Contributions of microorganisms to industrial biology

Molecular Biotechnology

Volumn 38, Issue 1, 2008, Pages 41-55

  Demain, Arnold L ^a   Adrio, Jose L ^b  

^a DREW UNIVERSITY   (United States)

^b NEURON BioPharma   (Spain)

Author keywords

Agriculture; Bioconversions; Biopharmaceuticals; Enzymes; Hosts; Metabolic engineering; Polymers; Primary metabolites; Secondary metabolites

Indexed keywords

BIOSYNTHESIS; CATALYST ACTIVITY; DNA; ENZYME ACTIVITY; METABOLISM;

BIOSYNTHETIC PATHWAYS; INDUSTRIAL BIOLOGY; INDUSTRIAL SCIENCE; METABOLIC ENGINEERING;

MICROORGANISMS;

ALPHA INTERFERON; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ANTIPARASITIC AGENT; BLEOMYCIN; COMPACTIN; CYCLOSPORIN A; DAUNORUBICIN; DNA VACCINE; DOXORUBICIN; EPOTHILONE DERIVATIVE; GAMMA INTERFERON; HEPATITIS C VACCINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; INTERFERON BETA SERINE; INTERLEUKIN 1; INTERLEUKIN 2; LASALOCID; MEVINOLIN; MITOMYCIN; MONENSIN; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PACLITAXEL; PRAVASTATIN; RAPAMYCIN; SALINOMYCIN; TACROLIMUS; UNINDEXED DRUG; AMINO ACID; ENZYME; IMMUNOSUPPRESSIVE AGENT; INSECTICIDE; RECOMBINANT PROTEIN; VITAMIN;

ARTICLE; BIOSYNTHESIS; BIOTRANSFORMATION; BREAST CANCER; CATALYSIS; CHRONIC GRANULOMATOUS DISEASE; CLINICAL TRIAL; CONDYLOMA ACUMINATUM; DRUG APPROVAL; DRUG MARKETING; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ENGINEERING; ESCHERICHIA COLI; FERMENTATION; FOOD AND DRUG ADMINISTRATION; GENOME; GENOMICS; HAIRY CELL LEUKEMIA; HANSENULA POLYMORPHA; HEPATITIS B; HEPATITIS C; HUMAN; KAPOSI SARCOMA; KIDNEY CARCINOMA; MEDICAL RESEARCH; METABOLIC ENGINEERING; METABOLITE; MICROORGANISM; MULTIPLE SCLEROSIS; NONHUMAN; OVARY CANCER; PICHIA PASTORIS; PLANT BIOTECHNOLOGY; SACCHAROMYCES CEREVISIAE; STREPTOMYCES; THROMBOCYTOPENIA; BIOTECHNOLOGY; METABOLISM; METHODOLOGY; MICROBIOLOGY; PHARMACEUTICS; PROTEIN ENGINEERING; REVIEW; TRANSGENIC PLANT;

AMINO ACIDS; ANTI-INFECTIVE AGENTS; ANTICHOLESTEREMIC AGENTS; ANTINEOPLASTIC AGENTS; BIOPHARMACEUTICS; BIOTECHNOLOGY; BIOTRANSFORMATION; ENZYMES; FERMENTATION; IMMUNOSUPPRESSIVE AGENTS; INDUSTRIAL MICROBIOLOGY; INSECTICIDES; PLANTS, GENETICALLY MODIFIED; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; VITAMINS;

EID: 38949203861     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12033-007-0035-z     Document Type: Article

References (127)

1. American Academy of Microbiology Colloquium (2004). Microbiology in the 21st Century. Where We Are and Where We Are Going. American Academy of Microbiology. Washington, DC.
2. Demain A. L. (2000). Microbial biotechnology. Trends Biotechnol, 18, 26-31.
3. Demain, A. L. (1996). Fungal secondary metabolism: regulation and functions. In B. Sutton (Ed.), A Century of Mycology (pp. 233-254). Cambridge, MA: Cambridge University Press..
4. Strohl, W. R. (1997). Industrial antibiotics: today and the future. In W.R. Strohl (ed.), Biotechnology of Antibiotics, 2nd ed., (pp. 1-47). New York, NY: Marcel Dekker.
5. Wall, M. E., & Wani, M. C. (1995). Campothecin and taxol: Discovery to clinic. Cancer Research, 55, 753-760.
6. Stierle, A., Strobel, G., & Stierle, D. (1993). Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew. Science, 260, 214-216.
7. Brown, A. G., Smale, T. C., King, T. J., Hasenkamp, R., & Thompson, R. H. (1976). Crystal and molecular structure of compactin: a new antifungal metabolite from Penicillium brevicompactum. Journal of the Chemical Society-Perkin Transactions, 1, 1165-1170.
8. Endo, A., Kuroda, M., & Tsujita, Y. (1976). ML-236B and ML-236C, new inhibitors of cholesterolgenesis produced by Penicillium citrinin. Journal of Antibiotics, 29, 1346-1348.
9. Endo, A. (1979). K Monacolin, a new hypocholesterolemic agent produced by Monascus species. Journal of Antibiotics, 32, 852-854.
10. Alberts, A. W., Chen, J., Kuron, G., Hunt, V., Huff, J., Hoffman, C., Rothrock, J., Lopez, M., Joshua, H., Harris, E., Patchett, A., Monaghan, H., Currie, S., Stapley, E., Albers-Schonberg, G., Hensens, O., Hirshfield, J., Hoogsteen, K., Liesch, J., & Springer, J. (1980). Mevinolin: A highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proceedings of the National Academy of Sciences of the United States of America, 77, 3957-3961.
11. Torget, R., Kim, J., & Lee, Y. Y. (2000). Fundamental aspects of dilute acid hydrolysis/fractionation kinetics of hardwood carbohydrates. 1. Cellulose hydrolysis. Industrial & Engineering Chemistry Research, 39, 2817-2825.
12. Johannes, T. W., & Zhao, H. (2006). Directed evolution of enzymes and biosynthetic pathways. Current Opinion in Microbiology, 9, 261-267.
13. Gusakov, A. V., Salanovich, T. N., Antonov, A. I., Ustinov, B. B., Okunev, O. N., Burlingame, R., Emalfarb, M., Baez, M., & Sinitsyn, A. P. (2007). Design of highly efficient cellulase mixtures for enzymatic hydrolysis of cellulose. Biotechnology and Bioengineering (in the press).
14. Rao, M. B., Tanksale, A. M., Ghatge, M. S., & Deshpande, V. V. (1998). Molecular and biotechnological aspects of microbial proteases. Microbiology and Molecular Biology Reviews, 62, 597-635.
15. Tzanov, T., Calafell, M., Guebitz, G. M., & Cavaco-Paulo, A. (2001). Bio-preparation of cotton fabrics. Enzyme Microbial Technology, 29, 357-362.
16. Farrell, R. L., Hata, K., & Wall, M. B. (1997). Solving pitch problems in pulp and paper processes by the use of enzymes or fungi. Advances in biochemical engineering/biotechnology, 57, 197-212.
17. Koeller, K. M., & Wong, C. H. (2001). Enzymes for chemical synthesis. Nature, 409, 232-240.
18. Kirchner, G., Scollar, M. P., & Klibanov, A. (1995). Resolution of racemic mixtures via lipase catalysis in organic solvents. Journal of the American Chemical Society, 107, 7072-7076.
19. Klibanov, A. (2001). Improving enzymes by using them in organic solvents. Nature, 409, 241-246.
20. Zaks, A., & Dodds, D. R. (1997). Application of biocatalysis and biotransformations to the synthesis of pharmaceuticals. Drug Discover Today, 2, 513-531.
21. Carrea, G., & Riva, S. (2000). Properties and synthetic applications of enzymes in organic solvents. Angewandte Chemie, 33, 2226-2254.
22. Lee, M. Y., & Dordick J. S. (2002). Enzyme activation for nonaqueous media. Current Opinion in Microbiology, 13, 376-384.
23. Kirk, O., Borchert, T. V., & Fulgsang, C. C. (2002). Industrial enzyme applications. Current Opinion in Microbiology, 13, 345-351.
24. Yamada, H., Shimizu, S., & Kobayashi, M. (2001). Hydratases involved in nitrile conversion: screening, characterization and application. Chemical Record, 1, 152-161.
25. Thomas, S. M., DiCosimo, R., & Nagarajan, V. (2002). Biocatalysis: applications and potentials for the chemical industry. Trends Biotechnology, 20, 238-242.
26. Swartz, J. R. (1996). Escherichia coli recombinant DNA technology. In F. C. Neidhardt (ed.), Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd ed., (pp. 1693-1771). Washington DC: American Society of Microbiology Press.
27. Romanos, M. A., Scorer, C. A., & Clare, J. J. (1992). Foreign gene expression in yeast: a review. Yeast, 8, 423-488.
28. Higgins, D. R., & Cregg, J. M. (1998). Introduction to Pichia pastoris, In D. R. Higgins & J. M. Cregg (Eds.), Pichia Protocols (pp. 1-15). Totowa, NJ: Humana Press.
29. Bretthauer, R. K., & Castellino, F. J. (1999). Glycosylation of Pichia pastoris-derived proteins. Biotechnology and Applied Biochemistry, 30, 193-200.
30. Romanos, M. A. (1995). Advances in the use of Pichia pastoris for high-level expression. Current Opinion in Microbiology, 6, 527-533.
31. Sohn, J. H., Kang, H. A., Rao, K. J., Kim, C. H., Choi, E. S., Chung, B. H., & Rhee, S. K. (2001). Current status of the anticoagulant hirudin: its biotechnological production and clinical practice. Applied Biochemistry and Biotechnology, 57, 606-613.
32. Giuseppin, M., van Eijk, H. M., & Bes, B. C. (1988). Molecular regulation of methanol oxidase activity in continuous cultures of Hansenula polymorpha. Biotechnology and Bioengineering, 32, 577-583.
33. Egli, T., van Dijken, J. P., Veenhuis, M., Harder, W., & Feichter, A. (1980). Methanol metabolism in yeasts: regulation of the synthesis of catabolite enzymes. Archives of Microbiology, 124, 115-121.
34. Shuster, J. R., & Connelley, M. B. (1999). Promoter-tagged restriction enzyme-mediated insertion mutagenesis in Aspergillus niger. Molecular & General Genetics, 262, 27-34.
35. Gouka, R. J., Gerk, C., Hooykaas, P. J. J., Bundock, P., Musters, W., Verrips, C. T., & de Groot, M. J. A. (1999). Transformation of Aspergillus awamori by Agrobacterium tumefaciens-mediated homologous recombination. Nature Biotechnology, 6, 598-601.
36. van der Hombergh, J. P., van de Vondervoort, P. J., van der Heijden, N. C., & Visser, J. (1997). New protease mutants in Aspergillus niger result in strongly reduced in vitro degradation of target proteins; genetical and biochemical characterization of seven complementation groups. Current Genetic, 28, 299-308.
37. Gouka, R. J., Punt, P. J., & van den Hondel, C. A. M. J. J. (1997). Efficient production of secreted proteins by Aspergillus: progress, limitations and prospects. Applied Microbiology and Biotechnology, 47, 1-11.
38. Moralejo, F. J., Cardoza, R. E., Gutierrez, S., & Martín, J. F. (1999). Thaumatin production in Aspergillus awamori by use of expression cassettes with strong fungal promoters and high gene dosage. Applied and Environmental Microbiology, 65, 1168-1174.
39. Ward P., Cunningham G. A., & Conneely O. M. (1997). Commercial production of lactoferrin, a multifunctional iron-binding glycoprotein. Biotechnology & Genetic Engineering Reviews, 14, 303-319.
40. Dunn-Coleman, N. S., Bloebaum, P., Berka, R., Bodie, E., Robinson, N., Armstrong, G., Ward, M., Przetak, M., Carter, G. L., LaCost, R., Wilson, L. J., Kodama, K. H., Baliu, E. F., Bower, B., Lamsa, M., & Heinsohn, H. (1991). Commercial levels of chymosin production by Aspergillus. Bio/Technology, 9, 976-981.
41. Verdoes, J. C., Punt, P. J., Burlingame, R., Bartels, J., van Dijk, R., Slump, E., Meens, M., Joosten, R., & Emalfarb, M. (2007). A dedicated vector for efficient library construction and high throughput screening in the hyphal fungus Chrysosporium lucknowense. Industrial Biotechnology, 3, 48-57.
42. Brown, K. S. (1996). Looking back at Jenner, vaccine developers prepare for 21st century. The Scientist 10 (April 1 issue), 14-17.
43. Gerngross, T. (2004). Advances in the production of human therapeutic proteins and filamentous fungi. Nature Biotechnology, 22, 1409-1414.
44. Stephanopoulos G., Aristodou A., & Nielsen J. (Eds.) (1998). Metabolic Engineering. San Diego, CA:Academic.
45. Ostergaard, S., Olsson, L., & Nielsen, J. (2000). Metabolic engineering of Saccharomyces cerevisiae. Microbiology and Molecular Biology Reviews, 64, 34-50.
46. Rohlin, L., Oh, M. K., & Liao, J. C. (2001). Microbial pathway engineering for industrial processes: evolution, combinatorial biosynthesis and rational design. Current Opinion in Microbiology, 4, 350-355.
47. Bongaerts, J., Kramer M., Muller, U., Raeven, L., & Wubbolts, M. (2001). Metabolic engineering for microbial production of aromatic amino acids and derived compounds. Metabolic Engineering, 3, 289-300.
48. Mielenz, J. R. (2001). Ethanol production from biomass: Technology and commercialization status. Current Opinion in Microbiology, 4, 324-329.
49. Ingram, L. O., Conway T., Clark D. P., Sewell G. W., & Preston J. F. (1987). Genetic engineering of ethanol production in Escherichia coli. Applied and Environmental Microbiology, 53, 2420-2425.
50. Green, D. (2005). Spinning straw into fuel. Biocycle, 46, 61-65.
51. Lynd, L. (1996). Overview and evaluation of fuel ethanol from cellulosic biomass: technology, economics and policy. Annual Review Of Energy And The Environment, 21, 403-465.
52. Jeffries, T. W. (2006). Engineering yeasts for xylose metabolism. Current Opinion in Biotechnology, 17, 320-326.
53. Wendisch, V. T., Bott, M., & Eikmanns, B. J. (2006). Metabolic engineering of Escherichia coli and Corynebacterium glutamicum for biotechnological production of organic acids and amino acids. Current Opinion in Microbiology, 9, 268-274.
54. Wendisch, V. F. (2006). Genetic regulation of Corynebacterium glutamicum metabolism. Journal of Microbiology and Biotechnology, 16, 999-1009.
55. Eggeling, L., & Sahm H. (1999). Amino acid production: principles of metabolic engineering. In S. Y. Lee & E. T. Papoutsakis (eds.), Metabolic Engineering, (pp. 153-176). Marcel Dekker:New York.
56. Shibasaki, T., Hashimoto, S., Mori, H., & Ozaki, A. (2000). Construction of a novel hydroxyproline-producing recombinant Escherichia coli by introducing a proline 4-hydroxylase gene. Journalof Bioscience and Bioengineering, 90, 522-525.
57. Weikert, C., Sauer, U., & Bailey, J.E (1998). Increased phenylalanine production by growing and nongrowing Escherichia coli strain CWML2. Biotechnology Progress, 14, 420-424.
58. Ikeda, M., & Katsumata, R. (1999). Hyperproduction of tryptophan by Corynebacterium glutamicum with the modified pentose phosphate pathway. Applied and Environmental Microbiology, 65, 2497-2502.
59. Levy-Schil, S., Debussche, L., Rigault, S., Soubrier, F., Bacchette, F., Lagneaux, D., Schleuniger, J., Blanche, F., Crouzet, J., & Mayaux, J.F (1993). Biotin biosynthetic pathway in a recombinant strain of Escherichia coli overexpressing bio genes: evidence for a limiting step upstream from KAPA. Applied Microbiology and Biotechnology, 38, 755-762.
60. Sakurai, N., Imai, Y., Masuda, M., Komatsubara, S., & Tosa, T. (1994). Improvement of a d-biotin-hyperproducing recombinant strain of Serratia marcescens. Journal of Biotechnology, 36, 63-73.
61. Masuda, M., Takahashi, K., Sakurai, N., Yanagiya, K., Komatsubara, S., & Tosa T. (1995). Further improvement of D-biotin production by a recombinant strain of Serratia marcescens. Process Biochemistry, 30, 553-562.
62. Hong, Y.-R., Chen, Y.-L., Farh, L., Yang, W.-J., Liao, C.-H., & Shiuan, D. (2006). Recombinant Candida utilis for the production of biotin. Applied Microbiology and Biotechnology, 71, 211-221.
63. Saito, Y., Ishii, Y., Hayashi, H., Imao, Y., Akashi, T., Yoshikawa, K., Noguchi, Y., Soeda, S., Yoshida, M., Niwa, M., Hosoda, J., & Shimomura K. (1997). Cloning of genes coding for L-sorbose and L-sorbosone dehydrogenases from Gluconobacter oxydans and microbial production of 2-keto-L-gulonate, a precursor of L-ascorbic acid, in a recombinant G. oxydans strain. Applied and Environmental Microbiology, 63, 454-460.
64. Shibata, T., Ichikawa, C., Matsuura, M., Takata, Y., Noguchi, Y., Saito, Y., & Yamashita, M. (2000). Cloning of a gene for D-sorbitol dehydrogenase from Gluconobacter oxydans G624 and expression of the gene in Pseudomonas putida IFO3738. Journal of Bioscience and Bioengineering, 89, 463-468.
65. Saito, Y., Hayashi, H., Yoshikawa, K., Noguchi, Y., Yoshida, S., Soeda, S., & Yoshida, M. (1998). Direct fermentation of 2-keto-l-gulonic acid in recombinant Gluconobacter oxydans. Biotechnology and Bioengineering, 58, 309-315.
66. Koizumi, S., Yonetani, Y., Maruyama, A., & Teshiba, S. (2000). Production of riboflavin by metabolically engineered Corynebacterium ammoniagenes. Applied Microbiology and Biotechnology,, 51, 674-679.
67. Perkins, J. B., Sloma, A., Hermann, T., Theriault, K., Zachgo, E., Erdenberger, T., Hannett, N., Chatterjee, N. P., Williams II V., Rufo Jr. G. A., Hatch, R., & Pero, J. (1999). Genetic engineering of Bacillus subtilis for the commercial production of riboflavin. Journal of Industrial Microbiology &Biotechnology, 22, 8-18.
68. Chen, C. W., Lin, H. F., Kuo, C. L., Tsai, H. L., & Tsai, J. F. Y. (1988). Cloning and expression of a DNA sequence conferring cephamycin C production. Bio/Technology, 6, 1222-1224.
69. Decker, H., Summers, R. G., & Hutchinson, C. R. (1994). Overproduction of the acyl carrier protein component of a type II polyketide synthase stimulates production of tetracenomycin biosynthetic intermediates in Streptomyces glaucescens. Journal of Antibiotics, 47, 54-63.
70. Malmberg, L.-H., Hu, W.-S., & Sherman, D. H. (1995). Effects of enhanced lysine ε-aminotransferase on cephamycin biosynthesis in Streptomyces clavuligerus. Applied Microbiology and Biotechnology, 44, 198-205.
71. Kennedy, J., & Turner, G. (1996). δ-l-α-aminoadipyl-l- cysteinyl-d-valine synthetase is a rate limiting enzyme for penicillin production in Aspergillus nidulans. Molecular & General Genetics, 253, 189-197.
72. Crawford, L., Stepan, A. M., McAda, P. C., Rambosek, J. A., Conder, M. J., Vinci, V. A., & Reeves, C. D. (1995). Production of cephalosporin intermediates by feeding adipic acid to recombinant Penicillium chrysogenum strains expressing ring expansion activity. Bio/Technology, 13, 58-62.
73. Velasco, J., Adrio, J. L., Moreno, M. A., Diez, B., Soler, G., & Barredo, J. L. (2000). Environmentally safe production of 7- aminodeacetoxycephalosporanic acid (7-ADCA) using recombinant strains of Acremonium chrysogenum. Nature Biotechnology, 18, 857-861.
74. Rodriguez, E., & McDaniel, R. (2001). Combinatorial biosynthesis of antimicrobials and other natural products. Current Opinion in Microbiology, 4, 526-534.
75. Mendez, C., & Salas, J. A. (2001). Altering the glycosylation pattern of bioactive compounds. Trends in Biotechnology, 19, 449-456.
76. Okanishi, M., Suzuki, N., & Furita, T. (1996). Variety of hybrid characters among recombinants obtained by interspecific protoplast fusion in streptomycetes. Bioscience Biotechnology and Biochemistyr, 6, 1233-1238.
77. Van Lanen, S. G., & Shen, B. (2006). Microbial genomics for the improvement of natural product discovery. Applied and Environmental Microbiology, 9, 252-260.
78. Greden, B. D., & Keller, M. (2006). Capturing the uncultivated majority. Applied Microbiology and Biotechnology, 17, 236-240.
79. Bodie, E. A., Armstrong, G. L., & Dunn-Coleman, N. S. (1994). Strain improvement of chymosin-producing strains of Aspergillus niger var awamori using parasexual recombination. Enzyme Microbial Technology, 16, 376-382.
80. Pariza, M. W., & Johnson, E. A (2001). Evaluating the safety of microbial enzyme preparations used in food processing: Update for a new century. Regulatory Toxicology And Pharmacology, 33, 173-186.
81. htpp://vm.cfsan.fda.gov.
82. Kirk, O., Borchert, T. V., & Fuglsang, C. C. (2002). Industrial enzyme applications. Current Opinion in Biotechnology, 13, 345-351.
83. Rondon, M. R., Goodman, R. M., & Handelsman, J. (1999). The Earth's bounty: assessing and accessing soil microbial diversity. Trends in Biotechnology, 17, 403-409.
84. htpp://www.diversa.com.
85. htpp://www.tigr.org.
86. htpp://www.ncbi.nlm.nih.gov.
87. Schiraldini, C., & De Rosa, M. (2002). The production of biocatalysts and biomolecules from extremophiles. Trends in Biotechnology, 20, 515-521.
88. Marrs, B., Delagrave, S., & Murphy, D. (1999). Novel approaches for discovering industrial enzymes. Applied and Environmental Microbiology, 2, 241-245.
89. Schmid, A., Dordick, J. S., Hauer, B., Kiener, A., Wubbolts, M., & Witholt, B. (2001). Industrial biocatalysis today and tomorrow. Nature, 409, 258-268.
90. Cedrone, F., Menez, A., & Quemeneur, E. (2000). Tailoring new enzyme functions by rational redesign. Current Opinion in Structural Biology, 10, 405-410.
91. Beppu, T. (1990). Modification of milk-clotting aspartic proteinases by recombinant DNA techniques. Annals of the New York Academy of Sciences, 613, 14-25.
92. Van den Burg, B., de Kreij, A., Van der Veek, P., Mansfeld, J., & Venema, G. (1998). Engineering an enzyme to resist boiling. Proceedings of the National Academy of Sciences of the United States of America, 95, 2056-2060.
93. Bolon, D. N., Voigt, C. A., & Mayo, S. L. (2002). De novo design of biocatalysts. Current Opinion in Structural Biology, 6, 125-129.
94. Shimaoka, M., Shiftman, J. M., Jing, H., Tagaki, J., Mayo, S. L., & Springer T. A. (2000). Computational design of an integrin I domain stabilized in the open high affinity conformation. Nature Structural Biology, 7, 674-678.
95. Arnold, F. H. (2001). Combinatorial and computational challenges for biocatalyst design. Nature, 409, 253-257.
96. Yuan, L., Kurek, I., English, J., & Keenan, R. (2005). Laboratory-directed protein evolution. Microbiology and Molecular Biology Reviews, 69, 373-392.
97. Leung, D. W., Chen, E., & Goeddel, D. V. (1989). A method for random mutagenesis of a defined DNA segment using a modified polymerase chain reaction. Technique, 1, 11-15.
98. Reidhaar-Olson, J., Bowie, J., Breyer, R. M., Hu, J. C., Knight, K. L., Lim, W. A., Mossing, M. C., Parsell, D. A., Shoemaker, K. R., & Sauer, R. T. (1991). Random mutagenesis of protein sequences using oligonucleotide cassettes. Methods in Enzymology, 208, 564-586.
99. Bornscheuer, U. T., Altenbuchner, J., & Meyer, H. H. (1998). Directed evolution of an esterase for the stereoselective resolution of a key intermediate in the synthesis of epithilones. Biotechnology and Bioengineering, 58, 554-559.
100. Taguchi, S., Ozaki, A., & Momose, H. (1998). Engineering of a cold-adapted protease by sequential random mutagenesis and a screening system. Applied and Environmental Microbiology, 64, 492-495.
101. Ness, J. E., Del Cardayre, S. B., Minshull, J., & Stemmer, W. P. (2000). Molecular breeding: the natural approach to protein design. Advances in Protein Chemistry, 55, 261-292.
102. Stemmer, W. P. (1994). Rapid evolution of a protein in vitro by DNA shuffling. Nature, 370, 389-391.
103. Zhao, H., & Arnold, F. H. (1997). Optimization of DNA shuffling for high fidelity recombination. Nucleic Acids Research, 25, 1307-1308.
104. Crameri, A., Raillard, S. A., Bermudez, E., & Stemmer, W. P. (1998). DNA shuffling of a family of genes from diverse species accelerates directed evolution. Nature, 391, 288-291.
105. Ness, J. E., Welch, M., Giver, L., Bueno, M., Cherry, J. R., Borchert, T. V., Stemmmer, W. P., & Minshull, J. (1999). DNA shuffling of subgenomic sequences of subtilisin. Nature Biotechnology, 17, 893-896.
106. Jaeger, K. E., & Reetz, M. T. (2000). Directed evolution of enantioselective enzymes for organic chemistry. Current Opinion in Chemical Biology, 4, 68-73.
107. Suenaga, H., Mitsokua, M., Ura, Y., Watanabe, T., & Furukawa, K. (2001). Directed evolution of biphenyl dioxygenase: emergence of enhanced degradation capacity for benzene, toluene, & alkylbenzenes. Journal of Bacteriology 183, 5441-5444.
108. Song, J. K., & Rhee, J. S. (2001). Enhancement of stability and activity of phospholipase A(1) in organic solvents by directed evolution. Biochimica et Biophysica Acta, 1547, 370-378.
109. Raillard, S., Krebber, A., Chen, Y., Ness, J. E., Bermudez, E., Trinidad, R., Fullem, R., Davis, C., Welch, M., Seffernick, J., Wackett, L. P., Stemmer W. P., & Minshull, J. (2001). Novel enzyme activities and functional plasticity revealed by recombining highly homologous enzymes. Chemistry & Biology, 8, 891-898.
110. Kurtzman, A. L., Govindarajan, S., Vahle, K., Jones, J. T., Heinrichs, V., & Patten, P. A. (2001). Advances in directed protein evolution by recursive genetic recombination: applications to therapeutic proteins. Current Opinion in Biotechnology, 12, 361-370.
111. Patten, P. A., Howard, R. J., & Stemmer W. P. (1997). Applications of DNA shuffling to pharmaceuticals and vaccines. Current Opinion in Biotechnology, 8, 724-733.
112. Tobin, M. B., Gustafsson, C., & Huisman, G. W. (2000). Directed evolution: the 'rational' basis for 'irrational' design. Current Opinion in Structural Biology, 10, 421-427.
113. Zhang, Y. X., Perry, K., Vinci, V. A., Powell, K., Stemmer, W. P., & del Cardayre, S. B. (2002). Genome shuffling leads to rapid phenotypic improvement in bacteria. Nature, 415, 644-646.
114. Patnaik, R., Louie, S., Gavrilovic, V., Perry, K., Stemmer, W. P., Ryan, C. M., & del Cardayre, S. B. (2002). Genome shuffling of Lactobacillus for improved acid tolerance. Nature Biotechnology, 20, 707-712.
115. Picataggio, S., Rohrer, T., Deanda, K., Lanning, D., Reynolds, R., Mielenz, J., & Eirich, L. D. (1992). Metabolic engineering of Candida tropicalis for the production of long-chain dicarboxylic acids. Bio/Technology, 10, 894-898.
116. Arisawa, A., Kawamura, N., Narita, T., Kojima, I., Okamura, K., Tsunekawa, H., Yoshioka, T, Okamoto, R. (1996). Direct fermentative production of acyltylosins by genetically-engineered strains of Streptomyces fradiae. Jornal of Antibiotics, 49, 349-354.
117. Ferrer, M., Martinez-Abarca, F., & Golyshin, P. N. (2005). Mining genomes and 'metagenomes' for novel catalysts. Current Opinion in Biotechnology, 16, 588-593.
118. Bigelas, R. (1989). Industrial Products of Biotechnology: Application of gene technology. In H. J. Rehm & G. Reed (eds.); G. K. Jacobson, & S. O. Jolly, (vol. Eds.) Biotechnology, vol. 7b (pp. 229-259). VCH, Weinheim.
119. Tseng, Y. H., Ting, W. Y., Chou, H. C., Yang, B. Y., & Chun, C. C. (1992). Increase of xanthan production by cloning xps genes into wild-type Xanthomonas campestris. Letters in Applied Microbiology, 14, 43-46.
120. Letisse, F., Chevallereau, P., Simon, J.-L., & Lindley, N. D. (2001). Kinetic analysis of growth and xanthan gum production with Xanthomonas campestris on sucrose, using sequentially consumed nitrogen sources. Applied Microbiology and Biotechnology, 55, 417-422.
121. Potera, C. (1997). Genencor & DuPont create "green" polyester. Genetic Engineering News, 17(11), 17.
122. Tong, I.-T., Liao, J. J., & Cameron, D. C. (1991). 1,3-Propane diol production by Escherichia coli expressing genes from the Klebsiella pneumoniae dha region. Applied and Environmental Microbiology, 57, 3541-3546.
123. Laffend, L. A., Nagarajan, V., & Nakamura, C. E. (1996). Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism. Patent WO 96/53.796 (E. I. DuPont de Nemours and Genencor International).
124. Vink, E. T. H., Glassner, D. A., Kolstad, J. J., Wooley, R. J., & O'Connor, R. P.(2007). The eco-profiles for current and near-future NatureWorks polylactide (PLA) production. Industrial Biotechnology, 3, 58-81.
125. Akkara, J. A., Ayyagari, M. S., & Bruno, F. F. (1999). Enzymatic synthesis and modification of polymers in nonaqueous solvents. Trends in Biotechnology, 17, 67-73.
126. National Academy of Sciences U.S.A. (2000). Transgenic Plants and World Agriculture. Washington, DC: National Academy Press.
127. Fox, S. (2000). Golden Rice intended for developing world. Genetic Engineering News, 20(12), 42-50.