메뉴 건너뛰기




Volumn 22, Issue 1, 1999, Pages 8-18

Genetic engineering of Bacillus subtilis for the commercial production of riboflavin

Author keywords

Bacillus subtilis; Metabolic engineering; Riboflavin

Indexed keywords

PURINE; RECOMBINANT DNA; RIBOFLAVIN;

EID: 0032993682     PISSN: 13675435     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jim.2900587     Document Type: Article
Times cited : (172)

References (61)
  • 2
    • 0027421124 scopus 로고
    • The transcriptional organization of the Bacillus subtilis 168 chromosome region between the spoVAF and serA genetic loci
    • Azevedo V, A Sorokin, D Ehrlich and P Serror. 1993. The transcriptional organization of the Bacillus subtilis 168 chromosome region between the spoVAF and serA genetic loci. Mol Microbiol 10: 397-405.
    • (1993) Mol Microbiol , vol.10 , pp. 397-405
    • Azevedo, V.1    Sorokin, A.2    Ehrlich, D.3    Serror, P.4
  • 3
    • 0000678343 scopus 로고    scopus 로고
    • Biosynthesis of riboflavin
    • (Neidhardt FC, R Curtiss III, JL Ingraham, ECC Lin, KB Low, B Magasanik, WS Reznikoff, M Riley, M Schaechter and HE Umbarger, eds), American Society for Microbiology, Washington, DC
    • Bacher A, S Eberhardt and G Richter. 1996. Biosynthesis of riboflavin. In: Escherichia coli and Salmonella typhimurium cellular and molecular biology, 2nd edn (Neidhardt FC, R Curtiss III, JL Ingraham, ECC Lin, KB Low, B Magasanik, WS Reznikoff, M Riley, M Schaechter and HE Umbarger, eds), pp 657-664, American Society for Microbiology, Washington, DC.
    • (1996) Escherichia Coli and Salmonella Typhimurium Cellular and Molecular Biology, 2nd Edn , pp. 657-664
    • Bacher, A.1    Eberhardt, S.2    Richter, G.3
  • 4
    • 0015535175 scopus 로고
    • Genetic control of riboflavin synthetase in B, subtilis
    • Bacher A, U Eggers and F Lingens. 1973. Genetic control of riboflavin synthetase in B, subtilis. Arch Mikrobiol 89: 73-77.
    • (1973) Arch Mikrobiol , vol.89 , pp. 73-77
    • Bacher, A.1    Eggers, U.2    Lingens, F.3
  • 5
    • 0000575685 scopus 로고
    • The lumazine synthase/riboflavin synthase complex of Bacillus subtilis
    • (Müller F, ed), Chemical Rubber Co, Boca Raton, FL
    • Bacher A and R Ladenstein. 1991. The lumazine synthase/riboflavin synthase complex of Bacillus subtilis. In: Chemistry and Biochemistry of Flavins (Müller F, ed), Chemical Rubber Co, Boca Raton, FL.
    • (1991) Chemistry and Biochemistry of Flavins
    • Bacher, A.1    Ladenstein, R.2
  • 6
    • 0017870987 scopus 로고
    • Bacteriocin and antibiotic resistance plasmids in Bacillus cereus and Bacillus subtilis
    • Bernard K, H Schrempf and W Goebel. 1978. Bacteriocin and antibiotic resistance plasmids in Bacillus cereus and Bacillus subtilis. J Bacteriol 133: 897-903.
    • (1978) J Bacteriol , vol.133 , pp. 897-903
    • Bernard, K.1    Schrempf, H.2    Goebel, W.3
  • 7
    • 84873799110 scopus 로고
    • Studies on lysogenesis I. The mode of phage liberation by lysogenic Escherichia coli
    • Bertani G. 1951. Studies on lysogenesis I. The mode of phage liberation by lysogenic Escherichia coli. J Bacteriol 62: 293-300.
    • (1951) J Bacteriol , vol.62 , pp. 293-300
    • Bertani, G.1
  • 8
    • 0018800089 scopus 로고
    • A rapid alkaline extraction procedure for screening recombinant plasmid DNA
    • Birnboim HC and J Doly. 1979. A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res 7: 1513-1523.
    • (1979) Nucleic Acids Res , vol.7 , pp. 1513-1523
    • Birnboim, H.C.1    Doly, J.2
  • 10
    • 0030989763 scopus 로고    scopus 로고
    • Molecular cloning and characterisation of the ribC gene from Bacillus subtilis: A point mutation in ribC results in riboflavin overproduction
    • Coquard D, H Huecas, M Ott, JM van Dijl, APGM van Loon and H-P Hohmann. 1997. Molecular cloning and characterisation of the ribC gene from Bacillus subtilis: a point mutation in ribC results in riboflavin overproduction. Mol Gen Genet 254: 81-84.
    • (1997) Mol Gen Genet , vol.254 , pp. 81-84
    • Coquard, D.1    Huecas, H.2    Ott, M.3    Van Dijl, J.M.4    Van Loon, A.P.G.M.5    Hohmann, H.-P.6
  • 11
    • 0002301028 scopus 로고
    • Genetic analysis
    • (Harwood C and S Cutting, eds). John Wiley and Sons, New York, NY
    • Cutting S and PB Vander Horn. 1990. Genetic analysis. In: Molecular Biological Methods for Bacillus (Harwood C and S Cutting, eds), p 74. John Wiley and Sons, New York, NY.
    • (1990) Molecular Biological Methods for Bacillus , pp. 74
    • Cutting, S.1    Vander Horn, P.B.2
  • 12
    • 0000072120 scopus 로고
    • The industrial use of bacilli
    • (Dubnau DA, ed), Academic Press, New York
    • Debabov VG. 1982. The industrial use of bacilli. In: The Molecular Biology of the Bacilli (Dubnau DA, ed), pp 331-370, Academic Press, New York.
    • (1982) The Molecular Biology of the Bacilli , pp. 331-370
    • Debabov, V.G.1
  • 13
    • 0015222721 scopus 로고
    • Fate of transforming DNA following uptake by competent Bacillus subtilis
    • Dubnau D and R Davidoff-Abelson. 1971. Fate of transforming DNA following uptake by competent Bacillus subtilis. J Mol Biol 56: 209-221.
    • (1971) J Mol Biol , vol.56 , pp. 209-221
    • Dubnau, D.1    Davidoff-Abelson, R.2
  • 14
    • 0020622262 scopus 로고
    • Purine salvage pathways of Bacillus subtilis and effect of guanine on growth of GMP reductase mutants
    • Endo T, B Uratani and E Freese. 1983. Purine salvage pathways of Bacillus subtilis and effect of guanine on growth of GMP reductase mutants. J Bacteriol 155: 169-179.
    • (1983) J Bacteriol , vol.155 , pp. 169-179
    • Endo, T.1    Uratani, B.2    Freese, E.3
  • 16
    • 0023973186 scopus 로고
    • Structure and expression of the Bacillus subtilis sin operon
    • Gaur NK, K Cabane and I Smith. 1988. Structure and expression of the Bacillus subtilis sin operon. J Bacteriol 170: 1046-1053.
    • (1988) J Bacteriol , vol.170 , pp. 1046-1053
    • Gaur, N.K.1    Cabane, K.2    Smith, I.3
  • 19
    • 0000268301 scopus 로고
    • Production of riboflavin by fermentation
    • (Underkofler LA and RJ Hickey, eds), Chemical Publishing Co, New York
    • Hickey RJ. 1954. Production of riboflavin by fermentation. In: Industrial Fermentation (Underkofler LA and RJ Hickey, eds), pp 157-190, Chemical Publishing Co, New York.
    • (1954) Industrial Fermentation , pp. 157-190
    • Hickey, R.J.1
  • 20
    • 0013608646 scopus 로고    scopus 로고
    • personal communication
    • Hohmann H-P. 1998. personal communication.
    • (1998)
    • Hohmann, H.-P.1
  • 21
    • 0020266466 scopus 로고
    • Nucleotide sequence and functional map of pC194, a plasmid that specifies inducible chloramphenicol resistance
    • Horinouchi S and B Weisblum. 1982. Nucleotide sequence and functional map of pC194, a plasmid that specifies inducible chloramphenicol resistance. J Bacteriol 150: 815-825.
    • (1982) J Bacteriol , vol.150 , pp. 815-825
    • Horinouchi, S.1    Weisblum, B.2
  • 22
    • 0033040385 scopus 로고    scopus 로고
    • GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase are rate-limiting enzymes in riboflavin synthesis of an industrial Bacillus subtilis strain used for riboflavin production
    • Hümbelin M, V Griesser, T Keller, W Schurter, M Haiker, H-P Hohmann, H Ritz, G Richter, A Bacher and APGM van Loon. 1998. GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase are rate-limiting enzymes in riboflavin synthesis of an industrial Bacillus subtilis strain used for riboflavin production. J Ind Microbiol Biotechnol 22: 1-7.
    • (1998) J Ind Microbiol Biotechnol , vol.22 , pp. 1-7
    • Hümbelin, M.1    Griesser, V.2    Keller, T.3    Schurter, W.4    Haiker, M.5    Hohmann, H.-P.6    Ritz, H.7    Richter, G.8    Bacher, A.9    Van Loon, A.P.G.M.10
  • 23
    • 0023032979 scopus 로고
    • Regulation of a promoter that is utilized by minor forms of RNA polymerase holoenzyme in Bacillus subtilis
    • Igo M and R Losick. 1986. Regulation of a promoter that is utilized by minor forms of RNA polymerase holoenzyme in Bacillus subtilis. J Mol Biol 191: 615-624.
    • (1986) J Mol Biol , vol.191 , pp. 615-624
    • Igo, M.1    Losick, R.2
  • 24
    • 0025675856 scopus 로고
    • High efficiency transformation of Escherichia coli with plasmids
    • Inoue H, H Nojima and H Okayama. 1990, High efficiency transformation of Escherichia coli with plasmids. Gene 96: 23-28.
    • (1990) Gene , vol.96 , pp. 23-28
    • Inoue, H.1    Nojima, H.2    Okayama, H.3
  • 25
    • 0013627959 scopus 로고
    • Improved inosine production and derepression of purine nucleotide biosynthetic enzymes in 8-azaguanine resistant mutants of Bacillus subtilis
    • Ishii K and I Shiio. 1972. Improved inosine production and derepression of purine nucleotide biosynthetic enzymes in 8-azaguanine resistant mutants of Bacillus subtilis. Agric Biol Chem 36: 1511-1522.
    • (1972) Agric Biol Chem , vol.36 , pp. 1511-1522
    • Ishii, K.1    Shiio, I.2
  • 26
    • 0015830556 scopus 로고
    • Regulation of purine nucleotide biosynthesis in Bacillus subtilis
    • Ishii K and I Shiio. 1973. Regulation of purine nucleotide biosynthesis in Bacillus subtilis. Agric Biol Chem 37: 287-300.
    • (1973) Agric Biol Chem , vol.37 , pp. 287-300
    • Ishii, K.1    Shiio, I.2
  • 27
    • 0022297242 scopus 로고
    • Stable gene amplification in the chromosome of Bacillus subtilis
    • Janniere L, B Niaudet, E Pierre and SD Ehrlich. 1985. Stable gene amplification in the chromosome of Bacillus subtilis. Gene 40: 47-55.
    • (1985) Gene , vol.40 , pp. 47-55
    • Janniere, L.1    Niaudet, B.2    Pierre, E.3    Ehrlich, S.D.4
  • 28
    • 0019814933 scopus 로고
    • Conserved nucleotide sequences in temporally controlled bacteriophage promoters
    • Lee G and J Pero. 1981. Conserved nucleotide sequences in temporally controlled bacteriophage promoters. J Mol Biol 152: 247-265.
    • (1981) J Mol Biol , vol.152 , pp. 247-265
    • Lee, G.1    Pero, J.2
  • 30
    • 0031882942 scopus 로고    scopus 로고
    • Regulation of riboflavin biosynthesis in Bacillus subtilis is affected by the activity of the favokinase/flavin adenine dinucleotide synthetase encoded by ribC
    • Mack M, APGM van Loon and H-P Hohmann. 1998. Regulation of riboflavin biosynthesis in Bacillus subtilis is affected by the activity of the favokinase/flavin adenine dinucleotide synthetase encoded by ribC. J Bacteriol 180: 950-955.
    • (1998) J Bacteriol , vol.180 , pp. 950-955
    • Mack, M.1    Van Loon, A.P.G.M.2    Hohmann, H.-P.3
  • 31
    • 0021715560 scopus 로고
    • The plC plasmid and phage vectors with versatile cloning sites for recombinant selection by insertional inactivation
    • Marsh JL, M Erfle and J Wykes. 1984. The plC plasmid and phage vectors with versatile cloning sites for recombinant selection by insertional inactivation. Gene 32: 481-485.
    • (1984) Gene , vol.32 , pp. 481-485
    • Marsh, J.L.1    Erfle, M.2    Wykes, J.3
  • 32
    • 0017652033 scopus 로고
    • Mutation of an inosine-producing strain of Bacillus subtilis to DL-methionine sulfoxide resistance for guanosine production
    • Matsui H, K Sato, H Enei and Y Hirose. 1977. Mutation of an inosine-producing strain of Bacillus subtilis to DL-methionine sulfoxide resistance for guanosine production. Appl Environ Microbiol 34: 337-341.
    • (1977) Appl Environ Microbiol , vol.34 , pp. 337-341
    • Matsui, H.1    Sato, K.2    Enei, H.3    Hirose, Y.4
  • 33
    • 84954955479 scopus 로고
    • A guanosine-producing mutant of Bacillus subtilis with high productivity
    • Matsui H, K Sato, H Enei and Y Hirose. 1979. A guanosine-producing mutant of Bacillus subtilis with high productivity. Agric Biol Chem 43: 393-394.
    • (1979) Agric Biol Chem , vol.43 , pp. 393-394
    • Matsui, H.1    Sato, K.2    Enei, H.3    Hirose, Y.4
  • 34
    • 0018589037 scopus 로고
    • Production of guanosine by psicofuranine and decoyinine resistant mutants of Bacillus subtilis
    • Matsui H, K Sato, H Enei and Y Hirose. 1979. Production of guanosine by psicofuranine and decoyinine resistant mutants of Bacillus subtilis. Agric Biol Chem 43: 1739-1744.
    • (1979) Agric Biol Chem , vol.43 , pp. 1739-1744
    • Matsui, H.1    Sato, K.2    Enei, H.3    Hirose, Y.4
  • 36
    • 0003785155 scopus 로고
    • Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Miller JH. 1972. Experiments in Molecular Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • (1972) Experiments in Molecular Genetics
    • Miller, J.H.1
  • 44
    • 85038189358 scopus 로고    scopus 로고
    • 1991. European Patent Application No. 0405370
    • Perkins JB, JG Pero and A Sloma. 1991. European Patent Application No. 0405370.
    • Perkins, J.B.1    Pero, J.G.2    Sloma, A.3
  • 46
    • 0030946770 scopus 로고    scopus 로고
    • Biosynthesis of riboflavin: Characterization of the bifunctional deaminase-reductase of Escherichia coli and Bacillus subtilis
    • Richter G, M Fischer, C Krieger, S Eberhardt, H Lüttgen, I Gerstenschläger and A Bacher. 1997. Biosynthesis of riboflavin: characterization of the bifunctional deaminase-reductase of Escherichia coli and Bacillus subtilis. J Bacteriol 179: 2022-2028.
    • (1997) J Bacteriol , vol.179 , pp. 2022-2028
    • Richter, G.1    Fischer, M.2    Krieger, C.3    Eberhardt, S.4    Lüttgen, H.5    Gerstenschläger, I.6    Bacher, A.7
  • 47
    • 0027236679 scopus 로고
    • Biosynthesis of riboflavin: Cloning, sequencing, and mapping, and expression of the gene coding for GTP cyclohydrolase II of Escherichia coli
    • Richter G, H Ritz, G Katzenmeier, R Volk, A Kohnle, F Lottspelch, D Allendorf and A Bacher. 1993. Biosynthesis of riboflavin: cloning, sequencing, and mapping, and expression of the gene coding for GTP cyclohydrolase II of Escherichia coli. J Bacteriol 175: 4045-4051.
    • (1993) J Bacteriol , vol.175 , pp. 4045-4051
    • Richter, G.1    Ritz, H.2    Katzenmeier, G.3    Volk, R.4    Kohnle, A.5    Lottspelch, F.6    Allendorf, D.7    Bacher, A.8
  • 48
    • 0026642218 scopus 로고
    • Biosynthesis of riboflavin: Cloning, sequencing, and expression of the gene coding for 3,4-dihydroxy-2-butanone 4-phosphate of Escherichia coli
    • Richter G, R Volk, C Krieger, H-W Lahm, U Röthlisberger and A Bacher. 1992. Biosynthesis of riboflavin: cloning, sequencing, and expression of the gene coding for 3,4-dihydroxy-2-butanone 4-phosphate of Escherichia coli. J Bacteriol 174: 4050-4056.
    • (1992) J Bacteriol , vol.174 , pp. 4050-4056
    • Richter, G.1    Volk, R.2    Krieger, C.3    Lahm, H.-W.4    Röthlisberger, U.5    Bacher, A.6
  • 50
    • 0023228531 scopus 로고
    • Genetic and physiological characterization of Bacillus subtilis mutants resistant to purine analogs
    • Saxild HH and P Nygaard. 1987. Genetic and physiological characterization of Bacillus subtilis mutants resistant to purine analogs. J Bacteriol 169: 2977-2983.
    • (1987) J Bacteriol , vol.169 , pp. 2977-2983
    • Saxild, H.H.1    Nygaard, P.2
  • 51
    • 0025217689 scopus 로고
    • Bacillopeptidase F of Bacillus subtilis: Purification of the protein and cloning of the gene
    • Sloma A, GA Rufo Jr, CF Rudolph, BJ Sullivan, KA Theriault and J Pero. 1990. Bacillopeptidase F of Bacillus subtilis: purification of the protein and cloning of the gene. J Bacteriol 172: 1470-1477.
    • (1990) J Bacteriol , vol.172 , pp. 1470-1477
    • Sloma, A.1    Rufo G.A., Jr.2    Rudolph, C.F.3    Sullivan, B.J.4    Theriault, K.A.5    Pero, J.6
  • 52
    • 0027368566 scopus 로고
    • The organization of the Bacillus subtilis 168 chromosome region between the spoVA and serA genetic loci, based on sequence data
    • Sorokin A, E Zumstein, V Azevedo, SD Ehrlich and P Serror. 1993. The organization of the Bacillus subtilis 168 chromosome region between the spoVA and serA genetic loci, based on sequence data. Mol Microbiol 10: 385-395.
    • (1993) Mol Microbiol , vol.10 , pp. 385-395
    • Sorokin, A.1    Zumstein, E.2    Azevedo, V.3    Ehrlich, S.D.4    Serror, P.5
  • 53
    • 0001615271 scopus 로고
    • Transformation of biochemically deficient strains of Bacillus subtilis by deoxyribonucleate
    • Spizizen J. 1958. Transformation of biochemically deficient strains of Bacillus subtilis by deoxyribonucleate. Proc Natl Acad Sci USA 44: 1072-1078.
    • (1958) Proc Natl Acad Sci USA , vol.44 , pp. 1072-1078
    • Spizizen, J.1
  • 56
    • 85038179726 scopus 로고    scopus 로고
    • 1992. European Patent Application No. 0531708
    • Usui N, Y Yamamoto and T Nakamatu. 1992. European Patent Application No. 0531708.
    • Usui, N.1    Yamamoto, Y.2    Nakamatu, T.3
  • 58
    • 0020442864 scopus 로고
    • The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers
    • Vieira J and J Messing. 1982. The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. Gene 19: 259-268.
    • (1982) Gene , vol.19 , pp. 259-268
    • Vieira, J.1    Messing, J.2
  • 59
    • 0021204113 scopus 로고
    • Construction of a cloning site near one end of Tn917 into which foreign DNA may be inserted without affecting transposition in Bacillus subtilis or expression of the transposon-borne erm gene
    • Youngman PJ, JB Perkins and R Losick. 1984. Construction of a cloning site near one end of Tn917 into which foreign DNA may be inserted without affecting transposition in Bacillus subtilis or expression of the transposon-borne erm gene. Plasmid 12: 1-9.
    • (1984) Plasmid , vol.12 , pp. 1-9
    • Youngman, P.J.1    Perkins, J.B.2    Losick, R.3
  • 60
    • 0013577479 scopus 로고
    • Localizing the site of spoO-dependent regulation in the spoVG promoter of Bacillus subtilis
    • (Hoch JA and P Setlow, eds), American Society for Microbiology, Washington, DC
    • Zuber P. 1985. Localizing the site of spoO-dependent regulation in the spoVG promoter of Bacillus subtilis. In: Molecular Biology of Microbial Differentiation (Hoch JA and P Setlow, eds), pp 149-156, American Society for Microbiology, Washington, DC.
    • (1985) Molecular Biology of Microbial Differentiation , pp. 149-156
    • Zuber, P.1
  • 61
    • 0023272642 scopus 로고
    • . and SpoOB-dependent utilization of a sporulation promoter in Bacillus subtilis
    • . and SpoOB-dependent utilization of a sporulation promoter in Bacillus subtilis. J Bacteriol 169: 2223-2230.
    • (1987) J Bacteriol , vol.169 , pp. 2223-2230
    • Zuber, P.1    Losick, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.