메뉴 건너뛰기




Volumn 9, Issue 3, 2006, Pages 252-260

Microbial genomics for the improvement of natural product discovery

Author keywords

[No Author keywords available]

Indexed keywords

6 DEOXYERYTHRONOLIDE B; BRYOSTATIN 1; COELICHELIN; CORONATINE; DAPTOMYCIN; DYNEMICIN; EPOTHILONE; ESPERAMICIN; JADOMYCIN; MADUROPEPTIN; MYXOCHROMIDE S1; NATURAL PRODUCT; NYSTATIN; ONNAMIDE A; OXYTETRACYCLINE; PEDERIN; PYOLUTEORIN; REBACCAMYCIN; STAUROSPORINE; UNCLASSIFIED DRUG;

EID: 33744533954     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mib.2006.04.002     Document Type: Review
Times cited : (133)

References (61)
  • 1
    • 0042844744 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the period 1981-2002
    • Newman D.J., Cragg G.M., and Snader K.M. Natural products as sources of new drugs over the period 1981-2002. J Nat Prod 66 (2003) 1022-1037
    • (2003) J Nat Prod , vol.66 , pp. 1022-1037
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 2
    • 33744536067 scopus 로고    scopus 로고
    • Antibiotic discovery from actinomycetes: will a renaissance follow the decline and fall?
    • Baltz R.H. Antibiotic discovery from actinomycetes: will a renaissance follow the decline and fall?. SIM News 55 (2005) 186-196
    • (2005) SIM News , vol.55 , pp. 186-196
    • Baltz, R.H.1
  • 3
    • 14944383798 scopus 로고    scopus 로고
    • The evolving role of natural products in drug discovery
    • Koehn F.E., and Carter G.T. The evolving role of natural products in drug discovery. Nat Rev Drug Discov 4 (2005) 206-220
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 206-220
    • Koehn, F.E.1    Carter, G.T.2
  • 4
    • 23444460405 scopus 로고    scopus 로고
    • Mutational biosynthesis - a tool for the generation of structural diversity in the biosynthesis of antibiotics
    • Weist S., and Sussmuth R. Mutational biosynthesis - a tool for the generation of structural diversity in the biosynthesis of antibiotics. Appl Microbiol Biotechnol 68 (2005) 141-150
    • (2005) Appl Microbiol Biotechnol , vol.68 , pp. 141-150
    • Weist, S.1    Sussmuth, R.2
  • 5
    • 27544456830 scopus 로고    scopus 로고
    • The impact of bacterial genomics on natural product research
    • Bode H.B., and Müller R. The impact of bacterial genomics on natural product research. Angew Chem Int Ed 44 (2005) 6828-6846
    • (2005) Angew Chem Int Ed , vol.44 , pp. 6828-6846
    • Bode, H.B.1    Müller, R.2
  • 6
    • 30544434619 scopus 로고    scopus 로고
    • Combinatorial biosynthesis of reduced polyketides
    • Weissman K.J., and Leadlay P.F. Combinatorial biosynthesis of reduced polyketides. Nat Rev Microbiol 3 (2005) 925-936
    • (2005) Nat Rev Microbiol , vol.3 , pp. 925-936
    • Weissman, K.J.1    Leadlay, P.F.2
  • 7
    • 30544434099 scopus 로고    scopus 로고
    • Fungal secondary metabolism - from biochemistry to genomics
    • Keller N.P., Turner G., and Bennett J.W. Fungal secondary metabolism - from biochemistry to genomics. Nat Rev Microbiol 3 (2005) 937-947
    • (2005) Nat Rev Microbiol , vol.3 , pp. 937-947
    • Keller, N.P.1    Turner, G.2    Bennett, J.W.3
  • 8
    • 14844312040 scopus 로고    scopus 로고
    • Novel natural compounds obtained by genome-based screening and genetic engineering
    • Pelzer S., Vente A., and Bechthold A. Novel natural compounds obtained by genome-based screening and genetic engineering. Curr Opin Drug Discov Devel 8 (2005) 228-238
    • (2005) Curr Opin Drug Discov Devel , vol.8 , pp. 228-238
    • Pelzer, S.1    Vente, A.2    Bechthold, A.3
  • 9
    • 0034887171 scopus 로고    scopus 로고
    • Polyketide biosynthesis: a millennium review
    • Staunton J., and Weissman K.J. Polyketide biosynthesis: a millennium review. Nat Prod Rep 18 (2001) 380-416
    • (2001) Nat Prod Rep , vol.18 , pp. 380-416
    • Staunton, J.1    Weissman, K.J.2
  • 10
    • 9244234513 scopus 로고    scopus 로고
    • Biosynthesis of nonribosomal peptides
    • Finking R., and Marahiel M.A. Biosynthesis of nonribosomal peptides. Annu Rev Microbiol 58 (2004) 453-488
    • (2004) Annu Rev Microbiol , vol.58 , pp. 453-488
    • Finking, R.1    Marahiel, M.A.2
  • 11
    • 1642304143 scopus 로고    scopus 로고
    • Polyketide and nonribosomal peptide antibiotics: modularity and versatility
    • Walsh C.T. Polyketide and nonribosomal peptide antibiotics: modularity and versatility. Science 303 (2004) 1805-1810
    • (2004) Science , vol.303 , pp. 1805-1810
    • Walsh, C.T.1
  • 12
    • 20844443657 scopus 로고    scopus 로고
    • The use of PCR for detecting genes that encode type I polyketide synthases in genomes of actinomycetes
    • Ostash B.E., Ogonyan S.V., Luzhetskyy A.N., Bechthold A., and Fedorenko V.A. The use of PCR for detecting genes that encode type I polyketide synthases in genomes of actinomycetes. Russ J Genet 41 (2005) 473-478
    • (2005) Russ J Genet , vol.41 , pp. 473-478
    • Ostash, B.E.1    Ogonyan, S.V.2    Luzhetskyy, A.N.3    Bechthold, A.4    Fedorenko, V.A.5
  • 13
    • 21344453076 scopus 로고    scopus 로고
    • A novel actinomycete strain de-replication approach based on the diversity of polyketide synthase and nonribosomal peptide synthetase biosynthetic pathways
    • A fingerprinting approach for polyketide synthase and NRPS was developed using PCR and restriction digest analysis of the amplified fragments.
    • Ayuso A., Clark D., González I., Salazar O., Anderson A., and Genilloud O. A novel actinomycete strain de-replication approach based on the diversity of polyketide synthase and nonribosomal peptide synthetase biosynthetic pathways. Appl Microbiol Biotechnol 67 (2005) 795-806. A fingerprinting approach for polyketide synthase and NRPS was developed using PCR and restriction digest analysis of the amplified fragments.
    • (2005) Appl Microbiol Biotechnol , vol.67 , pp. 795-806
    • Ayuso, A.1    Clark, D.2    González, I.3    Salazar, O.4    Anderson, A.5    Genilloud, O.6
  • 14
    • 24744433982 scopus 로고    scopus 로고
    • Evolutionary implications of bacterial polyketide synthases
    • Jenke-Kodama H., Sandmann A., Müller R., and Dittmann E. Evolutionary implications of bacterial polyketide synthases. Mol Biol Evol 22 (2005) 2027-2039
    • (2005) Mol Biol Evol , vol.22 , pp. 2027-2039
    • Jenke-Kodama, H.1    Sandmann, A.2    Müller, R.3    Dittmann, E.4
  • 16
    • 27544477567 scopus 로고    scopus 로고
    • Discovery of a new peptide natural product by Streptomyces coelicolor genome mining
    • A new iron-chelating compound, coelichelin, was isolated from S. coelicolor by mining the entire sequence genome of the strain.
    • Lautru S., Deeth R.J., Bailey L.M., and Challis G.L. Discovery of a new peptide natural product by Streptomyces coelicolor genome mining. Nat Chem Biol 1 (2005) 265-269. A new iron-chelating compound, coelichelin, was isolated from S. coelicolor by mining the entire sequence genome of the strain.
    • (2005) Nat Chem Biol , vol.1 , pp. 265-269
    • Lautru, S.1    Deeth, R.J.2    Bailey, L.M.3    Challis, G.L.4
  • 17
    • 0033762192 scopus 로고    scopus 로고
    • The myxochelin iron transport regulon of the myxobacterium Stigmatella aurantiaca Sg a15
    • Silakowski B., Kunze B., Nordsiek G., Blöcker H., Höfle G., and Müller R. The myxochelin iron transport regulon of the myxobacterium Stigmatella aurantiaca Sg a15. Eur J Biochem 267 (2000) 6476-6485
    • (2000) Eur J Biochem , vol.267 , pp. 6476-6485
    • Silakowski, B.1    Kunze, B.2    Nordsiek, G.3    Blöcker, H.4    Höfle, G.5    Müller, R.6
  • 18
    • 0035831486 scopus 로고    scopus 로고
    • The dhb operon of Bacillus subtilis encodes the biosynthetic template for the catecholic siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin
    • May J.J., Wendrich T.M., and Marahiel M.A. The dhb operon of Bacillus subtilis encodes the biosynthetic template for the catecholic siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin. J Biol Chem 276 (2001) 7209-7217
    • (2001) J Biol Chem , vol.276 , pp. 7209-7217
    • May, J.J.1    Wendrich, T.M.2    Marahiel, M.A.3
  • 20
    • 0347721776 scopus 로고    scopus 로고
    • Biosynthesis of the enediyne antitumor antibiotic C-1027
    • Liu W., Christenson S.D., Standage S., and Shen B. Biosynthesis of the enediyne antitumor antibiotic C-1027. Science 297 (2002) 1170-1173
    • (2002) Science , vol.297 , pp. 1170-1173
    • Liu, W.1    Christenson, S.D.2    Standage, S.3    Shen, B.4
  • 22
    • 0142027815 scopus 로고    scopus 로고
    • Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model
    • Liu W., Ahlert J., Gao Q., Wendt-Pienkowski E., Shen B., and Thorson J.S. Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model. Proc Natl Acad Sci USA 100 (2003) 11959-11963
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11959-11963
    • Liu, W.1    Ahlert, J.2    Gao, Q.3    Wendt-Pienkowski, E.4    Shen, B.5    Thorson, J.S.6
  • 23
    • 0034682033 scopus 로고    scopus 로고
    • An approach for obtaining perfect hybridization probes for unknown polyketide synthase genes: a search for the epothilone gene cluster
    • Santi D.V., Siani M.A., Julien B., Kupfer D., and Roe B. An approach for obtaining perfect hybridization probes for unknown polyketide synthase genes: a search for the epothilone gene cluster. Gene 247 (2000) 97-102
    • (2000) Gene , vol.247 , pp. 97-102
    • Santi, D.V.1    Siani, M.A.2    Julien, B.3    Kupfer, D.4    Roe, B.5
  • 24
    • 0031662188 scopus 로고    scopus 로고
    • Impact of culture-independent studies on the emerging phylogenetic view of bacterial diversity
    • Hugenholtz P., Goebel B.M., and Pace N.R. Impact of culture-independent studies on the emerging phylogenetic view of bacterial diversity. J Bacteriol 180 (1998) 4765-4774
    • (1998) J Bacteriol , vol.180 , pp. 4765-4774
    • Hugenholtz, P.1    Goebel, B.M.2    Pace, N.R.3
  • 26
    • 13544277388 scopus 로고    scopus 로고
    • Effects of growth medium, inoculum size, and incubation time on culturability and isolation of soil bacteria
    • Davis K.E.R., Joseph S.J., and Janssen P.H. Effects of growth medium, inoculum size, and incubation time on culturability and isolation of soil bacteria. Appl Environ Microbiol 71 (2005) 826-834
    • (2005) Appl Environ Microbiol , vol.71 , pp. 826-834
    • Davis, K.E.R.1    Joseph, S.J.2    Janssen, P.H.3
  • 27
  • 28
    • 0034935496 scopus 로고    scopus 로고
    • An integrated method for the enrichment and selective isolation of Actinokineospora spp. in soil and plant litter
    • Otoguro M., Hayakawa M., Yamazaki T., and Iimura Y. An integrated method for the enrichment and selective isolation of Actinokineospora spp. in soil and plant litter. J Appl Microbiol 91 (2001) 118-130
    • (2001) J Appl Microbiol , vol.91 , pp. 118-130
    • Otoguro, M.1    Hayakawa, M.2    Yamazaki, T.3    Iimura, Y.4
  • 30
    • 23944495106 scopus 로고    scopus 로고
    • Metagenomics for studying unculturable microorganisms: cutting the Gordian knot
    • Schloss P.D., and Handelsman J. Metagenomics for studying unculturable microorganisms: cutting the Gordian knot. Genome Biol 6 (2005) 229
    • (2005) Genome Biol , vol.6 , pp. 229
    • Schloss, P.D.1    Handelsman, J.2
  • 31
    • 0037195174 scopus 로고    scopus 로고
    • A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles
    • Piel J. A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles. Proc Natl Acad Sci USA 99 (2002) 14002-14007
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 14002-14007
    • Piel, J.1
  • 32
    • 0347717826 scopus 로고    scopus 로고
    • Unprecedented diversity of catalytic domains in the first four modules of the putative pederin polyketide synthase
    • Piel J., Wen G., Platzer M., and Hui D. Unprecedented diversity of catalytic domains in the first four modules of the putative pederin polyketide synthase. Chem Bio Chem 5 (2004) 93-98
    • (2004) Chem Bio Chem , vol.5 , pp. 93-98
    • Piel, J.1    Wen, G.2    Platzer, M.3    Hui, D.4
  • 33
    • 4344675456 scopus 로고    scopus 로고
    • Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes of uncultured bacterial consortia
    • A method was developed to target from metagenomic samples the family of polyketide synthases that use trans-acting ATs. By using this approach, two pederin-type polyketide synthase systems were identified.
    • Piel J., Hui D., Fusetani N., and Matsunaga S. Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes of uncultured bacterial consortia. Environ Microbiol 6 (2004) 921-927. A method was developed to target from metagenomic samples the family of polyketide synthases that use trans-acting ATs. By using this approach, two pederin-type polyketide synthase systems were identified.
    • (2004) Environ Microbiol , vol.6 , pp. 921-927
    • Piel, J.1    Hui, D.2    Fusetani, N.3    Matsunaga, S.4
  • 34
    • 9244230571 scopus 로고    scopus 로고
    • Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei
    • Piel J., Hui D., Wen G., Butzke D., Platzer M., Fusetani N., and Matsunaga S. Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei. Proc Natl Acad Sci USA 101 (2004) 16222-16227
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 16222-16227
    • Piel, J.1    Hui, D.2    Wen, G.3    Butzke, D.4    Platzer, M.5    Fusetani, N.6    Matsunaga, S.7
  • 35
    • 8844270242 scopus 로고    scopus 로고
    • BryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina
    • Hildebrand M., Waggoner L.E., Liu H., Sudek S., Allen S., Anderson C., Sherman D.H., and Haygood M. BryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina. Chem Biol 11 (2004) 1543-1552
    • (2004) Chem Biol , vol.11 , pp. 1543-1552
    • Hildebrand, M.1    Waggoner, L.E.2    Liu, H.3    Sudek, S.4    Allen, S.5    Anderson, C.6    Sherman, D.H.7    Haygood, M.8
  • 36
    • 0037452928 scopus 로고    scopus 로고
    • Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis
    • Cheng Y., Tang G., and Shen B. Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis. Proc Natl Acad Sci USA 100 (2003) 3149-3154
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3149-3154
    • Cheng, Y.1    Tang, G.2    Shen, B.3
  • 37
    • 0037398774 scopus 로고    scopus 로고
    • Polyketide biosynthesis beyond the type I, II, and III polyketide synthase paradigms
    • Shen B. Polyketide biosynthesis beyond the type I, II, and III polyketide synthase paradigms. Curr Opin Chem Biol 7 (2003) 285-295
    • (2003) Curr Opin Chem Biol , vol.7 , pp. 285-295
    • Shen, B.1
  • 38
    • 25144510054 scopus 로고    scopus 로고
    • Formation of novel secondary metabolites by bacterial multimodular assembly lines: deviations from textbook biosynthetic logic
    • Wenzel S.C., and Müller R. Formation of novel secondary metabolites by bacterial multimodular assembly lines: deviations from textbook biosynthetic logic. Curr Opin Chem Biol 9 (2005) 447-458
    • (2005) Curr Opin Chem Biol , vol.9 , pp. 447-458
    • Wenzel, S.C.1    Müller, R.2
  • 39
    • 27844461167 scopus 로고    scopus 로고
    • Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways
    • Wenzel S.C., and Müller R. Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways. Curr Opin Biotechnol 16 (2005) 594-606
    • (2005) Curr Opin Biotechnol , vol.16 , pp. 594-606
    • Wenzel, S.C.1    Müller, R.2
  • 40
    • 0036306047 scopus 로고    scopus 로고
    • Process and metabolic strategies for improved production of escherichia coli-derived 6-deoxyerythronolide B
    • Pfeifer B., Hu Z., Licari P., and Khosla C. Process and metabolic strategies for improved production of escherichia coli-derived 6-deoxyerythronolide B. Appl Environ Microbiol 68 (2002) 3287-3292
    • (2002) Appl Environ Microbiol , vol.68 , pp. 3287-3292
    • Pfeifer, B.1    Hu, Z.2    Licari, P.3    Khosla, C.4
  • 41
    • 8144226497 scopus 로고    scopus 로고
    • Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster
    • Kodumal S.J., Patel K.G., Reid R., Menzella H.G., Welch M., and Santi D.V. Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster. Proc Natl Acad Sci USA 101 (2004) 15573-15578
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 15573-15578
    • Kodumal, S.J.1    Patel, K.G.2    Reid, R.3    Menzella, H.G.4    Welch, M.5    Santi, D.V.6
  • 42
    • 2942635105 scopus 로고    scopus 로고
    • Precursor-directed biosynthesis of epothilone in Escherichia coli
    • Boddy C.N., Hotta K., Tse M.L., Watts R.E., and Khosla C. Precursor-directed biosynthesis of epothilone in Escherichia coli. J Am Chem Soc 126 (2004) 7436-7437
    • (2004) J Am Chem Soc , vol.126 , pp. 7436-7437
    • Boddy, C.N.1    Hotta, K.2    Tse, M.L.3    Watts, R.E.4    Khosla, C.5
  • 43
    • 26944437043 scopus 로고    scopus 로고
    • Shotgun cloning and heterologous expression of the patellamide gene cluster as a strategy to achieving sustained metabolite production
    • Long P.F., Dunlap W.C., Battershill C.N., and Jaspars M. Shotgun cloning and heterologous expression of the patellamide gene cluster as a strategy to achieving sustained metabolite production. Chem Bio Chem 6 (2005) 1760-1765
    • (2005) Chem Bio Chem , vol.6 , pp. 1760-1765
    • Long, P.F.1    Dunlap, W.C.2    Battershill, C.N.3    Jaspars, M.4
  • 44
    • 18844410256 scopus 로고    scopus 로고
    • Patellamide A and C biosynthesis by a microcin-like pathway in prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella
    • The entire patellamide A and C gene cluster from an uncultured symbiont was heterologously expressed in E. coli to confirm its function.
    • Schmidt E.W., Nelson J.T., Rasko D.A., Sudek S., Eisen J.A., Haygood M.G., and Ravel J. Patellamide A and C biosynthesis by a microcin-like pathway in prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella. Proc Natl Acad Sci USA 102 (2005) 7315-7320. The entire patellamide A and C gene cluster from an uncultured symbiont was heterologously expressed in E. coli to confirm its function.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 7315-7320
    • Schmidt, E.W.1    Nelson, J.T.2    Rasko, D.A.3    Sudek, S.4    Eisen, J.A.5    Haygood, M.G.6    Ravel, J.7
  • 45
    • 12244279574 scopus 로고    scopus 로고
    • Combinatorial biosynthesis of antitumor indolocarbazole compounds
    • A systematic approach was used to analyze the biosynthetic steps of rebeccamycin by engineering a variety of gene cassettes and introducing them into a heterologous host, S. albus. Furthermore, the process of combinatorial engineering was applied to produce more than 30 new compounds.
    • Sánchez C., Zhu L., Braña A.F., Salas A.P., Rohr J., Méndez C., and Salas J.A. Combinatorial biosynthesis of antitumor indolocarbazole compounds. Proc Natl Acad Sci USA 102 (2005) 461-466. A systematic approach was used to analyze the biosynthetic steps of rebeccamycin by engineering a variety of gene cassettes and introducing them into a heterologous host, S. albus. Furthermore, the process of combinatorial engineering was applied to produce more than 30 new compounds.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 461-466
    • Sánchez, C.1    Zhu, L.2    Braña, A.F.3    Salas, A.P.4    Rohr, J.5    Méndez, C.6    Salas, J.A.7
  • 46
    • 28444466613 scopus 로고    scopus 로고
    • Cloning, sequence, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus
    • Wendt-Pienkowski E., Huang Y., Zhang J., Li B., Jiang H., Kwon H., Hutchinson C.R., and Shen B. Cloning, sequence, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus. J Am Chem Soc 127 (2005) 16442-16452
    • (2005) J Am Chem Soc , vol.127 , pp. 16442-16452
    • Wendt-Pienkowski, E.1    Huang, Y.2    Zhang, J.3    Li, B.4    Jiang, H.5    Kwon, H.6    Hutchinson, C.R.7    Shen, B.8
  • 47
    • 21044448952 scopus 로고    scopus 로고
    • Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry
    • The daptomycin gene cluster, spanning nearly 130 kb, was introduced into the heterologous host S. lividans to confirm the identity of the gene cluster.
    • Miao V., Coëffet-LeGal M., Brian P., Brost R., Penn J., Whiting A., Martin S., Ford R., Parr I., Bouchard M., et al. Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry. Microbiol 151 (2005) 1507-1523. The daptomycin gene cluster, spanning nearly 130 kb, was introduced into the heterologous host S. lividans to confirm the identity of the gene cluster.
    • (2005) Microbiol , vol.151 , pp. 1507-1523
    • Miao, V.1    Coëffet-LeGal, M.2    Brian, P.3    Brost, R.4    Penn, J.5    Whiting, A.6    Martin, S.7    Ford, R.8    Parr, I.9    Bouchard, M.10
  • 48
    • 15744370033 scopus 로고    scopus 로고
    • Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via Red/ET recombineering
    • 1, was produced in P. putida by piecing together the entire cluster in E. coli by using genetic recombination.
    • 1, was produced in P. putida by piecing together the entire cluster in E. coli by using genetic recombination.
    • (2005) Chem Biol , vol.12 , pp. 349-356
    • Wenzel, S.C.1    Gross, F.2    Zhang, Y.3    Fu, J.4    Stewart, F.5    Müller, R.6
  • 49
    • 11144303459 scopus 로고    scopus 로고
    • Biochemical analysis of the substrate specificity of the β-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase
    • Wu J., Kinoshita K., Khosla C., and Cane D.E. Biochemical analysis of the substrate specificity of the β-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase. Biochemistry 43 (2004) 16301-16310
    • (2004) Biochemistry , vol.43 , pp. 16301-16310
    • Wu, J.1    Kinoshita, K.2    Khosla, C.3    Cane, D.E.4
  • 50
    • 8344270313 scopus 로고    scopus 로고
    • Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase
    • Kim C., Alekseyev V.Y., Chen A.Y., Tang Y., Cane D.E., and Khosla C. Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase. Biochemistry 43 (2004) 13892-13898
    • (2004) Biochemistry , vol.43 , pp. 13892-13898
    • Kim, C.1    Alekseyev, V.Y.2    Chen, A.Y.3    Tang, Y.4    Cane, D.E.5    Khosla, C.6
  • 51
    • 24144485937 scopus 로고    scopus 로고
    • Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis
    • The cyclopropyl functionality of coronatine was shown to originate by the tandem action of two enzymes: a halogenase CmaB that introduces chlorine, and a previously unknown enzyme CmaC that forms the cyclopropyl ring with concomitant release of the chlorine.
    • Vaillancourt F.H., Yeh E., Vosburg D.A., O'Connor S.E., and Walsh C.T. Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis. Nature 436 (2005) 1191-1194. The cyclopropyl functionality of coronatine was shown to originate by the tandem action of two enzymes: a halogenase CmaB that introduces chlorine, and a previously unknown enzyme CmaC that forms the cyclopropyl ring with concomitant release of the chlorine.
    • (2005) Nature , vol.436 , pp. 1191-1194
    • Vaillancourt, F.H.1    Yeh, E.2    Vosburg, D.A.3    O'Connor, S.E.4    Walsh, C.T.5
  • 53
    • 20444496509 scopus 로고    scopus 로고
    • Functional analyses of oxygenases in jadomycin biosynthesis and identification of JadH as a bifunctional oxygenase/dehydrase
    • Chen Y., Wang C., Greenwell L., Rix U., Hoffmeister D., Vining L.C., Rohr J., and Yang K. Functional analyses of oxygenases in jadomycin biosynthesis and identification of JadH as a bifunctional oxygenase/dehydrase. J Biol Chem 280 (2005) 22508-22514
    • (2005) J Biol Chem , vol.280 , pp. 22508-22514
    • Chen, Y.1    Wang, C.2    Greenwell, L.3    Rix, U.4    Hoffmeister, D.5    Vining, L.C.6    Rohr, J.7    Yang, K.8
  • 54
    • 22144470117 scopus 로고    scopus 로고
    • An unexpected role for the putative 4′-phosphopantetheinyl transferase-encoding gene nysF in the regulation of nystatin biosynthesis in streptomyces noursei ATCC 11455
    • Volokhan O., Sletta H., Sekurova O.N., Ellingsen T.E., and Zotchev S.B. An unexpected role for the putative 4′-phosphopantetheinyl transferase-encoding gene nysF in the regulation of nystatin biosynthesis in streptomyces noursei ATCC 11455. FEMS Microbiol Lett 249 (2005) 57-64
    • (2005) FEMS Microbiol Lett , vol.249 , pp. 57-64
    • Volokhan, O.1    Sletta, H.2    Sekurova, O.N.3    Ellingsen, T.E.4    Zotchev, S.B.5
  • 55
    • 27844463580 scopus 로고    scopus 로고
    • Ablation of the otcC gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in streptomyces rimosus results in novel polyketides with altered chain length
    • Peric-Concha N., Borovicka B., Long P.F., Hranueli D., Waterman P.G., and Hunter I.S. Ablation of the otcC gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in streptomyces rimosus results in novel polyketides with altered chain length. J Biol Chem 280 (2005) 37455-37460
    • (2005) J Biol Chem , vol.280 , pp. 37455-37460
    • Peric-Concha, N.1    Borovicka, B.2    Long, P.F.3    Hranueli, D.4    Waterman, P.G.5    Hunter, I.S.6
  • 56
    • 4644242447 scopus 로고    scopus 로고
    • Antibacterial research and development in the 21st Century-an industry perspective of the challenges
    • Thomson C.J., Power E., Ruebsamen-Waigmann H., and Labischinski H. Antibacterial research and development in the 21st Century-an industry perspective of the challenges. Curr Opin Microbiol 7 (2004) 445-450
    • (2004) Curr Opin Microbiol , vol.7 , pp. 445-450
    • Thomson, C.J.1    Power, E.2    Ruebsamen-Waigmann, H.3    Labischinski, H.4
  • 57
    • 18344396306 scopus 로고    scopus 로고
    • Biochemical applications of mass spectrometry in pharmaceutical drug discovery
    • Geoghegan K.F., and Kelly M.A. Biochemical applications of mass spectrometry in pharmaceutical drug discovery. Mass Spectrom Rev 24 (2005) 347-366
    • (2005) Mass Spectrom Rev , vol.24 , pp. 347-366
    • Geoghegan, K.F.1    Kelly, M.A.2
  • 58
    • 27444438893 scopus 로고    scopus 로고
    • Chemoenzymatic approaches for streamlined detection of active site modifications on thiotemplate assembly lines using mass spectrometry
    • McLoughlin S.M., Mazur M.T., Miller L.M., Yin J., Liu F., Walsh C.T., and Kelleher N.L. Chemoenzymatic approaches for streamlined detection of active site modifications on thiotemplate assembly lines using mass spectrometry. Biochemistry 44 (2005) 14159-14169
    • (2005) Biochemistry , vol.44 , pp. 14159-14169
    • McLoughlin, S.M.1    Mazur, M.T.2    Miller, L.M.3    Yin, J.4    Liu, F.5    Walsh, C.T.6    Kelleher, N.L.7
  • 59
    • 1642453829 scopus 로고    scopus 로고
    • Mining the microbial metabolome: a new frontier for natural product lead discovery
    • Peric-Concha N., and Long P.F. Mining the microbial metabolome: a new frontier for natural product lead discovery. Drug Discov Today 8 (2003) 1078-1084
    • (2003) Drug Discov Today , vol.8 , pp. 1078-1084
    • Peric-Concha, N.1    Long, P.F.2
  • 60
    • 33644802711 scopus 로고    scopus 로고
    • A genome sequencing center in every lab
    • Zwick M.E. A genome sequencing center in every lab. Eur J Hum Genet 13 (2005) 1167-1168
    • (2005) Eur J Hum Genet , vol.13 , pp. 1167-1168
    • Zwick, M.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.