Capsaicin Inhibits in Vitro and in Vivo Angiogenesis

Cancer Research

Volumn 64, Issue 2, 2004, Pages 644-651

  Min, Jeong Ki ^a   Han, Kyu Yeon ^c   Kim, Eok Cheon ^a   Kim, Young Myeong ^a   Lee, Sae Won ^d   Kim, Ok Hee ^b   Kim, Kyu Won ^d   Gho, Yong Song ^c   Kwon, Young Guen ^a  

^a Kangwon National University   (South Korea)

^b Korea Food and Drug Administration   (South Korea)

^c Kyung Hee University   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; CYCLIN DEPENDENT KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; RETINOBLASTOMA PROTEIN; SYNAPTOPHYSIN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CULTURE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CHICKEN; CHORIOALLANTOIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA SYNTHESIS; DRUG MECHANISM; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MITOSIS INHIBITION; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; UMBILICAL VEIN;

ALLANTOIS; ANIMALS; CAPSAICIN; CATTLE; CELL CYCLE; CELL DIVISION; CHEMOTAXIS; CHORION; ENDOTHELIUM, VASCULAR; G1 PHASE; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 1642556787     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-3250     Document Type: Article

References (43)

1. Folkman, J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med., 285: 1182-1186, 1971.
2. Hanahan, D., and Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell, 86: 353-364, 1996.
3. Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med., 1: 27-31, 1995.
4. Risau, W. Mechanisms of angiogenesis. Nature (Lond.), 386: 671-674, 1997.
5. Folkman, S., and Chesney, M. Grief. Vancouver Conference Review. AIDS Care, 9: 39-43, 1997.
6. Bussolino, F., Mantovani, A., and Persico, G. Molecular mechanisms of blood vessel formation. Trends Biochem. Sci., 22: 251-256, 1997.
7. Inser, J. M., and Asahara, T. Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization. J. Clin. Investig., 103: 1231-1236, 1999.
8. Ferguson, L. R. Antimutagens as cancer chemopreventive agents in the diet. Mutat. Res., 307: 395-410, 1994.
9. Stavric, B. Role of chemopreventers in human diet. Clin. Biochem., 27: 319-332, 1994.
10. Suzuki, T., and Iwai, K. Constitution of red pepper species: chemistry, biochemistry, pharmacology, and food science of the pungent principle of Capsicum species. In: A. Brosi, Ed., The Alkaloides, pp. 227-299. New York: Academic Press, 1994.
11. Cordell, G. A., and Araujo, O. E. Capsaicin: identification, nomenclature, and pharmacotherapy. Ann. Pharmacother., 27: 330-336, 1993.
12. Surh, Y. J., Lee, E., and Lee, J. M. Chemopreventive properties of some pungent ingredients present in red pepper and ginger. Mutat. Res., 402: 259-267, 1998.
13. Morre, D. J., Chuen, P. J., and Morre, D. M. Capsaicin inhibits preferentially the NADH oxidase and growth of transformed cells in culture. Proc. Natl. Acad. Sci. USA, 92: 1831-1835, 1995.
14. Morre, D. J., Sun, E., Geilen, C., Wu, L. Y., de Cabo, R., Krasgakis, K., Orfanos, C. E., and Morre, D. E. Capsaicin inhibits plasma membrane NADH oxidase and growth of human and mouse melanoma lines. Eur. J. Cancer, 32: 1995-2003, 1996.
15. Kim, J. D., Kim, J. M., Pyo, J. O., Kim, S. Y., Kim, B. S., Yu, R., and Han, I. S. Capsaicin can alter the expression of tumor forming-related genes which might be followed by induction of apoptosis of a Korean stomach cancer cell line, SNU-1. Cancer Lett., 120: 235-241, 1997.
16. Jaffe, E. A., Nachman, R. L., Becker, C. G., and Minick, C. R. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Investig., 52: 2745-2756, 1973.
17. Lee, O. H., Kim, Y. M., Lee, Y. M., Moon, E. J., Lee, D. J., Kim, J. H., Kim, K. W., and Kwon, Y. G. Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun., 264: 743-750, 1999.
18. Gho, Y. S., Kleinman, H. K., and Sosne, G. Angiogenic activity of human soluble intercellular adhesion molecule-1. Cancer Res., 59: 5128-5132, 1999.
19. Nicosia, R. F., and Ottinetti, A. Modulation of microvascular growth and morphogenesis by reconstituted basement membrane gel in three-dimensional cultures of rat aorta: a comparative study of angiogenesis in Matrigel, collagen, fibrin, and plasma clot. In Vitro Cell Dev. Biol., 26: 119-128, 1990.
20. Drabkin, D. S., and Ausin, J. H. Spectrophotometric constants for common hemoglobin derivatives in human, dog, and rabbit blood. J. Biol. Chem., 98: 719, 1932.
21. Kim, C. W., Lee, H. M., Lee, T. H., Kang, C., Kleinman, H. K., and Gho, Y. S. Extracellular membrane vesicles from tumor cells promote angiogenesis via sphingomyelin. Cancer Res., 62(21): 6312-6317, 2002.
22. Szallasi, A., and Blumberg, P. M. Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol. Rev., 51: 159-212, 1999.
23. Meyer, R. D., and Rahimi, N. Comparative structure-function analysis of VEGFR-1 and VEGFR-2: What have we learned from chimeric systems? Ann. N. Y. Acad. Sci., 995: 200-207, 2003.
24. Papapetropoulos, A., Garcia-Cardena, G., Madri, J. A., and Sessa, W. C. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J. Clin. Investig., 100: 3131-3139, 1997.
25. Morbidelli, L., Chang, C. H., Douglas, J. G., Granger, H. J., Ledda, F., and Ziche, M. Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium. Am. J. Physiol., 270: H411-H415, 1996.
26. Dimmeler, S., Fisslthaler, B., Fleming, I., Hermann, C., Busse, R., and Zeiher, A. M. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature (Lond.), 399: 601-605, 1999.
27. Dimmeler, S., Dernbach, E., and Zeiher, A. M. Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration. FEBS Lett., 477: 258-262, 2000.
28. Sindrup, S. H., and Jensen, T. S. Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action. Pain, 83: 389-400, 1999.
29. Surh, Y. J. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat. Res./Fund. Mol. Mech. Mutagen., 428: 305-327, 1999.
30. Archer, V. E., and Jones, D. W. Capsaicin pepper, cancer and ethnicity. Med. Hyp., 59: 450-457, 2002.
31. Veikkola, T., and Alitalo, K. VEGFs, receptors and angiogenesis. Semin. Cancer Biol., 9: 211-220, 1999.
32. McMahon, G. VEGF Receptor signaling in tumor angiogenesis. Oncologist, 5: 3-10, 2000.
33. Zhang, J., Nagasaki, M., Tanaka, Y., and Morikawa, S. Capsaicin inhibits growth of adult T-cell leukemia cells. Leuk. Res., 27: 275-283, 2003.
34. Patel, P. S., Yang, S., Li, A., Varney, M. L., and Singh, R. K. Capsaicin regulates vascular endothelial cell growth factor expression by modulation of hypoxia inducing factor-1α in human malignant melanoma cells. J. Cancer Res. Clin. Oncol., 128: 461-468, 2002.
35. Sherr, C. J. D-type cyclins. Trends Biochem. Sci., 20: 187-190, 1995.
36. Mukhopadhyay, A., Banerjee, S., Stafford, L. J., Xia, C., Liu, M., and Aggarwal, B. B. Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Oncogene, 21: 8852-8861, 2002.
37. Hanai, J., Dhanabal, M., Karumanchi, S. A., Albanese, C., Waterman, M., Chan, B., Ramchandran, R., Pestell, R., and Sukhatme, V. P. Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1. J. Biol. Chem., 277: 16464-16469, 2002.
38. Bernatchez, P. N., Soker, S., and Sirois, M. G. Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent. J. Biol. Chem., 274: 31047-31054, 1999.
39. Davis-Smyth, T., Chen, H., Park, J., Presta, L. G., and Ferrara, N. The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade. EMBO J., 15: 4919-4927, 1996.
40. Zachary, I., and Gliki, G. Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc. Res., 49: 568-581, 2001.
41. Morré, D. J., Sun, E., Geilen, C., Wu, L. Y., de Cabo, R., Krasagakis, K., Orfanos, C. E., and Morré, D. M. Capsaicin inhibits plasma membrane NADH oxidase and growth of human and mouse melanoma lines. Eur. J. Cancer, 328: 1995-2003, 1996.
42. Yoshitani, S. I., Tanaka, T., Kohno, H., and Takashima, S. Chemoprevention of azoxymethane-induced rat colon carcinogenesis by dietary capsaicin and rotenone. Int. J. Oncol., 19: 929-939, 2001.
43. Seegers, H. C., Hood, V. C., Kidd, B. L., Cruwys, S. C., and Walsh, D. A. Enhancement of angiogenesis by endogenous substance P release and neurokinin-1 receptors during neurogenic inflammation. J. Pharmacol. Exp. Ther., 306: 8-12, 2003.