Genistein, a tyrosine kinase inhibitor, enhanced radiosensitivity in human esophageal cancer cell lines in vitro: Possible involvement of inhibition of survival signal transduction pathways

International Journal of Radiation Oncology Biology Physics

Volumn 50, Issue 1, 2001, Pages 195-201

  Goodman, Robert L ^a   Grann, Alison ^a   Saracco, Patricia ^a   Needham, Michael F ^a  

^a SAINT BARNABAS MEDICAL CENTER   (United States)

Author keywords

AKT; Genistein; p42; p44 ERK; PKB; Radiation; Survival signal

Indexed keywords

CELLS; IRRADIATION; PROTEINS; TUMORS;

RADIOSENSITIVITY;

ENZYME INHIBITION;

GENISTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P42; PROTEIN P44; PROTEIN P53; PROTEIN TYROSINE KINASE INHIBITOR;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL SURVIVAL; CLONOGENIC ASSAY; CONTROLLED STUDY; DRUG MECHANISM; ESOPHAGUS CANCER; HUMAN; HUMAN CELL; IRRADIATION; MUTANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; RADIOSENSITIZATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME INHIBITORS; ESOPHAGEAL NEOPLASMS; GENISTEIN; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RADIATION-SENSITIZING AGENTS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035341495     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(00)01560-1     Document Type: Article

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