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Volumn 24, Issue 7, 2004, Pages 2905-2914

Growth Factor-Mediated Induction of HDM2 Positively Regulates Hypoxia-Inducible Factor 1α Expression

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CYCLOHEXIMIDE; GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 12144288115     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.7.2905-2914.2004     Document Type: Article
Times cited : (91)

References (39)
  • 1
    • 0037134442 scopus 로고    scopus 로고
    • Lack of evidence for the involvement of the phosphoinositide 3-kinase/ Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension
    • Alvarez-Tejado, M., A. Alfranca, J. Aragones, A. Vara, M. O. Landazuri, and L. del Peso. 2002. Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension. J. Biol. Chem. 277:13508-13517.
    • (2002) J. Biol. Chem. , vol.277 , pp. 13508-13517
    • Alvarez-Tejado, M.1    Alfranca, A.2    Aragones, J.3    Vara, A.4    Landazuri, M.O.5    Del Peso, L.6
  • 3
    • 0037177867 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription
    • Arsham, A. M., D. R. Plas, C. B. Thompson, and M. C. Simon. 2002. Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. J. Biol. Chem. 277:15162-15170.
    • (2002) J. Biol. Chem. , vol.277 , pp. 15162-15170
    • Arsham, A.M.1    Plas, D.R.2    Thompson, C.B.3    Simon, M.C.4
  • 5
    • 0034003005 scopus 로고    scopus 로고
    • Stress signals utilize multiple pathways to stabilize p53
    • Ashcroft, M., Y. Taya, and K. H. Vousden. 2000. Stress signals utilize multiple pathways to stabilize p53. Mol. Cell. Biol. 20:3224-3233.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3224-3233
    • Ashcroft, M.1    Taya, Y.2    Vousden, K.H.3
  • 7
    • 0035477438 scopus 로고    scopus 로고
    • Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3′-kinase/Akt signaling pathway
    • Blancher, C., J. W. Moore, N. Robertson, and A. L. Harris. 2001. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3′-kinase/Akt signaling pathway. Cancer Res. 61:7349-7355.
    • (2001) Cancer Res. , vol.61 , pp. 7349-7355
    • Blancher, C.1    Moore, J.W.2    Robertson, N.3    Harris, A.L.4
  • 9
    • 0037131271 scopus 로고    scopus 로고
    • Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha
    • Chan, D. A., P. D. Sutphin, N. C. Denko, and A. J. Giaccia. 2002. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. J. Biol. Chem. 277:40112-40117.
    • (2002) J. Biol. Chem. , vol.277 , pp. 40112-40117
    • Chan, D.A.1    Sutphin, P.D.2    Denko, N.C.3    Giaccia, A.J.4
  • 11
    • 0029590161 scopus 로고
    • MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest
    • Dubs-Poterszman, M. C., B. Tocque, and B. Wasylyk. 1995. MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest. Oncogene 11:2445-2449.
    • (1995) Oncogene , vol.11 , pp. 2445-2449
    • Dubs-Poterszman, M.C.1    Tocque, B.2    Wasylyk, B.3
  • 12
    • 0029079275 scopus 로고
    • The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    • Franke, T. F., S. I. Yang, T. O. Chan, K. Datta, A. Kazlauskas, D. K. Morrison, D. R. Kaplan, and P. N. Tsichlis. 1995. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81:727-736.
    • (1995) Cell , vol.81 , pp. 727-736
    • Franke, T.F.1    Yang, S.I.2    Chan, T.O.3    Datta, K.4    Kazlauskas, A.5    Morrison, D.K.6    Kaplan, D.R.7    Tsichlis, P.N.8
  • 13
    • 0037064010 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    • Fukuda, R., K. Hirota, F. Fan, Y. D. Jung, L. M. Ellis, and G. L. Semenza. 2002. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J. Biol. Chem. 277:38205-38211.
    • (2002) J. Biol. Chem. , vol.277 , pp. 38205-38211
    • Fukuda, R.1    Hirota, K.2    Fan, F.3    Jung, Y.D.4    Ellis, L.M.5    Semenza, G.L.6
  • 14
    • 0034999951 scopus 로고    scopus 로고
    • Selected contribution: Osteocytes upregulate HIF-1alpha in response to acute disuse and oxygen deprivation
    • Gross, T. S., N. Akeno, T. L. Clemens, S. Komarova, S. Srinivasan, D. A. Weimer, and S. Mayorov. 2001. Selected contribution: osteocytes upregulate HIF-1alpha in response to acute disuse and oxygen deprivation. J. Appl. Physiol. 90:2514-2519.
    • (2001) J. Appl. Physiol. , vol.90 , pp. 2514-2519
    • Gross, T.S.1    Akeno, N.2    Clemens, T.L.3    Komarova, S.4    Srinivasan, S.5    Weimer, D.A.6    Mayorov, S.7
  • 15
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris, A. L. 2002. Hypoxia - a key regulatory factor in tumour growth. Nat. Rev. Cancer 2:38-47.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 20
    • 0030787469 scopus 로고    scopus 로고
    • Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension
    • Jiang, B. H., J. Z. Zheng, S. W. Leung, R. Roe, and G. L. Semenza. 1997. Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension. J. Biol. Chem. 272:19253-19260.
    • (1997) J. Biol. Chem. , vol.272 , pp. 19253-19260
    • Jiang, B.H.1    Zheng, J.Z.2    Leung, S.W.3    Roe, R.4    Semenza, G.L.5
  • 21
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • Laughner, E., P. Taghavi, K. Chiles, P. C. Mahon, and G. L. Semenza. 2001. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol. Cell. Biol. 21:3995-4004.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 22
    • 0033771948 scopus 로고    scopus 로고
    • Identification of a cryptic nucleolar-localization signal in MDM2
    • Lohrum, M. A., M. Ashcroft, M. H. Kubbutat, and K. H. Vousden. 2000. Identification of a cryptic nucleolar-localization signal in MDM2. Nat. Cell Biol. 2:179-181.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 179-181
    • Lohrum, M.A.1    Ashcroft, M.2    Kubbutat, M.H.3    Vousden, K.H.4
  • 23
    • 0027999512 scopus 로고
    • The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes
    • Marechal, V., B. Elenbaas, J. Piette, J. C. Nicolas, and A. J. Levine. 1994. The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes. Mol. Cell. Biol. 14:7414-7420.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 7414-7420
    • Marechal, V.1    Elenbaas, B.2    Piette, J.3    Nicolas, J.C.4    Levine, A.J.5
  • 25
    • 0037085271 scopus 로고    scopus 로고
    • PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy
    • Mayo, L. D., J. E. Dixon, D. L. Durden, N. K. Tonks, and D. B. Donner. 2002. PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy. J. Biol. Chem. 277:5484-5489.
    • (2002) J. Biol. Chem. , vol.277 , pp. 5484-5489
    • Mayo, L.D.1    Dixon, J.E.2    Durden, D.L.3    Tonks, N.K.4    Donner, D.B.5
  • 26
    • 0035949588 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
    • Mayo, L. D., and D. B. Donner. 2001. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc. Natl. Acad. Sci. USA 98:11598-11603.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 11598-11603
    • Mayo, L.D.1    Donner, D.B.2
  • 27
    • 0043234256 scopus 로고    scopus 로고
    • Regulation of HIF-1alpha protein level during hypoxic conditions by the PI3K/AKT/GSK3beta pathway in HepG2 cells
    • Mottet, D., V. Dumont, Y. Deccache, C. Demazy, N. Ninane, M. Raes, and C. Michiels. 2003. Regulation of HIF-1alpha protein level during hypoxic conditions by the PI3K/AKT/GSK3beta pathway in HepG2 cells. J. Biol. Chem. 33:31277-31286.
    • (2003) J. Biol. Chem. , vol.33 , pp. 31277-31286
    • Mottet, D.1    Dumont, V.2    Deccache, Y.3    Demazy, C.4    Ninane, N.5    Raes, M.6    Michiels, C.7
  • 29
    • 0033231615 scopus 로고    scopus 로고
    • E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways
    • Phillips, A. C., M. K. Ernst, S. Bates, N. R. Rice, and K. H. Vousden. 1999. E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways. Mol. Cell 4:771-781.
    • (1999) Mol. Cell , vol.4 , pp. 771-781
    • Phillips, A.C.1    Ernst, M.K.2    Bates, S.3    Rice, N.R.4    Vousden, K.H.5
  • 34
    • 0036216692 scopus 로고    scopus 로고
    • HIF-1 and tumor progression: Pathophysiology and therapeutics
    • Semenza, G. L. 2002. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol. Med. 8:S62-S67.
    • (2002) Trends Mol. Med. , vol.8
    • Semenza, G.L.1
  • 35
    • 0037008770 scopus 로고    scopus 로고
    • Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
    • Treins, C., S. Giorgetti-Peraldi, J. Murdaca, G. L. Semenza, and E. Van Obberghen. 2002. Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J. Biol. Chem. 277:27975-27981.
    • (2002) J. Biol. Chem. , vol.277 , pp. 27975-27981
    • Treins, C.1    Giorgetti-Peraldi, S.2    Murdaca, J.3    Semenza, G.L.4    Van Obberghen, E.5
  • 36
    • 0037075898 scopus 로고    scopus 로고
    • Activation of the p53 tumor suppressor protein
    • Vousden, K. H. 2002. Activation of the p53 tumor suppressor protein. Biochim. Biophys. Acta 1602:47-59.
    • (2002) Biochim. Biophys. Acta , vol.1602 , pp. 47-59
    • Vousden, K.H.1
  • 37
    • 0035859692 scopus 로고    scopus 로고
    • HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation
    • Yu, F., S. B. White, Q. Zhao, and F. S. Lee. 2001. HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc. Natl. Acad. Sci. USA 98:9630-9635.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9630-9635
    • Yu, F.1    White, S.B.2    Zhao, Q.3    Lee, F.S.4
  • 38
    • 0035736487 scopus 로고    scopus 로고
    • HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
    • Zhou, B. P., Y. Liao, W. Xia, Y. Zou, B. Spohn, and M. C. Hung. 2001. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat. Cell Biol. 3:973-982.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 973-982
    • Zhou, B.P.1    Liao, Y.2    Xia, W.3    Zou, Y.4    Spohn, B.5    Hung, M.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.