Malignant hematopoietic cells induce an increased expression of VEGFR-1 and VEGFR-3 on bone marrow endothelial cells via AKT and mTOR signalling pathways
    • Mirshahi, P.; Toprak, S. K.; Faussat, A. M.; Dubrulle, S.; Marie, J. P.; Soria, C.; Soria, J.; Mirshahi, M. Malignant hematopoietic cells induce an increased expression of VEGFR-1 and VEGFR-3 on bone marrow endothelial cells via AKT and mTOR signalling pathways. Biochem. Biophys. Res. Commun. 2006, 349, 1003-1010.
    • (2006) Biochem. Biophys. Res. Commun , vol.349 , pp. 1003-1010
    • Mirshahi, P.1    Toprak, S.K.2    Faussat, A.M.3    Dubrulle, S.4    Marie, J.P.5    Soria, C.6    Soria, J.7    Mirshahi, M.8
  • 103
    • 0029944965 scopus 로고    scopus 로고
    • Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
    • Jiang, B. H.; Rue, E.; Wang, G. L.; Roe, R.; Semenza, G. L. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J. Biol. Chem. 1996, 271, 17771-17778.
    • (1996) J. Biol. Chem , vol.271 , pp. 17771-17778
    • Jiang, B.H.1    Rue, E.2    Wang, G.L.3    Roe, R.4    Semenza, G.L.5
  • 104
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang, G. L.; Jiang, B. H.; Rue, E. A.; Semenza, G. L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. USA 1995, 92, 5510-5514.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 105
    • 0033079597 scopus 로고    scopus 로고
    • Oncogenic alterations of metabolism
    • Dang, C. V.; Semenza, G. L. Oncogenic alterations of metabolism. Trends Biochem. Sci. 1999, 24, 68-72.
    • (1999) Trends Biochem. Sci , vol.24 , pp. 68-72
    • Dang, C.V.1    Semenza, G.L.2
  • 106
    • 0036216692 scopus 로고    scopus 로고
    • HIF-1 and tumor progression: Pathophysiology and therapeutics
    • Semenza, G. L. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol. Med. 2002, 8, S62-S67.
    • (2002) Trends Mol. Med , vol.8
    • Semenza, G.L.1
  • 107
    • 0030659531 scopus 로고    scopus 로고
    • V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression
    • Jiang, B. H.; Agani, F.; Passaniti, A.; Semenza, G. L. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res. 1997, 57, 5328-5335.
    • (1997) Cancer Res , vol.57 , pp. 5328-5335
    • Jiang, B.H.1    Agani, F.2    Passaniti, A.3    Semenza, G.L.4
  • 109
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1 alpha is required for solid tumor formation and embryonic vascularization
    • Ryan, H. E.; Lo, J.; Johnson, R. S. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 1998, 17, 3005-3015.
    • (1998) EMBO J , vol.17 , pp. 3005-3015
    • Ryan, H.E.1    Lo, J.2    Johnson, R.S.3
  • 111
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4- hydroxylases that modify HIF
    • Bruick, R. K.; McKnight, S. L. A conserved family of prolyl-4- hydroxylases that modify HIF. Science 2001, 294, 1337-1340.
    • (2001) Science , vol.294 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 112
    • 17944375360 scopus 로고    scopus 로고
    • Epstein, A. C.; Gleadle, J. M.; McNeill, L. A.; Hewitson, K. S.; O'Rourke, J.; Mole, D. R.; Mukherji, M.; Metzen, E.; Wilson, M. I.; Dhanda, A.; Tian, Y. M.; Masson, N.; Hamilton, D. L.; Jaakkola, P.; Barstead, R.; Hodgkin, J.; Maxwell, P. H.; Pugh, C. W.; Schofield, C. J.; Ratcliffe, P. J. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001, 107, 43-54.
    • Epstein, A. C.; Gleadle, J. M.; McNeill, L. A.; Hewitson, K. S.; O'Rourke, J.; Mole, D. R.; Mukherji, M.; Metzen, E.; Wilson, M. I.; Dhanda, A.; Tian, Y. M.; Masson, N.; Hamilton, D. L.; Jaakkola, P.; Barstead, R.; Hodgkin, J.; Maxwell, P. H.; Pugh, C. W.; Schofield, C. J.; Ratcliffe, P. J. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001, 107, 43-54.
  • 113
    • 0035859692 scopus 로고    scopus 로고
    • HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation
    • Yu, F.; White, S. B.; Zhao, Q.; Lee, F. S. HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc. Natl. Acad. Sci. USA 2001, 98, 9630-9635.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9630-9635
    • Yu, F.1    White, S.B.2    Zhao, Q.3    Lee, F.S.4
  • 114
    • 27544504817 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases
    • Hirota, K.; Semenza, G. L. Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases. Biochem. Biophys. Res. Commun. 2005, 338, 610-616.
    • (2005) Biochem. Biophys. Res. Commun , vol.338 , pp. 610-616
    • Hirota, K.1    Semenza, G.L.2
  • 116
    • 0034925041 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1
    • Jiang, B. H.; Jiang, G.; Zheng, J. Z.; Lu, Z.; Hunter, T.; Vogt, P. K. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ. 2001, 12, 363-369.
    • (2001) Cell Growth Differ , vol.12 , pp. 363-369
    • Jiang, B.H.1    Jiang, G.2    Zheng, J.Z.3    Lu, Z.4    Hunter, T.5    Vogt, P.K.6
  • 117
    • 0035949588 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
    • Mayo, L. D.; Donner, D. B. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc. Natl. Acad. Sci. USA 2001, 98, 11598-11603.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 11598-11603
    • Mayo, L.D.1    Donner, D.B.2
  • 118
    • 12144288115 scopus 로고    scopus 로고
    • Growth factor-mediated induction of HDM2 positively regulates hypoxia-inducible factor 1alpha expression
    • Bardos, J. I.; Chau, N. M.; Ashcroft, M. Growth factor-mediated induction of HDM2 positively regulates hypoxia-inducible factor 1alpha expression. Mol. Cell Biol. 2004, 24, 2905-2914.
    • (2004) Mol. Cell Biol , vol.24 , pp. 2905-2914
    • Bardos, J.I.1    Chau, N.M.2    Ashcroft, M.3
  • 119
    • 0023907053 scopus 로고
    • Induction of angiogenesis in vitro by vanadate, an inhibitor of phosphotyrosine phosphatases
    • Montesano, R.; Pepper, M. S.; Belin, D.; Vassalli, J. D.; Orci, L. Induction of angiogenesis in vitro by vanadate, an inhibitor of phosphotyrosine phosphatases. J. Cell Physiol 1988, 134, 460-466.
    • (1988) J. Cell Physiol , vol.134 , pp. 460-466
    • Montesano, R.1    Pepper, M.S.2    Belin, D.3    Vassalli, J.D.4    Orci, L.5
  • 121
    • 0037200012 scopus 로고    scopus 로고
    • Vanadate-induced expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species
    • Gao, N.; Ding, M.; Zheng, J. Z.; Zhang, Z.; Leonard, S. S.; Liu, K. J.; Shi, X.; Jiang, B. H. Vanadate-induced expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species. J. Biol. Chem. 2002, 277, 31963-31971.
    • (2002) J. Biol. Chem , vol.277 , pp. 31963-31971
    • Gao, N.1    Ding, M.2    Zheng, J.Z.3    Zhang, Z.4    Leonard, S.S.5    Liu, K.J.6    Shi, X.7    Jiang, B.H.8
  • 122
    • 0742271942 scopus 로고    scopus 로고
    • Arsenite induces p70S6K1 activation and HIF-1alpha expression in prostate cancer cells
    • Skinner, H. D.; Zhong, X. S.; Gao, N.; Shi, X.; Jiang, B. H. Arsenite induces p70S6K1 activation and HIF-1alpha expression in prostate cancer cells. Mol. Cell Biochem. 2004, 255, 19-23.
    • (2004) Mol. Cell Biochem , vol.255 , pp. 19-23
    • Skinner, H.D.1    Zhong, X.S.2    Gao, N.3    Shi, X.4    Jiang, B.H.5
  • 123
    • 33646930317 scopus 로고    scopus 로고
    • Critical roles of AMP-activated protein kinase in the carcinogenic metal-induced expression of VEGF and HIF-1 proteins in DU145 prostate carcinoma
    • Lee, M.; Hwang, J. T.; Yun, H.; Kim, E. J.; Kim, M. J.; Kim, S. S.; Ha, J. Critical roles of AMP-activated protein kinase in the carcinogenic metal-induced expression of VEGF and HIF-1 proteins in DU145 prostate carcinoma. Biochem. Pharmacol. 2006, 72, 91-103.
    • (2006) Biochem. Pharmacol , vol.72 , pp. 91-103
    • Lee, M.1    Hwang, J.T.2    Yun, H.3    Kim, E.J.4    Kim, M.J.5    Kim, S.S.6    Ha, J.7
  • 124
    • 10344221004 scopus 로고    scopus 로고
    • AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells
    • Hwang, J. T.; Lee, M.; Jung, S. N.; Lee, H. J.; Kang, I.; Kim, S. S.; Ha, J. AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells. Carcinogenesis 2004, 25, 2497-2507.
    • (2004) Carcinogenesis , vol.25 , pp. 2497-2507
    • Hwang, J.T.1    Lee, M.2    Jung, S.N.3    Lee, H.J.4    Kang, I.5    Kim, S.S.6    Ha, J.7
  • 125
    • 0025171686 scopus 로고
    • Ecological correlation between arsenic level in well water and age-adjusted mortality from malignant neoplasms
    • Chen, C. J.; Wang, C. J. Ecological correlation between arsenic level in well water and age-adjusted mortality from malignant neoplasms. Cancer Res. 1990, 50, 5470-5474.
    • (1990) Cancer Res , vol.50 , pp. 5470-5474
    • Chen, C.J.1    Wang, C.J.2
  • 126
  • 127
    • 0026498334 scopus 로고
    • Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water
    • Chen, C. J.; Chen, C. W.; Wu, M. M.; Kuo, T. L. Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water. Br. J. Cancer 1992, 66, 888-892.
    • (1992) Br. J. Cancer , vol.66 , pp. 888-892
    • Chen, C.J.1    Chen, C.W.2    Wu, M.M.3    Kuo, T.L.4
  • 128
    • 0742289407 scopus 로고    scopus 로고
    • Arsenite induces HIF-1alpha and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells
    • Gao, N.; Shen, L.; Zhang, Z.; Leonard, S. S.; He, H.; Zhang, X. G.; Shi, X.; Jiang, B. H. Arsenite induces HIF-1alpha and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells. Mol. Cell Biochem. 2004, 255, 33-45.
    • (2004) Mol. Cell Biochem , vol.255 , pp. 33-45
    • Gao, N.1    Shen, L.2    Zhang, Z.3    Leonard, S.S.4    He, H.5    Zhang, X.G.6    Shi, X.7    Jiang, B.H.8
  • 129
    • 0035930627 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite
    • Duyndam, M. C.; Hulscher, T. M.; Fontijn, D.; Pinedo, H. M.; Boven, E. Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite. J. Biol. Chem. 2001, 276, 48066-48076.
    • (2001) J. Biol. Chem , vol.276 , pp. 48066-48076
    • Duyndam, M.C.1    Hulscher, T.M.2    Fontijn, D.3    Pinedo, H.M.4    Boven, E.5
  • 130
    • 0025765960 scopus 로고
    • Molecular mechanisms of nickel carcinogenesis
    • Costa, M. Molecular mechanisms of nickel carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 1991, 31, 321-337.
    • (1991) Annu. Rev. Pharmacol. Toxicol , vol.31 , pp. 321-337
    • Costa, M.1
  • 131
    • 1642494851 scopus 로고    scopus 로고
    • Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells
    • Li, J.; Davidson, G.; Huang, Y.; Jiang, B. H.; Shi, X.; Costa, M.; Huang, C. Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. Cancer Res. 2004, 64, 94-101.
    • (2004) Cancer Res , vol.64 , pp. 94-101
    • Li, J.1    Davidson, G.2    Huang, Y.3    Jiang, B.H.4    Shi, X.5    Costa, M.6    Huang, C.7
  • 133
    • 0025176844 scopus 로고
    • Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice
    • Wei, H.; Tye, L.; Bresnick, E.; Birt, D. F. Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice. Cancer Res. 1990, 50, 499-502.
    • (1990) Cancer Res , vol.50 , pp. 499-502
    • Wei, H.1    Tye, L.2    Bresnick, E.3    Birt, D.F.4
  • 134
    • 34047132303 scopus 로고    scopus 로고
    • Apigenin inhibits tumor angiogenesis through decreasing HIF-1{alpha} and VEGF expression
    • Fang, J.; Zhou, Q.; Liu, L. Z.; Xia, C.; Hu, X.; Shi, X.; Jiang, B. H. Apigenin inhibits tumor angiogenesis through decreasing HIF-1{alpha} and VEGF expression. Carcinogenesis 2007, 28, 858-864.
    • (2007) Carcinogenesis , vol.28 , pp. 858-864
    • Fang, J.1    Zhou, Q.2    Liu, L.Z.3    Xia, C.4    Hu, X.5    Shi, X.6    Jiang, B.H.7
  • 135
    • 7444272077 scopus 로고    scopus 로고
    • Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3′-kinase activity
    • Bagli, E.; Stefaniotou, M.; Morbidelli, L.; Ziche, M.; Psillas, K.; Murphy, C.; Fotsis, T. Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3′-kinase activity. Cancer Res. 2004, 64, 7936-7946.
    • (2004) Cancer Res , vol.64 , pp. 7936-7946
    • Bagli, E.1    Stefaniotou, M.2    Morbidelli, L.3    Ziche, M.4    Psillas, K.5    Murphy, C.6    Fotsis, T.7
  • 136
    • 34047110804 scopus 로고    scopus 로고
    • Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells
    • Fang, J.; Zhou, Q.; Shi, X. L.; Jiang, B. H. Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells. Carcinogenesis 2007, 28, 713-723.
    • (2007) Carcinogenesis , vol.28 , pp. 713-723
    • Fang, J.1    Zhou, Q.2    Shi, X.L.3    Jiang, B.H.4
  • 137
    • 33847277462 scopus 로고    scopus 로고
    • J. cis-9,trans-11-Conjugated linoleic acid down-regulates phorbol ester-induced NF-{kappa}B activation and subsequent COX-2 expression in hairless mouse skin by targeting I{kappa}B kinase and PI3K-Akt
    • Hwang, D. M.; Kundu, J. K.; Shin, J. W.; Lee, H. J.; Surh, Y. J. cis-9,trans-11-Conjugated linoleic acid down-regulates phorbol ester-induced NF-{kappa}B activation and subsequent COX-2 expression in hairless mouse skin by targeting I{kappa}B kinase and PI3K-Akt. Carcinogenesis 2007, 28, 361-391.
    • (2007) Carcinogenesis , vol.28 , pp. 361-391
    • Hwang, D.M.1    Kundu, J.K.2    Shin, J.W.3    Lee, H.J.4    Surh, Y.5
  • 138
    • 30944458833 scopus 로고    scopus 로고
    • Lycopene induces apoptosis in immortalized fibroblasts exposed to tobacco smoke condensate through arresting cell cycle and down-regulating cyclin D1, pAKT and pBad
    • Palozza, P.; Sheriff, A.; Serini, S.; Boninsegna, A.; Maggiano, N.; Ranelletti, F. O.; Calviello, G.; Cittadini, A. Lycopene induces apoptosis in immortalized fibroblasts exposed to tobacco smoke condensate through arresting cell cycle and down-regulating cyclin D1, pAKT and pBad. Apoptosis. 2005, 10, 1445-1456.
    • (2005) Apoptosis , vol.10 , pp. 1445-1456
    • Palozza, P.1    Sheriff, A.2    Serini, S.3    Boninsegna, A.4    Maggiano, N.5    Ranelletti, F.O.6    Calviello, G.7    Cittadini, A.8
  • 139
    • 0035341495 scopus 로고    scopus 로고
    • Genistein, a tyrosine kinase inhibitor, enhanced radiosensitivity in human esophageal cancer cell lines in vitro: Possible involvement of inhibition of survival signal transduction pathways
    • Akimoto, T.; Nonaka, T.; Ishikawa, H.; Sakurai, H.; Saitoh, J. I.; Takahashi, T.; Mitsuhashi, N. Genistein, a tyrosine kinase inhibitor, enhanced radiosensitivity in human esophageal cancer cell lines in vitro: possible involvement of inhibition of survival signal transduction pathways. Int. J. Radiat. Oncol. Biol. Phys. 2001, 50, 195-201.
    • (2001) Int. J. Radiat. Oncol. Biol. Phys , vol.50 , pp. 195-201
    • Akimoto, T.1    Nonaka, T.2    Ishikawa, H.3    Sakurai, H.4    Saitoh, J.I.5    Takahashi, T.6    Mitsuhashi, N.7
  • 140
    • 0041802820 scopus 로고    scopus 로고
    • Targeting mTOR signaling for cancer therapy
    • Huang, S.; Houghton, P. J. Targeting mTOR signaling for cancer therapy. Curr. Opin. Pharmacol. 2003, 3, 371-377.
    • (2003) Curr. Opin. Pharmacol , vol.3 , pp. 371-377
    • Huang, S.1    Houghton, P.J.2
  • 141
    • 33748194240 scopus 로고    scopus 로고
    • Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway
    • Smolewski, P. Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway. Anticancer Drugs 2006, 17, 487-494.
    • (2006) Anticancer Drugs , vol.17 , pp. 487-494
    • Smolewski, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.