Microbial pathway engineering for industrial processes: Evolution, combinatorial biosynthesis and rational design

Current Opinion in Microbiology

Volumn 4, Issue 3, 2001, Pages 330-335

  Rohlin, Lars ^a   Oh, Min Kyu ^a   Liao, James C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAROTENOID; ISOPRENOID; POLYKETIDE;

ANTIOXIDANT ACTIVITY; BACTERIAL METABOLISM; BIOENGINEERING; BIOSYNTHESIS; MICROORGANISM; NONHUMAN; REVIEW;

EID: 0034986950     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5274(00)00213-7     Document Type: Review

References (61)

1. The biotechnological potential and design of novel carotenoids by gene combination in Escherichia coli
2. Metabolic engineering of isoprenoids
3. Increased carotenoid production by the food yeast Candida utilis through metabolic engineering of the isoprenoid pathway
4. Engineered isoprenoid pathway enhances astaxanthin production in Escherichia coli
5. Novel hydroxycarotenoids with improved antioxidative properties produced by gene combination in Escherichia coli
6. Metabolic engineering of carotenoid accumulation in Escherichia coli by modulation of the isoprenoid precursor pool with expression of deoxyxylulose phosphate synthase
7. Metabolic engineering of the terpenoid biosynthetic pathway of Escherichia coli for production of the carotenoids β-carotene and zeaxanthin
8. Directed evolution of metabolically engineered Escherichia coli for carotenoid production
9. Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway in Escherichia coli enhances lycopene production
10. Biosynthesis of terpenoids: 4-diphosphocytidyl-2-C-methyl-D- erythritol kinase from tomato
11. Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: A novel system for the genetic analysis of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis
12. Molecular breeding of carotenoid biosynthetic pathways
13. Improving lycopene production in Escherichia coli by engineering metabolic control
14. Precursor balancing for metabolic engineering of lycopene production in Escherichia coli
15. Molecular cloning of a taxa-4(20),11(12)-dien-5α-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli
16. Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli
17. Taxol biosynthesis: Molecular cloning of a benzoyl-CoA : Taxane 2 α-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli
18. Comprehensive evaluation of isoprenoid biosynthesis regulation in Saccharomyces cerevisiae utilizing the Genome Reporter Matrix
19. Alternative modular polyketide synthase expression controls macrolactone structure
20. Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes
21. A multiplasmid approach to preparing large libraries of polyketides
22. A two-plasmid system for the glycosylation of polyketide antibiotics: Bioconversion of epsilon-rhodomycinone to rhodomycin D
23. Dissecting the chain length specificity in bacterial aromatic polyketide synthases using chimeric genes
24. Dissecting and exploiting intermodular communication in polyketide synthases
25. Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel 'unnatural' natural products
26. Cloning and heterologous expression of the epothilone gene cluster
27. Identification of a cyclohexylcarbonyl CoA biosynthetic gene cluster and application in the production of doramectin
28. Identification and analysis of the polyhydroxyalkanoate-specific β-ketothiolase and acetoacetyl coenzyme A reductase genes in the cyanobacterium Synechocystis sp strain PCC6803
29. FabG, an NADPH-dependent 3-ketoacyl reductase of Pseudomonas aeruginosa, provides precursors for medium-chain-length poly-3-hydroxyalkanoate biosynthesis in Escherichia coli
30. Molecular cloning of two (R)-specific enoyl-CoA hydratase genes from Pseudomonas aeruginosa and their use for polyhydroxyalkanoate synthesis
31. A novel genetically engineered pathway for synthesis of poly(hydroxyalkanoic acids) in Escherichia coli
32. Lipases provide a new mechanistic model for polyhydroxybutyrate (PHB) synthases: Characterization of the functional residues in Chromatium vinosum PHB synthase
33. Proteome analysis of metabolically engineered Escherichia coli producing poly(3-hydroxybutyrate)
34. Chiral compounds from bacterial polyesters: Sugars to plastics to fine chemicals
35. Enhanced production of (R)-1,2-propanediol by metabolically engineered Escherichia coli
36. Fed-batch fermentor synthesis of 3-dehydroshikimic acid using recombinant Escherichia coli
37. Microbial synthesis of 3-dehydroshikimic acid: A comparative analysis of D-xylose, L-arabinose, and D-glucose carbon sources
38. Synthesis of gallic acid and pyrogallol from glucose: Replacing natural product isolation with microbial catalysis
39. Engineering of a novel biochemical pathway for the biosynthesis of L-2-aminobutyric acid in Escherichia coli K12
40. Expression of the Escherichia coli catabolic threonine dehydratase in Corynebacterium glutamicum and its effect on isoleucine production
41. Optimization of tryptophan production in bacteria. Design of a strategy for genetic manipulation of the tryptophan operon for tryptophan flux maximization
42. Effect of variation of Klebsiella pneumoniae acetolactate synthase expression on metabolic flux redistribution in Escherichia coli
43. Increasing galactose consumption by Saccharomyces cerevisiae through metabolic engineering of the GAL gene regulatory network
44. Inverting enantioselectivity by directed evolution of hydantoinase for improved production of L-methionine
45. Directed evolution of a novel N-carbamylase/D-hydantoinase fusion enzyme for functional expression with enhanced stability
46. Directed evolution of toluene dioxygenase from Pseudomonas putida for improved selectivity toward cis-indandiol during indene bioconversion
47. Directed evolution of new catalytic activity using the α/β-barrel scaffold
48. Chromosomal integration of heterologous DNA in Escherichia coli with precise removal of markers and replicons used during construction
49. Antisense RNA strategies for metabolic engineering of Clostridium acetobutylicum
50. Simultaneous identification of two cyclohexanone oxidation genes from an environmental Brevibacterium isolate using mRNA differential display
51. Heterogeneous distribution of lysine 6-aminotransferase during cephamycin C biosynthesis in Streptomyces clavuligerus demonstrated using green fluorescent protein as a reporter
52. 13C labeling and two dimensional NMR spectroscopy
53. Metabolic flux ratio analysis of genetic and environmental modulations of Escherichia coli central carbon metabolism
54. Metabolite and isotopomer balancing in the analysis of metabolic cycles: II. Applications
55. 13C NMR evidence for pyruvate kinase flux attenuation underlying suppressed acid formation in Bacillus subtilis
56. 13C-labeled glucose
57. The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities
58. Application of metabolic flux analysis for the identification of metabolic bottlenecks in the biosynthesis of penicillin-G
59. Gene expression profiling by DNA microarrays and metabolic fluxes in Escherichia coli
60. DNA microarray detection of metabolic responses of protein overproduction in Escherichia coli
61. Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli