Novel enzyme activities and functional plasticity revealed by recombining highly homologous enzymes

Chemistry and Biology

Volumn 8, Issue 9, 2001, Pages 891-898

  Raillard, SunAi ^a   Krebber, Anke ^a   Chen, Yonghong ^a   Ness, Jon E ^a   Bermudez, Ericka ^a   Trinidad, Rossana ^a   Fullem, Rachel ^a   Davis, Christopher ^a   Welch, Mark ^a   Seffernick, Jennifer ^b   Wackett, Lawrence P ^b   Stemmer, Willem P C ^a   Minshull, Jeremy ^a  

^a MAXYGEN INC   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Enzyme activity; Functional plasticity; Homologous enzymes; Triazine hydrolases

Indexed keywords

ATRAZINE CHLOROHYDROLASE; HYDROLASE; MELAMINE DEAMINASE; PROTEIN; TRIAZINE DERIVATIVE;

ARTICLE; CHEMISTRY; DIRECTED MOLECULAR EVOLUTION; ENZYME SPECIFICITY; ESCHERICHIA COLI; GENETICS; METABOLISM; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

AMINOHYDROLASES; DIRECTED MOLECULAR EVOLUTION; ESCHERICHIA COLI; HYDROLASES; MUTAGENESIS, SITE-DIRECTED; PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TRIAZINES;

EID: 0034833072     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00061-8     Document Type: Article

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