Direct fermentative production of acyltylosins by genetically-engineered strains of Streptomyces fradiae

Journal of Antibiotics

Volumn 49, Issue 4, 1996, Pages 349-354

  Arisawa, Akira ^a   Kawamura, Naoto ^a   Narita, Takao ^a   Kojima, Ikuo ^a,b   Okamura, Kazuhiko ^a   Tsunekawa, Hiroshi ^a   Yoshioka, Takeo ^a   Okamoto, Rokuro ^a  

^a MERCIAN CORPORATION   (Japan)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; MACROLIDE; TYLOSIN DERIVATIVE;

ACYLATION; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; FERMENTATION; GENETIC ENGINEERING; GENETIC TRANSFORMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PLASMID; PRIORITY JOURNAL; STREPTOMYCES FRADIAE;

EID: 0029965386     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.49.349     Document Type: Article

References (22)

1. OKAMOTO, R.; H. NOMURA, M. TSUCHIYA, H. TSUNEKAWA, T. FUKUMOTO, T. INUI, T. SAWA, T. TAKEUCHI & H. UMEZAWA: The activity of 4″-acylated tylosin derivatives against macrolide-resistant Gram-positive bacteria. J. Antibiotics 32: 542-544, 1979
2. OKAMOTO, R.; M. TSUCHIYA, H. NOMURA, H. IGUCHI, K. KIYOSHIMA, S. HORI, T. INUI, T. SAWA, T. TAKEUCHI & H. UMEZAWA: Biological properties of new acyl derivatives of tylosin. J. Antibiotics 33: 1309-1315, 1980
3. MCGUIR, J. M.; W. S. BONIECE, C. E. HIGGENS, M. M. HOEHN, W. M. STARK, J. WESTHEAD & R. N. WOLFE: Tylosin, a new antibiotic. I. Microbiological studies. Antibiot. Chemoth. 11: 320-327, 1961
4. ŌMURA, S. & H. TANAKA: Macrolide Antibiotics Chemistry, Biology, and Practice, pp. 318-331, Academic Press Inc., New York, 1984
5. OKAMOTO, R.; T. FUKUMOTO, H. NOMURA, K. KIYOSHIMA, K. NAKAMURA, A. TAKAMATSU, H. NAGANAWA, T. TAKEUCHI & H. UMEZAWA: Physico-chemical properties of new acyl derivatives of tylosin produced by microbial transformation. J. Antibiotics 33: 1300-1308, 1980
6. ARISAWA, A.; N. KAWAMURA, K. TAKEDA, H. TSUNEKAWA, K. OKAMURA & R. OKAMOTO: Cloning of the macrolide antibiotic biosynthesis gene acyA, which encodes 3-O-acyltransferase, from Streptomyces thermotolerans and its use for direct fermentative production of a hybrid macrolide antibiotic. Appl. Env. Microbiol. 60: 2657-2660, 1994
7. ARISAWA, A.; H. TSUNEKAWA, K. OKAMURA & R. OKAMOTO: Nucleotide sequence analysis of the carbomycin biosynthetic genes including the 3-O-acyltransferase gene from Streptomyces thermotolerans. Biosci. Biotech. Biochem. 59: 582-588, 1995
8. ARISAWA, A.; N. KAWAMURA, H. TSUNEKAWA, K. OKAMURA, H. TONE & R. OKAMOTO: Cloning and nucleotide sequences of two genes involved in the 4″-O-acylation of macrolide antibiotics from Streptomyces thermotolerans. Biosci. Biotech. Biochem. 57: 2020-2025, 1993
9. EPP, J. K.; M. L. B. HUBER, J. R. TURNER, T. GOODSON & B. E. SCHONER: Production of a hybrid macrolide antibiotic in Streptomyces ambofaciens and Streptomyces lividans by introduction of a cloned carbomycin biosynthetic gene from Streptomyces thermotolerans. Gene 85: 293-301, 1989
10. WEBER, J. M.; J. O. LEUNG, S. J. SWANSON, K. B. IDLER & J. B. MCALPINE: An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea. Science 252: 114-117, 1991
11. IKEDA, H. & S. ŌMURA: Genetic aspects of the selective production of useful components in the avermectin producer Streptomyces avermitilis. Actinomycetol. 7: 133-144, 1993
12. HOPWOOD, D. A.; F. MALPARTIDA, H. M. KIESER, H. IKEDA, J. DUNCAN, I. FUJII, B. A. RUDD, H. G. FLOSS & S. ŌMURA: Production of 'hybrid' antibiotics by genetic engineering. Naure 312: 642-644, 1985
13. ŌMURA, S.; H. IKEDA, F. MALPARTIDA, H. M. KIESER & D. A. HOPWOOD: Production of new hybrid antibiotics, mederrhodins A and B, by a genetically engineered strain. Antimicrob. Agents Chemother. 29: 13-19, 1986
14. MCDANIEL, R.; S. EBERT-KHOSLA, D. A. HOPWOOD & C. KHOSLA: Engineered biosynthesis of novel polyketides. Science 262: 1546-1550, 1993
15. HOPWOOD, D. A.; M. J. BIBB, K. F. CHATER, T. KIESER, C. J. BRUTON, H. M. KIESER, D. J. LYDIATE, C. P. SMITH, J. M. WARD & H. SCHREMPF: Genetic manipulation of Streptomyces - a laboratory manual. The John Innes Foundation, Norwich, UK, 1985
16. THOMAS, D. I.; J. H. COVE, S. BAUMBERG, C. A. JONES & B. A. M. RUDD: Plasmid effects on secondary metabolite production by a streptomycete synthesizing an anthelmintic macrolide. J. Gen. Microbiol. 137: 2331-2337, 1991
17. NAVARRETE, R. M.; J. A. VARA & C. R. HUTCHINSON: Purification of an inducible L-valine dehydrogenase of Streptomyces coelicolor A3(2). J. Gen. Microbiol. 136: 273-281, 1990
18. VANCURA, A.; I. VANCUROVA, J. VOLC, S. M. FUSSEY, M. FLIEGER, J. NEUZIL, J. MARSALEK & V. BEHAL: Valine dehydrogenase from Streptomyces fradiae: purification and properties. J. Gen. Microbiol. 138: 3213-3219, 1988
19. TANG, L.; Y.-X. ZHANG & C. R. HUTCHINSON: Amino acid catabolism and antibiotic synthesis: valine is a source of precursors for macrolide biosynthesis in Streptomyces ambofaciens and Streptomyces fradiae. J. Bacteriol. 176: 6107-6119, 1994
20. HAFNER, E. W.; B. W. HOLLEY, K. S. HOLDOM, S. E. LEE, R. G. WAX, D. BECK, H. A. I. MCARTHUR & W. C. WERNAU: Branched-chain fatty acid requirement for avermectin production by a mutant of Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity. J. Antibiotics 44: 349-356, 1991
21. DENOYA, C. D.; R. W. FEDECHKO, E. W. HAFNER, H. A. I. MCARTHUR, M. R. MORGENSTERN, D. D. SKINNER, K. STUTZMAN-ENGWALL, R. G. WAX & W. C. WERNAU: A second branched-chain α-keto acid dehydrogenase gene cluster (bkdFGH) from Streptomyces avermitilis: its relationship to avermectin biosynthesis and the construction of a bkdF mutant suitable for the production of novel antiparasitic avermectins. J. Bacteriol. 177: 3504-3511, 1995
22. BERNAN, V.; D. FILPULA, W. HERBER, M. BIBB & E. KATZ: The nucleotide sequence of the tyrosinase gene from Streptomyces antibiotcus and characterization of the gene product. Gene 37: 101-110, 1985