Computational design of an integrin I domain stabilized in the open high affinity conformation

Nature Structural Biology

Volumn 7, Issue 8, 2000, Pages 674-678

  Shimaoka, Motomu ^a   Shifman, Julia M ^b   Jing, Hua ^a   Takagi, Junichi ^a   Mayo, Stephen L ^b   Springer, Timothy A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN;

ARTICLE; CELL SURFACE; CONFORMATIONAL TRANSITION; CRYSTALLOGRAPHY; GENE MUTATION; LIGAND BINDING; MATHEMATICAL MODEL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN;

AMINO ACID SUBSTITUTION; BINDING SITES; CELL LINE; COMPLEMENT C3B; COMPUTER SIMULATION; DIMERIZATION; HUMANS; INTEGRINS; LIGANDS; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TRANSFECTION;

EID: 0033900165     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/77978     Document Type: Article

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